H J Girschick

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Bone metabolism and bone mineral density in childhood hypophosphatasia
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Bone 25:361-7. 1999
  2. ncbi Treatment of childhood hypophosphatasia with nonsteroidal antiinflammatory drugs
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Bone 25:603-7. 1999
  3. ncbi Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Orphanet J Rare Dis 1:24. 2006
  4. ncbi Seronegative Lyme arthritis
    A Holl Wieden
    Children s Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wuerzburg, Josef Schneider Str 2, 97090 Wuerzburg, Germany
    Rheumatol Int 27:1091-3. 2007
  5. ncbi Crohn's disease during etanercept therapy in juvenile idiopathic arthritis: a case report and review of the literature
    V Wiegering
    Pediatric Rheumatology, Immunology, Gastroenterology and Infectious Diseases, Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080, Wurzburg, Germany
    Rheumatol Int 30:801-4. 2010
  6. ncbi How can calcium pyrophosphate crystals induce inflammation in hypophosphatasia or chronic inflammatory joint diseases?
    C Beck
    Children s Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wurzburg, Josef Schneider Str 2, 97090, Wurzburg, Germany
    Rheumatol Int 29:229-38. 2009
  7. ncbi Whole-body MRI in the childhood form of hypophosphatasia
    C Beck
    Section of Pediatric Rheumatology, Osteology, Immunology and Infectious Diseases, Children s Hospital, University of Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Rheumatol Int 31:1315-20. 2011
  8. ncbi Do B cells play a role in the pathogenesis of juvenile idiopathic arthritis?
    H Morbach
    Pediatric Rheumatology, Immunology and Infectious Diseases, Children s Hospital, University of Wurzburg, Wurzburg, Germany
    Autoimmunity 42:373-5. 2009
  9. ncbi Reference values for B cell subpopulations from infancy to adulthood
    H Morbach
    Department of Pediatrics, University of Wurzburg, Germany
    Clin Exp Immunol 162:271-9. 2010
  10. ncbi Infection of an urachal cyst during etanercept therapy in juvenile idiopathic arthritis
    A Holl-Wieden
    Children s Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wuerzburg, Wuerzburg, Germany
    Rheumatol Int 28:819-22. 2008

