Research Topics
| ERIKA HOLZBAURSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Differential regulation of dynein and kinesin motor proteins by tauRam Dixit
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 319:1086-9. 2008..The differential modulation of dynein and kinesin motility suggests that MAPs can spatially regulate the balance of microtubule-dependent axonal transport...- Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neuronsLee A Ligon
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Neuroreport 16:533-6. 2005..Thus, inhibition of dynein/dynactin function may have a role in motor neuron degeneration in amyotrophic lateral sclerosis... - Dynein at odd angles?Adam G Hendricks
Adam G Hendricks, Jacob E Lazarus and Erika L F Holzbaur are in the Department of Physiology and the Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Nat Cell Biol 12:1126-8. 2010..New data on the effect of one such dynein mutation provide insight into the intramolecular communication and flexible stepping of this essential cellular motor... - Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosisErika L F Holzbaur
Department of Physiology, University of Pennsylvania School of Medicine, D400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104 6085, USA
Neurobiol Dis 23:697-707. 2006.... - Motor neurons rely on motor proteinsErika L F Holzbaur
University of Pennsylvania, D400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104 6085, USA
Trends Cell Biol 14:233-40. 2004..More broadly, cytoskeletal abnormalities might also be at the root of related disorders such as spinal muscular atrophy, supporting a key role for axonal transport in the pathogenesis of many neurodegenerative diseases... - Coordination of molecular motors: from in vitro assays to intracellular dynamicsErika L F Holzbaur
Pennsylvania Muscle Institute and Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States
Curr Opin Cell Biol 22:4-13. 2010..Together, these studies are providing new insights into the coordination of motors during intracellular transport... - Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degenerationBernadette H LaMonte
Department of Physiology, School of Medicine, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia 19104, USA
Neuron 34:715-27. 2002..In this report, we describe a mouse model that confirms the critical role of disrupted axonal transport in the pathogenesis of motor neuron degenerative disease... - A switch in retrograde signaling from survival to stress in rapid-onset neurodegenerationEran Perlson
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosci 29:9903-17. 2009..Hence, a shift from survival-promoting to death-promoting retrograde signaling may be key to the rapid onset of neurodegeneration seen in ALS... - Retrograde axonal transport: pathways to cell death?Eran Perlson
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19067, USA
Trends Neurosci 33:335-44. 2010..Defects in transport are sufficient to induce neurodegeneration, but recent progress suggests that changes in retrograde signaling pathways correlate with rapidly progressive neuronal cell death... - Axonal transport and neurodegenerative diseaseErica Chevalier-Larsen
University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6046, USA
Biochim Biophys Acta 1762:1094-108. 2006..Data linking disruption of axonal transport to diseases such as ALS are discussed. Finally, we explore the pathways that may cause neuronal dysfunction and death... - Cytoplasmic dynein/dynactin function and dysfunction in motor neuronsJennifer R Levy
University of Pennsylvania, D400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA
Int J Dev Neurosci 24:103-11. 2006..Recent progress in understanding the cellular mechanisms of dynein/dynactin function, and the effects of dynein/dynactin dysfunction has provided new insight into the roles of microtubule-based motility in the neuron... - Axonal transport: CDKs as traffic signals for motor-ists along the axon?ERIKA HOLZBAUR
University of Pennsylvania, School of Medicine, 3700 Hamilton Walk, Philadelphia, PA 19104 6085, USA
Curr Biol 20:R641-2. 2010..A screen for axonal cargo mislocalization in Caenorhabditis elegans neurons implicates the cyclin-dependent kinases CDK-5 and PCT-1 and the cyclin CCY-1 in the regulation of the microtubule motor cytoplasmic dynein... - Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactinErica S Chevalier-Larsen
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
Hum Mol Genet 17:1946-55. 2008.... - Huntingtin facilitates dynein/dynactin-mediated vesicle transportJuliane P Caviston
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 104:10045-50. 2007..Together these findings indicate that Htt binds to dynein and acts in a complex along with dynactin and Htt-associated protein-1 to facilitate vesicular transport... - Microtubule motors at the intersection of trafficking and transportJuliane P Caviston
Department of Physiology, University of Pennsylvania School of Medicine, D400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104-6085, USA
Trends Cell Biol 16:530-7. 2006..Here, we discuss this coordinated regulation of trafficking and transport, which provides a powerful mechanism for temporal and spatial control of cellular dynamics... - Regulation of dynactin through the differential expression of p150Glued isoformsRam Dixit
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 283:33611-9. 2008..Together, these studies provide further insight into the regulation of dynein-dynactin function in the cell... - Processive bidirectional motion of dynein-dynactin complexes in vitroJennifer L Ross
