Research Topics
Species | Peter GarlickSummaryAffiliation: University of Illinois Country: USA Publications
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Publications
The role of leucine in the regulation of protein metabolismPeter J Garlick
Department of Animal Sciences, University of Illinois, Urbana, 61801, USA
J Nutr 135:1553S-6S. 2005..It is concluded that the role of leucine in vivo is to provide a signal that amino acids are available, which in combination with the signal of energy availability from insulin, stimulates muscle protein synthesis...- The nature of human hazards associated with excessive intake of amino acidsPeter J Garlick
Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
J Nutr 134:1633S-1639S; discussion 1664S-1666S, 1667S-1672S. 2004..This article is a brief summary of the available evidence regarding the safety of individual amino acids when taken in excess relative to the amounts absorbed from dietary protein... - Toxicity of methionine in humansPeter J Garlick
Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
J Nutr 136:1722S-1725S. 2006..In infants, methionine intakes of 2-5 times normal resulted in impaired growth and extremely high plasma methionine levels, but no adverse long-term consequences were observed... - In vivo urea kinetic studies in conscious miceJuan C Marini
Animal Science Department, University of Illinois, Urbana IL, USA
J Nutr 136:202-6. 2006..This is especially relevant because mouse targeting technologies will likely facilitate the generation of organ and tissue specific nulls of the various urea cycle enzymes... - Reduced ornithine transcarbamylase activity does not impair ureagenesis in Otc(spf-ash) miceJuan C Marini
Animal Science Department, University of Illinois, Urbana, IL 61801, USA
J Nutr 136:1017-20. 2006..This implies that Otc(spf-ash) mice are able to dispose of ammonia, without apparent adverse effects, when a balance mixture of amino acids is provided, despite reduced enzyme activity... - The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in ratsLayne E Norton
Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
J Nutr 139:1103-9. 2009..These studies demonstrate that peak activation but not duration of MPS is proportional to the Leu content of a meal... - Protein and amino acid requirements and the composition of complementary foodsPeter J Reeds
Department of Animal Sciences, University of Illinois at Urbana-Champaign, IL, USA
J Nutr 133:2953S-61S. 2003..The calculations of the dietary requirement for whole protein imply that achieving a minimum protein-energy ratio of 6.3% is desirable. The amount of protein needed from complementary foods for breast-fed children is discussed... - Protein requirements of infants and childrenPeter J Garlick
Department of Animal Sciences, University of Illinois, Urbana, IL, USA
Nestle Nutr Workshop Ser Pediatr Program 58:39-47; discussion 47- 50. 2006..12 g/kg/day at age 6 months to 0.74 g/kg/day at 10 years, with a small decline towards the adult value thereafter. The corresponding values for the safe level are 1.43 g/kg/day at 6 months and 0.91 g/kg/day at 10 years... - Ornithine restores ureagenesis capacity and mitigates hyperammonemia in Otc(spf-ash) miceJuan C Marini
Molecular and Human Genetics and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
J Nutr 136:1834-8. 2006..These data strongly suggest that ornithine has the potential for the biochemical correction of OTCD in Otc(spf-ash) mice... - Effect of insulin with concurrent amino acid infusion on protein metabolism in rapidly growing pubertal children with type 1 diabetesMushtaq A Godil
Department of Pediatrics, State University of New York, Stony Brook, NY 11794, USA
Pediatr Res 58:229-34. 2005..The data suggest that insulin alone does not increase protein synthesis in pubertal children with type 1 diabetes... - Glucose flux is normalized by compensatory hyperinsulinaemia in growth hormone-induced insulin resistance in healthy subjects, while skeletal muscle protein synthesis remains unchangedJonas Nygren
Centre for Gastrointestinal Disease, Ersta Hospital, Box 4622, Karolinska Institute, 116 91 Stockholm, Sweden
