Research Topics
Species | Myron D GinsbergSummaryAffiliation: University of Miami Country: USA Publications
| Collaborators
|
Detail Information
Publications
Current status of neuroprotection for cerebral ischemia: synoptic overviewMyron D Ginsberg
Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
Stroke 40:S111-4. 2009..Taken together, these factors identify areas of needed improvement for future trials...- Neuroprotection for ischemic stroke: past, present and futureMyron D Ginsberg
Department of Neurology D4 5, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Neuropharmacology 55:363-89. 2008..The potential of combination therapies is highlighted. Issues of clinical-trial funding, the need for improved translational strategies and clinical-trial design, and "thinking outside the box" are emphasized... - Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 eraMyron D Ginsberg
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Stroke 38:1967-72. 2007.... - The albumin in acute stroke (ALIAS) multicenter clinical trial: safety analysis of part 1 and rationale and design of part 2Myron D Ginsberg
Department of Neurology D4 5, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Stroke 42:119-27. 2011..enrollment in the Albumin in Acute Stroke (ALIAS) Trial was suspended in late 2007 due to a safety concern. We present the safety data of that Trial ("Part 1") and the rationale for the design of Part 2... - Albumin therapy augments the effect of thrombolysis on local vascular dynamics in a rat model of arteriolar thrombosis: a two-photon laser-scanning microscopy studyHee Pyoung Park
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
Stroke 39:1556-62. 2008..Here, we explored the microvascular hemodynamic effects of this combined therapy in a laboratory model of cortical arteriolar thrombosis... - The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--I: Physiological responses and safety resultsMyron D Ginsberg
Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
Stroke 37:2100-6. 2006..In preclinical stroke models, high-dose human albumin confers robust neuroprotection. We investigated the safety and tolerability of this therapy in patients with acute ischemic stroke... - Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemiaMyron D Ginsberg
Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Ann Neurol 54:330-42. 2003..The potency of STAZN was orders-of-magnitude greater than other nitrones such as NXY-059. These results suggest that STAZN has great promise for ischemic stroke... - The ALIAS Pilot Trial: a dose-escalation and safety study of albumin therapy for acute ischemic stroke--II: neurologic outcome and efficacy analysisYuko Y Palesch
Department of Neurology (D4-5, University of Miami Miller School of Medicine, PO Box 016960, Miami, Florida 33101, USA
Stroke 37:2107-14. 2006..These results have led to a multicenter, randomized, placebo-controlled efficacy trial of ALB in acute ischemic stroke-the ALIAS Phase III Trial... - Experimental intracerebral hematoma in the rat: characterization by sequential magnetic resonance imaging, behavior, and histopathology. Effect of albumin therapyLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
Brain Res 1157:146-55. 2007..Taken together, sequential MRI plus histopathology provides a comprehensive characterization of experimental ICH. Albumin treatment improves neurological deficit after ICH but does not affect MRI or histological hematoma size... - Neuroprotective effect of darbepoetin alfa, a novel recombinant erythropoietic protein, in focal cerebral ischemia in ratsLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
Stroke 36:1071-6. 2005..In this study, we determined whether darbepoetin alfa would protect in a rat model of transient focal cerebral ischemia... - Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: neurobehavior, histopathology, and pharmacokineticsJames J Ley
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, FL 33101, USA
J Pharmacol Exp Ther 313:1090-100. 2005..These results establish that STAZN confers enduring ischemic neuroprotection, has a long circulating half-life, and penetrates well into brain and other organs-characteristics favoring its potential therapeutic utility... - Caffeinol confers cortical but not subcortical neuroprotection after transient focal cerebral ischemia in ratsLudmila Belayev
Department of Neurology D4 5, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
Brain Res 1008:278-83. 2004..Caffeinol therapy significantly improved the neurological score, reduced the total infarct volume (by 52%) and cortical infarct areas at multiple coronal levels, but subcortical infarction and brain swelling were not affected... - Experimental intracerebral hemorrhage in the mouse: histological, behavioral, and hemodynamic characterization of a double-injection modelLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, FL 33101, USA