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Nat Cell Biol 8:562-70. 2006..The unique motility characteristics observed may reflect the flexibility of the dynein structure that leads to an enhanced ability to navigate around obstacles in the cell... - A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activityLee A Ligon
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
J Biol Chem 279:19201-8. 2004..There is also a vesicle population with both dynein and kinesin I bound that may be capable of bi-directional motility along cellular microtubules... - The interaction of neurofilaments with the microtubule motor cytoplasmic dyneinOliver I Wagner
Institute of Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
Mol Biol Cell 15:5092-100. 2004..Together these data suggest that a specific interaction between neurofilament subunit M and cytoplasmic dynein is involved in the saltatory bidirectional motility of neurofilaments undergoing axonal transport in the neuron... - A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregationJennifer R Levy
Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cell Biol 172:733-45. 2006..These data support a model in which a point mutation in p150Glued causes both loss of dynein/dynactin function and gain of toxic function, which together lead to motor neuron cell death... - PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contactSher Karki
Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085, USA
Mol Biol Cell 13:1722-34. 2002.... - The microtubule plus-end proteins EB1 and dynactin have differential effects on microtubule polymerizationLee A Ligon
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
Mol Biol Cell 14:1405-17. 2003..Differences in the expression and regulation of plus-end proteins in different cell types may underlie previously noted differences in microtubule dynamics... - Special delivery: dynamic targeting via cortical capture of microtubulesJennifer R Levy
University of Pennsylvania School of Medicine, D400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104, USA
Dev Cell 12:320-2. 2007..implicate microtubule tip tracking proteins in the trafficking of connexin43 to adherens junctions (Shaw et al., 2007). This finding suggests a mechanism for targeted delivery of membrane proteins by microtubule capture at the cortex... - Huntingtin as an essential integrator of intracellular vesicular traffickingJuliane P Caviston
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6085, USA
Trends Cell Biol 19:147-55. 2009..Here, we discuss current progress on the role of huntingtin in vesicular trafficking, focusing on the proposal that huntingtin might be a crucial regulator of organelle transport along the cellular cytoskeleton... - Microtubule plus-end tracking by CLIP-170 requires EB1Ram Dixit
Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 106:492-7. 2009..Together, our data provide insight into the mechanisms driving plus-end tracking by mammalian +TIPs and suggest that EB1 specifically recognizes the distinct lattice structure at the growing microtubule end... - Microtubule binding proteins CLIP-170, EB1, and p150Glued form distinct plus-end complexesLee A Ligon
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
FEBS Lett 580:1327-32. 2006..Based on these observations, we propose a model in which the formation of distinct plus-end complexes may differentially affect microtubule dynamics in vivo... - Kinesin and dynein-dynactin at intersecting microtubules: motor density affects dynein functionJennifer L Ross
Pennsylvania Muscle Institute and Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biophys J 94:3115-25. 2008..These results suggest that regulating the number of active dynein molecules could change a motile cargo into one that is anchored at an intersection, consistent with dynein's proposed transport and tethering functions in the cell... - Tangled NUDELs?Erika L F Holzbaur
Nat Cell Biol 6:569-70. 2004 - Mutant dynactin in motor neuron diseaseImke Puls
Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 33:455-6. 2003..Binding assays show decreased binding of the mutant protein to microtubules. Our results show that dysfunction of dynactin-mediated transport can lead to human motor neuron disease... - Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assemblyLee A Ligon
Department of Biology and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
Traffic 8:808-19. 2007....
Research Grants
- Dynamic Interactions of the CytoskeletonERIKA HOLZBAUR; Fiscal Year: 2007..abstract_text> ..
- The Interaction of Cytoplasmic Dynein and DynactinERIKA HOLZBAUR; Fiscal Year: 2007....
- Mechanistic analysis of axonal transport defects in motor neuron degenerative disERIKA HOLZBAUR; Fiscal Year: 2009....
- The Interaction of Cytoplasmic Dynein and DynactinERIKA HOLZBAUR; Fiscal Year: 2009....
- Mechanistic analysis of axonal transport defects in motor neuron degenerative disErika L Holzbaur; Fiscal Year: 2010....
- The Interaction of Cytoplasmic Dynein and DynactinERIKA HOLZBAUR; Fiscal Year: 2005..abstract_text> ..
- INTERACTION OF CYTOPLASMIC DYNEIN AND DYNACTINERIKA HOLZBAUR; Fiscal Year: 2001..Therefore, it is clear that we must continue to improve our understanding of these proteins and how they function both in normal and pathological cellular processes. ..
- The Interaction of Cytoplasmic Dynein and DynactinErika L Holzbaur; Fiscal Year: 2010....