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Genomes and GenesSpecies | Sudhir GuptaSummaryAffiliation: University of California Country: USA Publications
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Publications
Primary immunodeficiencies in India: a perspectiveSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, California, USA
Ann N Y Acad Sci 1250:73-9. 2012..We highlight some of the limitations and challenges in the diagnosis and therapy of PID, and more recent efforts to establish PID Centers of Excellence and a national PID registry in India...- T and B cell deficiency associated with yellow nail syndromeS Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA
Scand J Immunol 75:329-35. 2012..Our data show that YNS is associated with both T and B cell defects. Furthermore, Immunoglobulin may be beneficial in clinical manifestations of lymphoedema... - Chemokine expression patterns in the systemic and genital tract compartments are associated with HIV-1 infection in women from BeninJulie Lajoie
Laboratoire d Immunogénétique, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Canada
J Clin Immunol 30:90-8. 2010..Understanding the genital mucosal immunity and the factors involved in linking innate to adaptive immunity is crucial for the design of efficient preventive strategies against human immunodeficiency virus (HIV)-1... - Role of IgA and IgA fc receptors in inflammationRenato C Monteiro
INSERM U699, Paris, France
J Clin Immunol 30:1-9. 2010..However, IgA can also, when aggregated, be deleterious to the host, inducing inflammatory diseases. This Janus-like nature of IgA is mainly due to their heterogeneity in molecular forms and their interaction with IgA receptors... - Molecular mechanisms of apoptosis in the cells of the immune system in human agingSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, 92697, USA
Immunol Rev 205:114-29. 2005.... - Effector memory CD8+ T cells are resistant to apoptosisSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
Ann N Y Acad Sci 1109:145-50. 2007..We show that both T(EM) and T(EMRA) CD8(+) T cells are resistant to apoptosis, whereas T(N) and T(CM) CD8(+) T cells are sensitive to apoptosis... - Effect of age on molecular signaling of TNF-alpha-induced apoptosis in human lymphocytesSudhir Gupta
Laboratories of Cellular and Molecular Immunology and Molecular Biology Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
Mech Ageing Dev 124:503-9. 2003..T cells and T cell subsets from aged humans are more sensitive to TNF-alpha-induced apoptosis, which appears to be due to both an increased apoptotic signaling and decreased survival signals... - Increased spontaneous, tumor necrosis factor receptor- and CD95 (Fas)-mediated apoptosis in cord blood T-cell subsets from Turner's syndromeS Gupta
University of California, Irvine, USA
Genes Immun 4:239-43. 2003..This study demonstrates that increased apoptosis of T-cell subsets in Turner's syndrome occurs via the death receptor pathway and may play a role in the pathogenesis of immunological defects associated with Turner's syndrome... - Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review)Sudhir Gupta
Medical Science I, C 240, University of California, Irvine, CA 92697, USA
Int J Oncol 22:15-20. 2003..These are some of the recent discoveries in death receptor and mitochondrial pathways of apoptosis that have been reviewed in this article... - A decision between life and death during TNF-alpha-induced signalingSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Irvine 92697, USA
J Clin Immunol 22:185-94. 2002..Furthermore, a role of DAP kinase in TNF-induced apoptosis is discussed. Finally, the molecular basis of the effect of age on TNF-alpha-induced apoptosis in human T cells is reviewed... - Arsenic trioxide induces apoptosis in peripheral blood T lymphocyte subsets by inducing oxidative stress: a role of Bcl-2Sudhir Gupta
Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
Mol Cancer Ther 2:711-9. 2003..These data indicate that As(2)O(3) induces apoptosis in T cells by enhancing oxidative stress and that Bcl-2 appears to play a major role in As(2)O(3)-induced apoptosis... - Molecular steps of tumor necrosis factor receptor-mediated apoptosisS Gupta
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine 92697, USA
Curr Mol Med 1:317-24. 2001..A role of RIP is emphasized and novel mechanisms of FLIP-mediated inhibition of apoptosis are discussed. In addition, various mechanisms of TNF-induced activation of mitochondrial pathway of apoptosis have been reviewed... - A role of fas-associated death domain (FADD) in increased apoptosis in aged humansSudhir Gupta
Molecular Biology and Cellular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, Irvine, California 92697, USA
