Research Topics
| ERIC ALFRED HOFFMANSummaryAffiliation: University of Iowa Country: USA Publications
Research Grants
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Detail Information
Publications
Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigationMichael H Cho
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
Respir Res 11:30. 2010..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity...- State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary diseaseEric A Hoffman
Department of Radiology, University of Iowa, 200 Hawkins Drive, CC701 GH, Iowa City, 52242, USA
Proc Am Thorac Soc 3:519-32. 2006.... - Computed tomography studies of lung ventilation and perfusionEric A Hoffman
Department of Radiology, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52240, USA
Proc Am Thorac Soc 2:492-8, 506. 2005..These dynamic CT methods for the study of regional lung function are discussed in the context of other methods that have been used to study heterogeneity of lung function... - The comprehensive imaging-based analysis of the lung: a forum for team scienceEric A Hoffman
Department of Radiology, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242, USA
Acad Radiol 11:1370-80. 2004 - Atlas-driven lung lobe segmentation in volumetric X-ray CT imagesLi Zhang
University of Iowa, Iowa City, IA 52242, USA
IEEE Trans Med Imaging 25:1-16. 2006..96 +/- 0.71 mm and the mean of the similarity indices between the manually defined and computer-defined lobe regions is 0.988. The results indicate a strong agreement between the automatic and manual lobe segmentations... - Differences in regional wash-in and wash-out time constants for xenon-CT ventilation studiesDeokiee Chon
Departments of Radiology and Biomedical Engineering, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Respir Physiol Neurobiol 148:65-83. 2005.... - Intrathoracic airway trees: segmentation and airway morphology analysis from low-dose CT scansJuerg Tschirren
Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA 52240, USA
IEEE Trans Med Imaging 24:1529-39. 2005..Measurements are conducted in the original gray-level volume. Validation on a phantom shows that subvoxel accuracy is achieved for all airway sizes and airway orientations... - Matching and anatomical labeling of human airway treeJuerg Tschirren
Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA 52240, USA
IEEE Trans Med Imaging 24:1540-7. 2005..92.9% of the verifiable branchpoint matches found by the computer agree with experts' results. For anatomical labeling, 97.1% of the automatically assigned segment labels were found to be correct... - MDCT-based 3-D texture classification of emphysema and early smoking related lung pathologiesYe Xu
Iowa Comprehension Lung Imaging Center, University of Iowa, Iowa City, IA 52240, USA
IEEE Trans Med Imaging 25:464-75. 2006..Furthermore, our results suggest that the 3-D AMFM may provide a means of discriminating subtle differences between smokers and nonsmokers both with normal PFTs... - Macro-optical color assessment of the pulmonary airways with subsequent three-dimensional multidetector-x-ray-computed-tomography assisted displayMelissa Suter
University of Iowa Hospitals and Clinics, Department of Internal Medicine, Iowa City, Iowa 52242, USA
J Biomed Opt 10:051703. 2005..The resulting 3-D true-color images of the pulmonary mucosa facilitate the combination of mucosal color and topography analysis as well as region of interest localization within the airway tree... - A new method for spherical object detection and its application to computer aided detection of pulmonary nodules in CT imagesXiangwei Zhang
University of Iowa, Iowa City, IA 52242, USA
Med Image Comput Comput Assist Interv 10:842-9. 2007..The proposed method was applied to computer aided detection of pulmonary nodules based on helical CT images. Experiments showed that this method attained a better performance compared to the original normal overlap technique... - Effect of low-xenon and krypton supplementation on signal/noise of regional CT-based ventilation measurementsDeokiee Chon
Department of Radiology, University of Iowa, Iowa City, Iowa 52242, USA
J Appl Physiol 102:1535-44. 2007..The 30% Xe/30% Kr mixture was comparable to that of 40% Xe, providing an important agent for CT-based assessment of regional ventilation in humans... - Automated detection of small-size pulmonary nodules based on helical CT imagesXiangwei Zhang
Dept. of Electrical Engineering, University of Iowa, Iowa City, IA 52242, USA
Inf Process Med Imaging 19:664-76. 2005..This showed that the proposed CAD system acted effectively as an assistant for human experts to detect small nodules and provided a "second opinion" to human observers... - The effects of geometry on airflow in the acinar region of the human lungHaribalan Kumar
Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, Iowa, USA
