Research Topics
Genomes and Genes | Fernando Gomez-PinillaSummaryAffiliation: University of California Country: USA Publications
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Publications
The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker useFernando Gomez-Pinilla
Department of Integrative Biology and Physiology, UCLA Brain Injury Research Center, University of California, Los Angeles, CA 90095, USA
Brain Res 1388:39-47. 2011..The critical action of experience on molecular substrates of plasticity seems to provide molecular basis for the design of experienced-based rehabilitative strategies to enhance brain function...- Brain foods: the effects of nutrients on brain functionFernando Gomez-Pinilla
Department of Neurosurgery, University of California at Los Angeles School of Medicine, Los Angeles 90095, California, USA
Nat Rev Neurosci 9:568-78. 2008..Understanding the molecular basis of the effects of food on cognition will help us to determine how best to manipulate diet in order to increase the resistance of neurons to insults and promote mental fitness... - A "deficient environment" in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampusF Gomez-Pinilla
Division of Neurosurgery, Department of Physiology Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
Exp Neurol 192:235-43. 2005..These findings have implications for disorders that involve a dysfunction in the BDNF system and are accompanied by cognitive deficits... - Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticityFernando Gomez-Pinilla
Department of Physiological Science, Los Angeles, California 90095, USA
J Neurophysiol 88:2187-95. 2002..These results indicate that basal levels of neuromuscular activity are required to maintain normal levels of BDNF in the neuromuscular system and the potential for neuroplasticity... - Exercise induces BDNF and synapsin I to specific hippocampal subfieldsShoshanna Vaynman
Department of Physiological Science, UCLA, Los Angeles, California 90095, USA
J Neurosci Res 76:356-62. 2004..These results indicate that exercise induces plasticity of select hippocampal transsynaptic circuitry, possibly comprising a spatial restriction on synapsin I regulation by BDNF... - The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exerciseGrace Sophia Griesbach
Division of Neurosurgery, Department of Surgery, UCLA, Los Angeles, CA, USA
Brain Res 1016:154-62. 2004..These results indicate that intracellular signaling proteins are increased during the first week following FPI and that premature voluntary exercise may compromise plasticity... - Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependentGrace S Griesbach
Division of Neurosurgery, University of California Los Angeles UCLA, Los Angeles, California, USA
J Neurotrauma 24:1161-71. 2007..These results indicate that the time window for exercise-induced increases in BDNF, synapsin I, and CREB is dependent on injury severity... - Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognitionFernando Gomez-Pinilla
Department of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, CA, USA
Eur J Neurosci 28:2278-87. 2008..These findings suggest that the effects of exercise on synaptic plasticity and cognitive function involve elements of energy metabolism, and that BDNF seems to work at the interface between the two processes as a metabotrophin... - Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognitionShoshanna Vaynman
Department of Physiological Science, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 20:2580-90. 2004..These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism... - Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activationGrace Sophia Griesbach
Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 7039, USA
Brain Res 1288:105-15. 2009..These studies provide evidence that BDNF has a major role in exercise's cognitive effects in traumatically injured brain... - The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain traumaAiguo Wu
Department of Integrative Biology and Physiology, University of California at Los Angeles UCLA, Los Angeles, California 90095, USA
J Neurotrauma 28:2113-22. 2011..The overall results emphasize the potential of dietary DHA to counteract broad and fundamental aspects of TBI pathology that may translate into preserved cognitive capacity... - The combined effects of exercise and foods in preventing neurological and cognitive disordersFernando Gomez-Pinilla
Dept of Integrative Biology and Physiology, and Dept of Neurosurgery, University of California Los Angeles, Los Angeles, CA 90095, USA
Prev Med 52:S75-80. 2011..New evidence indicates that exercise, in combination with dietary factors, exerts its effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity... - Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cordZhe Ying
Department of Physiological Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
Brain Res 987:93-9. 2003.... - Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticityGrace Sophia Griesbach
Division of Neurosurgery, Department of Surgery, UCLA School of Medicine, Los Angeles, California 90024 7039, USA