J Clin Immunol 24:24-9. 2004..These data suggest that FADD plays an important role in increased apoptosis in aged lymphocytes signaled via TNF-R... - Characterization of naïve, memory and effector CD8+ T cells: effect of ageSudhir Gupta
Division of Basic and Clinical Immunology, Medical Sciences C C 240, University of California, Irvine, CA 92697 4069, USA
Exp Gerontol 39:545-50. 2004..In this article, we have further defined naïve, central memory, effector memory, and effector CD8+ T cells in humans and their changes in aged humans... - Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathwaysSudhir Gupta
Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
Autoimmun Rev 6:476-81. 2007..In this review we have discussed relative sensitivity/resistance of naïve and different subsets of memory T cells to apoptosis via different signaling pathways. Molecular basis for differential sensitivity to apoptosis is discussed... - CD95-mediated apoptosis in naïve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humansSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Medical Sciences I, Irvine, CA 92697, United States
Exp Gerontol 43:266-74. 2008..Our data suggest that increased CD95-mediated apoptosis of T(N) and T(CM) CD8+ and CD4+ T cells may play a role in their decline in human aging... - Differential sensitivity of naïve and memory subsets of human CD8+ T cells to TNF-alpha-induced apoptosisSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
J Clin Immunol 26:193-203. 2006..These data suggest that signaling molecules downstream of TNFRs may be responsible for differential sensitivity among subsets of CD8+ T cells to TNF-alpha-induced apoptosis... - Differential effect of human herpesvirus 6A on cell division and apoptosis among naive and central and effector memory CD4+ and CD8+ T-cell subsetsSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
J Virol 83:5442-50. 2009..These data show that HHV-6 differentially influences the functions of naïve T cells and different subsets of memory CD4(+) and CD8(+) T cells, which in part may be due to differential susceptibility to HHV-6A-induced apoptosis... - TNF-alpha-induced apoptosis in human naïve and memory CD8+ T cells in aged humansSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Med Sci I C 240, Irvine, CA 92697 4096, USA
Exp Gerontol 41:69-77. 2006..However, apoptosis does not appear to play a major role in increased accumulation of effector memory CD8+ T cells during human aging... - Central memory and effector memory subsets of human CD4(+) and CD8(+) T cells display differential sensitivity to TNF-{alpha}-induced apoptosisSudhir Gupta
Medical Sci I, C 240, University of California, Irvine, CA 92697, USA
Ann N Y Acad Sci 1050:108-14. 2005..We also provide evidence for the molecular mechanisms underlying the differential sensitivity of naive and different sets of memory T cells to TNF-alpha-induced apoptosis... - Molecular mechanisms of TNF-alpha-induced apoptosis in aging human T cell subsetsSudhir Gupta
Laboratories of Cellular and Molecular Immunology and Molecular Biology, Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
Int J Biochem Cell Biol 37:1034-42. 2005.... - Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humansS Gupta
Cellular and Molecular Immunology and Molecular Biology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
Cell Death Differ 12:177-83. 2005..These data suggest a deficiency of NF-kappaB signaling pathway and a role of IKKbeta, at least in part, for increased sensitivity of lymphocytes from aged humans to TNF-alpha-induced apoptosis... - Differential sensitivity of naïve and subsets of memory CD4+ and CD8+ T cells to hydrogen peroxide-induced apoptosisS Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
Genes Immun 8:560-9. 2007..These data demonstrate that H2O2 induces apoptosis preferentially in human naïve and central memory CD4+ and CD8+ T cells via the mitochondrial pathway by regulating intracellular GSH and the expression of Bax and VDAC... - Tumor necrosis factor-alpha-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling moleculesSudhir Gupta
Cellular and Molecular Immunology and Molecular Biology Laboratories, Division of Basic and Clinical Immunology, Department of Medicine, Medical Sciences 1, C 240, University of California, Irvine, CA 92697, USA
Exp Gerontol 37:293-9. 2002..A role of impaired TNF-RII-mediated signaling in increased apoptosis in aged subjects is also discussed... - Immunological treatments for autismS Gupta
Division of Basic and Clinical Immunology, Medical Sciences I, University of California, Irvine 92697, USA
J Autism Dev Disord 30:475-9. 2000..Based upon immunological abnormalities, various treatment modalities have been applied to children with autism. In this brief review, these immunological changes and various biological therapies are analyzed and summarized... - Death of memory T-cell subsets in humans: changes during agingSudhir Gupta
