Research Topics
| Irving F HoffmanSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Drug choice, spatial distribution, HIV risk, and HIV prevalence among injection drug users in St. Petersburg, RussiaGina Rae Kruse
Department of Epidemiology and Public Health and the Center for Interdisciplinary Research on AIDS, Yale School of Public Health, PO Box 208034, 60 College Street New Haven, CT 06520 8034 USA
Harm Reduct J 6:22. 2009..However, attention to neighborhood differences might improve the intervention impact for injectors who favor different drugs...- Nonoxynol-9 100 mg gel: multi-site safety study from sub-Saharan AfricaIrving F Hoffman
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
AIDS 18:2191-5. 2004..To evaluate the safety of 100 mg nonoxynol-9 (N-9) gel, a vaginal microbicide, on the genital mucosa of women from Malawi and Zimbabwe in preparation for a phase III efficacy study... - The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentrationI F Hoffman
University of North Carolina, Division of Infectious Diseases, Chapel Hill, USA
AIDS 13:487-94. 1999..This study was undertaken to determine the relative effect of malaria infection on HIV concentration in blood plasma, and prospectively to monitor viral concentrations after antimalarial therapy... - The year-long effect of HIV-positive test results on pregnancy intentions, contraceptive use, and pregnancy incidence among Malawian womenIrving F Hoffman
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
J Acquir Immune Defic Syndr 47:477-83. 2008.... - Morbidity and mortality among a cohort of human immunodeficiency virus type 1-infected and uninfected pregnant women and their infants from Malawi, Zambia, and TanzaniaDavid Chilongozi
University of North Carolina Project, Lilongwe, Malawi
Pediatr Infect Dis J 27:808-14. 2008..Morbidity and mortality patterns among pregnant women and their infants (before antiretroviral therapy was widely available) determines HIV-1 diagnostic, monitoring, and care interventions... - Human immunodeficiency virus type 1 RNA in breast-milk componentsIrving F Hoffman
Center for Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599 7030, USA
J Infect Dis 188:1209-12. 2003..Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk... - Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infectionChristopher D Pilcher
Center for Infectious Diseases, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7030, USA
AIDS 21:1723-30. 2007..This study was conducted to compare viral dynamics in blood and semen between subjects with antibody negative, acute HIV-1 infection and other subjects with later stages of infection... - Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithmKimberly A Powers
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
AIDS 21:2237-42. 2007..To facilitate the efficient use of these tests, we sought to develop a risk score algorithm for identifying likely AHI cases and targeting the tests towards those individuals... - The role of acute and early HIV infection in the spread of HIV and implications for transmission prevention strategies in Lilongwe, Malawi: a modelling studyKimberly A Powers
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7030, USA
Lancet 378:256-68. 2011..We estimated the contribution of early infection to HIV incidence in Lilongwe, Malawi, and predict the future effect of hypothetical prevention interventions targeted at early infection only, chronic infection only, or both stages... - HIV partner notification is effective and feasible in sub-Saharan Africa: opportunities for HIV treatment and preventionLillian B Brown
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7435, USA
J Acquir Immune Defic Syndr 56:437-42. 2011..However, many African countries do not have a standardized protocol for partner notification, and the effectiveness of partner notification has not been evaluated in developing countries ... - Sexual partnership patterns in malawi: implications for HIV/STI transmissionKimberly A Powers
Department s of Epidemiology, The University of North Carolina, Chapel Hill, NC 27599 7030, USA
Sex Transm Dis 38:657-66. 2011..To contribute to the understanding of sexual partnership patterns in this region, we estimated partnership lengths, temporal gaps between partners, and periods of overlap across partners at an STI clinic in Lilongwe, Malawi... - Impact of aciclovir on ulcer healing, lesional, genital and plasma HIV-1 RNA among patients with genital ulcer disease in MalawiSAM PHIRI
Lighthouse Centre, Kamuzu Central Hospital, Lilongwe, Malawi
Sex Transm Infect 86:345-52. 2010..By a randomised, double-blind, placebo-controlled trial of aciclovir 800 mg twice daily for 5 days added to the syndromic management of genital ulcer disease (GUD) to determine the impact on ulcer healing and HIV outcomes... - Trichomoniasis in men and HIV infection: data from 2 outpatient clinics at Lilongwe Central Hospital, MalawiMatthew A Price
