Research Topics
| Michael GravettSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infectionMichael G Gravett
Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
J Proteome Res 6:89-96. 2007..Protein expression signatures and immunodetection of specific biomarkers identified can be employed for noninvasive detection of IAI...- Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate modelMichael G Gravett
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
Am J Obstet Gynecol 197:518.e1-8. 2007..The purpose of this study was to determine whether treatment with ampicillin together with dexamethasone and indomethacin delays preterm birth that is induced by intraamniotic group B Streptococcus in a nonhuman primate model... - Global report on preterm birth and stillbirth (2 of 7): discovery scienceMichael G Gravett
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
BMC Pregnancy Childbirth 10:S2. 2010..About two-thirds of late fetal deaths occur during the antepartum period; the other third occur during childbirth. Intrapartum asphyxia is a leading cause of stillbirths in low- and middle-income countries... - Dexamethasone or interleukin-10 blocks interleukin-1beta-induced uterine contractions in pregnant rhesus monkeysDrew W Sadowsky
Division of Reproductive Sciences, Oregon Regional Primate Research Center, Oregon Health Sciences University, Portland, OR 97201, USA
Am J Obstet Gynecol 188:252-63. 2003..Dexamethasone and interleukin-10 are likely to be useful adjuncts in the treatment of preterm labor that is associated with inflammation or infection... - Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate modelDrew W Sadowsky
Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR, USA
Am J Obstet Gynecol 195:1578-89. 2006..The purpose of this study was to determine the relative contributions of individual proinflammatory cytokines and chemokines to the triggering of preterm labor... - Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluidJane Hitti
Department of Obstetrics Gynecology, University of Washington, Seattle, WA, USA
Am J Obstet Gynecol 203:32.e1-8. 2010..We analyzed the vaginal fluid proteome to identify biomarkers of intraamniotic infection among women in preterm labor... - Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkersMichael G Gravett
Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Ore, USA
JAMA 292:462-9. 2004..Intra-amniotic infection (IAI) is commonly associated with preterm birth and adverse neonatal sequelae. Early diagnosis of IAI, however, has been hindered by insensitive or nonspecific tests... - Pretreatment with toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeysKristina M Adams Waldorf
University of Washington, Seattle, WA 98195, USA
Reprod Sci 15:121-7. 2008..05). Toll-like receptor antagonists, together with antibiotics, may delay or prevent infection-associated preterm birth... - Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaquesMiles J Novy
Divisions of Reproductive Sciences Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Reprod Sci 16:56-70. 2009..U parvum or M hominis, as sole pathogens, elicit a robust proinflammatory response which contributes to preterm labor and fetal lung injury... - Choriodecidual inflammation: a harbinger of the preterm labor syndromePeta L Grigsby
Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
Reprod Sci 17:85-94. 2010.... - Detection of intra-amniotic infection in a rabbit model by proteomics-based amniotic fluid analysisLaura L Klein
Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, CO, USA
Am J Obstet Gynecol 193:1302-6. 2005..CONCLUSION: Amniotic fluid proteomic analysis was able to detect intra-amniotic infection in this experimental rabbit model. S100 proteins may be involved in the host inflammatory response to intra-amniotic infection... - Global report on preterm birth and stillbirth (7 of 7): mobilizing resources to accelerate innovative solutions (Global Action Agenda)Craig E Rubens
Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children s, Seattle, Washington, USA
BMC Pregnancy Childbirth 10:S7. 2010..Participants and others have already completed or launched work on key milestones identified in the GAA. Updates will be provided at www.gapps.org... - Amniocentesis results and novel proteomic analysis in a case of occult candidal chorioamnionitisJulie T Crawford
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA
J Matern Fetal Neonatal Med 19:667-70. 2006..We hypothesize that since amniotic fluid culture of yeast may take days, novel tests such as proteomic profiling may lead to the development of rapid diagnostic tests for fungal intra-amniotic infections... - Global report on preterm birth and stillbirth (6 of 7): ethical considerationsMaureen Kelley
Department of Pediatrics, Bioethics Division, University of Washington School of Medicine, Seattle Children s Hospital, Seattle, Washington, USA
BMC Pregnancy Childbirth 10:S6. 2010..This analysis identifies ethical issues impacting definitions, discovery, development, and delivery of effective interventions to decrease the global burden of preterm birth and stillbirth... - Insights into the multifactorial nature of preterm birth: proteomic profiling of the maternal serum glycoproteome and maternal serum peptidome among women in preterm laborLeonardo Pereira
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA
Am J Obstet Gynecol 202:555.e1-10. 2010..The purpose of this study was to identify peptide classifiers that predict spontaneous preterm birth (SPTB) among women in preterm labor (PTL) and to demonstrate specific protein pathways that are activated in PTL... - Identification of matrix metalloproteinase-9 in amniotic fluid and amniochorion in spontaneous labor and after experimental intrauterine infection or interleukin-1 beta infusion in pregnant rhesus monkeysFelipe Vadillo-Ortega
Department of Research Direction and Electron Microscopy, , Mexico City, Mexico
Am J Obstet Gynecol 186:128-38. 2002..Amniotic fluid matrix metalloproteinase-9 may serve as a clinical marker for the onset of both preterm and term labor... - Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluidLeonardo Pereira
Department of Pediatrics and Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA
J Proteome Res 6:1269-76. 2007..Further characterization and quantification of these markers in a larger cohort of subjects may provide the basis for new tests for the early, noninvasive positive prediction of SPTB... - Comprehensive proteomic analysis of human cervical-vaginal fluidSurendra Dasari
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
J Proteome Res 6:1258-68. 2007..This data set provides a foundation for evaluation of these proteins as potential CVF biomarkers for noninvasive diagnosis of pregnancy-related disorders... - Proteomic analysis of maternal serum in down syndrome: identification of novel protein biomarkersSrinivasa R Nagalla
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
J Proteome Res 6:1245-57. 2007..Further characterization and quantification of these markers in a larger cohort of subjects may provide the basis for new tests for improved DS screening... - Comprehensive proteomic analysis of the human amniotic fluid proteome: gestational age-dependent changesJohn Edward A Michaels
ProteoGenix, Inc, Portland, Oregon 97213, USA
J Proteome Res 6:1277-85. 2007..A systematic analysis of proteins present both in AF and maternal serum could lead to the development of new noninvasive diagnostic procedures to monitor fetal status...
Research Grants
- EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITYMichael Gravett; Fiscal Year: 1999..It has the unique potential to reveal biological innovations reflective of the prokaryotic/eukaryotic divergence. ..
- EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITYMichael Gravett; Fiscal Year: 2005..These studies will clarify the pathophysiology of infection-associated preterm labor and will suggest effective interventional strategies. ..