Bin He

..We evaluated the seroprevalence and potential risk factors of HHV-8 infection in blood donors in one region. We surveyed HHV-8 infection among 4461 blood donors in Xinjiang, China, a unique endemic area for HHV-8 and KS...

..The present study elucidates the potential to use herpes simplex virus (HSV) derived vectors for expression of antisense RNA to HPV -16 E7 oncogene...

..5 null mutant. Therefore, in addition to PKR, ?(1)34.5 negatively regulates TBK1, which contributes viral replication and spread in vivo...

..This review highlights recent progress in these areas...

..These results suggest that engagement of the ?(1)34.5 null mutant with CD8(+) DCs elicits innate immunity to activate NF-?B, which translates into protective immunity...

..5 abrogate viral replication in the eye and spread to the trigeminal ganglia and brain. Intriguingly, inhibition of antiviral gene induction by gamma(1)34.5 is not sufficient to exhibit viral virulence...

..Our work highlights a critical role of VP35 in viral interference in DC function with resultant deficiency in T-cell function, which may contribute to the profound virulence of Ebola virus infection...

..These data indicate that gamma(1)34.5 is involved in the impairment of innate immunity by inhibiting both type I interferon production and DC maturation, leading to defective T-cell activation...

..Hence, GAL fiber hyperinnervation appears to preserve the expression of genes subserving multiple neuroprotective pathways suggesting that GAL overexpression regulates CBF neuron survival in AD...

..Together, these results show that the VP35 protein targets multiple pathways of the interferon system...

..Hence, control of TBK1-mediated cell signaling by the gamma(1)34.5 protein contributes to herpes simplex virus infection. These results reveal that TBK1 plays a pivotal role in limiting replication of a DNA virus...

..Deletions or mutations in either domain abolish the activity of ?(1)34.5. These results suggest that the control of I?B kinase dephosphorylation by ?(1)34.5 represents a critical viral mechanism to disrupt dendritic cell functions...

..Together, these observations suggest that regulation of eIF-2alpha phosphorylation by the gamma(1)34.5 protein is an efficient way to antagonize the inhibitory activity of PKR as well as PERK during productive infection...

..Fibers containing galanin (GAL) enlarge and hyperinnervate cholinergic basal forebrain (CBF) nucleus basalis (NB) neurons in late-stage Alzheimer's disease (AD), yet the physiological consequences of this phenomenon are unclear...

..Accordingly, these mutant viruses are predominantly present within infected cells. These results indicate that deletions in the central domain of the gamma134.5 protein impair virus egress, but not virus response to interferon...

..These data demonstrate that cholinotrophic alterations in 3xTg-AD mice are age- and gender-dependent and more pronounced in the hippocampus, a structure more severely affected by A? plaque pathology...

..Computer simulation studies have been conducted to evaluate the performance of the SCEA and to compare its performance to that of the LORETA and the FOCUSS algorithms...

..Finally, in vitro DHA treatment prevented amyloid toxicity in cell cultures. Our findings support the concept that increased DHA consumption may play and important role in reducing brain insults in female AD patients...

..These results indicate that efficient viral replication depends on the gamma(1)34.5 functions required to prevent the PKR response and to facilitate virus egress in the different stages during virus infection...

..The results suggest that the SL ECG may provide an alternative for noninvasive mapping of cardiac electrical activity...

..The heart-model-based localization approach may become an alternative tool in localizing the site of origin of cardiac activation...

..CONCLUSIONS: The CPI technique may become a useful alternative for noninvasive mapping of cortical regions displaying epileptiform activity from scalp electroencephalogram recordings...

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..Several cortical imaging approaches, such as the epicortical potentials and a dipole layer accounting for the cortical activity, have been used to represent brain electrical activity...

..These results highlight the advantages of the equivalent current source imaging and suggest that it may become an alternative approach to imaging spatially distributed current sources-sinks in the brain and other organ systems...

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..These analyses show how the CPI can be used to relate the scalp electrical recordings to the underlying brain activity...