Professor of Medicine, Pathology and Laboratory Medicine, and Microbiology and Molecular Genetics, and Chief, Division Basic and Clinical Immunology, University of California, Division of Basic and Clinical Immunology, Medical Science I, C 240, Irvine, CA 92697, USA
Expert Rev Clin Immunol 3:637-45. 2007..In this article, we briefly review different pathways of death signaling and alterations in apoptotic signaling pathways in order to understand changes in various T cells in human aging... - A possible role of multidrug resistance-associated protein (MRP) in basic fibroblast growth factor secretion by AIDS-associated Kaposi's sarcoma cells: a survival molecule?S Gupta
Department of Medicine, University of California, Irvine 92697, USA
J Clin Immunol 18:256-63. 1998..Furthermore, probenecid appears to induce apoptosis in AIDS-KS cells by depriving them of the growth promoting activity of bFGF. These data suggest that MRP may play a role as a survival molecule in AIDS-KS cells... - Molecular and biochemical pathways of apoptosis in lymphocytes from aged humansS Gupta
Laboratory of Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697 4069, USA
Vaccine 18:1596-601. 2000..These data suggest that increased sensitivity of lymphocytes from aged subjects to death signals may play an important role in the pathogenesis of lymphopenia and T cell deficiency associated with the aging process... - Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autismS Gupta
Department of Medicine, University of California, Irvine 92697 4075, USA
J Neuroimmunol 85:106-9. 1998..These data suggest that an imbalance of Th1- and Th2-like cytokines in autism may play a role in the pathogenesis of autism... - Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cellsAbdullah Baysan
Cellular and Molecular Immunology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
Int J Oncol 30:313-8. 2007..Altogether, these data indicate that As2O3 induces apoptosis in B cells, regardless of Bcl-2 expression, via the mitochondrial pathway by enhancing oxidative stress... - Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondriaLeman Yel
Department of Medicine, University of California, Irvine, CA 92697, USA
Int J Mol Med 16:971-7. 2005..Finally, caspase-9 and caspase-3 were activated in the absence of caspase-8 activation. Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironment... - Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNAAnshu Agrawal
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
J Immunol 182:1138-45. 2009..This activated state of DCs may be responsible for their increased reactivity to self-Ags such as DNA, which in turn contributes to the age-associated chronic inflammation... - Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosisRama Yerramasetti
Division of Basic and Clinical Immunology University of California, Irvine 92697, USA
J Clin Immunol 22:37-47. 2002.... - Impaired pneumovax-23-induced monocyte-derived cytokine production in patients with common variable immunodeficiencyRaymond Hong
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
J Clin Immunol 30:435-41. 2010..pneumoniae. In humans, monocyte/macrophage-derived cytokines in response to S. pneumoniae have not been studied. Patients with CVID respond poorly to Pneumovax-23 (containing all capsular polysaccharides) vaccination... - Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathwayAnshu Agrawal
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
J Immunol 178:6912-22. 2007..Increased phosphatase and tensin homolog may thus be responsible for the defect in AKT phosphorylation and, therefore, the altered innate immune response of DCs from elderly humans... - Molecular mechanisms of TNF-alpha-induced apoptosis in naïve and memory T cell subsetsSudhir Gupta
Division of Basic and Clinical Immunology, University of California, Irvine, 92697, USA
Autoimmun Rev 5:264-8. 2006..In this brief review we will discuss molecular mechanisms of apoptosis in naïve and various types of memory T cells to possibly explain the changes observed in aging, which are very similar to certain autoimmune diseases... - Molecular basis of rifampicin-induced inhibition of anti-CD95-induced apoptosis of peripheral blood T lymphocytes: the role of CD95 ligand and FLIPsSastry Gollapudi
Laboratory of Cellular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
J Clin Immunol 23:11-22. 2003..These data suggest that rifampicin inhibits anti-CD95-mediated apoptosis in lymphocytes by modulating the expression of certain proteins that regulate apoptosis, at least in part, via glucocorticoid receptors... - Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cellsAnshu Agrawal
