M M Griffiths

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Genetic analysis of collagen-induced arthritis in rats: a polygenic model for rheumatoid arthritis predicts a common framework of cross-species inflammatory/autoimmune disease loci
    M M Griffiths
    Salt Lake City Veterans Affairs Salt Lake City Health Care System, Department of Medicine, University of Utah School of Medicine, USA
    Immunol Rev 184:172-83. 2001
  2. ncbi Mapping autoimmunity genes
    M M Griffiths
    Veteran Affairs Medical Center, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UI, USA
    Curr Opin Immunol 11:689-700. 1999
  3. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
  4. ncbi Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
    P S Gulko
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 41:2122-31. 1998
  5. ncbi Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases
    R L Wilder
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplant Proc 31:1585-8. 1999
  6. ncbi Genetic factors involved in central nervous system/immune interactions
    R L Wilder
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Adv Exp Med Biol 493:59-67. 2001
  7. ncbi Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci
    T Furuya
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1820, USA
    Hum Mol Genet 9:2241-50. 2000
  8. ncbi An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains
    S V Dracheva
    The Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Genomics 63:202-26. 2000
  9. ncbi Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats
    S V Dracheva
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, 10 Center Drive MSC 1820, Bethesda, MD 20892, USA
    Immunogenetics 49:787-91. 1999
  10. ncbi An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Transplant Proc 31:1549-54. 1999

Collaborators

Detail Information

Publications14

  1. ncbi Genetic analysis of collagen-induced arthritis in rats: a polygenic model for rheumatoid arthritis predicts a common framework of cross-species inflammatory/autoimmune disease loci
    M M Griffiths
    Salt Lake City Veterans Affairs Salt Lake City Health Care System, Department of Medicine, University of Utah School of Medicine, USA
    Immunol Rev 184:172-83. 2001
    ..Continued dissection of the genetic underpinnings of rat arthritis models should provide candidate genes for investigation in human patients and lead to a clearer understanding of the complex genetics of RA...
  2. ncbi Mapping autoimmunity genes
    M M Griffiths
    Veteran Affairs Medical Center, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UI, USA
    Curr Opin Immunol 11:689-700. 1999
    ..Candidate genes are being identified. Polymorphic alleles associated with these chromosomal segments may represent predisposing genetic elements common to a number of human diseases with very different clinical presentations...
  3. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
    ..Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats...
  4. ncbi Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
    P S Gulko
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 41:2122-31. 1998
    ..To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type II collagen-induced arthritis (CIA)...
  5. ncbi Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases
    R L Wilder
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Transplant Proc 31:1585-8. 1999
  6. ncbi Genetic factors involved in central nervous system/immune interactions
    R L Wilder
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Adv Exp Med Biol 493:59-67. 2001
    ..Further genetic dissection and identification of the underlying genes will be necessary to infer a mechanistic link between autoimmune and neuroendocrine traits...
  7. ncbi Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci
    T Furuya
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1820, USA
    Hum Mol Genet 9:2241-50. 2000
    ..Our data support the view that multiple autoimmune diseases may share genetic risk factors, and suggest that many of these loci are gender influenced...
  8. ncbi An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains
    S V Dracheva
    The Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Genomics 63:202-26. 2000
    ..Two hundred forty genes are incorporated in the map. This integrated map should allow comparison of rat genetic maps from different groups and thereby facilitate genetic studies of rat autoimmune and related disease models...
  9. ncbi Identification of a new quantitative trait locus on chromosome 7 controlling disease severity of collagen-induced arthritis in rats
    S V Dracheva
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, 10 Center Drive MSC 1820, Bethesda, MD 20892, USA
    Immunogenetics 49:787-91. 1999
    ....
  10. ncbi An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Transplant Proc 31:1549-54. 1999
  11. ncbi Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases
    Y Kawahito
    The Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 1820, USA
    J Immunol 161:4411-9. 1998
    ..The rat models appear to provide a powerful complementary approach to identify and characterize candidate genes that may contribute to autoimmune diseases in several species...
  12. ncbi Genetic maps of polymorphic DNA loci on rat chromosome 1
    Y P Ding
    Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:320-7. 1996
    ..Homologs of the rat chromosome 1 genes that we mapped are located on human chromosomes 6, 10, 11, 12, 15, 16, and 19...
  13. ncbi A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Genet 14:82-5. 1996
    ..These genes may also represent novel targets for therapy...
  14. ncbi HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis
    G H Nabozny
    Department of Immunology, Mayo Medical School, Rochester, Minnesota 55905, USA
    J Exp Med 183:27-37. 1996
    ..Therefore, these results strongly suggest that HLA-DQ8 molecules contribute to genetic susceptibility to arthritis and also establish a novel animal model for the study of human arthritis...