..A new realistic geometry (RG) spline Laplacian estimation technique has been developed for high-resolution EEG imaging...

..The present theoretical study suggests that the Laplacian-based inverse imaging technique may have important applications to epicardial inverse imaging and other bioelectric inverse imaging...

..The remaining challenges, future trends, and potential applications of the high-resolution functional neuroimaging research are discussed...

..The present study demonstrates that the cortical potentials can be directly estimated from the scalp potentials using the BEM in a realistically shaped inhomogeneous head model...

..The present investigation suggests body surface Laplacian mapping provides an important means in interpreting bioelectrical signals...

..In summary, the present computer simulation suggests that the proposed 3-D cardiac current source imaging and localization approach appears to be a promising candidate for localizing and imaging sites of origins of cardiac activation...

..The simulation results suggest the feasibility of applying the heart-model-based imaging approach to the estimation of myocardial infarction from body surface potentials...

..Although alterations in these AChRs occur in the AD cortex, there is little information detailing whether defects in nAChR and mAChR gene expression occur in cholinergic NB neurons during disease progression...

..5 protein is required for HSV response to interferon but is not sufficient for viral replication. Additional functions or activities of the gamma(1)34.5 protein contribute to efficient viral infection...

..SIGNIFICANCE: The present method promises to provide a useful alternative as a general purpose classification procedure for MI classification...

..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system...

..5 is functionally active in the absence of any other HSV proteins. In addition to a PP1 binding domain, the carboxyl terminus of gamma(1)34.5 contains an effector domain that is required to form a functional complex...

..These findings provide evidence that the gamma 1 34.5 protein contributes to HSV-1 resistance to interferon-alpha/beta by inhibiting PKR function...

..The findings expose interconnected genes and propose a role of genomic expression discovery in functional genomics of living systems...

..The results yield a genetic analysis of gliomas and identify classes of genetic expression that link novel genes to the biology of gliomas...

..The false discovery rates are significantly lower than other methods. The discovered states of genetic expression facilitate functional discovery and are validated by real-time RT-PCR. Better quality improves sensitivity...

..The aim of the present study was to validate the 3DCEI in an intact large mammalian model (swine) during acute ventricular pacing...

..The value of the proposed noninvasive technique for estimating epileptiform activity was supported by satisfactory surgery outcomes...

..The aim of the present study was to evaluate source reconstruction techniques by means of the intracranial electrocorticograms (ECoGs) and functional MRI...

..To develop and evaluate a new cortical activation mapping (CAM) method to obtain the neuronal activation sequences from the cortical potential distributions...

..The feasibility of MAT-MI in providing high spatial resolution images containing impedance-related information has also been demonstrated in a phantom experiment...

..Each step of the ictal source analysis is statistically evaluated in order to guarantee the confidence in the results...

..The present results suggest that the spatial resolution of the EEG cortical source imaging can correctly discriminate cortical activation changes in V1 corresponding to less than 3 degrees visual field changes...

..The application of this inverse method has the potential of enhancing electrocardiographic mapping by catheters in electrophysiology laboratories, aiding cardiac resynchronization therapy, and other clinical applications...

..The present results suggest that the meshless FEM may provide an alternative for ECG forward solutions...

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..The present simulation results indicated that the equivalent dipole sources was accurately estimated by ICA and dipole imaging. We also applied the proposed method to human visual evoked potential...

..The proposed methods demonstrated that the contralateral premotor cortex was preponderantly activated In relation to movement performance...

..The present results suggest that L(1)-norm methods gave the most accurate results in terms of cortical current density imaging of brain responses invoked by somatosensory stimulation...

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..89, RE = 0.22, and LE = 6.85mm. The simulation results demonstrate that the present 3-D imaging approach has reasonable accuracy and robustness against recording noises...

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..The proposed Twomey approach may make an important contribution to the multimodal neuroimaging integrating fMRI with EEG...

