Research Topics
Species | MURRAY E GROSSMANSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Difficulty processing temporary syntactic ambiguities in Lewy body spectrum disorderMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, United States
Brain Lang 120:52-60. 2012..These findings emphasize the role of prefrontal disease in the executive limitations that interfere with processing ambiguous sentences in LBSD...- Biomarkers to identify the pathological basis for frontotemporal lobar degenerationMurray Grossman
Department of Neurology 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
J Mol Neurosci 45:366-71. 2011..While progress has been made in developing biomarkers for FTLD, additional work is needed to extend these advances so that the histopathologic abnormality causing FTLD can be specified in an individual patient... - Category-specific effects in semantic memory: category-task interactions suggested by fMRIMurray Grossman
Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Neuroimage 30:1003-9. 2006.... - Sentence processing in frontotemporal dementiaMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia 19104 4283, USA
Cortex 41:764-77. 2005.... - Frontotemporal dementia: introductionMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
Alzheimer Dis Assoc Disord 19:S1-2. 2005 - Primary progressive aphasia: a reviewMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Neurocase 10:3-18. 2004..Testing hypotheses about finer-grained syndromes such as progressive dysarthria or progressive anomia has important consequences for improving our understanding of language organization and the neural basis for language... - A longitudinal study of sentence comprehension difficulty in primary progressive aphasiaM Grossman
Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
J Neurol Neurosurg Psychiatry 76:644-9. 2005..Patients with primary progressive aphasia have sentence comprehension difficulty, but the longitudinal course of this deficit has not been investigated... - What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degenerationMurray Grossman
Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Brain 127:628-49. 2004..These findings are consistent with the hypothesis that a large-scale neural network supports naming, and that this network is interrupted in several distinct ways in patients with neurodegenerative diseases... - Neural basis for verb processing in Alzheimer's disease: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neuropsychology 17:658-74. 2003..These findings imply that poor performance with verbs in AD is due in part to altered activation of the large-scale neural network that supports verb processing... - How necessary are the stripes of a tiger? Diagnostic and characteristic features in an fMRI study of word meaningMurray Grossman
Department of Neurology 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Neuropsychologia 45:1055-64. 2007.... - Verb acquisition and representation in Alzheimer's diseaseMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, USA
Neuropsychologia 45:2508-18. 2007.... - Primary progressive aphasia: clinicopathological correlationsMurray Grossman
Department of Neurology, 2 Gibson, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Nat Rev Neurol 6:88-97. 2010.... - TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusionsMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, 2 Gibson, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Arch Neurol 64:1449-54. 2007..TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)... - Distinct antemortem profiles in patients with pathologically defined frontotemporal dementiaMurray Grossman
Department of Neurology, 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Arch Neurol 64:1601-9. 2007..Clinical-pathologic studies are crucial to understanding brain-behavior relations and improving diagnostic accuracy in neurodegenerative diseases... - Longitudinal decline in autopsy-defined frontotemporal lobar degenerationM Grossman
Department of Neurology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Neurology 70:2036-45. 2008..The natural history of patients with pathologically proven frontotemporal lobar degeneration (FTLD) is important from clinical and biologic perspectives, but is not well documented quantitatively... - Impaired action knowledge in amyotrophic lateral sclerosisM Grossman
Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Neurology 71:1396-401. 2008..This study examined performance on measures requiring knowledge of actions, and related performance to MRI cortical atrophy in ALS... - The role of ventral medial prefrontal cortex in social decisions: converging evidence from fMRI and frontotemporal lobar degenerationMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neuropsychologia 48:3505-12. 2010..These converging results support the role of vmPFC in social decision-making where potentially negative consequences must be considered... - Biomarkers in frontotemporal lobar degenerationMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
Curr Opin Neurol 23:643-8. 2010..Recent findings assessing the utility of neuroimaging and biofluid biomarkers are reviewed that help identify patients with frontotemporal lobar degeneration (FTLD) spectrum abnormality... - Neural basis for semantic memory difficulty in Alzheimer's disease: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Brain 126:292-311. 2003..Components of the large-scale neural network underlying semantic memory may modify themselves to maintain performance in the face of a neurodegenerative disease... - The neural basis for categorization in semantic memoryMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA
