Thomas E Gunter

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi The Ca2+ transport mechanisms of mitochondria and Ca2+ uptake from physiological-type Ca2+ transients
    T E Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1366:5-15. 1998
  2. ncbi Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms
    Thomas E Gunter
    Department of Biochemistry and Biophysics and Mitochondrial Research and Innovation Group, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1787:1291-308. 2009
  3. ncbi Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity
    Thomas E Gunter
    Department of Biophysics and Biochemistry, University of Rochester School of Medicine and Dentistry, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Neurotoxicology 27:765-76. 2006
  4. ncbi Calcium and mitochondria
    Thomas E Gunter
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, 575 Elmwood Avenue, Rochester, NY 14642, USA
    FEBS Lett 567:96-102. 2004
  5. ncbi Determination of the oxidation states of manganese in brain, liver, and heart mitochondria
    Thomas E Gunter
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurochem 88:266-80. 2004
  6. ncbi An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays
    Thomas E Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Toxicol Appl Pharmacol 249:65-75. 2010
  7. ncbi Mitochondrial calcium transport: mechanisms and functions
    T E Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Cell Calcium 28:285-96. 2000
  8. ncbi Uptake of calcium by mitochondria: transport and possible function
    T E Gunter
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, New York 14642, USA
    IUBMB Life 52:197-204. 2001
  9. ncbi Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A
    Michael J Zuscik
    Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
    J Orthop Res 20:1079-90. 2002
  10. ncbi Determining the oxidation states of manganese in PC12 and nerve growth factor-induced PC12 cells
    Karlene K Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 39:164-81. 2005

Research Grants

  1. A MITOCHONDRIAL ROLE IN MANGANESE TOXICITY
    Thomas Gunter; Fiscal Year: 2003
  2. Mitochondrial Role in Manganese Toxicity
    Thomas Gunter; Fiscal Year: 2007
  3. Mitochondrial Role in Manganese Toxicity
    Thomas Gunter; Fiscal Year: 2010

Detail Information

Publications17

  1. ncbi The Ca2+ transport mechanisms of mitochondria and Ca2+ uptake from physiological-type Ca2+ transients
    T E Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1366:5-15. 1998
    ..Possible ways in which the differences in transport via the RaM and the uniporter may be used to differentiate between metabolic and apoptotic signaling are discussed...
  2. ncbi Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms
    Thomas E Gunter
    Department of Biochemistry and Biophysics and Mitochondrial Research and Innovation Group, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1787:1291-308. 2009
    ..The characteristics of these mechanisms of Ca(2+) transport and a discussion of how they might function are described in this paper...
  3. ncbi Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity
    Thomas E Gunter
    Department of Biophysics and Biochemistry, University of Rochester School of Medicine and Dentistry, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Neurotoxicology 27:765-76. 2006
    ....
  4. ncbi Calcium and mitochondria
    Thomas E Gunter
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, 575 Elmwood Avenue, Rochester, NY 14642, USA
    FEBS Lett 567:96-102. 2004
    ..STKE re1 (2004) 1-9], may also influence this story...
  5. ncbi Determination of the oxidation states of manganese in brain, liver, and heart mitochondria
    Thomas E Gunter
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurochem 88:266-80. 2004
    ..While the presence of Mn3+ complexes cannot be proven in the spectrum of endogenous mitochondrial manganese, the shape of this spectrum could suggest the presence of Mn3+ near the limit of detection, probably as MnSOD...
  6. ncbi An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays
    Thomas E Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Toxicol Appl Pharmacol 249:65-75. 2010
    ....
  7. ncbi Mitochondrial calcium transport: mechanisms and functions
    T E Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Cell Calcium 28:285-96. 2000
    ....
  8. ncbi Uptake of calcium by mitochondria: transport and possible function
    T E Gunter
    Department of Biochemistry and Biophysics, University of Rochester, School of Medicine and Dentistry, New York 14642, USA
    IUBMB Life 52:197-204. 2001
    ....
  9. ncbi Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A
    Michael J Zuscik
    Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
    J Orthop Res 20:1079-90. 2002
    ..These data demonstrate that although activation of PKC or Ca2+ signals is not required, the cylic AMP-dependent A kinase is required for PTHrP to regulate key hallmarks of GPC phenotype...
  10. ncbi Determining the oxidation states of manganese in PC12 and nerve growth factor-induced PC12 cells
    Karlene K Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Free Radic Biol Med 39:164-81. 2005
    ....
  11. ncbi Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect
    Roman A Eliseev
    Center for Musculoskeletal Research and Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:9692-9. 2009
    ..The fact that some tumors overexpress CypD suggests that this may be an additional mechanism of suppression of apoptosis in cancer...
  12. ncbi Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition
    Roman A Eliseev
    Musculoskeletal Research Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States roman
    Neurobiol Aging 28:1532-42. 2007
    ..This may be a protection mechanism that raises the threshold of brain tissue against injuries...
  13. ncbi Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB
    Roman A Eliseev
    Musculo-Skeletal Research Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 279:46748-54. 2004
    ..We, therefore, conclude that diazoxide-mediated preconditioning against apoptosis involves activation of the pro-survival transcription factors CREB and NFkappaB...
  14. ncbi Determining the oxidation states of manganese in NT2 cells and cultured astrocytes
    Karlene K Gunter
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 575 Elmwood Ave, Rochester, NY 14642, USA
    Neurobiol Aging 27:1816-26. 2006
    ..Again we find no evidence for stabilization or accumulation of any Mn(3+) complex derived from oxidation of Mn(2+) under a range of conditions...
  15. ncbi Bcl-2 prevents abnormal mitochondrial proliferation during etoposide-induced apoptosis
    Roman A Eliseev
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Exp Cell Res 289:275-81. 2003
    ..Our data suggest that proliferation of mitochondria may be an integral part of a cascade of apoptotic events...
  16. ncbi Bcl-2 and tBid proteins counter-regulate mitochondrial potassium transport
    Roman A Eliseev
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochim Biophys Acta 1604:1-5. 2003
    ..The described counter-regulation of mitochondrial potassium transport by bcl-2 and Bid suggests a novel view of a mechanism of cytochrome c release from mitochondria in apoptosis...
  17. ncbi Growth plate chondrocyte maturation is regulated by basal intracellular calcium
    Michael J Zuscik
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Exp Cell Res 276:310-9. 2002
    ..These findings underscore the importance of cellular Ca(2+) in GPC function and suggest that PTHrP action in the growth plate is at least partially regulated by changes in basal [Ca(2+)](i)...

Research Grants9

  1. A MITOCHONDRIAL ROLE IN MANGANESE TOXICITY
    Thomas Gunter; Fiscal Year: 2003
    ..abstract_text> ..
  2. Mitochondrial Role in Manganese Toxicity
    Thomas Gunter; Fiscal Year: 2007
    ....
  3. Mitochondrial Role in Manganese Toxicity
    Thomas Gunter; Fiscal Year: 2010
    ....