KAREN GYLYS

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Rapid annexin-V labeling in synaptosomes
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919, Factor Building, Los Angeles, CA 90095, USA
    Neurochem Int 44:125-31. 2004
  2. ncbi Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry
    K H Gylys
    UCLA School of Nursing, Los Angeles, California 90095 6919, USA
    J Neurosci Res 61:186-92. 2000
  3. ncbi Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex
    Karen Hoppens Gylys
    UCLA School of Nursing, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:8-17. 2007
  4. ncbi Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
    Karen Hoppens Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919 Factor Bldg, Los Angeles, CA 90095 6919, USA
    Am J Pathol 165:1809-17. 2004
  5. ncbi Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cytometry A 60:90-6. 2004
  6. ncbi Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095 6919, USA
    J Neurochem 84:1442-51. 2003
  7. ncbi Caspase inhibition protects nerve terminals from in vitro degradation
    Karen H Gylys
    UCLA School of Nursing, Brain Research Institute, Box 956919, Los Angeles, California 90095, USA
    Neurochem Res 27:465-72. 2002
  8. ncbi Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection
    Dorothy J Wiley
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 6919, USA
    Cancer Epidemiol Biomarkers Prev 15:915-20. 2006
  9. ncbi Smoking enhances risk for new external genital warts in men
    Dorothy J Wiley
    Division of Primary Care, School of Nursing, University of California at Los Angeles UCLA, Los Angeles, California, USA
    Int J Environ Res Public Health 6:1215-34. 2009
  10. ncbi Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, UCLA Department of Neurology, Los Angeles, CA, United States
    Neurosci Lett 487:287-92. 2011

Research Grants

  1. ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    KAREN GYLYS; Fiscal Year: 2009
  2. ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    Karen H Gylys; Fiscal Year: 2010

Detail Information

Publications11

  1. ncbi Rapid annexin-V labeling in synaptosomes
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919, Factor Building, Los Angeles, CA 90095, USA
    Neurochem Int 44:125-31. 2004
    ..These data demonstrate that PS externalization and caspase activation occur rapidly in this widely used neurochemical preparation...
  2. ncbi Quantitative characterization of crude synaptosomal fraction (P-2) components by flow cytometry
    K H Gylys
    UCLA School of Nursing, Los Angeles, California 90095 6919, USA
    J Neurosci Res 61:186-92. 2000
    ..These results suggest that flow cytometry may be used to take advantage of the increased viability, yield, and convenience of the P-2 fraction for studies of nerve terminal function...
  3. ncbi Increased cholesterol in Abeta-positive nerve terminals from Alzheimer's disease cortex
    Karen Hoppens Gylys
    UCLA School of Nursing, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:8-17. 2007
    ..These results suggest that Abeta accumulation in synaptic terminals may underly dysfunction prior to or independent of extracellular amyloid deposition...
  4. ncbi Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
    Karen Hoppens Gylys
    UCLA School of Nursing and Brain Research Institute, Box 956919 Factor Bldg, Los Angeles, CA 90095 6919, USA
    Am J Pathol 165:1809-17. 2004
    ....
  5. ncbi Enrichment of presynaptic and postsynaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cytometry A 60:90-6. 2004
    ....
  6. ncbi Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta protein into synaptic terminals
    Karen H Gylys
    UCLA School of Nursing and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90095 6919, USA
    J Neurochem 84:1442-51. 2003
    ..These results suggest that complex formation with apoE enhances internalization of soluble Abeta uptake into terminals...
  7. ncbi Caspase inhibition protects nerve terminals from in vitro degradation
    Karen H Gylys
    UCLA School of Nursing, Brain Research Institute, Box 956919, Los Angeles, California 90095, USA
    Neurochem Res 27:465-72. 2002
    ..These results indicate activation of both caspase and calpain in the P-2 fraction and suggest a role for these cysteine proteases in the in vitro degradation of nerve terminals...
  8. ncbi Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection
    Dorothy J Wiley
    School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095 6919, USA
    Cancer Epidemiol Biomarkers Prev 15:915-20. 2006
    ..Main Outcome Measure: HPV16-L1 antibody (anti-HPV16 antibody) detected from serum using RIA or ELISA...
  9. ncbi Smoking enhances risk for new external genital warts in men
    Dorothy J Wiley
    Division of Primary Care, School of Nursing, University of California at Los Angeles UCLA, Los Angeles, California, USA
    Int J Environ Res Public Health 6:1215-34. 2009
    ..Multivariate analyses showed smoking, prior episodes of EGWs, HIV infection and CD4+ T-lymphocyte count among the infected, each differentially influenced the risk for new EGWs...
  10. ncbi Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, UCLA Department of Neurology, Los Angeles, CA, United States
    Neurosci Lett 487:287-92. 2011
    ..We describe biochemical, imaging, and neuropathological changes in a pedigree with a novel PSEN1 mutation. This allows us to validate the pathogenicity of this mutation and the indices used to assess AD...
  11. ncbi Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes
    Jeffrey A Fein
    School of Nursing, University of California at Los Angeles School of Medicine, Sepulveda Veterans Administration Medical Center, Los Angeles, California 90095 6919, USA
    Am J Pathol 172:1683-92. 2008
    ..0001). These results showing overlapping Abeta and tau pathology are consistent with a model in which both synaptic loss and dysfunction are linked to a synaptic amyloid cascade within the synaptic compartment...

Research Grants2

  1. ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    KAREN GYLYS; Fiscal Year: 2009
    ..These experiments will help us to understand how cholesterol may contribute to Alzheimer's pathology. ..
  2. ApoE and Cholesterol Effects on Amyloid-beta in Synaptic Terminals in AD
    Karen H Gylys; Fiscal Year: 2010
    ..These experiments will help us to understand how cholesterol may contribute to Alzheimer's pathology. ..