Stroke 34:2221-7. 2003..We investigated the effect of intrastriatal injection of blood or cerebrospinal fluid (CSF) on cerebral blood flow (CBF), neurological score, hematoma volume, and brain swelling... - Neuroprotective effect of SolCD39, a novel platelet aggregation inhibitor, on transient middle cerebral artery occlusion in ratsLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Stroke 34:758-63. 2003..The purpose of this study was to examine the effect of solCD39 on neurological deficit, infarct size, and extent of edema after transient middle cerebral artery occlusion (MCAO) in rats... - Delayed post-ischemic albumin treatment neither improves nor worsens the outcome of transient focal cerebral ischemia in ratsLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
Brain Res 998:243-6. 2004..9% saline, 5 ml/kg; n=9) were administered at 19 h. Neurological status was evaluated daily, and histopathology and brain swelling were quantified at 3 days. Delayed albumin treatment, while ineffective, failed to show adverse effects... - Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampusRainald Schmidt-Kastner
Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
Brain Res 1001:133-42. 2004..Nuclear location of BNIP3 after brain ischemia indicates a novel role for the regulation of cell survival in neurons or a general disturbance of the nuclear envelope... - A selective endothelin ET(A) receptor antagonist, SB 234551, improves cerebral perfusion following permanent focal cerebral ischemia in ratsYongbo Zhang
Cerebral Vascular Disease Research Center, Department of Neurology (D4-5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Brain Res 1045:150-6. 2005..This study demonstrates that SB 234551 therapy results in significant improvement of local cerebral perfusion in the ischemic as well as in the non-ischemic hemispheres after permanent MCAo... - Albumin therapy improves local vascular dynamics in a rat model of primary microvascular thrombosis: a two-photon laser-scanning microscopy studyAnitha Nimmagadda
Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
Stroke 39:198-204. 2008..To explore the hypothesis that albumin's protective effect is mediated in part by salutary intravascular mechanisms, we assessed microvascular hemodynamics in a model of laser-induced cortical arteriolar thrombosis... - Astrocytes react to oligemia in the forebrain induced by chronic bilateral common carotid artery occlusion in ratsRainald Schmidt-Kastner
Department of Neurology, Cerebral Vascular Disease Research Center, D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Brain Res 1052:28-39. 2005..These results indicate that chronic BCCAO and, by inference, oligemia have a transient effect on the neocortex and a long-lasting effect on white matter structures... - Adventures in the pathophysiology of brain ischemia: penumbra, gene expression, neuroprotection: the 2002 Thomas Willis LectureMyron D Ginsberg
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
Stroke 34:214-23. 2003..This presentation first highlights insights into the ischemic penumbra enabled by a multimodal experimental approach; second, discusses gene expression in ischemia; and third, confronts the challenges of neuroprotectant therapy... - Albumin treatment reduces neurological deficit and protects blood-brain barrier integrity after acute intracortical hematoma in the ratLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology D4 5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Stroke 36:326-31. 2005.... - Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotectionLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
Stroke 36:118-23. 2005.... - Enriched environment delays the onset of hippocampal damage after global cerebral ischemia in ratsAndrey Belayev
Cerebral Vascular Disease Research Center, Department of Neurology (D4-5, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Brain Res 964:121-7. 2003..5+/-7.2 vs. 2.6+/-0.6, respectively). The present data suggest that housing in EE for 2 months before and 6 days after ischemia can delay the onset of damage to hippocampal pyramidal neurons, which eventually occurs despite 2-month EE... - Neuroprotective antioxidant STAZN protects against myocardial ischemia/reperfusion injuryJames J Ley
Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33101, United States
Biochem Pharmacol 75:448-56. 2008.... - Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in ratsLudmila Belayev
Department of Neurology, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
J Neurosurg 96:1077-83. 2002..Azulenyl nitrones appear to represent a promising class of neuroprotective agents for combating this devastating condition... - DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in ratRainald Schmidt-Kastner
Department of Neurology D4 5, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, P O Box 016960, FL 33101, USA
Brain Res Mol Brain Res 108:81-93. 2002..DNA microarray analysis allows one to develop novel working hypotheses for responses to brain ischemia based on the regulation of annotated genes... - Pixel-based statistical analysis by a 3D clustering approach: application to autoradiographic imagesWeizhao Zhao
Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124 0640, USA