Detail Information

Publications15

  1. ncbi Bone metabolism and bone mineral density in childhood hypophosphatasia
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Bone 25:361-7. 1999
    ..Hypermineralization/sclerosis of trabecular bone might serve as a compensation for a mechanically incompetent bony structure due to an impaired mineralization of cartilage caused by the genetic deficiency of alkaline phosphatase...
  2. ncbi Treatment of childhood hypophosphatasia with nonsteroidal antiinflammatory drugs
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Bone 25:603-7. 1999
    ..Elevated PG might play a role in the bone metabolism of HP patients...
  3. ncbi Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Orphanet J Rare Dis 1:24. 2006
    ..There is a lack of knowledge as to how the variability and clinical severity of the HP phenotype (especially pain and walking impairment) are related to metabolic disturbances or impairments, subsequent to the molecular defect...
  4. ncbi Seronegative Lyme arthritis
    A Holl Wieden
    Children s Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wuerzburg, Josef Schneider Str 2, 97090 Wuerzburg, Germany
    Rheumatol Int 27:1091-3. 2007
    ..No humoral immune response to Borrelia burgdorferi was detectable before, at the time of diagnosis and up to 3 years later...
  5. ncbi Crohn's disease during etanercept therapy in juvenile idiopathic arthritis: a case report and review of the literature
    V Wiegering
    Pediatric Rheumatology, Immunology, Gastroenterology and Infectious Diseases, Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080, Wurzburg, Germany
    Rheumatol Int 30:801-4. 2010
    ..This case indicates that immunodysregulatory and even proinflammatory effects of etanercept are of relevance in the clinical practice. Furthermore, TNFalpha as a part of its function seems to downregulate mucosal inflammation in CD...
  6. ncbi How can calcium pyrophosphate crystals induce inflammation in hypophosphatasia or chronic inflammatory joint diseases?
    C Beck
    Children s Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wurzburg, Josef Schneider Str 2, 97090, Wurzburg, Germany
    Rheumatol Int 29:229-38. 2009
    ..They might support the development of new therapeutic strategies for crystal-induced inflammation. Eventually, patients with HP might as well profit from such strategies addressing these metabolic disorders secondary to the gene defect...
  7. ncbi Whole-body MRI in the childhood form of hypophosphatasia
    C Beck
    Section of Pediatric Rheumatology, Osteology, Immunology and Infectious Diseases, Children s Hospital, University of Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Rheumatol Int 31:1315-20. 2011
    ..Differential diagnosis includes an inflammatory process being active in these locations...
  8. ncbi Do B cells play a role in the pathogenesis of juvenile idiopathic arthritis?
    H Morbach
    Pediatric Rheumatology, Immunology and Infectious Diseases, Children s Hospital, University of Wurzburg, Wurzburg, Germany
    Autoimmunity 42:373-5. 2009
    ..We discuss whether BC play a role in the pathogenesis of JIA appraising the question for an immunological basis of BC directed therapy...
  9. ncbi Reference values for B cell subpopulations from infancy to adulthood
    H Morbach
    Department of Pediatrics, University of Wurzburg, Germany
    Clin Exp Immunol 162:271-9. 2010
    ....
  10. ncbi Infection of an urachal cyst during etanercept therapy in juvenile idiopathic arthritis
    A Holl-Wieden
    Children s Hospital, Section of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Wuerzburg, Wuerzburg, Germany
    Rheumatol Int 28:819-22. 2008
    ..We report on a 17-year-old boy with enthesitis-related arthritis who developed a major infection of an urachal cyst 18 months after initiation of etanercept therapy, which required surgery. The urachus had not been symptomatic before...
  11. ncbi B-cell pathology in juvenile idiopathic arthritis
    V Wiegering
    Pediatric Hematology, Oncology and Neurooncology, Pediatric Stem Cell Transplantation Program, Children s Hospital, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Arthritis 2010:759868. 2010
    ..In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA...
  12. ncbi Differential expression of matrix metalloproteinases and cyclooxygenases in synovial cells exposed to Borrelia burgdorferi
    S K Singh
    Pediatric Rheumatology and Infectious Diseases, Children s Hospital, University of Wuerzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Inflamm Res 53:689-96. 2004
    ..In the present study we analyzed the induction of matrix metalloproteinases (MMPs) and cyclooxygenases (COXs) in human synoviocytes exposed to different B. burgdorferi sensu stricto isolates (Geho and B31)...
  13. ncbi Chronic non-bacterial osteomyelitis in children
    H J Girschick
    Section of Paediatric Rheumatology, Children s Hospital, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Ann Rheum Dis 64:279-85. 2005
    ..Some children affected by chronic non-bacterial osteomyelitis (CNO) do not have multiple lesions or a recurrent course...
  14. ncbi Cytogenetic and histopathologic studies of congenital supratentorial primitive neuroectodermal tumors: a case report
    H J Girschick
    University of Wurzburg, Children s Hospital, Germany
    Pathol Oncol Res 7:67-71. 2001
    ..Despite unremarkable genetic analysis in our case prognosis was poor, suggesting that there are additional, yet unknown constitutional genetic aberrations in the pathogenesis of congenital supratentorial PNET...
  15. ncbi The lambda gene immunoglobulin repertoire of human neonatal B cells
    P Richl
    Children s Hospital, Pediatric Immunology, Rheumatology and Infections Diseases, University of Wuerzburg, Wuerzburg, Germany
    Mol Immunol 45:320-7. 2008
    ..This suggests that selection into the productive Vlambda repertoire in principal might be driven mainly by autoantigens in the newborn, as well as in adulthood, since newborns have not been exposed to exogenous antigens...