Research Topics
Genomes and Genes | Sunil R HingoraniSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in miceSunil R Hingorani
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Cell 7:469-83. 2005..These findings have clear implications for understanding mechanisms of disease pathogenesis, and for the development of detection and targeted treatment strategies...- Ras redux: rethinking how and where Ras actsSunil R Hingorani
Abramson Family Cancer Research Institute, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Curr Opin Genet Dev 13:6-13. 2003..Recent findings have provided new and unexpected insights into the predominant pathways Ras employs to transform human cells and the subcellular platforms from which it can act... - N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruptionTherese B Deramaudt
Gastroenterology Division, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104 2144, USA
Mol Cell Biol 26:4185-200. 2006..Thus, we are able to define molecules that in part are directly affected by Ki-RAS and p53 during pancreatic ductal carcinogenesis, and this provides a platform for potential new molecularly based therapeutic interventions... - In search of an early warning system for pancreatic cancerSunil R Hingorani
Departments of Cancer Biology and Medicine, Abromson Family Cancer Research Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Cancer Biol Ther 2:84-6. 2003 - Targeting oncogene dependence and resistanceSunil R Hingorani
Abramson Family Cancer Research Institute, Abramson Cancer Center of the University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia 19104, USA
Cancer Cell 3:414-7. 2003..Recent findings reveal several mechanisms of resistance and suggest ways to overcome them... - New pathways to pancreatic cancerSunil R Hingorani
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center, 421 Curie Blvd, 521 BRB II/III, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 3:170-2. 2004 - Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defectsDavid A Tuveson
Abramson Family Cancer Research Institute, Abramson Cancer Center and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
Cancer Cell 5:375-87. 2004..Our results suggest that endogenous oncogenic ras is sufficient to initiate transformation by stimulating proliferation, while further genetic lesions may be necessary for progression to frank malignancy... - Dynamics of the immune reaction to pancreatic cancer from inception to invasionCAROLYN E CLARK
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Cancer Res 67:9518-27. 2007..Efforts to test potent inhibitors of MDSC, tumor-associated macrophages, and Treg, particularly early in the disease represent important next steps for developing novel immunotherapy of cancer... - Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouseSunil R Hingorani
Department of Medicine, Abramson Family Cancer Research Institute, Abramson Center at the University of Pennsylvania, Philadelphia, PA 19104, USA
Cancer Cell 4:437-50. 2003..Finally, mice with PanINs have an identifiable serum proteomic signature, suggesting a means of detecting the preinvasive state in patients... - ATP citrate lyase inhibition can suppress tumor cell growthGeorgia Hatzivassiliou
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Cancer Cell 8:311-21. 2005..ACL inhibition by RNAi or the chemical inhibitor SB-204990 limits in vitro proliferation and survival of tumor cells displaying aerobic glycolysis. The same treatments also reduce in vivo tumor growth and induce differentiation... - Detecting and diagnosing ampullary neoplasmsLi-Fu Wang
Departments of Cancer Biology and Medicine, Abramson Family Cancer Research Institute, The Abramson Cancer Center at the University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 3:657-9. 2004 - A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxelKeith T Flaherty
The Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Cancer Res 14:4836-42. 2008..Pharmacokinetic analyses were done for sorafenib on days 2 and 19 of cycle 1 and for paclitaxel on day 1 of cycles 1 and 2. Pretreatment tumor samples from 17 melanoma patients were analyzed for BRAF mutations... - Suppression of BRAF(V599E) in human melanoma abrogates transformationSunil R Hingorani
Abramson Family Cancer Research Institute at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 63:5198-202. 2003..Thus, when present, BRAF(V599E) appears to be essential for melanoma cell viability and transformation and, therefore, represents an attractive therapeutic target in the majority of melanomas that harbor the mutation... - Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreasKamel Izeradjene
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Cell 11:229-43. 2007..Our findings suggest that the sequence, as well as the context, in which these critical mutations are acquired helps determine the ensuing pathology... - The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progressionRyan M Thomas
Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Cancer Res 67:6075-82. 2007..Taken together, these findings suggest that RON receptor signaling may contribute to pancreatic carcinogenesis, and that further investigation is warranted to assess the potential of RON-directed therapies in this deadly disease... - Location, location, location: precursors and prognoses for pancreatic cancerSunil R Hingorani
Gastroenterology 133:345-50. 2007 - Targets, trials, and travails in pancreas cancerKamel Izeradjene
Clinical Research and Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Natl Compr Canc Netw 5:1042-53. 2007..New potential targets in the treatment of this formidable disease are suggested based on recent findings... - EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancerSharmila Shankar
Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas 75703, USA
Front Biosci 13:440-52. 2008..Overall, our data suggest that EGCG inhibits pancreatic cancer growth, invasion, metastasis and angiogenesis, and thus could be used for the management of pancreatic cancer prevention and treatment...