J Biomech 42:1635-42. 2009..The flow in the terminal alveolar sac is non-recirculating and not affected by variation in geometrical features... - Characteristics of airflow in a CT-based ovine lung: a numerical studySenthil Kabilan
Department of Radiology, The University of Iowa, Iowa City, IA 52242, USA
J Appl Physiol 102:1469-82. 2007..This work may contribute to understanding the interplay between structure and function in the lung... - The Lung Image Database Consortium (LIDC): an evaluation of radiologist variability in the identification of lung nodules on CT scansSamuel G Armato
The University of Chicago, Department of Radiology, MC 2026, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
Acad Radiol 14:1409-21. 2007.... - Regional pulmonary blood flow in dogs by 4D-X-ray CTDeokiee Chon
Department of Radiology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
J Appl Physiol 101:1451-65. 2006..We conclude that PBFgm distribution was posture dependent in RL but not LL. Support of the heart may play a role. We demonstrate that normalization factors can lead to differing attributions of gravitational effects on PBF heterogeneity... - Registration-derived estimates of local lung expansion as surrogates for regional ventilationJoseph M Reinhardt
Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
Inf Process Med Imaging 20:763-74. 2007..We compare lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation, and have shown good agreement (linear regression, r2 = 0.89 during gas wash-in) in one animal... - Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airwaysChing Long Lin
Department of Mechanical and Industrial Engineering, The University of Iowa, Iowa City, IA 52242, USA
Respir Physiol Neurobiol 157:295-309. 2007..Thus, airflow modeling, particularly subject specific evaluations, should consider upper as well as intra-thoracic airway geometry... - Static versus prospective gated non-breath hold volumetric MDCT imaging of the lungsOsama I Saba
Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
Acad Radiol 12:1371-84. 2005..High-resolution volumetric image data sets are achievable while the scanned subject is breathing. Images are quantitatively similar to breath hold images, with differences likely explained by known pressure-volume hysteresis effects... - Longitudinal assessment of lung cancer progression in the mouse using in vivo micro-CT imagingEman Namati
Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide 5042, Australia
Med Phys 37:4793-805. 2010..Furthermore, no standard mouse lung imaging protocols exist for longitudinal assessment, with each group needing to develop their own systematic approach... - Lung lobar slippage assessed with the aid of image registrationYoubing Yin
Department of Mechanical and Industrial Engineering The University of Iowa, Iowa City, IA 52242, USA
Med Image Comput Comput Assist Interv 13:578-85. 2010..The capability of this new method is demonstrated using two-dimensional (2-D) synthetic examples with complete or incomplete "fissures" and three-dimensional (3-D) computed tomography (CT) lung datasets... - Evaluation of lobar biomechanics during respiration using image registrationKai Ding
Department of Biomedical Engineering, The University of Iowa, Iowa City, IA 52242, USA
Med Image Comput Comput Assist Interv 12:739-46. 2009..The results show a superior-inferior gradient in the magnitude of lobar sliding. We compare whole-lung-based registration accuracy to lobe-by-lobe registration accuracy using vessel bifurcation landmarks... - Establishing a normative atlas of the human lung: intersubject warping and registration of volumetric CT imagesBaojun Li
Department of Biomedical Engineering, University of Iowa, 1402 SC, Iowa City, IA 52242, USA
Acad Radiol 10:255-65. 2003.... - Computer-aided classification of interstitial lung diseases via MDCT: 3D adaptive multiple feature method (3D AMFM)Ye Xu
Department of Radiology, University of Iowa, CC701, General Hospital, Iowa City, IA 52242, USA
Acad Radiol 13:969-78. 2006..Additionally, support vector machine and Bayesian methods are comparable classifiers for characterization of interstitial lung diseases on MDCT images... - Segmentation and analysis of the human airway tree from three-dimensional X-ray CT imagesDeniz Aykac
Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
IEEE Trans Med Imaging 22:940-50. 2003..Compared to manual analysis on 3-mm-thick electron-beam CT images, the automatic approach has an overall airway branch detection sensitivity of approximately 73%... - Topomorphologic separation of fused isointensity objects via multiscale opening: separating arteries and veins in 3-D pulmonary CTPunam K Saha
Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA 52242, USA
IEEE Trans Med Imaging 29:840-51. 2010..Our method is very promising for semiautomated separation of arteries and veins in pulmonary CT images even when there is no object-specific intensity variation at conjoining locations... - Mass preserving nonrigid registration of CT lung images using cubic B-splineYoubing Yin
