Research Topics
Species | B H HahnSummaryAffiliation: University of California Country: USA Publications
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Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressorsBevra H Hahn
Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 175:7728-37. 2005....- Targeted therapies in systemic lupus erythematosus: successes, failures and futureBevra H Hahn
Correspondence to Dr Bevra H Hahn, Division of Rheumatology, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 32 59, Los Angeles, CA 90095, USA
Ann Rheum Dis 70:i64-i66. 2011..The author's goal is to review recent phase III clinical trials in patients with systemic lupus erythematosus (SLE), with emphasis on outcomes and on mechanisms by which the experimental drugs/biological agents suppress autoimmunity... - The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemiaBevra H Hahn
Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
J Autoimmun 28:69-75. 2007..In this review we will discuss the mechanisms involved as well as an overview of the natural history in pathobiology... - Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritisBevra H Hahn
Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
Arthritis Res Ther 10:213. 2008.... - Atherosclerosis and systemic lupus erythematosus: the role of altered lipids and of autoantibodiesB H Hahn
David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Lupus 17:368-70. 2008..Thus, piHDL and anti-OxPL promote plaque formation, plaque instability and thrombosis, accounting for some of the large increase in atherosclerosis and coronary artery events in SLE... - Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patientsBevra H Hahn
Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
Arthritis Rheum 58:2488-97. 2008..This study was undertaken to test the possibility that functional human Treg cells can be induced by exposure to anti-DNA Ig-based peptides... - Pro-inflammatory high-density lipoproteins and atherosclerosis are induced in lupus-prone mice by a high-fat diet and leptinB H Hahn
Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
Lupus 19:913-7. 2010..These data suggest that environmental factors associated with obesity and metabolic syndrome can accelerate atherosclerosis and disease in a lupus-prone background... - Cellular and molecular mechanisms of regulation of autoantibody production in lupusBevra H Hahn
Division of Rheumatology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 91436, USA
Ann N Y Acad Sci 1051:433-41. 2005..Therefore, strategies described here might ultimately be useful in therapy of the human disease... - Evidence for multiple mechanisms of polyclonal T cell activation in murine lupusR R Singh
Autoimmunity and Tolerance Laboratory, Department of Medicine, UCLA, Los Angeles, California 90095, USA
J Clin Invest 102:1841-9. 1998..Thus, determinant spreading and degenerate recognition in T cells coupled with recurring use of T cell determinant sequences among autoantibodies result in polyclonality that is restricted to certain autoantigens... - CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expressionRam Pyare Singh
Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1001 Veteran Avenue, Los Angeles, CA 90095, USA
J Immunol 178:7649-57. 2007.... - Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupusB H Hahn
University of California, Los Angeles, USA
Arthritis Rheum 44:432-41. 2001..A striking effect is the ability of the peptide to tolerize T cell help for anti-DNA that is induced by multiple, structurally unrelated self antigens... - Interferon-inducible gene 202b controls CD8(+) T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus miceR Dinesh
Division of Rheumatology, Department of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Genes Immun 12:360-9. 2011..Our findings indicate a potential role for Ifi202b in the suppressive capacity of peptide-induced regulatory CD8(+) Ti cells through effects on the expression of Foxp3 and the synthesis of TGF?... - Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodiesGabriela Riemekasten
University of California, Los Angeles, USA
Arthritis Rheum 48:475-85. 2003..This study was undertaken to test the hypothesis that SmD1(83-119)-reactive T cells play a crucial role in the generation of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies... - Protection against renal disease in (NZB x NZW)F(1) lupus-prone mice after somatic B cell gene vaccination with anti-DNA immunoglobulin consensus peptideFrancesca Ferrera
David Geffen School of Medicine, University of California, Los Angeles, California, USA
Arthritis Rheum 56:1945-53. 2007..The purpose of the present study was to test our hypothesis that T cells that recognize an Ig consensus sequence presented by B cells will modulate lupus-like disease in mice... - Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosusB P Tsao
University of California, Los Angeles, USA
J Clin Invest 99:725-31. 1997..01). We concluded that this candidate 1q41-q42 region probably contains a susceptibility gene(s) that confers risk for SLE in multiple ethnic groups... - Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti-DNA Ig peptideR P Singh