Neuroimage 17:1549-61. 2002..The caudate may support resource demands that are not specific for a particular categorization process. These findings associate partially distinct large-scale neural networks with different forms of categorization in semantic memory... - Sentence processing in Parkinson's diseaseM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelpha 19104 4283, USA
Brain Cogn 40:387-413. 1999..The physiological basis for this deficit appears to be associated with the disruption of a fronto-striatal cerebral network that is compromised following degradation of the DA projection system... - Assessing resource demands during sentence processing in Parkinson's diseaseMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, USA
Brain Lang 80:603-16. 2002.... - Sentence processing strategies in healthy seniors with poor comprehension: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, USA
Brain Lang 80:296-313. 2002..Moreover, these observations emphasize the crucial role of the left perisylvian network for grammatically guided sentence processing in subjects with good comprehension... - Categorization of object descriptions in Alzheimer's disease and frontotemporal dementia: limitation in rule-based processingMurray Grossman
Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
Cogn Affect Behav Neurosci 3:120-32. 2003..These findings suggest that semantic memory difficulty in AD is due in part to a deficit in executive processes that are central to rule-based categorization in semantic memory... - Neural representation of verb meaning: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
Hum Brain Mapp 15:124-34. 2002..We suggest that left posterolateral temporal activation supports aspects of lexical semantic processing concerned with the neural representation of propositional knowledge contributing to COGNITION verbs... - Progressive aphasic syndromes: clinical and theoretical advancesMurray Grossman
Department of Neurology 2 Gibson, University Hospital, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Curr Opin Neurol 15:409-13. 2002..Knowledge of the neural basis for language and related aspects of cognition has been advanced through detailed studies of patients with primary progressive aphasia. This brief review highlights some recent work... - Neural basis for sentence comprehension: grammatical and short-term memory componentsAyanna Cooke
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
Hum Brain Mapp 15:80-94. 2002.... - Cognitive resources during sentence processing in Alzheimer's diseaseM Grossman
Department of Neurology 3 Gates, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Neuropsychologia 39:1419-31. 2001.... - Cognitive resource limitations during sentence comprehension in Parkinson's diseaseM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
Brain Lang 73:1-16. 2000..The sensitivity of PD patients' sentence comprehension accuracy to secondary task resource demands is most consistent with the hypothesis that limited cognitive resources contribute to sentence comprehension difficulty in PD... - Sentence comprehension in Alzheimer's diseaseM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104 4283, USA
Brain Lang 62:186-201. 1998..These findings are consistent with the hypothesis that impaired sentence comprehension in AD is multifactorial in nature, including difficulty processing cognitive resource and semantic aspects of sentences... - Semantic memory in Alzheimer's disease: representativeness, ontologic category, and materialM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
Neuropsychology 12:34-42. 1998..The similarity process for relating coordinate members of a taxonomic category contributes to the normal appreciation of word and picture meaning, and this process is compromised in AD patients with semantic difficulty... - Progressive peripheral agraphiaM Grossman
Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Neurocase 7:339-49. 2001..This disruption of grapheme retrieval is associated with interruption of a superior frontal-parietal system in the left hemisphere... - Object recognition difficulty in visual apperceptive agnosiaM Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
Brain Cogn 33:306-42. 1997.... - Information processing speed and sentence comprehension in Parkinson's diseaseMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
Neuropsychology 16:174-81. 2002..Findings suggest that slowed information processing speed contributes to sentence comprehension difficulty in PD... - Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosisManuela Neumann
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Science 314:130-3. 2006..TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders... - Quantifier comprehension in corticobasal degenerationCorey T McMillan
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Brain Cogn 62:250-60. 2006..29; p<.001]. An important implication of these findings is that the meaning of generalized quantifiers appears to involve two dissociable components, number knowledge and working memory, which are supported by distinct brain regions... - Neuropsychological decline in frontotemporal lobar degeneration: a longitudinal analysisDavid J Libon
Department of Neurology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
Neuropsychology 23:337-46. 2009..These data indicate that distinct patterns of neuropsychological impairment are maintained longitudinally, reflecting the unique anatomic distribution of relative disease burden in AD and FTLD... - Large-scale neural network for sentence processingAyanna Cooke