Department of Mechanical and Industrial Engineering, and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242, USA
Med Phys 36:4213-22. 2009..Over 100 annotated landmarks located at vessel bifurcations were generated using a semiautomatic system. The results show that the SSTVD method yields smaller average landmark errors than the SSD method across all six registration pairs... - Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilationJoseph M Reinhardt
Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
Med Image Anal 12:752-63. 2008..Using 3D image registration to match images acquired at 10 cm H(2)O and 15 cm H(2)O airway pressures gave the best match between the average Jacobian and the xenon CT specific ventilation (linear regression, average r(2)=0.73)... - Functional imaging: CT and MRIEdwin J R van Beek
Department of Radiology, Carver College of Medicine, University of Iowa, C 751 GH, 200 Hawkins Drive, Iowa City, IA 52242 1077, USA
Clin Chest Med 29:195-216, vii. 2008.... - The use of MDCT-based computer-aided pathway finding for mediastinal and perihilar lymph node biopsy: a randomized controlled prospective trialGeoffrey McLennan
Pulmonary Division, Department of MedicineUniversity of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
Respiration 74:423-31. 2007.... - Evaluation of lung MDCT nodule annotation across radiologists and methodsCharles R Meyer
Department of Radiology, School of Medicine, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
Acad Radiol 13:1254-65. 2006..Thus assessing the source of variability in defining the spatial location of lung nodules by expert radiologists using different software tools as an alternative form of truth is necessary... - Heterogeneity of pulmonary perfusion as a mechanistic image-based phenotype in emphysema susceptible smokersSara K Alford
Departmentsof Radiology, University of Iowa, Iowa City, IA 52242, USA
Proc Natl Acad Sci U S A 107:7485-90. 2010..These findings demonstrate a functional lung-imaging measure that provides a more mechanistically oriented phenotype that differentiates smokers with and without evidence of emphysema susceptibility... - Characterization of the interstitial lung diseases via density-based and texture-based analysis of computed tomography images of lung structure and functionEric A Hoffman
Department of Radiology, University of Iowa, Iowa City, IA, USA
Acad Radiol 10:1104-18. 2003..Furthermore, there is the growing need for scanner manufacturers to focus on not just visually pleasing images, but on quantitatifiably accurate images... - Maximizing quantitative accuracy of lung airway lumen and wall measures obtained from X-ray CT imagingOsama I Saba
Department of Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA
J Appl Physiol 95:1063-75. 2003.... - Segmentation and quantitative analysis of intrathoracic airway trees from computed tomography imagesJuerg Tschirren
Department of Electrical and Computer Engineering, 4016 SC, University of Iowa, Iowa City, IA 52242, USA
Proc Am Thorac Soc 2:484-7, 503-4. 2005..Validation on a phantom shows that subvoxel accuracy is achieved for all airway sizes and airway orientations. The utility of the reported method is demonstrated in a comparative analysis of normal and cystic fibrosis airway trees... - The effect of maxillary sinus antrostomy size on xenon ventilation in the sheep modelKevin T Brumund
Department of Otolarygology-Head and Neck Surgery, University of Iowa, Iowa City, USA
Otolaryngol Head Neck Surg 131:528-33. 2004..No significant further ventilation increase is obtained by creating a large antrostomy in the sheep model. This lends credence to the use of small antrostomies to improve maxillary sinus ventilation in human sinus surgery... - Imaging of pulmonary embolism and t-PA therapy effects using MDCT and liposomal iohexol blood pool agent: preliminary results in a rabbit modelStephen J Burke
Department of Radiology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA, USA
Acad Radiol 14:355-62. 2007..Also, visualization of the (real-time) therapeutic effects of tissue plasminogen activator (t-PA) on pulmonary embolism (PE) was attempted... - Lung image database consortium: developing a resource for the medical imaging research communitySamuel G Armato
Department of Radiology, MC 2026, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
Radiology 232:739-48. 2004..This article is intended to share with the community the breadth and depth of these key issues... - CT-based assessment of regional pulmonary microvascular blood flow parametersChulho Won
Department of Radiology, University of Iowa, Iowa City, Iowa 52241, USA
J Appl Physiol 94:2483-93. 2003..We conclude that deconvolution methods, in association with electrocardiogram-gated high-speed X-ray computed tomography, can provide insights into regional heterogeneity of pulmonary microvascular MTT in vivo... - Use of 3-dimensional computed tomography reconstruction studies in the preoperative assessment of patients undergoing balloon dilatation for tracheobronchial stenosisCyril P Rooney