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
J Leukoc Biol 81:474-82. 2007..These data suggest that modulation of TH2 responses by mercury and thimerosal, in particular, is through depletion of GSH in DC... - Axon reactive B cells clonally expanded in the cerebrospinal fluid of patients with multiple sclerosisYiping Zhang
Department of Neurology, University of California, Irvine, California 92697-4275, USA
J Clin Immunol 25:254-64. 2005..These findings suggest a B cell axonal specific immune response in the CNS in MS... - Age-associated epigenetic modifications in human DNA increase its immunogenicityAnshu Agrawal
Division of Basic and Clinical Immunology, Med Sci I C 240A, University of California, Irvine CA 92697, USA
Aging (Albany NY) 2:93-100. 2010..Increased immunogenicity of self DNA may thus be another mechanism that may contribute to the increase in age-associated chronic inflammation, autoimmunity and cancer... - Biology of dendritic cells in agingAnshu Agrawal
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
J Clin Immunol 28:14-20. 2008..We have discussed certain mechanisms responsible for the defective dendritic cell function associated with aging... - Human dendritic cells activated via dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responsesSudhanshu Agrawal
Division of Basic and Clinical Immunology, Department of Medicine, University of California Irvine, Irvine, California, United States of America
PLoS ONE 5:e13418. 2010..The type of adaptive immune T cell response generated is dependent upon the type of PRR activated by the microbes. Dectin-1 is a C-type lectin receptor present on dendritic cells... - Changes in mitochondrial membrane potential and mitochondrial mass occur independent of the activation of caspase-8 and caspase-3 during CD95-mediated apoptosis in peripheral blood T cellsSastry Gollapudi
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697-4069, USA
Int J Oncol 22:597-600. 2003.... - Impaired functions of peripheral blood monocyte subpopulations in aged humansJoseph Nyugen
Division of Basic and Clinical Immunology, University of California, Med Sci I, C 240, Irvine, CA 92697, USA
J Clin Immunol 30:806-13. 2010.... - Leptin activates human B cells to secrete TNF-?, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathwaySudhanshu Agrawal
Laboratories of Cellular and Molecular Immunology, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
J Clin Immunol 31:472-8. 2011..These data demonstrate that leptin activates human B cells to secrete cytokines via activation of JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathways, which may contribute to its inflammatory and immunoregulatory properties... - Dendritic cells in human agingAnshu Agrawal
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, United States
Exp Gerontol 42:421-6. 2007..A role of DCs in immunosenescence and chronic inflammation associated with aging has not been investigated in detail. In this article, we will briefly review DCs biology and changes associated with human aging... - Polyclonal B-cell expansion in the cerebrospinal fluid of patients with pseudotumor cerebriReng-Rong Da
Department of Neurology, University of California, Irvine, California 92697, USA
J Clin Immunol 24:674-82. 2004..Our results suggest that both T-cell-dependent and T-cell-independent humoral immunity are present in the CSF of PTC... - Vaccinia virus proteins activate human dendritic cells to induce T cell responses in vitroSudhanshu Agrawal
Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
Vaccine 27:88-92. 2009..Overall D13L and H3L proteins are more immunogenic than D8L. Taken together data suggest that these peptides are highly immunogenic and can modulate an effective innate and adaptive response in humans in vitro... - Impact of aging on dendritic cell functions in humansAnshu Agrawal
Division of Basic and Clinical Immunology, Med Sci I C 240A, University of California, Irvine 92697, CA, USA
Ageing Res Rev 10:336-45. 2011..Aging thus has a profound affect on DC functions. Present review summarizes the effect of advancing age on DC functions in humans in the context of both immunity and tolerance... - Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cellsS Gupta
Department of Microbiology and Molecular Genetics, College of Medicine, University of California-Irvine, Irvine, CA 92697-4025, USA
Mol Cell Biol 21:5846-56. 2001..This latter observation is consistent with our previous observation that overstimulation of the activity of endogenous members of Ras signaling pathways, activated MEK in particular, is a prerequisite for aggressive tumorigenic growth... - Age-related alterations of gene expression patterns in human CD8+ T cellsJia Ning Cao