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Brain Lang 96:14-36. 2006.... - Clinical and pathological continuum of multisystem TDP-43 proteinopathiesFelix Geser
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Arch Neurol 66:180-9. 2009.... - Neuropsychological patterns in magnetic resonance imaging-defined subgroups of patients with degenerative dementiaJohn Listerud
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
J Int Neuropsychol Soc 15:459-70. 2009..We conclude that classifying patients with degenerative dementia by specific pattern of cortical atrophy has the potential to predict individual patterns of cognitive deficits... - Resolving sentence ambiguity with planning and working memory resources: Evidence from fMRISusana Novais Santos
Department of Bioengineering, University of Pennsylvania, USA
Neuroimage 37:361-78. 2007..These findings are consistent with a large-scale neural network for sentence processing that recruits distinct planning and working memory processing resources as needed to support the comprehension of sentences... - Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's diseaseMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Ann Neurol 57:721-9. 2005..We conclude that CSF tau levels are significantly reduced in many patients with FTD... - Numerosity impairment in corticobasal syndromeShira Koss
Department of Neurology, University of Pennsylvania, PA, USA
Neuropsychology 24:476-92. 2010..We assessed the representation of numerosity in corticobasal syndrome (CBS), a neurodegenerative condition affecting the parietal lobe... - Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutationsVivianna M Van Deerlin
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Arch Neurol 64:1148-53. 2007..Patients with frontotemporal dementia due to mutation of progranulin may have a distinct phenotype... - Knowledge of natural kinds in semantic dementia and Alzheimer's diseaseKaty Cross
Department of Neurology 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Brain Lang 105:32-40. 2008..We suggest that SD patients may be impaired in part at identifying the features critical to diagnosing membership in a semantic category, while AD patients' performance is consistent with their semantic categorization deficit... - Too much to count on: impaired very small numbers in corticobasal degenerationCasey Halpern
Department of Neurology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Brain Cogn 64:144-9. 2007..Difficulty judging very small numbers is impaired in CBD, suggesting degraded representation of precise number knowledge that does not depend on language functioning... - Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's diseaseCasey H Halpern
Department of Neurosurgery, Neurology and Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Int J Geriatr Psychiatry 24:443-51. 2009..The following review sought to provide a clearer understanding of the various cognitive sequelae of bilateral subthalamic nucleus (STN) DBS while taking into account corresponding neuroanatomy and potential confounding variables... - Shape-based alignment of hippocampal subfields: evaluation in postmortem MRIPaul A Yushkevich
Department of Radiology, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv 11:510-7. 2008.... - Frontotemporal dementia: a reviewMurray Grossman
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104-4283, USA
J Int Neuropsychol Soc 8:566-83. 2002..The clinical, neuroimaging and neuropathological profiles associated with these clinically defined subgroups are examined... - Neural basis for sentence comprehension deficits in frontotemporal dementiaAyanna Cooke
Department of Neurology-2 Gibson, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
Brain Lang 85:211-21. 2003..We conclude that FTD subgroups have distinct patterns of sentence comprehension difficulty in part because of selective interruptions of a large-scale neural network for sentence processing... - Verbal mediation of number knowledge: evidence from semantic dementia and corticobasal degenerationCasey Halpern
Department of Neurology, University of Pennsylvania, USA
Brain Cogn 56:107-15. 2004..CBD patients' impairment with larger numbers despite minimal aphasia, and SD patients' intact performance despite an aphasia, challenge the proposal that understanding larger numbers depends on verbal mediation... - Neural processing during older adults' comprehension of spoken sentences: age differences in resource allocation and connectivityJonathan E Peelle
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cereb Cortex 20:773-82. 2010..We conclude that decreased activation of specialized processing regions, and limited ability to coordinate activity between regions, contribute to older adults' difficulty with sentence comprehension under difficult listening conditions... - Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairmentWilliam T Hu
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 119:669-78. 2010..In summary, our targeted proteomic screen revealed novel CSF biomarkers that can improve the distinction between AD and non-AD cases by established biomarkers alone... - Frontotemporal dementia: clinicopathological correlationsMark S Forman
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
Ann Neurol 59:952-62. 2006.... - Hierarchical organization of scripts: converging evidence from FMRI and frontotemporal degenerationChristine Farag
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Cereb Cortex 20:2453-63. 2010..Our findings suggest that frontal cortex contributes to clustering events during script comprehension, underlining the role of frontal cortex in the hierarchical organization of a script... - Is it logical to count on quantifiers? Dissociable neural networks underlying numerical and logical quantifiersVanessa Troiani
