LINDSAY E HINCK

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis
    Karpagam Srinivasan
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Dev Cell 4:371-82. 2003
  2. ncbi The versatile roles of "axon guidance" cues in tissue morphogenesis
    Lindsay Hinck
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064 USA
    Dev Cell 7:783-93. 2004
  3. ncbi Key stages in mammary gland development: the mammary end bud as a motile organ
    Lindsay Hinck
    Sinsheimer Laboratories, Department of Cell, Molecular and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Breast Cancer Res 7:245-51. 2005
  4. ncbi Sensitization of ruthenium nitrosyls to visible light via direct coordination of the dye resorufin: trackable NO donors for light-triggered NO delivery to cellular targets
    Michael J Rose
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Am Chem Soc 130:8834-46. 2008
  5. ncbi Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis
    Phyllis Strickland
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 95064, USA
    Development 133:823-32. 2006
  6. ncbi Netrin-1-independent adenosine A2b receptor activation regulates the response of axons to netrin-1 by controlling cell surface levels of UNC5A receptors
    William L McKenna
    Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA
    J Neurochem 104:1081-90. 2008
  7. ncbi Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction
    Joseph L Bartoe
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    J Neurosci 26:3192-205. 2006
  8. ncbi UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1
    Megan E Williams
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Nat Neurosci 9:996-8. 2006
  9. ncbi Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism
    Megan E Williams
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    J Neurosci 23:11279-88. 2003
  10. ncbi SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium
    Rebecca Marlow
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    Cancer Res 68:7819-27. 2008

Research Grants

  1. CHEMOREPULSION MEDIATED NETRIN RECEPTORS UNC5H AND DCC
    Lindsay Hinck; Fiscal Year: 2003
  2. Molecular Basis of Slits as Tumor Suppressors Controlling CXCR4/SDF1 in Breast
    LINDSAY E HINCK; Fiscal Year: 2010
  3. Molecular Basis of Slits as Tumor Suppressors Controlling CXCR4/SDF1 in Breast
    LINDSAY E HINCK; Fiscal Year: 2010

Collaborators

  • ZAVEN J KAPRIELIAN
  • J S Lee
  • GARY SILBERSTEIN
  • Robert Darrell Cardiff
  • PRADIP MASCHARAK
  • E Camilla Forsberg
  • Robert Callahan
  • Luigi Strizzi
  • Phyllis Strickland
  • Rebecca Marlow
  • William L McKenna
  • Megan E Williams
  • Joseph L Bartoe
  • Mikhail Binnewies
  • Hector Macias
  • Michael J Rose
  • Marc Tessier-Lavigne
  • Aya Sasaki
  • Grace C Shin
  • Karpagam Srinivasan
  • Stefanie D Monica
  • Lise K Sorensen
  • Dean Y Li
  • Saraswati Sukumar
  • Angel Moran
  • Nicole L Fry
  • Milana Pebenito
  • Elizabeth K Le
  • Xinyan Wu
  • Caroline Wong-Staal
  • Grace C Kim
  • Jun Xia
  • Allison Dillon
  • Richard L Huganir
  • Adam Boyette
  • Jenna A Moore
  • Xiaowei Lu
  • Benjamin K Stafford
  • Kogo Takamiya
  • Raesha Washington
  • Tiffani K Quan
  • Andrew Plump
  • Ken Watanabe
  • Ana Valdes
  • Sareina C Y Wu
  • Sareina C-Y Wu