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Medical Sciences I, C 240 Irvine, CA 92697, USA
Aging Cell 9:19-31. 2010.... - Anti-P-glycoprotein antibody-induced apoptosis of activated peripheral blood lymphocytes: a possible role of P-glycoprotein in lymphocyte survivalS Gollapud
Department of Medicine, University of California, Irvine 92697, USA
J Clin Immunol 21:420-30. 2001..These data demonstrate that anti-P-gp mAb promotes apoptosis in activated T lymphocytes by up-regulating CD95L expression and via CD95-CD95L interactions and suggest a possible role of P-gp in lymphocyte survival... - Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathwayS Makani
Cellular and Molecular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine 92697, USA
Genes Immun 3:270-8. 2002..These data suggest that thimerosal induces apoptosis in T cells via mitochondrial pathway by inducing oxidative stress and depletion of GSH... - Ciprofloxacin inhibits activation of latent human immunodeficiency virus type 1 in chronically infected promonocytic U1 cellsS Gollapudi
Department of Medicine, University of California, Irvine 92697, USA
AIDS Res Hum Retroviruses 14:499-504. 1998..Furthermore, ciprofloxacin inhibited TNF-alpha-induced HIV expression in U1 cells. The concentrations of ciprofloxacin that inhibited HIV production are readily achievable in vivo... - P-glycoprotein (encoded by multidrug resistance genes) is not required for interleukin-2 secretion in mice and humansS Gollapudi
Molecular Biology and Cellular Immunology Laboratories, Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697 4069, USA
Genes Immun 1:371-9. 2000..These data show that P-gp is not required for secretion of IL-2, IFN-gamma, IL-4, and IL-10 secretion in mice and IL-2 secretion in humans... - Cellular immunodeficiency and autoimmunity in long-term mineral oil administrationLeman Yel
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
Ann Allergy Asthma Immunol 92:88-91. 2004..Infection, ulceration, subcutaneous nodules, and autoimmune activation are among the known adverse effects. Immunodeficiency has not been previously reported in association with mineral oil injection... - Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunityAishwarya Sridharan
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
Age (Dordr) 33:363-76. 2011..In summary, our study demonstrates that advancing age has a profound effect on PDC function at multiple levels and may therefore, be responsible for the increased susceptibility to infections in the elderly... - Severe T- and B-cell immune deficiency associated with malignant thymomaLeman Yel
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, California 92697, USA
Ann Allergy Asthma Immunol 91:501-5. 2003..Typically, thymic tumors are benign, and gradually developing immunodeficiency consists of hypogammaglobulinemia with low B-cell counts and an inverted CD4+/CD8+ T-cell ratio due to excessive CD8+ T cells... - Hyperimmunoglobulinemia E syndrome associated with coronary artery aneurysms: deficiency of central memory CD4+ T cells and expansion of effector memory CD4+ T cellsTed Y Young
Division of Basic and Clinical Immunology, University of California, Irvine, California, USA
Ann Allergy Asthma Immunol 98:389-92. 2007..Autosomal dominant, autosomal recessive, and sporadic forms have been described. Coronary artery aneurysms and analysis of central (TCMs) and effector (TEMs) memory T cells have not been previously reported with this syndrome... - TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factorsSudhanshu Agrawal
Division of Basic and Clinical Immunology, Medical Sciences I, C 240, University of California, Irvine, CA 92697, USA
J Clin Immunol 31:89-98. 2011.... - A role of inhibitor of apoptosis (IAP) proteins in increased lymphocyte apoptosis in aged humansSudhir Gupta
Department of Medicine, Division of Basic and Medical Sciences 1, C 240, University of California, Irvine, CA 92697, USA
Mech Ageing Dev 125:99-101. 2004..These data may suggest that decreased cIAP2 may play a role in increased apoptosis in aged humans. Possible mechanisms for the regulation of IAPs in aging are discussed... - Chronic HIV type 1 infection down-regulates expression of DAP kinase and p19ARF-p53 checkpoint and is associated with resistance to CD95-mediated apoptosis in HUT78 T cellsChoong H Kim
Molecular Biology Laboratory, Division of Basic and Clinical Immunology, University of California, Irvine, California 92697, USA
AIDS Res Hum Retroviruses 20:183-9. 2004..These data suggest that down-regulation of DAP kinase and downstream signaling factors may be one of the mechanism that HIV-1 may employ to protect the infected host cells from cell death and to allow persistent HIV-1 replication... - Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human heartsNezam Haider