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
Neuropsychologia 47:104-11. 2009.... - Interaction between process and content in semantic memory: an fMRI study of noun feature knowledgeJonathan E Peelle
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neuropsychologia 47:995-1003. 2009..Together, these results support the hypothesis that various classes of nouns are represented differently in semantic memory, and emphasize the dynamic interaction of process and content in semantic memory... - Left inferior parietal representations for skilled hand-object interactions: evidence from stroke and corticobasal degenerationLaurel J Buxbaum
Moss Rehabilitation Research Institute, Philadelphia, PA 19141, USA
Cortex 43:411-23. 2007.... - The neural basis for category-specific knowledge: an fMRI studyMurray Grossman
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Neuroimage 15:936-48. 2002.... - Reversal of the concreteness effect for verbs in patients with semantic dementiaHyon Ah Yi
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neuropsychology 21:9-19. 2007..Second, visual feature knowledge is degraded in patients with SD because of the anatomic distribution of the disease in visual association cortex, causing relatively greater difficulty for concrete verbs compared to abstract verbs... - Calculation impairment in neurodegenerative diseasesCasey Halpern
Department of Neurology-3 Gates, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia 19104-4283, USA
J Neurol Sci 208:31-8. 2003..FTD had more difficulty relative to AD in their performance of reverse digit span, consistent with our hypothesis that FTD patients' executive resource limitation contributes to their pattern of calculation impairment... - Impaired information integration contributes to communication difficulty in corticobasal syndromeRachel G Gross
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Cogn Behav Neurol 23:1-7. 2010..To investigate the cognitive and neural correlates of discourse impairment in corticobasal syndrome (CBS)... - TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusionsManuela Neumann
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Neuropathol Exp Neurol 66:177-83. 2007..Taken together, these results expand the spectrum of TDP-43 pathology in FTLD-U, suggesting that white matter pathology might contribute to the neurodegenerative process and clinical symptoms in FTLD-U... - Co-morbidity of TDP-43 proteinopathy in Lewy body related diseasesHanae Nakashima Yasuda
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
Acta Neuropathol 114:221-9. 2007..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders... - Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathiesKunihiro Uryu
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Neuropathol Exp Neurol 67:555-64. 2008..These findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis... - Attentional resource and processing speed limitations during sentence processing in Parkinson's diseaseChristine Lee
Department of Neurology, Hospital of the University of Pennsylvania, 3 Gates Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA
Brain Lang 85:347-56. 2003..Our findings are consistent with the claim that limited executive resources for strategic attention and processing speed contribute to the sentence comprehension difficulties of PD patients... - TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysisVivianna M Van Deerlin
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Lancet Neurol 7:409-16. 2008..Our aim was to investigate whether TARDBP is a candidate disease gene for familial ALS that is not associated with mutations in superoxide dismutase 1 (SOD1)... - Lexical acquisition in progressive aphasia and frontotemporal dementiaRyan Murray
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Cogn Neuropsychol 24:48-69. 2007.... - Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodiesDeepak M Sampathu
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor Maloney Bldg, Philadelphia, PA 19104, USA
Am J Pathol 169:1343-52. 2006..Identification of the disease proteins recognized by these mAbs will further advance understanding of molecular substrates of FTLD-U neurodegenerative pathways... - Speech errors in progressive non-fluent aphasiaSharon Ash
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Brain Lang 113:13-20. 2010..We conclude that the speech errors produced by PNFA patients are mainly errors at the phonemic level of language processing and are not caused by a motor planning impairment... - The correlation of cognitive decline with frontotemporal dementia induced annualized gray matter loss using diffeomorphic morphometryBrian Avants
University of Pennsylvania School of Medicine, Philadelphia, 19104 6389, USA
Alzheimer Dis Assoc Disord 19:S25-8. 2005..This study gives insight into the relationship between FTD-related progressive cortical atrophy and loss in cognitive function... - Survival profiles of patients with frontotemporal dementia and motor neuron diseaseWilliam T Hu
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Arch Neurol 66:1359-64. 2009..Frontotemporal dementia and amyotrophic lateral sclerosis are neurodegenerative diseases associated with TAR DNA-binding protein 43- and ubiquitin-immunoreactive pathologic lesions... - Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosisLionel M Igaz
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3600 Spruce St, 3rd Floor, Maloney Bldg, Philadelphia, PA 19104, USA
