James R Goss

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi The therapeutic potential of gene transfer for the treatment of peripheral neuropathies
    James R Goss
    Molecular Genetics and Biochemistry, Center for Biotechnology and Bioengineering, University of Pittsburgh, 300 Technology Drive, Rm 208, Pittsburgh, PA 15219, USA
    Expert Rev Mol Med 9:1-20. 2007
  2. ncbi Gene therapy applications for the treatment of neuropathic pain
    James R Goss
    University of Pittsburgh, Molecular Genetics and Biochemistry, Pittsburgh, PA 15219, USA
    Expert Rev Neurother 7:487-506. 2007
  3. ncbi Premature aging-related peripheral neuropathy in a mouse model of progeria
    James R Goss
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213 1863, USA
    Mech Ageing Dev 132:437-42. 2011
  4. ncbi Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin
    Hitoshi Yokoyama
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Gene Ther 20:63-71. 2009
  5. ncbi Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats
    Minoru Miyazato
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Urol 184:1204-10. 2010
  6. ncbi HSV delivery of a ligand-regulated endogenous ion channel gene to sensory neurons results in pain control following channel activation
    James R Goss
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    Mol Ther 19:500-6. 2011
  7. ncbi Herpes vector-mediated expression of proenkephalin reduces bone cancer pain
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Ann Neurol 52:662-5. 2002
  8. ncbi Delivery of herpes simplex virus-based vectors to the nervous system
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, and GRECC, VA Medical Center, Pittsburgh, PA, USA
    Methods Mol Biol 246:309-22. 2004
  9. ncbi Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Diabetes 51:2227-32. 2002

Research Grants

  1. Antioxidant Gene Therapy to Treat Diabetic Neuropathy
    James Goss; Fiscal Year: 2007
  2. Antioxidant Gene Therapy to Treat Diabetic Neuropathy
    James Goss; Fiscal Year: 2009

Collaborators

Detail Information

Publications9

  1. ncbi The therapeutic potential of gene transfer for the treatment of peripheral neuropathies
    James R Goss
    Molecular Genetics and Biochemistry, Center for Biotechnology and Bioengineering, University of Pittsburgh, 300 Technology Drive, Rm 208, Pittsburgh, PA 15219, USA
    Expert Rev Mol Med 9:1-20. 2007
    ..Many published studies support the feasibility of this approach, although several questions still need to be addressed as gene therapy to treat peripheral neuropathy moves out of the laboratory and into the clinic...
  2. ncbi Gene therapy applications for the treatment of neuropathic pain
    James R Goss
    University of Pittsburgh, Molecular Genetics and Biochemistry, Pittsburgh, PA 15219, USA
    Expert Rev Neurother 7:487-506. 2007
    ..Candidate gene products include directly analgesic proteins as well as proteins that interfere with pain-associated biochemical changes in nerve or other tissues underlying the disease process...
  3. ncbi Premature aging-related peripheral neuropathy in a mouse model of progeria
    James R Goss
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213 1863, USA
    Mech Ageing Dev 132:437-42. 2011
    ..This provides strong evidence that DNA damage can drive peripheral neuropathy and offers a rapid and novel model to test therapies...
  4. ncbi Gene therapy for bladder overactivity and nociception with herpes simplex virus vectors expressing preproenkephalin
    Hitoshi Yokoyama
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hum Gene Ther 20:63-71. 2009
    ..Thus, gene therapy may represent a potentially useful treatment modality for bladder hypersensitive disorders such as IC/PBS...
  5. ncbi Suppression of detrusor-sphincter dyssynergia by herpes simplex virus vector mediated gene delivery of glutamic acid decarboxylase in spinal cord injured rats
    Minoru Miyazato
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Urol 184:1204-10. 2010
    ....
  6. ncbi HSV delivery of a ligand-regulated endogenous ion channel gene to sensory neurons results in pain control following channel activation
    James R Goss
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    Mol Ther 19:500-6. 2011
    ..Use of an endogenous inhibitory receptor not normally present on sensory neurons both minimizes immunogenicity and maximizes therapeutic selectivity...
  7. ncbi Herpes vector-mediated expression of proenkephalin reduces bone cancer pain
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Ann Neurol 52:662-5. 2002
    ..These results suggest that gene transfer with an enkephalin-expressing vector may be used to treat pain resulting from cancer in bone...
  8. ncbi Delivery of herpes simplex virus-based vectors to the nervous system
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, and GRECC, VA Medical Center, Pittsburgh, PA, USA
    Methods Mol Biol 246:309-22. 2004
    ....
  9. ncbi Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse
    James R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Diabetes 51:2227-32. 2002
    ..3 microV). These results suggest that gene transfer with an NGF-producing herpes-based vector may prove useful in the treatment of diabetic neuropathy...

Research Grants4

  1. Antioxidant Gene Therapy to Treat Diabetic Neuropathy
    James Goss; Fiscal Year: 2007
    ..We will test this idea in diabetic mice, if successful; this research could lead to a possible treatment for diabetic neuropathy in humans. ..
  2. Antioxidant Gene Therapy to Treat Diabetic Neuropathy
    James Goss; Fiscal Year: 2009
    ..We will test this idea in diabetic mice, if successful; this research could lead to a possible treatment for diabetic neuropathy in humans. ..