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Respiration 72:579-86. 2005..CONCLUSIONS: 3D-CT offers accurate definition of TBS, including anatomic location, number of lesions present and status of airway distal to lesion. In this study, all preoperative lesions were correctly identified prior to BD... - Reproducibility and validity of lung density measures from cardiac CT Scans--The Multi-Ethnic Study of Atherosclerosis (MESA) Lung StudyEric A Hoffman
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, USA
Acad Radiol 16:689-99. 2009..The reproducibility of lung density measures from cardiac computed tomography and their validity compared to lung density measures from full-lung scans is unknown... - A process model for direct correlation between computed tomography and histopathology application in lung cancerJessica C Sieren
Department of Internal Medicine, C325 GH, University of Iowa, Iowa City, IA 55242, USA
Acad Radiol 17:169-80. 2010..In the past, the incorporation of histopathology into these multimodal datasets has been complicated by the large differences in image quality, content, and spatial association... - Advanced emphysema in African-American and white patients: do differences exist?Wissam M Chatila
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, USA
Chest 130:108-18. 2006..Epidemiologic studies have not addressed, nor explained, the observed racial differences in emphysema... - Regional pulmonary blood flow in humans and dogs by 4D computed tomographyJonathan H Dakin
Imperial College of Science, Technology and Medicine, Unit of Critical Care, National Heart and Lung Institute, Royal Brompton Hospital, Dovehouse St, London SW3 6LY UK
Acad Radiol 15:844-52. 2008..Pulmonary vascular control mechanisms are complex and likely to differ between species. We wish to quantify regional perfusion and the effects of gravity using computed tomography... - CT-based geometry analysis and finite element models of the human and ovine bronchial treeMerryn H Tawhai
Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
J Appl Physiol 97:2310-21. 2004..The resulting models are subject-specific computational meshes with anatomically consistent geometry, suitable for application in simulation studies... - Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanicsGeorge R Washko
Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, Massachusetts 02115, USA
COPD 5:177-86. 2008..The CT based quantification of emphysema may augment pulmonary function testing in the characterization of COPD by providing complementary phenotypic information... - Three-dimensional human airway segmentation methods for clinical virtual bronchoscopyAtilla P Kiraly
Department of Computer Science and Engineering, Penn State University, PA, USA
Acad Radiol 9:1153-68. 2002..The times required for all segmentations were acceptable, and the results were suitable for the authors' VB application needs... - CT-measured regional specific volume change reflects regional ventilation in supine sheepMatthew K Fuld
Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Appl Physiol 104:1177-84. 2008..Regional sVol, which involves significantly reduced exposure to radiation and Xe gas compared with the Xe-CT method, represents a safe and efficient surrogate for measuring regional ventilation in experimental studies and patients... - Subsecond multisection CT of regional pulmonary ventilationJehangir K Tajik
Department of Physiology, University of Iowa College of Medicine, Iowa City 52242, USA
Acad Radiol 9:130-46. 2002..CONCLUSION: With careful attention to lung volume and use of cardiac gating, it is now possible to correlate lung structure with function to a degree heretofore not possible... - Mechanism of hypoxemia in acute lung injury evaluated by multidetector-row CTR Blaine Easley
Department of Anesthesiology and Critical Care Medicine, Blalock 941, Johns Hopkins Hospital, 600 N Wolfe Street, The Johns Hopkins University, Baltimore, MD 21287 8711, USA
Acad Radiol 13:916-21. 2006..We present the use of computed tomographic (CT) volume and perfusion imaging to show differences in the mechanisms of hypoxemia from alterations in blood flow distribution within different animal models of acute lung injury (ALI)... - Computational models of structure-function relationships in the pulmonary circulation and their validationMerryn H Tawhai
Bioengineering Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand
Exp Physiol 91:285-93. 2006..Validation of such predictions against measures from functional imaging holds significant potential for explaining and differentiating normal and disease-related heterogeneity in regional blood flow calculated using perfusion imaging... - An imaging-based computational approach to model ventilation distribution and soft-tissue deformation in the ovine lungMerryn H Tawhai