Division of Rheumatology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
Genes Immun 11:294-309. 2010..However, silencing of Foxp3 reduced expression of Foxp3, Ifi202b and PD1-all of which are involved in the suppressive capacity of CD8(+) Treg in this model... - Reciprocal T-B determinant spreading develops spontaneously in murine lupus: implications for pathogenesisR R Singh
Department of Medicine, University of California, Los Angeles 90095 1670, USA
Immunol Rev 164:201-8. 1998..Understanding the diversification patterns in autoimmune responses has enormous implications in developing peptide-targeted therapies... - Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like diseaseS D Liu
University of California, Los Angeles, CA, USA
Lupus 20:473-84. 2011..Together, the findings highlight galectin-1 as a novel potential therapeutic immune modulator for treatment of lupus-like disease... - Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteasesWei Shiang Lin
University of California, Los Angeles, CA 90095 1670, USA
Arthritis Rheum 56:1638-47. 2007.... - Assessment of American College of Rheumatology quality criteria for rheumatoid arthritis in a pre-quality criteria patient cohortK L Kahn
University of California at Los Angeles, California 90095 1736, USA
Arthritis Rheum 57:707-15. 2007..To evaluate the American College of Rheumatology (ACR) starter set of quality measures for rheumatoid arthritis (RA) in an actual patient cohort that preceded publication of the quality measures... - Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosusElizabeth R Volkmann
David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1670, USA
Arthritis Care Res (Hoboken) 62:258-65. 2010..To investigate the association between physical activity, functional activity of high-density lipoprotein (HDL), and subclinical cardiovascular disease in patients with systemic lupus erythematosus (SLE)... - Modulation of p38 MAPK activity in regulatory T cells after tolerance with anti-DNA Ig peptide in (NZB x NZW)F1 lupus miceElaine V Lourenço
Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Immunol 182:7415-21. 2009..Transfer experiments confirmed the role of p38 in Tregs on disease activity in the NZB/W mice. These data indicate that the modulation of p38 activity in lupus Tregs can significantly influence the disease activity... - Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone miceBrian J Skaggs
Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Hum Immunol 69:790-6. 2008..This review will discuss the similarities and differences in CD8(+) Ts subsets, the concept of tolerance as a therapy, and the current understanding of CD8(+) Ts in mouse SLE models... - Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritisMaureen McMahon
University of California at Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
Arthritis Rheum 54:2541-9. 2006..This study was undertaken to determine whether patients with SLE, who have chronic inflammation that causes oxidative damage, have more proinflammatory HDL and higher levels of ox-LDL, thus predisposing them to atherosclerosis... - Potential for anti-DNA immunoglobulin peptide therapy in systemic lupus erythematosusNoriko Iikuni
University of California Los Angeles, Division of Rheumatology, Department of Medicine, 1000 Veteran Avenue 32 59, Los Angeles, California 90095 1670, USA
Expert Opin Biol Ther 9:201-6. 2009..Some patients may not respond well to some treatments because of inter-individual variability of the disease. More specific and safer therapies are needed... - Development and evaluation of a patient self-report case-finding method for rheumatoid arthritisAndrew L Wong
Olive View UCLA Medical Center, Sylmar, CA 91342, USA
Semin Arthritis Rheum 34:484-99. 2004..To describe the development and evaluation of a patient self-report case-finding method for rheumatoid arthritis (RA) not dependent on direct contact with the treating physicians... - Tuning immune suppression in systemic autoimmunity with self-derived peptidesRam Pyare Singh
Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, CA 90095 1670, USA
Inflamm Allergy Drug Targets 7:253-9. 2008.... - The complexity of care for patients with rheumatoid arthritis: metrics for better understanding chronic disease careKatherine L Kahn
University of California at Los Angeles, Greater Los Angeles VA Healthcare System, Los Angeles, California 90095 1736, USA
Med Care 45:55-65. 2007..Patients with rheumatoid arthritis (RA) provide an important opportunity for understanding care of patients with a serious chronic condition... - Atherosclerosis and systemic lupus erythematosus: mechanistic basis of the associationMaureen McMahon
Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
Curr Opin Immunol 19:633-9. 2007..As in the pathogenesis of many lupus disease processes, the increased risk of atherosclerosis seen in SLE is likely due to the complex interplay of many of these inflammatory and immune mediators... - pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 moleculesRam Pyare Singh
Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
J Immunol 180:2069-80. 2008..Our data suggest that tolerization with pCons activates different subsets of inhibitory/cytotoxic CD8+ T cells whose targets are both CD4+CD25- effector T cells and B cells... - Cutaneous vasculitis in breast cancer treated with chemotherapyMaida Wong
Department of Medicine, Division of Rheumatology, University of California Los Angeles, FOCIS Center of Excellence, Los Angeles, CA 90095 1670, USA
Clin Immunol 129:3-9. 2008.... - Manipulation of immune regulation in systemic lupus erythematosusAntonio La Cava
Division of Rheumatology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
Autoimmun Rev 4:515-9. 2005.... - Familiality and co-occurrence of clinical features of systemic lupus erythematosusBetty P Tsao
Division of Rheumatology, Department of Medicine, Rehabilitation Center, Room 32 59, University of California Los Angeles School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
Arthritis Rheum 46:2678-85. 2002..To evaluate familiality of 15 clinical and laboratory features in systemic lupus erythematosus (SLE)-affected sibpairs, and to estimate correlations with the age at SLE diagnosis in affected sibpairs and parent-offspring pairs... - Linkage and interaction of loci on 1q23 and 16q12 may contribute to susceptibility to systemic lupus erythematosusBetty P Tsao
Department of Medicine, Rehabilitation Center, Room 32 59, 1000 Veteran Avenue, UCLA School of Medicine, Los Angeles, CA 90095 1670, USA
Arthritis Rheum 46:2928-36. 2002.... - A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein CKwan Ki Hwang
Medicine Rheumatology, University of California, Los Angeles, CA 90095 1670, USA
Arthritis Rheum 48:1622-30. 2003..To test the hypotheses that some thrombin-reactive anticardiolipin antibodies (aCL) may bind to protein C (PC) and/or activated PC (APC), and that some of the PC- and APC-reactive aCL may inhibit PC activation and/or the function of APC... - Leptin-based immune intervention: current status and future directionsAntonio La Cava
Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, CA 90095 1670, USA
Curr Opin Investig Drugs 4:1327-32. 2003..This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions... - Blockade of programmed death-1 in young (New Zealand black x New Zealand white)F1 mice promotes the activity of suppressive CD8+ T cells that protect from lupus-like diseaseMaida Wong
Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
J Immunol 185:6563-71. 2010..PD-1 regulation could represent a target to preserve tolerance and prevent autoimmunity... - Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFR?, chemotaxis and TNF? productionBrian J Skaggs
Division of Rheumatology, David Geffen UCLA School of Medicine, 32 59 Rehab Center, Los Angeles, CA 90095, USA
Clin Immunol 137:147-56. 2010..Dysfunctional piHDL directly influences expression of a small number of transcripts and proteins, and piHDL inhibition through reducing piHDL oxidation or blocking PDGFR? kinase activity restored normal monocyte chemotaxis... - Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNAAntonio La Cava
Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 173:3542-8. 2004..These findings suggest possible relevance of Ag specificity in the mechanism of T(R)-mediated immune tolerance to Ig-derived peptides in NZB/W F(1) mice... - Systemic lupus erythematosus genome scan: support for linkage at 1q23, 2q33, 16q12-13, and 17q21-23 and novel evidence at 3p24, 10q23-24, 13q32, and 18q22-23Rita M Cantor
David Geffen School of Medicine, University of California, Los Angeles, 90095 7088, USA
Arthritis Rheum 50:3203-10. 2004..To identify chromosome regions likely to harbor genes that predispose to the development of systemic lupus erythematosus (SLE) by analyzing a full genome scan in nuclear families ascertained for siblings with SLE... - Systemic lupus erythematosus: modern strategies for management: a moving targetJennifer K King
University of California Los Angeles, Division of Rheumatology, Rehab Center 32 59, Los Angeles, CA 90095, USA
Best Pract Res Clin Rheumatol 21:971-87. 2007..Recent clinical trials have also shed light on the optimal utility of several traditional therapies used in our SLE armamentarium... - Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosusMaureen McMahon
David Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, CA 90095, USA
Arthritis Rheum 60:2428-37. 2009..The aim of this study was to determine whether dysfunctional proinflammatory HDL (piHDL) is associated with subclinical atherosclerosis in SLE... - Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic interventionMaureen McMahon
Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
Expert Rev Clin Immunol 7:227-41. 2011..Future preventive strategies may include therapies that counteract the immunologic responses that lead to plaque formation... - PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosusB P Tsao
Division of Rheumatology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1670