School of Medicine, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7030, USA
J Infect Dis 190:1448-55. 2004..Among men presenting for care for symptomatic sexually transmitted infections (STIs) in Malawi, trichomoniasis is not considered for first-line treatment... - Neisseria gonorrhoeae antimicrobial susceptibility in Lilongwe, Malawi, 2007Lillian B Brown
Division of Infectious Diseases, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
Sex Transm Dis 37:169-72. 2010..We sought to establish current laboratory-based Neisseria gonorrhoeae antibiotic susceptibility patterns for Malawi and describe the pattern of susceptibility since syndromic management began... - Rapid, real-time detection of acute HIV infection in patients in AfricaSusan A Fiscus
Department of Microbiology and Immunology, University of North Carolina UNC at Chapel Hill, Chapel Hill, NC 27599 7290, USA
J Infect Dis 195:416-24. 2007..We conducted a prospective study to evaluate methods of detecting clients with sexually transmitted diseases (STDs) who were acutely coinfected with human immunodeficiency virus (HIV) in Lilongwe, Malawi... - Hospital-based injury data in Malawi: strategies for data collection and feasibility of trauma scoring toolsJonathan C Samuel
Department of Surgery, Kamuzu Central Hospital, Lilongwe, Malawi
Trop Doct 40:98-9. 2010.... - Frequent detection of acute primary HIV infection in men in MalawiChristopher D Pilcher
Departments of Medicine and Epidemiology at the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
AIDS 18:517-24. 2004..Alternative screening methods are required for diagnosis of acute HIV infection; such screening could be important for research and for prevention of the sexual transmission of HIV in select populations... - HIV-1 populations in blood and breast milk are similarGavin J Henderson
UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA
Virology 330:295-303. 2004..The absence of unique variants and the lack of significant differences in the relative abundance of variants between these compartments support the conclusion that viruses in the blood plasma and breast milk are well equilibrated... - Detection of acute HIV infection: a field evaluation of the determine® HIV-1/2 Ag/Ab combo testNora E Rosenberg
Departments of Epidemiology, University of North Carolina, Chapel Hill 27599, USA
J Infect Dis 205:528-34. 2012..In the absence of antibodies, p24 antigen and RNA typically indicate acute HIV infection. We conducted a field evaluation of the Determine® HIV-1/2 Ag/Ab Combo rapid test (Combo RT)... - Prevention of HIV-1 infection with early antiretroviral therapyMyron S Cohen
University of North Carolina at Chapel Hill, Institute for Global Health and Infectious Diseases, Suite 2115, Bioinformatics Bldg, 130 Mason Farm Rd, CB 7030, Chapel Hill, NC 27599, USA
N Engl J Med 365:493-505. 2011..Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples... - Use of nutritional and water hygiene packages for diarrhoeal prevention among HIV-exposed infants in Lilongwe, Malawi: an evaluation of a pilot prevention of mother-to-child transmission post-natal care serviceJiayin Xue
The University of North Carolina School of Medicine, Chapel Hill, NC, USA
Trop Med Int Health 15:1156-62. 2010..To evaluate a pilot prevention of mother-to-child transmission post-natal programme in Lilongwe, Malawi, through observed retention and infant diarrhoeal rates... - Bacterial infections in Lilongwe, Malawi: aetiology and antibiotic resistanceMwai H Makoka
National AIDS Commission, Lilongwe, Malawi
BMC Infect Dis 12:67. 2012..abstract:.. - Maternal or infant antiretroviral drugs to reduce HIV-1 transmissionCharles S Chasela
University of North Carolina Project, Lilongwe, Malawi
N Engl J Med 362:2271-81. 2010..We evaluated the efficacy of a maternal triple-drug antiretroviral regimen or infant nevirapine prophylaxis for 28 weeks during breast-feeding to reduce postnatal transmission of human immunodeficiency virus type 1 (HIV-1) in Malawi... - Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural MalawiPadmaja Patnaik
Department of Epidemiology, University of North Carolina at Chapel Hill, 27599, USA
J Infect Dis 192:984-91. 2005.... - Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research GroupM S Cohen
Department of Medicine, University of North Carolina, Chapel Hill 27599 7030, USA
Lancet 349:1868-73. 1997..We investigated the hypothesis that STDs increase the likelihood of transmission of HIV-1 through increased concentration of the virus in semen... - Selective screening for chlamydial infection: which criteria to use?W C Miller
Department of Medicine School of Medicine, University of North Carolina at Chapel Hill, USA