University of California Irvine School of Medicine, Irvine, CA, USA
Nat Clin Pract Cardiovasc Med 6:250-61. 2009..We investigated whether activation of endogenous apoptosis inhibitors plays a part when death receptor and mitochondrial apoptotic pathways have been triggered... - Clinical and immunological features in IgM deficiencyLeman Yel
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
Int Arch Allergy Immunol 150:291-8. 2009..Patients with IgM deficiency may exhibit various clinical manifestations. However, IgM deficiency still remains to be explored with regard to diagnosis and treatment... - The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantationB Reddy
Department of Medicine, Marion Bessin Research Liver Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Transplantation 71:801-11. 2001..Strategies to specifically antagonize CD8+ T cells or to modulate MHC class I expression in association with costimulatory blockade by CTLA4Ig may enhance the clinical feasibility of transplanting allogeneic hepatocytes... - HSP60, Bax, apoptosis and the heartS Gupta
Molecular and Cellular Cardiology, Department of Medicine, University of California, Davis, CA 95616, USA
J Cell Mol Med 9:51-8. 2005..HSP60 has also been shown to accelerate the cleavage of pro-caspase3. Thus, HSP60 has a complex role in apoptosis in the cell. Its binding to Bax under normal conditions suggests a key regulatory role in apoptosis... - Molecular steps of death receptor and mitochondrial pathways of apoptosisS Gupta
Department of Medicine Medical Sciences, University of California, Irvine 92697, USA
Life Sci 69:2957-64. 2001..During the past 5 years, rapid progress has been made in understanding the molecular basis of apoptosis. In this brief review, I will summarize the various molecular steps of apoptosis... - The primary vasculitides: a clinicopathologic correlationNavneet Narula
Department of Pathology, University of California Medical Center, Irvine, Orange 92868, USA
Am J Clin Pathol 124:S84-95. 2005..Incorporation of antineutrophil cytoplasmic antibodies in defining the pathogenesis of vasculitis has been particularly useful in diagnosing those small vessel vasculitides that are life threatening and need immediate intervention... - Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imagingMasayoshi Sarai
University of California, Irvine, California
J Am Coll Cardiol 50:2305-12. 2007..The purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in atherosclerotic lesions as evaluated by imaging with annexin A5... - Mortals turn me onSudhir Gupta
School of Medicine, University of California-Irvine, 101 The City Drive, Irvine, CA 92868, USA
J Nucl Med 46:906-8. 2005 - Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteinsS Gupta
Department of Medicine, Columbia University, New York, NY 10032, USA
J Immunol 166:6104-11. 2001..These findings thus support a model whereby IRF-4 function is modulated in a stage-specific manner by its interaction with developmentally restricted sets of Krüppel-type zinc finger proteins... - HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosisLi Lin
Molecular and Cellular Cardiology, Cardiovascular Division, University of California, Davis, California 95616, USA
Am J Physiol Heart Circ Physiol 293:H2238-47. 2007..Thus abnormal trafficking of HSP60 to the cell surface may be an early trigger for myocyte loss and the progression of heart failure... - IFN-gamma potentiates atherosclerosis in ApoE knock-out miceS Gupta
Department of Medicine, Columbia University, New York 10032, USA
J Clin Invest 99:2752-61. 1997..Therefore, therapeutic inhibition of IFN-gamma signaling may lead to the formation of more lipid-poor and stable atheromata... - Expression of P-glycoprotein, encoded by MDR 1 gene, a metabolically active efflux pump in murine mast cellsD Wein
Division of Basic and Clinical Immunology, Medical Sciences I, University of California, Irvine 92717, USA
Cancer Lett 101:241-6. 1996..These data suggest the presence of a functionally active P-gp in mast cells. A possible physiologic role for P-gp in the secretion of certain mediators/cytokines from mast cells is suggested... - Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary reportS Gupta
Division of Basic and Clinical Immunology, University of California, Irvine 92717
Int J Immunopharmacol 16:197-204. 1994..The most striking change was observed in PKC-zeta isozymes levels. This study for the first time demonstrates that HIV-1 gp120 affects calcium-independent PKC isozymes in U937 cells... - Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCRA E Nel
Department of Medicine, UCLA School of Medicine 90024, USA
