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Genomes and Genes | Marc A GavinSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivoMarc A Gavin
Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
Nat Immunol 3:33-41. 2002..DNA array analyses identified genes that may inhibit responsiveness at a number of levels in multiple signaling cascades in T(S) cells, as well as several anti-apoptotic genes that may mediate their survival...- Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell developmentMarc A Gavin
Department of Immunology and Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 103:6659-64. 2006..This observation raises the possibility that the severe autoimmunity in FOXP3 deficiency can be attributed, in part, to aggressive T helper cells that have developed from T(R) precursors... - Control of immune homeostasis by naturally arising regulatory CD4+ T cellsMarc Gavin
Department of Immunology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
Curr Opin Immunol 15:690-6. 2003..T(R) cells are capable of robust antigen-driven proliferation in vivo, and may participate in clonal expansion in response to infection, similar to all other adaptive immune lineages... - A function for interleukin 2 in Foxp3-expressing regulatory T cellsJason D Fontenot
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 6:1142-51. 2005..Thus, IL-2 signaling seems to be critically required for maintaining the homeostasis and competitive fitness of T(reg) cells in vivo... - Foxp3-dependent programme of regulatory T-cell differentiationMarc A Gavin
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nature 445:771-5. 2007..This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis... - Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cellsYe Zheng
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nature 445:936-40. 2007..Together, our studies suggest that distinct transcriptional sub-programmes implemented by Foxp3 establish T(R) lineage during differentiation and its proliferative and functional competence in the periphery... - G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cellsLi Fan Lu
Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
Mol Cell Biol 27:8065-72. 2007..Collectively, our results demonstrate that GPR83 is dispensable for Treg-cell development and function... - FOXP3 and NFAT: partners in toleranceAlexander Y Rudensky
Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
Cell 126:253-6. 2006.... - TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cellsJulien C Marie
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Exp Med 201:1061-7. 2005..Thus, our results establish an essential link between TGF-beta1 signaling in peripheral T reg cells and T reg cell maintenance in vivo... - Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsJason D Fontenot
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
Nat Immunol 4:330-6. 2003..Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function... - Dual TCR T cells: gaining entry into the peripheryMarc A Gavin
Nat Immunol 3:109-10. 2002