Bioengineering Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand
Acad Radiol 13:113-20. 2006..The aim of this approach is to enable predictions of the effect of perturbations in geometry or functional parameters on imaged function of the lung... - Effective population sizes and temporal stability of genetic structure in Rana pipiens, the northern leopard frogEric A Hoffman
3029 Cordley Hall, Oregon State University, Department of Zoology, Corvallis, Oregon 97331, USA
Evolution 58:2536-45. 2004..The method may be more sensitive to choice of source frequencies than was previously appreciated, and so should be used with caution if the most likely source of immigrants cannot be identified clearly... - Influence of gravity on radiographic contrast material-based measurements of regional blood flow distributionAnne V Clough
Department of Mathematics, Statistics and Computer Science Marquette University, Milwaukee, Wis, USA
Acad Radiol 10:128-38. 2003.... - Long-residence-time nano-scale liposomal iohexol for X-ray-based blood pool imagingChen-Yu Kao
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
Acad Radiol 10:475-83. 2003..Future experiments with long-residence-time iohexol formulations may lead eventually to applications in cardiac imaging and in early tumor detection... - Genetic variation of the beta2-adrenergic receptor is associated with differences in lung fluid accumulation in humansEric M Snyder
Department of Internal Medicine, Mayo Clinic College of Medicine, 200 1st St, SW, Rochester, MN 55905, USA
J Appl Physiol 102:2172-8. 2007..Gly16, respectively, means+/-SD). These data suggest that subjects homozygous for Arg at amino acid 16 of the beta2AR have a greater susceptibility for lung fluid accumulation relative to subjects homozygous for Gly at this position... - Predictors of operative mortality and cardiopulmonary morbidity in the National Emphysema Treatment TrialKeith S Naunheim
Division of Cardiothoracic Surgery, St Louis University Health Sciences Center, St Louis, Mo 63110 0250, USA
J Thorac Cardiovasc Surg 131:43-53. 2006..We sought to identify predictors of operative mortality, pulmonary morbidity, and cardiovascular morbidity after lung volume reduction surgery... - An analysis of selection on a colour polymorphism in the northern leopard frogEric A Hoffman
Department of Biology, University of Central Florida, Orlando, Florida 32816, USA
Mol Ecol 15:2627-41. 2006..This study illustrates the importance of using a locus comparison approach to detect evidence for selective maintenance before conducting studies to measure the selective mechanisms maintaining a polymorphism... - Genetic determinants of emphysema distribution in the national emphysema treatment trialDawn L DeMeo
Channing Laboratory, Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 176:42-8. 2007.... - Sex differences in severe pulmonary emphysemaFernando J Martinez
University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan 48109 0360, USA
Am J Respir Crit Care Med 176:243-52. 2007..Limited data on sex differences in advanced COPD are available... - A mouse optical simulation environment (MOSE) to investigate bioluminescent phenomena in the living mouse with the Monte Carlo methodHui Li
Medical Image Processing Group, Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Science, Beijing, China
Acad Radiol 11:1029-38. 2004..With graduate refinements and enhancements, it is hoped that the MOSE will become a standard tool for bioluminescence tomography... - Hyperpolarized media MR imaging--expanding the boundaries?Eric A Hoffman
Acad Radiol 13:929-31. 2006
Research Grants
- Quantitative CT-Based Lung Atlas of the MouseEric Hoffman; Fiscal Year: 2007....
- Image and Model Based Analysis of Lung DiseasesEric Hoffman; Fiscal Year: 2007..Construct and evaluate population-specific atlases (smokers,COPD, experimental emphysema) to detect deviations from normal; 5: Maintain these atlases/models in the public domain through our open source MIFAR project. ..
- Image and Model Based Analysis of Lung DiseasesEric Hoffman; Fiscal Year: 2009..Construct and evaluate population-specific atlases (smokers,COPD, experimental emphysema) to detect deviations from normal; 5: Maintain these atlases/models in the public domain through our open source MIFAR project. ..
- Micro CT for Variable Spatial-Temporal ResolutionEric Hoffman; Fiscal Year: 2004..The well-qualified staff will provide technical assistance and necessary training. ..
- IMAGE AND MODEL BASED ANALYSIS OF LUNG DISEASEEric Hoffman; Fiscal Year: 2003..abstract_text> ..
- INFLAMMATORY PARENCHYMAL LUNG DISEASE STRUCTURE/FUNCTIONEric Hoffman; Fiscal Year: 2003..In the human population, without such measures of pathophysiology and outcomes, other mechanistic studies and tests of newly emerging interventions have not and will not be practically achievable. ..
- Quantitative CT-Based Lung Atlas of the MouseERIC ALFRED HOFFMAN; Fiscal Year: 2010....