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..In four human subjects, an averaged accuracy of classification of 80% was achieved. The present study suggests the merits and feasibility of applying EEG inverse solutions to BCI applications from noninvasive EEG recordings...

..The present promising results suggest the feasibility of estimating important conductivity values within the head from noninvasive magnetic flux density measurements...

..The feasibility of the proposed approach has been shown in a human study using high-resolution EEG recordings related to finger tapping movements...

..The present promising results suggest that the source analysis approach could manifest a clearer picture on the cortical activity, and thus facilitate the classification of MI tasks from scalp EEGs...

..The present simulation study suggests the feasibility of localizing the site of origin of reentrant arrhythmia from non-invasive BSPMs, with the aid of a cardiac arrhythmia model...

..We conclude that the estimation of cortical connectivity can be performed not only with hemodynamic measurements, but also with EEG signals treated with advanced computational techniques...

..The effects of dipole eccentricity, size of finite elements and local mesh refinement on solution accuracy are also addressed in the present simulation study...

..The present approach has yielded good classification results and promises to have potential for further refinement for increased accuracy as well as application in online brain computer interface (BCI)...

..The present simulation results indicate that the proposed time-variant tPPF method provides enhanced performance in rejecting time-varying noise, as compared with the time-invariant parametric projection filter...

..In comparison with RAP-MUSIC, FINES' performance is also better for the cases studied when the noise level is high and/or correlations among dipole sources exist...

..In conclusion, our algorithm to estimate the SEMD parameters from body surface ECG can potentially be a useful method for rapidly positioning the catheter tip to the arrhythmic focus during an RCA procedure...

..Based on these equivalent physical models, closed solutions of ECL and EDL corresponding to a dipole enclosed by a spherical layer are given. These results provide the theoretical basis of ESL applications in high-resolution EEG mapping...

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..SIGNIFICANCE: The successful estimation of the number of ECDs will play an important role in expanding the applicability of dipole source localization to multiple sources...

..This new 3-D electrocardiographic imaging modality has the potential to guide catheter-based ablative interventions for the treatment of life-threatening cardiac arrhythmias...

..PVC was important for small structures such as tumours or for organs in close proximity to regions with high activity. The improved quantitative accuracy from QSPECT methods has the potential for improving organ dose estimations in TRT...

..The present study suggests that the information criterion method may provide a useful means in estimating the number of independent brain electrical sources from EEG/MEG measurements...

..20 and the localization error was 5.1 mm. The present simulation and experimental results suggest the merits of the 3DECI imaging approach, and the validity of intracardiac mapping as a tool to evaluate the 3DECI...

..The present study suggests that FINE provides enhanced performance in localizing multiple closely spaced, and inter-correlated sources under low SNR, and may become an important alternative to brain source localization from EEG or MEG...

..The present study may lead to the establishment of a high-resolution source localization technique from scalp-recorded EEGs for aiding presurgical planning in epilepsy patients...

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..The enhanced performance in terms of classification accuracy was found for the proposed approach, with a mean accuracy rate of 91.1% for two subjects studied...

..SIGNIFICANCE: The proposed method promises to provide a useful alternative for multimodal neuroimaging integrating fMRI and EEG...

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..The present results demonstrate that reliable cortical source images can be acquired during simultaneous fMRI scanning and they may be used for multimodal functional source imaging studies...

..The FEM-based CPI technique provides a means of connecting the simultaneous recorded ECoG and the scalp EEG and promises to become an effective tool to evaluate and validate CPI techniques using clinic data...

..The present simulation results suggest that the use of the RG head model reduces the localization error of LORETA, and that the RG head model based LORETA is desirable if high localization accuracy is needed...

..The promising pilot experimental results suggest the feasibility of the proposed MAT-MI approach...

..It is concluded that these regions work jointly across both spatial and temporal domains to promote verbal memory formation...

..5 protein can be functionally substituted by the corresponding homologous domain of the cellular protein GADD34/MyD116, these studies may also shed light on cell growth control. ..

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