Research Topics
Species | MARK HAUSSLERSummaryAffiliation: University of Arizona Country: USA Publications
Research Grants
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Publications
1,25-dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoterEric R Hines
Department of Pediatrics, College of Medicine, Steele Memorial Children s Research Center, University of Arizona, Tucson, Arizona 85724, USA
J Biol Chem 279:46406-14. 2004..Thus, we have identified a cis-element required for PHEX gene transcription that participates in negative feedback control of PHEX expression and thereby modulates the actions of phosphatonin...- The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axisMark R Haussler
Department of Basic Medical Sciences, University of Arizona College of Medicine Phoenix, Phoenix, AZ 85004, USA
Rev Endocr Metab Disord 13:57-69. 2012..Comprehension of these skeletal and renal actions of 1,25D should facilitate the development of novel mimetics to prevent ectopic calcification, chronic renal and vascular disease, and promote healthful aging... - Vitamin D receptor (VDR)-mediated actions of 1?,25(OH)2vitamin D3: genomic and non-genomic mechanismsMark R Haussler
Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ 85004, USA
Best Pract Res Clin Endocrinol Metab 25:543-59. 2011..1?,25(OH)(2)D(3)/VDR control of gene expression and rapid responses also delays chronic diseases of aging such as osteoporosis, cancer, type-1 and -2 diabetes, arteriosclerosis, vascular disease, and infection... - The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful agingMark R Haussler
Department of Basic Medical Sciences, The University of Arizona, College of Medicine Phoenix in Partnership with Arizona State University, Phoenix, AZ 85004 2157, United States
J Steroid Biochem Mol Biol 121:88-97. 2010..Hair provides a shield against UV-induced skin damage and cancer in terrestrial mammals, illuminating another function of VDR that facilitates healthful aging... - Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease preventionMark R Haussler
The Department of Basic Medical Sciences, University of Arizona College of Medicine Phoenix, in Partnership with Arizona State University, Phoenix, Arizona 85004 2157, USA
Nutr Rev 66:S98-112. 2008..We report novel dietary ligands for VDR including curcumin, gamma-tocotrienol, and essential fatty acid derivatives that likely play a role in the bioactions of VDR... - 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolismThomas K Barthel
Department of Biochemistry and Molecular Biophysics, The University of Arizona, Tucson, AZ 85724, USA
J Steroid Biochem Mol Biol 103:381-8. 2007..This newly revealed FGF23/1,25D/Pi axis is comparable in significance to phosphate and bone metabolism as the PTH/1,25D/Ca axis is to calcium homeostasis... - Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycleJui Cheng Hsieh
Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona 85004, USA
J Cell Biochem 110:671-86. 2010.... - Cloning of a functional vitamin D receptor from the lamprey (Petromyzon marinus), an ancient vertebrate lacking a calcified skeleton and teethG Kerr Whitfield
Department of Biochemistry and Molecular Biophysics, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
Endocrinology 144:2704-16. 2003..We propose that, in this evolutionarily ancient vertebrate, VDR may function in part, like pregnane X receptors and constitutive androstane receptors, to induce P450 enzymes for xenobiotic detoxification... - Two basic amino acids C-terminal of the proximal box specify functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid-responsive elementJui Cheng Hsieh
Department of Biochemistry and Molecular Biophysics, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
Endocrinology 144:5065-80. 2003..Examination of DNA specificity element amino acids in other nuclear receptors in terms of conservation and base contact in cocrystal structures supports the conclusion that these residues are crucial for selective DNA recognition... - Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4Peter W Jurutka
Department of Biochemistry and Molecular Biophysics, University of Arizona College of Medicine, Tucson, AZ 85724, USA
J Cell Biochem 94:917-43. 2005.... - Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cyclingJui Cheng Hsieh
Department of Biochemistry and Molecular Biophysics, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
J Biol Chem 278:38665-74. 2003.... - Vitamin D receptor as an intestinal bile acid sensorMakoto Makishima
Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
Science 296:1313-6. 2002..These studies offer a mechanism that may explain the proposed protective effects of vitamin D and its receptor against colon cancer... - 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transportOlga I Kolek
Dept of Pediatrics, Steele Children s Research Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
Am J Physiol Gastrointest Liver Physiol 289:G1036-42. 2005..Our data also establish FGF23 induction by 1,25(OH)(2)D(3) in osteoblasts as a feedback loop between these two hormones that completes a kidney-intestine-bone axis that mediates phosphate homeostasis... - Phosphorylation of human vitamin D receptor serine-182 by PKA suppresses 1,25(OH)2D3-dependent transactivationJui Cheng Hsieh
Department of Biochemistry and Molecular Biophysics, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
Biochem Biophys Res Commun 324:801-9. 2004..These data suggest that hVDR serine-182 is a primary site for PKA phosphorylation, an event that leads to an attenuation of both RXR heterodimerization and resultant transactivation of 1,25(OH)2D3 target genes... - Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligandsPeter W Jurutka
Department of Integrated Natural Sciences, Arizona State University at the West Campus, Glendale, Arizona, USA
J Bone Miner Res 22:V2-10. 2007..Activation of VDR by PUFAs and curcumin may elicit unique, 1,25(OH)(2)D(3)-independent signaling pathways to orchestrate the bioeffects of these lipids in intestine, bone, skin/hair follicle, and other VDR-containing tissues... - Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elementsPaul D Thompson
Department of Biochemistry and Molecular Biophysics, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
Biochem Biophys Res Commun 299:730-8. 2002..These data suggest that 1,25D(3)-dependent, VDR-mediated induction of CYP3A4 may constitute a chemoprotective mechanism for detoxification of enteric xenobiotics and carcinogens... - Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptorPeter W Jurutka
Department of Biochemistry and Molecular Biophysics, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
J Cell Biochem 85:435-57. 2002..These studies point to a significant role for phosphorylation of VDR in regulating high-affinity VDR-RXR interactions with VDREs, and also in modulating 1,25(OH)2D3-elicited transcriptional activation in target cells...
Research Grants
- NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASEMARK HAUSSLER; Fiscal Year: 2003..abstract_text> ..
- VITAMIN D HORMONE MECHANISM OF ACTION IN CULTURED CELLSMARK HAUSSLER; Fiscal Year: 2004....
- NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASEMARK HAUSSLER; Fiscal Year: 2006..abstract_text> ..
- NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASEMARK HAUSSLER; Fiscal Year: 2007..abstract_text> ..
- Vitamin D Hormone Signaling in Bone Mineral HomeostasisMARK HAUSSLER; Fiscal Year: 2007..may not only reveal new therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and ..
- Vitamin D Hormone Signaling in Bone Mineral HomeostasisMARK HAUSSLER; Fiscal Year: 2009..new therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and ..
- FUNCTION OF THE VITAMIN D RECEPTOR AND BONE DISEASEMARK HAUSSLER; Fiscal Year: 2002....
- VITAMIN D HORMONE MECHANISM OF ACTION IN CULTURED CELLSMARK HAUSSLER; Fiscal Year: 1991....
- Vitamin D Hormone Signaling in Bone Mineral HomeostasisMark R Haussler; Fiscal Year: 2010..new therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and ..