Am J Pathol 173:182-94. 2008..Therefore, regionally different pathogenic processes may underlie the development of abnormal TDP-43 proteinopathies... - Variations in the progranulin gene affect global gene expression in frontotemporal lobar degenerationAlice S Chen-Plotkin
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Hum Mol Genet 17:1349-62. 2008..In addition, these data from a large number of human brains provide a valuable resource for future testing of disease hypotheses... - Dementia induces correlated reductions in white matter integrity and cortical thickness: a multivariate neuroimaging study with sparse canonical correlation analysisBrian B Avants
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Neuroimage 50:1004-16. 2010..We conclude that SCCA is a potentially valuable approach in image analysis that can be applied productively to distinguishing between neurodegenerative conditions... - Alzheimer's disease and frontotemporal dementia exhibit distinct atrophy-behavior correlates: a computer-assisted imaging studyJames Gee
Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 370, Philadelphia, PA 19104 2644, USA
Acad Radiol 10:1392-401. 2003..The purpose of this study was to test the hypothesis that distinct patterns of gray matter atrophy are responsible for unique interruptions of the naming process in Alzheimer's disease (AD) and frontotemporal dementia (FTD)... - Visual perceptual functions predict instrumental activities of daily living in patients with dementiaGuila Glosser
Department of Neurology, University of Pennsylvannia School of Medicine, Philadelphia 19104 4283, USA
Neuropsychiatry Neuropsychol Behav Neurol 15:198-206. 2002..To assess relations between discrete visual perceptual functions commonly affected in patients with neurodegenerative dementia and the performance of instrumental activities of daily living (IADL)... - Design of comprehensive Alzheimer's disease centers to address unmet national needsJohn Q Trojanowski
Institute on Aging, Philadelphia, PA, USA
Alzheimers Dement 6:150-5. 2010..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders... - TDP-43 and frontotemporal dementiaWilliam T Hu
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19106, USA
Curr Neurol Neurosci Rep 9:353-8. 2009.... - Novel concepts mediate word retrieval from human episodic associative memory: evidence from event-related potentialsJohn Kounios
Institute for Research in Cognitive Science, University of Pennsylvania, 3401 Walnut Street, Suite 400A, Philadelphia, PA 19104 6228, USA
Neurosci Lett 345:157-60. 2003..Estimates of current source density at the cortical surface showed that fusion-mediated retrieval elicited left inferior-prefrontal/anterior-temporal activity not typically observed in episodic memory retrieval studies... - The new classification of primary progressive aphasia into semantic, logopenic, or nonfluent/agrammatic variantsMichael F Bonner
Department of Neurology, 2 Gibson, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Neurol Neurosci Rep 10:484-90. 2010..Improved reliability of diagnoses will be increasingly important as trials for etiology-specific treatments become available. We also discuss the implications of these syndromes for theories of language function... - Sparse unbiased analysis of anatomical variance in longitudinal imagingBrian Avants
Dept of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389 USA
Med Image Comput Comput Assist Interv 13:324-31. 2010.... - Relating structural and functional connectivity to performance in a communication taskJeffrey T Duda
Department of Bioengineering, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv 13:282-9. 2010..Multiple regression analysis demonstrated that combining equidimensional measures of functional and structural connectivity identified the network components that most significantly predict performance... - Memory encoding and retrieval in frontotemporal dementia and Alzheimer's diseaseGuila Glosser
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
Neuropsychology 16:190-6. 2002..FTD patients' retained capacity for encoding new information into long-term declarative memory is likely due to relatively spared medial temporal lobe involvement... - Longitudinal patterns of semantic and episodic memory in frontotemporal lobar degeneration and Alzheimer's diseaseSharon X Xie
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
J Int Neuropsychol Soc 16:278-86. 2010..These data suggest the presence of specific longitudinal patterns of impairment for episodic and semantic memory in AD and FTLD patients suggesting that all forms of dementia do not necessarily converge into a single phenotype... - Medial temporal lobe involvement in an implicit memory task: evidence of collaborating implicit and explicit memory systems from FMRI and Alzheimer's diseasePhyllis Koenig
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cereb Cortex 18:2831-43. 2008..These findings suggest that implicit and explicit memory systems collaborate in neurologically intact individuals performing an ostensibly implicit memory task... - Patient care and management of frontotemporal lobar degenerationLauren Massimo
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Am J Alzheimers Dis Other Demen 23:125-31. 2008..Nonpharmacologic management such as behavioral interventions and environmental engineering are also efficacious in optimizing quality of life... - Spatiotemporal normalization for longitudinal analysis of gray matter atrophy in frontotemporal dementiaBrian Avants