J Neurotrauma 19:803-14. 2002.... - Controlled contusion injury alters molecular systems associated with cognitive performanceGrace Sophia Griesbach
Department of Neurosurgery, University of California, Los Angeles, California 90024 7039, USA
J Neurosci Res 87:795-805. 2009..In addition, the delayed increase in the expression of BDNF and synapsin I within the cortex contralateral to CCI may reflect restorative processes in areas homotypical to the injury... - A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain traumaSandeep Sharma
Department of Integrative Biology and Physiology, University of California, LA, CA 90095, USA
Exp Neurol 226:191-9. 2010.... - Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain traumaGabriela Chytrova
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 27:1-11. 2008..These results indicate that exercise promotes a permissive cellular environment for repair after TBI, in a process in which BDNF plays a central role... - Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growthCristina A Ghiani
Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Neurobiology and Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Glia 55:966-75. 2007..Overall, these results show that exercise promotes a permissive cellular environment for axonal growth in the adult spinal cord requiring BDNF action... - Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats- Aiguo Wu
University of California at Los Angeles, Los Angeles, California 90095, USA
Neurorehabil Neural Repair 24:290-8. 2010..The elevation of superoxide dismutase (SOD) and Sir2 (silent information regulator 2) play an important role in resistance to oxidative stress... - Afferent input modulates neurotrophins and synaptic plasticity in the spinal cordFernando Gomez-Pinilla
Department of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, California 90095, USA
J Neurophysiol 92:3423-32. 2004..Combined, these results indicate that the level of supraspinal and muscle afferent input plays an important role in modulating the levels of BDNF and NT-3 in the spinal cord... - A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factorA Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA H-1450, USA
Neuroscience 119:365-75. 2003..The results suggest that FPI and diet impose a risk factor to the molecular machinery in charge of maintaining neuronal function under homeostatic and challenging situations... - Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortexAiguo Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 23:2573-80. 2006..The present results show that oxidative stress and energy homeostasis associated with the consumption of the high-fat diet are critical for the regulation of Sir2alpha, with important implications for mechanisms of neural repair... - Exercise differentially regulates synaptic proteins associated to the function of BDNFShoshanna S Vaynman
Department of Physiological Science, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Brain Res 1070:124-30. 2006..Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF... - Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systemsGabriela Chytrova
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Brain Res 1341:32-40. 2010..The overall findings reveal a mechanism by which exercise can interact with the function of DHA dietary enrichment to elevate the capacity of the adult brain for axonal growth, synaptic plasticity, and cognitive function... - Voluntary exercise may engage proteasome function to benefit the brain after traumaZsofia Szabo
Department of Physiological Science, Brain Injury Research Center, UCLA, Los Angeles, California 90095, USA
Brain Res 1341:25-31. 2010..The overall results indicate that the action of exercise interfaces with that of brain injury on molecular systems involved with protein fate and function, which may be significant for synaptic plasticity... - Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticityShoshanna Vaynman
Department of Neurosurgery and Physiological Science and Brain Injury Research Center, UCLA School of Medicine, Los Angeles, California 90095, USA
J Neurosci Res 84:699-715. 2006..The ability of exercise and diet to impact systems that promote cell survival and plasticity may be applicable for combating the deleterious effects of disease and ageing on brain health and cognition... - Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injuryAiguo Wu
Department of Physiological Science, University of California at Los Angeles UCLA, Los Angeles, California 90095, USA
J Neurotrauma 24:1587-95. 2007..In addition, results show the capacity of omega-3 fatty acids to counteract some of the effects of TBI by normalizing levels of molecular systems associated with energy homeostasis... - Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive functionQ Ding
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 140:823-33. 2006..Our results illustrate a possible mechanism by which insulin-like growth factor-I interfaces with the brain-derived neurotrophic factor system to mediate exercise-induced synaptic and cognitive plasticity... - Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain traumaAiguo Wu
