J S Gunn

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi Bacterial modification of LPS and resistance to antimicrobial peptides
    J S Gunn
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Endotoxin Res 7:57-62. 2001
  2. ncbi Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP
    J S Gunn
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Infect Immun 68:3758-62. 2000
  3. ncbi Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium
    J S Gunn
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Infect Immun 68:6139-46. 2000
  4. ncbi Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bile
    A M Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC 7758, San Antonio, TX 78229 3900, USA
    FEMS Immunol Med Microbiol 41:177-85. 2004
  5. ncbi Identification of Proteus mirabilis mutants with increased sensitivity to antimicrobial peptides
    A J McCoy
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Antimicrob Agents Chemother 45:2030-7. 2001
  6. ncbi Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides
    L Guo
    Department of Microbiology, University of Washington, Seattle 98195, USA
    Cell 95:189-98. 1998
  7. ncbi Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium
    A M Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA
    Microbiology 150:775-83. 2004
  8. ncbi Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core
    R Tamayo
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Bacteriol 187:3391-9. 2005
  9. ncbi Comparative analysis of Salmonella enterica serovar Typhimurium biofilm formation on gallstones and on glass
    A M Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Infect Immun 71:7154-8. 2003
  10. ncbi PhoP-PhoQ-regulated loci are required for enhanced bile resistance in Salmonella spp
    J C van Velkinburgh
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7758, USA
    Infect Immun 67:1614-22. 1999

Collaborators

  • S I Miller
  • S Falkow
  • R Belas
  • A M Prouty
  • R Tamayo
  • I E Brodsky
  • A J McCoy
  • J C van Velkinburgh
  • L Guo
  • R Carlson
  • A Septer
  • M Merighi
  • B Choudhury
  • J Manos
  • W H Schwesinger
  • T J Falla
  • H Liu
  • M Daniel
  • C M Poduje
  • M Hackett
  • K B Lim

Detail Information

Publications11

  1. ncbi Bacterial modification of LPS and resistance to antimicrobial peptides
    J S Gunn
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Endotoxin Res 7:57-62. 2001
    ..Therefore, LPS modification in Gram-negative bacteria plays a significant role during infection in resistance to host antimicrobial factors, avoidance of immune system recognition, and maintenance of virulence phenotypes...
  2. ncbi Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP
    J S Gunn
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Infect Immun 68:3758-62. 2000
    ..As the first constitutive mutant of phoP identified, this allele will be invaluable to future genetic and biochemical studies of this and likely other regulatory systems...
  3. ncbi Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium
    J S Gunn
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Infect Immun 68:6139-46. 2000
    ....
  4. ncbi Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bile
    A M Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, MC 7758, San Antonio, TX 78229 3900, USA
    FEMS Immunol Med Microbiol 41:177-85. 2004
    ..These data further demonstrate that bile is an important environmental signal sensed by Salmonella spp. and that bile plays a role in regulating bacterial gene expression in multiple virulence-associated pathways...
  5. ncbi Identification of Proteus mirabilis mutants with increased sensitivity to antimicrobial peptides
    A J McCoy
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Antimicrob Agents Chemother 45:2030-7. 2001
    ..These data further support the role of LPS modifications as an elaborate mechanism in the resistance of certain bacterial species to APs and suggest that LPS surface charge alterations may play a role in P. mirabilis swarming motility...
  6. ncbi Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides
    L Guo
    Department of Microbiology, University of Washington, Seattle 98195, USA
    Cell 95:189-98. 1998
    ..Similarly, in response to Mg2+ limited growth, other enteric Gram-negative bacteria demonstrated increased lipid A acylation. Compounds that inhibit the ability to increase lipid A acylation may have utility as new antimicrobial agents...
  7. ncbi Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium
    A M Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA
    Microbiology 150:775-83. 2004
    ..These data suggest that bile interacts with salmonellae to increase resistance to bile and other antimicrobials and that this can occur by marRAB- and acrAB-dependent pathways that function independently with respect to bile activation...
  8. ncbi Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core
    R Tamayo
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Bacteriol 187:3391-9. 2005
    ..Therefore, factors other than surface charge/electrostatic interaction contribute to resistance to antimicrobial peptides such as polymyxin B...
  9. ncbi Comparative analysis of Salmonella enterica serovar Typhimurium biofilm formation on gallstones and on glass
    A M Prouty
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Infect Immun 71:7154-8. 2003
    ..These studies show the complex nature of biofilms and demonstrate that characteristics observed for each biofilm are unique to the particular culture condition...
  10. ncbi PhoP-PhoQ-regulated loci are required for enhanced bile resistance in Salmonella spp
    J C van Velkinburgh
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284 7758, USA
    Infect Immun 67:1614-22. 1999
    ..These bile- and PhoP-PhoQ-regulated products may play an important role in the survival of Salmonella spp. in the intestine or gallbladder...
  11. ncbi Biofilm formation and interaction with the surfaces of gallstones by Salmonella spp
    A M Prouty
    Department of Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
    Infect Immun 70:2640-9. 2002
    ..If the basis of carrier development can be understood, it may be possible to identify effective strategies to prevent or treat this chronic infection...