Dept of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Med Image Comput Comput Assist Interv 10:303-10. 2007..This paper shows the statistical power of symmetric diffeomorphic normalization for performing deformation-based studies of longitudinal atrophy... - Motor neuron disease and frontotemporal lobar degeneration: a tale of two disorders linked to TDP-43Lauren B Elman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neurosignals 16:85-90. 2008..Moreover, biochemical studies of ubiquinated histopathologic abnormalities in MND and FTLD reveal identical inclusions of TDP-43. These findings underline a fundamental link between MND and FTLD. This paper reviews this body of work... - Deep brain stimulation in the treatment of obesityCasey H Halpern
Department of Neurosurgery, Center for Weight and Eating Disorders, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neurosurg 109:625-34. 2008..The authors conclude that deep brain stimulation should be strongly considered as a promising therapeutic option for patients suffering from refractory obesity... - A high-resolution computational atlas of the human hippocampus from postmortem magnetic resonance imaging at 9.4 TPaul A Yushkevich
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 44:385-98. 2009..An example application examining subfield-level hippocampal atrophy in temporal lobe epilepsy demonstrates the application of the atlas to in vivo studies... - Categorization of novel animals by patients with Alzheimer's disease and corticobasal degenerationPhyllis Koenig
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neuropsychology 21:193-206. 2007..Moreover, AD patients' impaired categorization correlated with performance on a measure of semantic memory, implicating this categorization deficit in AD patients' semantic memory difficulty... - Registration based cortical thickness measurementSandhitsu R Das
Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Neuroimage 45:867-79. 2009..Evaluation of this method is presented on synthetic images. As an application to brain images, a longitudinal study of thickness change in frontotemporal dementia (FTD) spectrum disorder is reported... - Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individualVivianna M Van Deerlin
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research and Institute on Aging, University of Pennsylvania, 3600 Spruce St, 3 Maloney Bldg, Philadelphia, PA, 19104, USA
Acta Neuropathol 113:471-9. 2007..This is also the first reported case of any MAPT mutation in an individual of African American ethnicity... - The neural basis for novel semantic categorizationPhyllis Koenig
Department of Neurology, University of Pennsylvania 19104 4283, USA
Neuroimage 24:369-83. 2005..These findings suggest that large-scale networks support relatively distinct categorization processes during the acquisition and judgment of semantic category knowledge... - Brain progranulin expression in GRN-associated frontotemporal lobar degenerationAlice S Chen-Plotkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Acta Neuropathol 119:111-22. 2010.... - Disturbed visual processing contributes to impaired reading in Alzheimer's diseaseGuila Glosser
Department of Neurology Gates 3 West, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Neuropsychologia 40:902-9. 2002.... - Categorization of novel tools by patients with Alzheimer's disease: category-specific content and processPhyllis Koenig
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, United States
Neuropsychologia 48:1877-85. 2010..The results suggest that categorization processes are sensitive to category content, which influences AD patients' success at acquiring a new category... - Neuropsychiatric features of amyotrophic lateral sclerosisLauren B Elman
Department of Neurology, Neuromuscular Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
NeuroRehabilitation 22:425-9. 2007 - Preserved musical semantic memory in semantic dementiaJessica Weinstein
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Arch Neurol 68:248-50. 2011..To understand the scope of semantic impairment in semantic dementia...
Research Grants
- Cognitive Impairments in Parkinson's Disease and AgingMurray Grossman; Fiscal Year: 2006..Our data support a componential neurocognitive architecture consisting of dynamically interactive networks modified to process sentences depending on available resources and relative demand. ..
- Conceptual Processing in Alzheimer's DiseaseMurray Grossman; Fiscal Year: 2007....
- Neural Basis of Generalized QuantifersMurray Grossman; Fiscal Year: 2007..The results of these studies will provide a novel and important perspective on the neural basis for semantic memory, and will improve diagnostic and prognostic accuracy in patients suffering from dementia. ..
- Conceptual Processing in Alzheimer's DiseaseMurray Grossman; Fiscal Year: 2009..This work will help facilitate communication in the day-to-day care of patients with AD, and advance our understanding of a fundamental aspect of cognition. ..
- Neural Basis of Generalized QuantifiersMurray Grossman; Fiscal Year: 2010..The proposed work will provide important insights into the cognitive neuroscience of language and number while improving diagnostic accuracy in an elusive neurodegenerative condition. ..
- COGNITIVE IMPAIRMENTS IN PARKINSONS DISEASE AND AGINGMurray Grossman; Fiscal Year: 2000..These findings will contribute to cognitive neuroscience by defining the anatomic basis for cognitive resources and the modular processes that underlie a distributed cerebral network supporting a complex cognitive process. ..
- CONCEPTUAL PROCESSING IN ALZHEIMERS DISEASEMurray Grossman; Fiscal Year: 2002....
- Conceptual Processing in Alzheimer's DiseaseMurray Grossman; Fiscal Year: 2010..This work will help facilitate communication in the day-to-day care of patients with AD, and advance our understanding of a fundamental aspect of cognition. ..