University of California at Los Angeles, Los Angeles, CA, USA
Neurorehabil Neural Repair 25:332-42. 2011..Moreover, there are no current efficient treatments that can counteract the broad pathology associated with TBI... - Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysisQinxue Ding
Department of Neurosurgery, Brain Injury Research Centre, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 24:1265-76. 2006.... - The influences of diet and exercise on mental health through hormesisFernando Gomez-Pinilla
Division of Neurosurgery, Brain Injury Research Center, UCLA Medical School, Los Angeles, CA 90095, USA
Ageing Res Rev 7:49-62. 2008..In particular, neurotrophins are emerging as main factors in the equation that may connect lifestyle factors and mental health... - Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticityS Vaynman
Department of Physiological Science, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Neuroscience 122:647-57. 2003..Since these molecules have a well-described association to BDNF action, our results illustrate a basic mechanism through which exercise may promote synaptic-plasticity in the adult brain... - Collaborative effects of diet and exercise on cognitive enhancementFernando Gomez-Pinilla
Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA 90095, USA
Nutr Health 20:165-9. 2011..Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults... - The influence of dietary factors in central nervous system plasticity and injury recoveryFernando Gomez-Pinilla
Department of Neurosurgery, University of California Los Angeles Brain Injury Research Center, Los Angeles, CA 90095, USA
PM R 3:S111-6. 2011..Therefore, exercise and dietary management appear as a noninvasive and effective strategy to help counteract neurologic and cognitive disorders... - The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognitionAiguo Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, California 90095, USA
Eur J Neurosci 19:1699-707. 2004.... - The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive functionS Vaynman
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 144:825-33. 2007..These findings indicate that hippocampal CAMKII may have a refined role in mediating the effects of exercise on cognition, selectively functioning to regulate memory retention... - License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophinsShoshanna Vaynman
Department of Neurosurgery and Physiological Science, and Brain Injury Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 19:283-95. 2005.... - Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticityS Vaynman
Department of Physiological Science, UCLA, Los Angeles, CA 90095, USA
Neuroscience 139:1221-34. 2006..Our results reveal a fundamental mechanism by which key elements of energy metabolism may modulate the substrates of hippocampal synaptic plasticity... - Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in ratsG S Griesbach
Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, Box 957039, Los Angeles, CA 90095 7039, USA
Neuroscience 154:530-40. 2008..These results indicate that, whereas exercise or AMPH treatment alone may induce plasticity and reduce oxidative stress after TBI, combining these treatments may cancel each other's therapeutic effects... - Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of functionG S Griesbach
David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
Neuroscience 125:129-39. 2004..However, when exercise is administered to soon after TBI, the molecular response to exercise is disrupted and recovery may be delayed... - Attenuated plasticity in neurons and astrocytes in the mouse model of Sanfilippo syndrome type BHong Hua Li
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, USA
J Neurosci Res 69:30-8. 2002..Our results showed important alterations in the expression of several genes involved in the maintenance of neuroplasticity in the MPS III B. This in turn may result in reduction of neuronal health and brain function... - Traumatic brain injury induced neuroprotection of retinal ganglion cells to optic nerve crushGuy J Ben Simon
Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurotrauma 23:1072-82. 2006..This neuroprotective effect, which appears unrelated to retinal BDNF, is inhibited by high-dose MP, commonly used clinically to treat traumatic optic neuropathy... - Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthoodHarsharan Singh Bhatia
Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e28451. 2011..Adequate levels of dietary DHA seem crucial for building long-term neuronal resilience for optimal brain performance and aiding in the battle against neurological disorders... - Brain and spinal cord interaction: protective effects of exercise prior to spinal cord injuryFernando Gomez-Pinilla
Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 7:e32298. 2012..In particular, exercise prior to the injury onset appears to foster protective mechanisms in the brain and spinal cord...