J Clin Invest 103:1135-40. 1999..004). Similar TDT analyses of TGFB2 and HLX1 polymorphisms yielded no evidence for association with SLE. These results suggest that PARP may be (or is close to) the susceptibility gene within the chromosome 1q41-q42 region linked to SLE... - Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone miceB J Skaggs
University of California, Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, USA
Lupus 20:912-20. 2011..Induction of oral tolerance using modified pCons peptides could lead to a novel targeted therapy for human SLE... - Some antiphospholipid antibodies bind to various serine proteases in hemostasis and tip the balance toward hypercoagulant statesP P Chen
Department of Medicine, Division of Rheumatology, University of California at Los Angeles, Los Angeles, CA, USA
Lupus 19:365-9. 2010.... - Identification of anti-plasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrinCheng-De Yang
Department of Medicine, Division of Rheumatology, University of California, Los Angeles, CA 90095, USA
J Immunol 172:5765-73. 2004.... - Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombinYao Hsu Yang
Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 182:1674-80. 2009..Because FIXa is an upstream procoagulant factor, impaired AT regulation of FIXa might contribute more toward thrombosis than the dysregulation of the downstream FXa and thrombin... - CD8+ Tregs in lupus, autoimmunity, and beyondRavi K Dinesh
Division of Rheumatology, Dept of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
Autoimmun Rev 9:560-8. 2010..We also discuss the potential role of CD8(+) Tregs in other diseases, including chronic infection and cancer... - Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid diseaseHui Wu
David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
Arthritis Rheum 52:2396-402. 2005..We performed family-based association studies of this polymorphism in 4 independent cohorts containing SLE patients and their parents and/or other family members... - A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosusThomas R Hawn
Department of Medicine, University of Washington School of Medicine, 1959 Northeast Pacific Street, Seattle, WA 98105, USA
Proc Natl Acad Sci U S A 102:10593-7. 2005..These data support a role for flagellated bacteria and the innate immune response in the development of SLE with implications for novel immunomodulatory treatment strategies... - Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosusHui Wu
Division of Rheumatology, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:3961-6. 2007..Our findings reveal that CR2 is a likely susceptibility gene for human lupus at 1q32.2, extending previous studies suggesting that CR2 participates in the pathogenesis of systemic lupus erythematosus... - Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombinK K Hwang
Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 167:7192-8. 2001..Because the latter anti-thrombin Ab are likely to promote clotting, it will be important to develop specific assays for such Ab and study their roles in thrombosis in APS patients... - The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structuresH Liu
Department of Medicine, University of Alabama at Birmingham 35294, USA
J Virol 69:7630-8. 1995..These results indicate that Vif represents an integral component of HIV and SIV particles and raise the possibility that it plays a direct role in early replication events... - PD-1, gender, and autoimmunityRavi K Dinesh
Division of Rheumatology, Department of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
Autoimmun Rev 9:583-7. 2010..Exploring the effects of sex hormones on the PD-1:PD-L pathway could shed light on the gender biased nature of many autoimmune conditions as well as aide in the development of therapeutics targeting the immune system... - Leptin in non-autoimmune inflammationChunlin Cai
Department of Medicine, University of California Los Angeles, Los Angeles, California 90095 1670, USA
Inflamm Allergy Drug Targets 8:285-91. 2009..This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis... - Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosusNoriko Iikuni
Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 183:1518-22. 2009..These results indicate that one way by which natural Tregs attempt to limit humoral autoimmunity in SLE is by directly targeting autoreactive B cells... - Nephritogenic anti-DNA antibodies regulate gene expression in MRL/lpr mouse glomerular mesangial cellsXiaoping Qing
Division of Rheumatology, Forchheimer 701N, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Arthritis Rheum 54:2198-210. 2006..We undertook this study to determine if pathogenic anti-DNA antibodies may also contribute to renal damage by directly influencing mesangial gene expression... - Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombinYao-Hsu Yang
Division of Rheumatology, Department of Medicine, University of California-Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