Comput Methods Programs Biomed 83:18-28. 2006..Different methods were also performed on the same data sets. Comparison among these methods shows that this method is suitable for the statistical analysis of autoradiographic images... - Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivationAmi P Raval
Department of Neurology and Neuroscience Program, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Florida 33101, USA
J Cereb Blood Flow Metab 25:730-41. 2005..Our results support the deleterious role of deltaPKC in reperfusion injury. We propose that early cytochrome c release and caspase 3 activation promote deltaPKC translocation/cleavage... - Mild cardiopulmonary arrest promotes synaptic dysfunction in rat hippocampusKunjan R Dave
Department of Neurology and Neuroscience, Cerebral Vascular Disease Research Center, University of Miami School of Medicine, Miami, FL-33101, USA
Brain Res 1024:89-96. 2004..These data suggest that synaptic dysfunction occurs before and without overt histopathology. We suggest that the synaptic dysfunction precedes and may be an early marker for delayed neuronal cell death in the hippocampus after CA... - Effect of ischemic preconditioning on the expression of putative neuroprotective genes in the rat brainJessie Truettner
The Cerebral Vascular Disease Research Center, Department of Neurology (D4-5, University of Miami School of Medicine, P.O. Box 16960, Miami, FL 33101, USA
Brain Res Mol Brain Res 103:106-15. 2002..The increase in expression of these stress-related, neurotrophic and immediate early genes in response to a mild preconditioning insult may help mediate the protection of vulnerable neurons to subsequent lethal ischemic insults... - Albumin therapy of transient focal cerebral ischemia: in vivo analysis of dynamic microvascular responsesLudmila Belayev
Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Miami, Fla 33101, USA
Stroke 33:1077-84. 2002.... - The albumin in acute stroke trial (ALIAS); design and methodologyMichael D Hill
Department of Clinical Neurosciences, Calgary Stroke Program, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
Int J Stroke 2:214-9. 2007.... - Therapeutic trials for traumatic brain injury--a journey in progressMyron D Ginsberg
Crit Care Med 30:935-6. 2002 - Systemic fatty acid responses to transient focal cerebral ischemia: influence of neuroprotectant therapy with human albuminElena B Rodriguez de Turco
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA
J Neurochem 83:515-24. 2002.... - Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: dose-response and therapeutic windowJames J Ley
Cerebral Vascular Disease Research Center, Department of Neurology D4 5 University of Miami Miller School of Medicine PO Box 016960 Miami, Florida 33101, USA
Brain Res 1180:101-10. 2007..0 ml/kg, n=6) was administered at 3, 5, 24 and 48 h. STAZN treatment initiated at 2 or 3 h after the onset of MCAo improved neurological scores (p<0.001) and reduced total infarction (42.2%, p<0.05) compared to controls... - Fluid resuscitation in traumatic brain injuryMyron D Ginsberg
Crit Care Med 36:661-2. 2008 - Moderate loss of cerebellar Purkinje cells after chronic bilateral common carotid artery occlusion in ratsOrsolya Kántor
Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
Acta Neuropathol 113:549-58. 2007..Remodeling of the basilar artery indicated that secondary vascular perturbations might be responsible for the effects of BCCAO on the cerebellar Purkinje cells... - Automated registration of laser Doppler perfusion images by an adaptive correlation approach: application to focal cerebral ischemia in the ratPanomkhawn Riyamongkol
Department of Electrical and Computer Engineering, University of Miami College of Engineering, PO Box 248294, Coral Gables, FL 33124-0640, USA
J Neurosci Methods 122:79-90. 2002..Cerebral perfusion data acquired in a pixel-based manner from different anatomic locations of the registered LD image sequence are also presented over the whole time-course of the experiment... - Mitochondria consume energy and compromise cellular membrane potential by reversing ATP synthetase activity during focal ischemia in ratsYoshimasa Takeda
Cerebral Vascular Disease Research Center, Department of Neurology and Neuroscience, University of Miami School of Medicine, FL, USA
J Cereb Blood Flow Metab 24:986-92. 2004..04). These observations suggest that mitochondria consume ATP during ischemia by reversing ATP synthetase activity, which compromises cellular membrane potential by consuming ATP... - Semi-automated image processing system for micro- to macro-scale analysis of immunohistopathology: application to ischemic brain tissueChunyan Wu
Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33124-0621, USA
Comput Methods Programs Biomed 78:75-86. 2005..Reliability tests show that the results obtained from immunostained images at high magnification and relatively low magnification are virtually the same... - Hyperglycemia and stroke outcome: vindication of the ischemic penumbraMyron D Ginsberg
Ann Neurol 52:5-6. 2002