Am J Prev Med 18:115-22. 2000..In order to guide local programs in the choice of selective screening criteria, we examined the performance of previously proposed screening criteria for C. trachomatis... - Trends of gonorrhea and chlamydial infection during 1985-1996 among active-duty soldiers at a United States Army installationA C Seña
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
Clin Infect Dis 30:742-8. 2000..STDs continue to lead to significant morbidity in this representative military population... - Plasma HIV burden in Malawian children co-infected with rotavirusC Jere
Department of Microbiology, University of North Carolina, Chapel Hill, USA
AIDS 15:1439-42. 2001..Low CD4 cell counts, but not HIV-1-RNA concentrations, were predictive of Death. Local, enteric rotavirus infection did not appear to affect blood HIV viral load or CD4 cell counts in this small group of children... - Genotypic analysis of the protease and reverse transcriptase of HIV type 1 subtype C isolates from antiretroviral drug-naive adults in MalawiL A Petch
UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
AIDS Res Hum Retroviruses 21:799-805. 2005..Further studies will be needed to determine the clinical impact of these polymorphisms on viral susceptibility to existing antiretroviral drugs... - Addition of treatment for trichomoniasis to syndromic management of urethritis in Malawi: a randomized clinical trialMatthew A Price
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Sex Transm Dis 30:516-22. 2003..Such treatment should be strongly considered as part of empirical therapy for urethritis in men in Malawi and places where T vaginalis infection in men is common... - Epidemiology of injuries at a tertiary care center in MalawiJonathan C Samuel
Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA
World J Surg 33:1836-41. 2009..Injury surveillance is an ongoing process required for primary, secondary, and tertiary injury prevention. In Malawi, hospital-based injury data are not available... - Spatial distribution of HIV prevalence and incidence among injection drugs users in St Petersburg: implications for HIV transmissionRobert Heimer
Center for Interdisciplinary Research on AIDS, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
AIDS 22:123-30. 2008..Understanding the dynamics of the epidemic is important in developing appropriate responses in the resource-constrained context of Russian cities such as St Petersburg... - Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfectionTracy L Pisell
HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA
AIDS 16:1503-9. 2002.... - Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort studyJames G Kublin
Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
Lancet 365:233-40. 2005..To assess the effect of Plasmodium falciparum malaria on concentrations of HIV in blood, we did a prospective cohort study in Malawi... - HIV incidence and factors associated with HIV acquisition among injection drug users in St Petersburg, RussiaAndrei P Kozlov
Biomedical Center and St Petersburg State University, St Petersburg, Russia
AIDS 20:901-6. 2006..The Russian HIV-1 epidemic has been driven by injection drug use... - Correlates of syphilis seroreactivity among pregnant women: the HIVNET 024 Trial in Malawi, Tanzania, and ZambiaDara Potter
School of Public Health, University of Alabama at Birmingham, USA
Sex Transm Dis 33:604-9. 2006..Younger HIV-infected women were at highest risk. Universal integrated antenatal HIV and syphilis screening and treatment is essential in sub-Saharan African settings... - HIV prevalence, sociodemographic, and behavioral correlates and recruitment methods among injection drug users in St. Petersburg, RussiaAlla V Shaboltas
The Biomedical Center and St Petersburg State University, 7 Pudozhskaya Street, St Petersburg, 197110 Russia
J Acquir Immune Defic Syndr 41:657-63. 2006.... - A phase III clinical trial of antibiotics to reduce chorioamnionitis-related perinatal HIV-1 transmissionTaha E Taha
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
AIDS 20:1313-21. 2006..A multisite study was conducted in Africa to assess the efficacy of antibiotics to reduce mother-to-child transmission (MTCT) of HIV-1... - Distribution of the CCR5 gene 32-base pair deletion and CCR5 expression in Chinese minoritiesTao Feng
Department of Clinical Immunology, Peking Union Medical College Hospital, Beijing, People's Republic of China
J Acquir Immune Defic Syndr 32:131-4. 2003..CCR5 expression appears to be greater in the Dai minority than in the other minorities investigated. The mechanism for this increased expression requires further study... - Syphilis management in St. Petersburg, Russia: 1995-2001Andrew Yakubovsky
Department of Dermatology and Venereal Diseases, Pavlov State Medical University, St. Petersburg, Russia
Sex Transm Dis 33:244-9. 2006..4 mu benzathine penicillin intramuscularly weekly for 3 weeks should be introduced as the standard of care for late syphilis. The efficacy of the locally manufactured bicillin-1 and bicillin-5 is in question...