Research Topics
| Jun HeSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Increased MCP-1 and microglia in various regions of the human alcoholic brainJun He
Bowles Center for Alcohol Studies, Department of Pharmacology and Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Exp Neurol 210:349-58. 2008..In VTA and midbrain, only GluT5, but not Iba-1 was increased in alcoholic brains. These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis...- Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in miceLeon G Coleman
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Alcohol Clin Exp Res 35:671-88. 2011..Therefore, adolescent binge ethanol may have long-term effects on the adult brain that alter brain structure and behaviors that are relevant to alcohol-use disorders... - Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P ratsJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
Alcohol Clin Exp Res 33:129-38. 2009..The goal of the current investigation was to study cellular alterations on neuro- and cell-genesis during abstinence following alcohol self-administration using alcohol-preferring rats (P rats)... - Neurogenesis decreases during brain maturation from adolescence to adulthoodJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Pharmacol Biochem Behav 86:327-33. 2007..However, the role of IGF-1 during adolescent development is still unclear... - Alcoholic neurobiology: changes in dependence and recoveryFulton T Crews
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill 27599 7178, USA
Alcohol Clin Exp Res 29:1504-13. 2005.... - Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatmentLiya Qin
Bowles Center for Alcohol Studies, School of Medicine, CB 7178 UNC CH, Chapel Hill, NC 27599, USA
J Neuroinflammation 5:10. 2008..The purpose of this study was to investigate the interaction of liver, serum and brain cytokines as well as whether ethanol would potentiate endotoxin (Lipopolysaccharide, LPS) responses once ethanol had cleared... - Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neuronsJun He
Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Eur J Neurosci 21:2711-20. 2005..These data implicate impaired hippocampal neurogenesis with the cognitive and affective dysfunction associated with chronic alcoholism... - Adolescent cortical development: a critical period of vulnerability for addictionFulton Crews
Bowles Center for Alcohol Studies, School of Medecine, University of North Carolina at Chapel Hill, NC 27599, USA
Pharmacol Biochem Behav 86:189-99. 2007..This review presents findings supporting adolescence as a critical period of cortical development important for establishing life long adult characteristics that are disrupted by alcohol and drug use... - BDNF acutely modulates synaptic transmission and calcium signalling in developing cortical neuronsJun He
The Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, Wuhan, China
Cell Physiol Biochem 16:69-76. 2005.... - Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injuryJun He
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Exp Neurol 189:404-12. 2004.... - The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteinsJun He
Life Sciences Division, Lawrence Berkeley National Laboratory, CA 94720 3206, USA
J Biol Chem 278:30540-7. 2003..This may account for the resistance to TGF-beta-induced growth arrest in some human cancer cell lines that express high levels of Ski or SnoN... - Simultaneous knockdown of p18INK4C, p27Kip1 and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow cells in vitroYan Y I Wang
Department of Pharmaceutical Engineering, College of Life Science, Guizhou University, Guiyang 550025, China
Acta Biochim Biophys Sin (Shanghai) 40:711-20. 2008..Thus, the simultaneous knockdown of p18, p27 and MAD1 with a medium of only SCF can induce LTC-IC expansion despite the loss of engraftment ability... - Inhalation of tobacco smoke induces increased proliferation of urinary bladder epithelium and endothelium in female C57BL/6 miceTakamasa Ohnishi
Department of Pathology and Microbiology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 3135, United States
Toxicology 241:58-65. 2007..The increased urothelial proliferation appeared to be due to superficial cell cytotoxicity with consequent regeneration... - A new 2-aminosteroid induces cellular differentiation and upregulates the expression of MafB and Egr-1 genes respectively in HL-60 and K562 leukemia cellsQun He
Research Laboratory of Blood Physiology, Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China
Chin Med J (Engl) 118:91-9. 2005..Here, we reported the actions of another new 2-aminosteroid designated as H89712 on human leukemia cells... - [Effect of dibutyl phthalate on the biochemical enzymes and lipid peroxidation in rat testes]Yubang Wang
Institute of Applied Toxicology, Nanjing Medical University, Nanjing, Jiangsu 210029, China
Zhonghua Nan Ke Xue 10:729-33. 2004..Lipid peroxidation is one possible toxic mechanism caused by DBP. SDH may be one of the most sensitive toxic indices when exposed to DBP... - The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokinesDeng Pan
Department of Molecular and Cell Biology, University of California, Berkeley and Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
J Biol Chem 280:15992-6001. 2005..Thus, MAN1 represents a new class of R-Smad regulators and defines a previously unrecognized regulatory step at the nuclear periphery... - Development of an enzyme-linked immunosorbent assay for podophyllotoxinDun Ming Xu
R and D Center of Biorational Pesticides, Northwest A and F University, Yangling 712100, China
Int Immunopharmacol 5:1583-92. 2005..These results indicate that the ELISA could be a convenient and supplemental analytical tool for monitoring podophyllotoxin and its analogues in waters without previous extraction or cleanup... - Cellular tropisms and co-receptor usage of HIV-1 isolates from vertically infected children with neurological abnormalities and rapid disease progressionMicheline McCarthy
Department of Veterans Affairs Medical Center, Miami, Florida 33125, USA
J Med Virol 67:1-8. 2002..Viral phenotypic properties determined in cell culture did not specifically predict clinical features or course, and the development of AIDS did not coincide with, or depend on, the appearance T-tropic, syncytia-inducing viruses...