J Biol Chem 270:18428-36. 1995..Taken together, these results indicate that anti-CD3 induces Grb2-hSos1-PLC-gamma 1-p36/p38-ZAP70 complexes, which localize in the vicinity of TCR-zeta... - Paired human fibrosarcoma cell lines that possess or lack endogenous mutant N-ras alleles as experimental model for Ras signaling pathwaysS Gupta
Department of Microbiology and Molecular Genetics, College of Medicine, University of California, Irvine, California 92697-4025, USA
Methods Enzymol 333:290-306. 2001..There are dramatic effects on both the transformed and tumorigenic phenotype, depending on the cell line and mutant cDNA that is transfected... - IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cellsS Gupta
Department of Medicine, Columbia University, New York 10032, USA
J Immunol 163:3834-41. 1999..Activation of Stat6 as well as of Stat2:Stat6 complexes by IFN-alpha in B cells may allow modulation of target genes in a cell type-specific manner... - Role of protein kinase beta isozyme in multidrug resistance in murine leukemia P388/ADR cellsS Gollapudi
Division of Basic and Clinical Immunology, University of California, Irvine 92717, USA
J Chemother 7:157-9. 1995..Furthermore, the technique of intracellular delivery of antibodies provides a new approach to discern the role of PKC isoforms in multidrug resistance in various tumor cells... - Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's diseaseA N Irani
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Mol Ther 3:302-9. 2001..These data indicate that liver repopulation with functionally intact cells can reverse pathophysiological perturbations and cure Wilson's disease... - Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cellsS J Berger
Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Biochem Biophys Res Commun 288:101-5. 2001..The possible role of EGCG as a chemotherapeutic agent needs to be investigated... - Liver repopulation with hepatocyte transplantation: new avenues for gene and cell therapyS Gupta
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Gene Med 1:386-92. 1999..Moreover, hepatocyte transplantation systems offer creative tools for defining critical mechanisms in gene regulation and survival of transduced cells... - HSP60, Bax, and cardiac apoptosisA A Knowlton
Cardiovascular Division, Department of Medicine, University of California, Davis 95616, USA
Cardiovasc Toxicol 3:263-8. 2003..Redistribution of cytosolic HSP60 to the plasma membrane during hypoxia appears to contribute to the initiation of the apoptotic cascade with hypoxia and reoxygenation... - Subpopulations of CD4+ (T4+) cells in homosexual/bisexual men with persistent generalized lymphadenopathyS Gupta
Division of Basic and Clinical Immunology, University of California, Irvine 92717
Clin Exp Immunol 68:1-4. 1987..This study demonstrates that HIV infection results in the depletion of both subsets of T4 cells to an almost similar extent... - Immunological and clinical profile of adult patients with selective immunoglobulin subclass deficiency: response to intravenous immunoglobulin therapyF Abrahamian
Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA
Clin Exp Immunol 159:344-50. 2010..IVIG appears to be an effective therapy... - T cells and aging, January 2002 updateGraham Pawelec
University of Tubingen, Center for Medical Research, ZMF, Waldhornlestr 22, D 72072 Tubingen, Germany
Front Biosci 7:d1056-183. 2002.... - Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at homeUwe Nicolay
Section of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
J Clin Immunol 26:65-72. 2006..Treatment satisfaction was significantly improved in Group A. The preference for the subcutaneous route and for home therapy was respectively 81% and 90% in Group A. In Group B, 69% preferred the subcutaneous route and 92% home therapy... - Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseasesHans D Ochs
Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98107, USA
J Clin Immunol 26:265-73. 2006..No treatment-related serious adverse events were reported. We conclude that subcutaneous administration of 16% SCIg is a safe and effective alternative to IVIg for replacement therapy of PIDD... - Disorders of apoptosis: mechanisms for autoimmunity in primary immunodeficiency diseasesJoão Bosco Oliveira
Molecular Immunology and Genetics Section, Universidade de Sao Paulo, Sao Paulo, Brazil
J Clin Immunol 28:S20-8. 2008.... - Neurological picture. Dengue haemorrhagic fever: an unusual cause of intracranial haemorrhageJyoti Kumar
Department of Radiology, All India Institute of Medical Sciences, New Delhi, India
J Neurol Neurosurg Psychiatry 78:253. 2007 - Heartache of fc receptorsSudhir Gupta
J Am Coll Cardiol 49:1693-5. 2007
Research Grants
- TNF-Induced Apoptosis of Lymphocytes in Aged HumansSudhir Gupta; Fiscal Year: 2004..These studied should mechanism (s) for increased TNF-a-induced apoptosis during aging. ..