Detail Information

Publications13

  1. ncbi Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis
    Karpagam Srinivasan
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Dev Cell 4:371-82. 2003
    ..Our results suggest that netrin-1 and its receptor neogenin provide an adhesive, rather than a guidance, function during nonneural organogenesis...
  2. ncbi The versatile roles of "axon guidance" cues in tissue morphogenesis
    Lindsay Hinck
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064 USA
    Dev Cell 7:783-93. 2004
    ....
  3. ncbi Key stages in mammary gland development: the mammary end bud as a motile organ
    Lindsay Hinck
    Sinsheimer Laboratories, Department of Cell, Molecular and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Breast Cancer Res 7:245-51. 2005
    ..Finally, a critical, motility-enabling role for the cellular architecture of the end bud is identified and the contribution of cadherins, the netrin/neogenin system, and ErbB2 to the structure and motility of end buds is discussed...
  4. ncbi Sensitization of ruthenium nitrosyls to visible light via direct coordination of the dye resorufin: trackable NO donors for light-triggered NO delivery to cellular targets
    Michael J Rose
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Am Chem Soc 130:8834-46. 2008
    ....
  5. ncbi Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis
    Phyllis Strickland
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 95064, USA
    Development 133:823-32. 2006
    ..Thus, our data establish a novel role for SLIT2 as an adhesive cue, acting in parallel with NTN1 to generate cell boundaries along ducts during bi-layered tube formation...
  6. ncbi Netrin-1-independent adenosine A2b receptor activation regulates the response of axons to netrin-1 by controlling cell surface levels of UNC5A receptors
    William L McKenna
    Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA
    J Neurochem 104:1081-90. 2008
    ..Our results demonstrate that netrin-1-independent A2bR signaling governs the responsiveness of a neuron to netrin-1 by regulating the levels of cell surface UNC5A receptor...
  7. ncbi Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction
    Joseph L Bartoe
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    J Neurosci 26:3192-205. 2006
    ..Together, these data provide a potential mechanism to explain how developing neurons alter their responsiveness to netrin-1 at intermediate choice points as they navigate to their targets...
  8. ncbi UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1
    Megan E Williams
    Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Nat Neurosci 9:996-8. 2006
    ..In contrast, loss of netrin-1 (Ntn1) did not affect the amount of apoptosis, suggesting that NTN1 is not required for neuronal apoptosis in vivo...
  9. ncbi Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism
    Megan E Williams
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    J Neurosci 23:11279-88. 2003
    ..Together, our results suggest that by regulating the surface expression of UNC5Hs, an axon can modulate its repellent response to netrin-1...
  10. ncbi SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium
    Rebecca Marlow
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA
    Cancer Res 68:7819-27. 2008
    ..These studies classify Slits as negative regulators of Sdf1 and Cxcr4 and identify a molecular signature in hyperplastic breast lesions that signifies inappropriate up-regulation of key prometastatic genes...
  11. ncbi Vascular Robo4 restricts proangiogenic VEGF signaling in breast
    Rebecca Marlow
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
    Proc Natl Acad Sci U S A 107:10520-5. 2010
    ..We identify a stromal, rather than epithelial, source of SLITs that inhibits blood vessel growth by signaling through endothelial ROBO4 to down-regulate VEGF/VEGFR2 signaling...
  12. ncbi Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo
    Luigi Strizzi
    Mammary Biology and Tumorigenesis Laboratory, NCI CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA
    J Cell Sci 118:4633-43. 2005
    ..Together, these results suggest that regulation of Netrin-1 expression is important in regulating Cripto-1-dependent invasion and migration of mammary epithelial cells...
  13. ncbi RumMAGE-D the members: structure and function of a new adaptor family of MAGE-D proteins
    Aya Sasaki
    Division of the Clinical Pathology, Sapporo Medical University Hospital, Hokkaido, Japan
    J Recept Signal Transduct Res 25:181-98. 2005
    ..Because some MAGE-D subfamily proteins share significant homology within the MHD, these recent discoveries on MAGE-D1 may give insight into the function of other MAGE-D proteins...

Research Grants9

  1. CHEMOREPULSION MEDIATED NETRIN RECEPTORS UNC5H AND DCC
    Lindsay Hinck; Fiscal Year: 2003
    ..These experiments provide the foundation for understanding how cells translate a netrin-1 signal into directed migrations. ..
  2. Molecular Basis of Slits as Tumor Suppressors Controlling CXCR4/SDF1 in Breast
    LINDSAY E HINCK; Fiscal Year: 2010
    ..The goal of this application is to understand how CXCR4 contributes to tumor progression using breast as a model system. ..
  3. Molecular Basis of Slits as Tumor Suppressors Controlling CXCR4/SDF1 in Breast
    LINDSAY E HINCK; Fiscal Year: 2010
    ..The goal of this application is to understand how CXCR4 contributes to tumor progression using breast as a model system. ..