John G Hodgson

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions
    Clifford L Wang
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414, USA
    Retrovirology 1:5. 2004
  2. ncbi Mammary carcinoma behavior is programmed in the precancer stem cell
    Patrizia Damonte
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
    Breast Cancer Res 10:R50. 2008
  3. ncbi miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008
  4. ncbi Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts
    J Graeme Hodgson
    Dept of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 11:477-87. 2009
  5. ncbi Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling
    J Graeme Hodgson
    Department of Laboratory Medicine and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA
    Cancer Res 65:9695-704. 2005
  6. ncbi Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8
    Chibo Hong
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143 0875, USA
    Cancer Res 65:3617-23. 2005
  7. ncbi microRNAs in gliomas: small regulators of a big problem
    Joachim Silber
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 92121, USA
    Neuromolecular Med 11:208-22. 2009
  8. ncbi Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging
    Ramon F Barajas
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Long L200B, Box 0628, San Francisco, CA 94143, USA
    Radiology 254:564-76. 2010
  9. ncbi Oncogene expression and genetic background influence the frequency of DNA copy number abnormalities in mouse pancreatic islet cell carcinomas
    Jeffrey H Hager
    Department of Biochemistry, University of California at San Francisco Diabetes and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer Res 64:2406-10. 2004
  10. ncbi The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis
    Emmy W Verschuren
    Comprehensive Cancer Center and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA
    Cancer Res 64:581-9. 2004

Research Grants

  1. Discovery and characterization of breast cancer genes
    John Hodgson; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. ncbi A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions
    Clifford L Wang
    Department of Microbiology and Immunology, University of California, San Francisco 94143 0414, USA
    Retrovirology 1:5. 2004
    ..This provirus can delete its envelope gene by LoxP/Cre mediated recombination and thereby allow superinfection of Cre recombinase expressing cells...
  2. ncbi Mammary carcinoma behavior is programmed in the precancer stem cell
    Patrizia Damonte
    Department of Pathology and Laboratory Medicine, Center for Comparative Medicine, UC Davis, County Road 98 and Hutchison Drive, Davis, California 95616, USA
    Breast Cancer Res 10:R50. 2008
    ..Transition to carcinoma has a consistent latency for each line, and three of the lines also exhibit pulmonary metastatic potential...
  3. ncbi miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008
    ..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells...
  4. ncbi Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts
    J Graeme Hodgson
    Dept of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 11:477-87. 2009
    ....
  5. ncbi Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling
    J Graeme Hodgson
    Department of Laboratory Medicine and Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA
    Cancer Res 65:9695-704. 2005
    ..Our studies highlight loci and genes important in the regulation of tumorigenic RTK signaling in mammary epithelial cells in vivo...
  6. ncbi Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8
    Chibo Hong
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143 0875, USA
    Cancer Res 65:3617-23. 2005
    ..The shared epigenetic inactivation of mSLC5A8 in mouse gliomas indicates an additional degree of commonality in the origin and/or pathway to tumorigenesis between primary human tumors and these mouse models of gliomas...
  7. ncbi microRNAs in gliomas: small regulators of a big problem
    Joachim Silber
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 92121, USA
    Neuromolecular Med 11:208-22. 2009
    ..This is a rapidly evolving field and it is likely that we have only begun to appreciate the involvement of microRNAs in relation to glioma formation, and the therapeutic potential of microRNAs to improve outcome for glioma patients...
  8. ncbi Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging
    Ramon F Barajas
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Long L200B, Box 0628, San Francisco, CA 94143, USA
    Radiology 254:564-76. 2010
    ..To determine whether magnetic resonance (MR) imaging is influenced by genetic and cellular features of glioblastoma multiforme (GBM) aggressiveness...
  9. ncbi Oncogene expression and genetic background influence the frequency of DNA copy number abnormalities in mouse pancreatic islet cell carcinomas
    Jeffrey H Hager
    Department of Biochemistry, University of California at San Francisco Diabetes and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer Res 64:2406-10. 2004
    ..These studies illustrate the utility of transgenic animal models for investigation of factors influencing genomic heterogeneity despite the commonalty of target cell type and initiating oncogene...
  10. ncbi The role of p53 in suppression of KSHV cyclin-induced lymphomagenesis
    Emmy W Verschuren
    Comprehensive Cancer Center and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, USA
    Cancer Res 64:581-9. 2004
    ..Together, our data support a model in which K cyclin-induced genome instability arises early in the pre-tumorigenic lymphocyte population and that loss of p53 licenses subsequent expansion of tumorigenic clones...
  11. ncbi Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors
    Christopher S Hackett
    Department of Neurology, University of California, San Francisco, California 94143-0114, USA
    Cancer Res 63:5266-73. 2003
    ..These data demonstrate conservation of many genetic changes in murine and human neuroblastoma and suggest that further delineation of genetic abnormalities in murine tumors may identify genes important in human disease...
  12. ncbi Genome amplification of chromosome 20 in breast cancer
    J Graeme Hodgson
    Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA
    Breast Cancer Res Treat 78:337-45. 2003
    ....
  13. ncbi Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior
    Alexander D Borowsky
    Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
    Clin Exp Metastasis 22:47-59. 2005
    ..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery...
  14. ncbi Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability
    Peter C Scacheri
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-2152, USA
    Cancer Res 64:7039-44. 2004
    ..Thus, the somatic genetic changes that are postulated to lead to tumorigenesis in a mouse model of MEN1 must be unusually subtle, occurring at either the nucleotide level or through epigenetic mechanisms...
  15. ncbi Induction of tumors in mice by genomic hypomethylation
    François Gaudet
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Science 300:489-92. 2003
    ..These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability...

Research Grants2

  1. Discovery and characterization of breast cancer genes
    John Hodgson; Fiscal Year: 2007
    ..Finally, effects on in vivo tumorigenic potential will be assessed by evaluating tumor growth in immunedeficient mice. ..