W F Goins

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Herpes simplex virus vector-mediated gene delivery for the treatment of lower urinary tract pain
    W F Goins
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Gene Ther 16:558-69. 2009
  2. ncbi Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats
    M Miyazato
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 16:660-8. 2009
  3. ncbi Herpes simplex virus mediated nerve growth factor expression in bladder and afferent neurons: potential treatment for diabetic bladder dysfunction
    W F Goins
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Urol 165:1748-54. 2001
  4. ncbi Herpesvirus-mediated systemic delivery of nerve growth factor
    D Wolfe
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Ther 3:61-9. 2001
  5. ncbi Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury
    R Kato
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 14:1344-52. 2007
  6. ncbi Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion
    J R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 8:551-6. 2001
  7. ncbi Multiple applications for replication-defective herpes simplex virus vectors
    E A Burton
    University of Pittsburgh School of Medicine, Department of Molecular Genetics and Biochemistry, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 19:358-77. 2001
  8. ncbi Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo
    C-S Hong
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA
    Gene Ther 13:1068-79. 2006
  9. ncbi Targeting gene expression using HSV vectors
    E A Burton
    University of Pittsburgh School of Medicine, Department of Molecular Genetics and Biochemistry, E1240 Biomedical Sciences Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Adv Drug Deliv Rev 53:155-70. 2001
  10. ncbi HSV trafficking and development of gene therapy vectors with applications in the nervous system
    A R Frampton
    Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, PA 15261, USA
    Gene Ther 12:891-901. 2005

Collaborators

  • M B Chancellor
  • N Yoshimura
  • S Huang
  • K Sugaya
  • T Tsukamoto
  • H Ozawa
  • J C Glorioso
  • E A Burton
  • D Wolfe
  • J R Goss
  • J Fradette
  • M Miyazato
  • R Kato
  • C-S Hong
  • A R Frampton
  • J B Wechuck
  • D J Fink
  • W C de Groat
  • J B Nelson
  • C H Coyle
  • D M Krisky
  • R M Flanigan
  • K Nakano
  • S K Wendell
  • S V Capuano
  • J B Cohen
  • P D Robbins
  • M Mata
  • H H Wu
  • Q Bai
  • T J Kaplan
  • M Murphey-Corb

Detail Information

Publications11

  1. ncbi Herpes simplex virus vector-mediated gene delivery for the treatment of lower urinary tract pain
    W F Goins
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Gene Ther 16:558-69. 2009
    ..This has led our group to develop a gene therapy strategy that could potentially alleviate chronic pelvic pain using the herpes simplex virus-directed delivery of analgesic proteins to the bladder...
  2. ncbi Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats
    M Miyazato
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 16:660-8. 2009
    ..Thus, HSV-based GAD gene transfer to bladder afferent pathways may represent a novel approach for treatment of neurogenic DO...
  3. ncbi Herpes simplex virus mediated nerve growth factor expression in bladder and afferent neurons: potential treatment for diabetic bladder dysfunction
    W F Goins
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Urol 165:1748-54. 2001
    ..This technique of gene transfer may be useful for treating certain types of neurogenic bladder dysfunction, such as diabetic cystopathy, in which decreased NGF transport may be a causative factor...
  4. ncbi Herpesvirus-mediated systemic delivery of nerve growth factor
    D Wolfe
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Ther 3:61-9. 2001
    ..These results represent the first demonstration of sustained systemic release of a transgene product using HSV vectors, raising the prospect of new applications for HSV-1 vectors in the treatment of systemic disease...
  5. ncbi Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury
    R Kato
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 14:1344-52. 2007
    ..The HSV-GDNF group also yielded more FG-positive MPG cells than the control vector group. HSV vector-mediated delivery of GDNF presents a viable approach for the treatment of ED following cavernous nerve injury...
  6. ncbi Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion
    J R Goss
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Gene Ther 8:551-6. 2001
    ..The antinociceptive effect was blocked completely by intrathecal naltrexone. These results suggest that gene therapy with an enkephalin-producing herpes-based vector may prove useful in the treatment of pain...
  7. ncbi Multiple applications for replication-defective herpes simplex virus vectors
    E A Burton
    University of Pittsburgh School of Medicine, Department of Molecular Genetics and Biochemistry, Pittsburgh, Pennsylvania 15261, USA
    Stem Cells 19:358-77. 2001
    ..Replication-defective HSV vectors are an effective and flexible vehicle for the delivery of transgenes to numerous tissues, with multiple applications...
  8. ncbi Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo
    C-S Hong
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA
    Gene Ther 13:1068-79. 2006
    ....
  9. ncbi Targeting gene expression using HSV vectors
    E A Burton
    University of Pittsburgh School of Medicine, Department of Molecular Genetics and Biochemistry, E1240 Biomedical Sciences Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Adv Drug Deliv Rev 53:155-70. 2001
    ..Our results indicate that targeted transduction may be a viable approach to achieving our goal of targeted HSV-mediated transgene expression...
  10. ncbi HSV trafficking and development of gene therapy vectors with applications in the nervous system
    A R Frampton
    Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, PA 15261, USA
    Gene Ther 12:891-901. 2005
    ..These findings demonstrate the importance of understanding basic virology in the design of vector systems and the powerful approach of exploiting favorable properties of the parent virus in the generation of gene transfer vectors...
  11. ncbi HSV vector-mediated transduction and GDNF secretion from adipose cells
    J Fradette
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Gene Ther 12:48-58. 2005
    ..These experiments establish the efficient transduction of adipose cells by HSV vectors and suggest that fat tissue may represent a useful site for HSV-mediated gene delivery with potential for therapeutic applications...