Clin Sci (Lond) 102:457-64. 2002..The nitrogen retention accompanying GH treatment seems to be due largely to improved nitrogen balance in non-muscle tissue... - Aminoacyl-tRNA enrichment after a flood of labeled phenylalanine: insulin effect on muscle protein synthesisGiuseppe Caso
Department of Surgery, State University of New York, Stony Brook, New York 11794 8191, USA
Am J Physiol Endocrinol Metab 282:E1029-38. 2002..This study confirms that, with a bolus injection of labeled phenylalanine, the enrichment of aminoacyl-tRNA, the true precursor pool for protein synthesis, can be assessed from more readily sampled plasma phenylalanine... - Introduction to Protein Summit 2007: exploring the impact of high-quality protein on optimal healthNancy R Rodriguez
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USA
Am J Clin Nutr 87:1551S-1553S. 2008 - Altered protein metabolism following coronary artery bypass graft (CABG) surgeryGiuseppe Caso
Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794 8191, USA
Clin Sci (Lond) 114:339-46. 2008..In conclusion, the results demonstrate that CABG surgery has a profound effect on protein metabolism, with a differential response of protein synthesis in muscle and liver... - Skeletal muscle protein synthesis after active or passive ascent to high altitudeReinhard Imoberdorf
Department of Internal Medicine, University of Berne, Inselspital, Berne, Switzerland
Med Sci Sports Exerc 38:1082-7. 2006..The effects of acute exposure to high altitude on muscle protein synthesis rates in human volunteers were examined after active and passive ascent... - Effects on skeletal muscle of intravenous glutamine supplementation to ICU patientsInga Tjader
Department of Anesthesiology and Intensive Care, Clinical Metabolic Research Center, Huddinge University Hospital, Karolinska Institutet, SE 141 86 Stockholm, Sweden
Intensive Care Med 30:266-75. 2004..To evaluate the effect of four doses of intravenous glutamine supplementation on skeletal muscle metabolism... - Acute metabolic acidosis inhibits muscle protein synthesis in ratsGiuseppe Caso
Dept of Surgery, HSC T19 048, State Univ of New York at Stony Brook, Stony Brook, NY 11794 8191, USA
Am J Physiol Endocrinol Metab 287:E90-6. 2004..Inhibition of muscle protein synthesis might be another mechanism contributing to the loss of muscle tissue observed in acidosis... - The increase in human muscle protein synthesis induced by food intake is similar when assessed with the constant infusion and flooding techniquesGiuseppe Caso
Department of Surgery, Stony Brook University, Stony Brook, NY 11794, USA
J Nutr 136:1504-10. 2006.... - Tumour cell growth in culture: dependence on arginineGiuseppe Caso
Department of Surgery, State University of New York, Stony Brook, NY 11794 8191, USA
Clin Sci (Lond) 107:371-9. 2004..Intracellular arginase activity may be the major factor determining the requirement for arginine of all cells in culture... - Impact of surgical trauma on human skeletal muscle protein synthesisInga Tjader
Department of Anaesthesiology and Intensive Care, Karolinska University Hospital at Huddinge, Karolinska Institutet, Stockholm, Sweden
Clin Sci (Lond) 107:601-7. 2004..This finding is discussed in relation to confounders, postoperative course and to muscle protein degradation. The shortage of knowledge in this field is emphasized... - Control of muscle protein kinetics by acid-base balanceGiuseppe Caso
Department of Surgery, State University of New York, Stony Brook, New York, USA
Curr Opin Clin Nutr Metab Care 8:73-6. 2005..This review aims at outlining the effects of acid-base balance abnormalities on muscle protein metabolism, and will in particular summarize and evaluate the most recent studies on the impact of pH on control of muscle protein metabolism... - Response of protein synthesis to hypercapnia in rats: independent effects of acidosis and hypothermiaGiuseppe Caso
Department of Surgery, State University of New York, Stony Brook, NY 11794 8191, USA
Metabolism 54:841-7. 2005....
Research Grants
- PH CONTROL OF PROTEIN SYNTHESISPeter Garlick; Fiscal Year: 2003..abstract_text> ..