J Immunol 177:8219-25. 2006..Combined, these results indicate that anti-FXa Ab may contribute to thrombosis by interfering with the anticoagulant function of AT on FXa in some APS patients... - Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndromeCai Sheng Lu
University of California, Los Angeles, CA 90095, USA
Arthritis Rheum 52:4018-27. 2005..To test the hypotheses that some plasmin-reactive anticardiolipin antibodies (aCL) may bind to tissue plasminogen activator (tPA) and that some of the tPA-reactive aCL may inhibit tPA activity... - Peptides from antibodies to DNA elicit cytokine release from peripheral blood mononuclear cells of patients with systemic lupus erythematosus: relation of cytokine pattern to disease durationJ K Kalsi
Division of Rheumatology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
Lupus 13:490-500. 2004.... - Application of explicit process of care measurement to rheumatoid arthritis: Moving from evidence to practiceK L Kahn
Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1736, USA
Arthritis Rheum 55:884-91. 2006..To construct quality measures with measurement validity and meaning for clinicians... - Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1cP A Sieling
Division of Dermatology and Rheumatology, University of California School of Medicine, Los Angeles, CA 90095, USA
J Immunol 165:5338-44. 2000..The data suggest that CD1c-restricted T cells from SLE patients can provide help to CD1c(+) B cells for IgG production and could therefore promote pathogenic autoantibody responses in SLE... - Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosusXuebing Feng
David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1670, USA
Arthritis Rheum 54:2951-62. 2006..IFN scores, or LY6E levels, may be useful as a biomarker for lupus nephritis therapy... - Induction of autoantibody production is limited in nonautoimmune miceRam Raj Singh
Department of Internal Medicine, University of Cincinnati College of Medicine and Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
J Immunol 169:587-94. 2002..The induction of such inhibitory T cells may play a role in protecting nonautoimmune mice from developing chronic autoimmunity... - Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus modelGeorge A Karpouzas
Rheumatology, Harbor/UCLA Medical Center, Torrance, USA
Eur J Immunol 34:2489-99. 2004..Understanding these defects might identify targets for therapy in systemic lupus erythematosus... - Identification and characterization of a peptide mimetic that may detect a species of disease-associated anticardiolipin antibodies in patients with the antiphospholipid syndromeSudha Visvanathan
University of California at Los Angeles, 90095, USA
Arthritis Rheum 48:737-45. 2003.... - Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cellsGabriela Riemekasten
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
J Immunol 173:5835-42. 2004..In conclusion, these results indicate that SmD1 83-119 peptide may play a dominant role in the activation of helper and regulatory T cells that influence autoantibody generation and murine lupus... - Maternal HLA class II compatibility in men with systemic lupus erythematosusAnne M Stevens
Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
Arthritis Rheum 52:2768-73. 2005..Male subjects were selected in order to avoid confounding due to fetal microchimerism, which may occur in women... - The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trialJill P Buyon
Hospital for Joint Diseases, New York University School of Medicine, New York, New York, USA
Ann Intern Med 142:953-62. 2005..There is concern that exogenous female hormones may worsen disease activity in women with systemic lupus erythematosus (SLE)... - Combined oral contraceptives in women with systemic lupus erythematosusMichelle Petri
Johns Hopkins University School of Medicine, Baltimore, USA
N Engl J Med 353:2550-8. 2005..CONCLUSIONS: Our study indicates that oral contraceptives do not increase the risk of flare among women with systemic lupus erythematosus whose disease is stable... - Improving joint disease in patients with rheumatoid arthritis: is this enough to treat the accompanying dyslipidemias?Bevra H Hahn
Am J Med 113:247-8. 2002 - Fcgamma receptor IIIA polymorphism in Korean patients with systemic lupus erythematosusEun Bong Lee
Department of Internal Medicine, Clinical Research Institute, Seoul National University College of Medicine, Korea
Rheumatol Int 21:222-6. 2002..In conclusion, FcgammaRIIIA-176F/V polymorphism is not associated with SLE in Koreans... - Gene vaccination for the induction of immune toleranceFrancesca Ferrera
Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
Ann N Y Acad Sci 1110:99-111. 2007..We review here the experimental evidence and most recent data supporting the use of DNA vaccination in the induction of immune tolerance...
Research Grants
- MECHANISMS OF IMMUNE TOLERANCE INDUCED IN MURINE LUPUSBevra Hahn; Fiscal Year: 2007..Since patients with SLE have T cells that recognize Ig-derived peptides from humanmonoclonal antibodies to DNA, the information from these experiments may suggest a novel therapeutic approach to this disease. ..