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Genomes and Genes | Lie GaoSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failureLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Hypertension 52:708-14. 2008..These data implicate a downregulation in the AT(2)R as a contributory factor in the sympathoexcitation in CHF...- Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failureLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Circulation 115:3095-102. 2007..In the present study, we therefore hypothesized that long-term exercise exerts its beneficial effect on autonomic activity in CHF via central antioxidative mechanisms... - Simvastatin inhibits central sympathetic outflow in heart failure by a nitric-oxide synthase mechanismLie Gao
Department of Cellular and Integrative Physiology University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Pharmacol Exp Ther 326:278-85. 2008.... - Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failureLie Gao
Dept of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, Omaha, 68198 5850, USA
Am J Physiol Heart Circ Physiol 298:H945-55. 2010..3 expression and subsequent decrease in K(+) current, thereby increasing the excitability of neurons in the RVLM. The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling... - Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal ratsLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Hypertension 51:521-7. 2008..1+/-0.5 microg in control rats and 2.4+/-0.5 microg in AT(2)R rats; P<0.05). These results suggest that overexpression of AT(2)R in the RVLM induced a diuresis that may be mediated, in part, by sympathoinhibition... - AT1 receptors in the nucleus tractus solitarii mediate the interaction between the baroreflex and the cardiac sympathetic afferent reflex in anesthetized ratsWei Zhong Wang
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Am J Physiol Regul Integr Comp Physiol 292:R1137-45. 2007.... - Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neuronsDongmei Liu
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Circ Res 103:186-93. 2008..Antioxidant agents may be beneficial in CHF and other states where brain Ang II is elevated by decreasing AT1R expression through the Jnk and AP1 pathway... - Sympathoexcitation by central ANG II: roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLMLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
Am J Physiol Heart Circ Physiol 288:H2271-9. 2005.... - Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart failure rabbitsYu-Long Li
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
Cardiovasc Res 71:129-38. 2006..CONCLUSIONS: These results indicate that elevation of Ang II and concomitant upregulation of AT1 receptor in the CB contribute to the increased CB chemoreceptor activity and enhanced peripheral chemoreflex function in CHF... - Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized ratsLie Gao
Department of Cellular and Integrative Physiology, Univ of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Appl Physiol 102:37-43. 2007..These results suggest that both the chemical and electrical stimulation of the CSAR augments chemoreceptor reflex and that central ANG II, specially located in the NTS, plays a major role in these reflex interactions... - Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidaseLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
Circ Res 95:937-44. 2004..These data demonstrate intense radical stress in autonomic areas of the brain in experimental CHF and provide evidence for a tight relationship between Ang II and ROS as contributors to sympathoexcitation in CHF... - Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failureLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
Hypertension 45:1173-81. 2005..9+/-0.2 to 3.1+/-0.2%/mm Hg; P<0.01). These results suggest that tonic cardiac sympathetic afferent input plays an important role in the blunted baroreflex associated with CHF, which is mediated by central AT1 receptors... - Exercise training prevents the exaggerated exercise pressor reflex in rats with chronic heart failureHan Jun Wang
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Appl Physiol 108:1365-75. 2010..These findings suggest a potential therapeutic role for ExT in minimizing arterial pressure and sympathetic outflow following activation of the EPR in the CHF state... - Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failureWei Zhong Wang
Department of Cellular and Integrative Physiology, University of Nebraska Medical Ctr, 985850 Nebraska Medical Ctr, Omaha, NE 68198 5850, USA
Am J Physiol Heart Circ Physiol 295:H1216-H1226. 2008..These results demonstrate that the enhanced cardiac sympathetic afferent input contributes to an excitatory effect of chemoreflex function in CHF, which is mediated by an NTS-AT1R-dependent mechanism... - Exercise training prevents arterial baroreflex dysfunction in rats treated with central angiotensin IIYan Xia Pan
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Hypertension 49:519-27. 2007..These results indicate that EX improves arterial baroreflex function in conditions of high brain Ang II, which is mediated by the central Ang II type 1 receptor and associated with a reduction in central oxidative stress... - Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failureIrving H Zucker
Dept of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Am J Physiol Heart Circ Physiol 297:H1557-66. 2009..Finally, exercise training reduces both central oxidative stress and AT(1)R expression in animals with CHF. These data strongly suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF... - NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbitsYu Long Li
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Cardiovasc Res 75:546-54. 2007..NADPH oxidase-derived superoxide anion mediates the effects of Ang II in many organs. We investigated whether this signaling pathway may mediate the enhanced peripheral chemoreceptor sensitivity induced by Ang II in CHF rabbits... - Differential effects of cardiac sympathetic afferent stimulation on neurons in the nucleus tractus solitariusWei-Zhong Wang
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
Neurosci Lett 409:146-50. 2006.... - Neuronal angiotensin II type 1 receptor upregulation in heart failure: activation of activator protein 1 and Jun N-terminal kinaseDongmei Liu
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
Circ Res 99:1004-11. 2006..These data suggest that central Ang II activates the AT(1)R, SAPK/JNK pathway. AP-1 may further regulate gene expression in RVLM in the CHF state... - Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidaseLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA
Circulation 112:1763-70. 2005..These data also demonstrate that SIM improves left ventricular function in pacing-induced CHF rabbits... - Central angiotensin (1-7) enhances baroreflex gain in conscious rabbits with heart failureSumit Kar
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Hypertension 58:627-34. 2011..These data suggest that augmentation of central Ang-(1-7) inhibits sympathetic outflow and increases vagal outflow in CHF, thus contributing to enhanced baroreflex gain in this disease state... - AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failureGuo-Qing Zhu
Dept. of Cellular and Integrative Physiology, University of Nebraska College of Medicine, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
Am J Physiol Heart Circ Physiol 287:H1828-35. 2004.... - Tonic glutamatergic input in the rostral ventrolateral medulla is increased in rats with chronic heart failureWei Zhong Wang
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, NE 68198 5850, USA
Hypertension 53:370-4. 2009..These data suggest that upregulated glutamate receptors, including NMDA and non-NMDA, in the RVLM are involved in tonic control of elevated sympathetic tone in CHF... - Alteration in skeletal muscle afferents in rats with chronic heart failureHan Jun Wang
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Physiol 588:5033-47. 2010..These data suggest that group III afferents are sensitized whereas group IV afferents are desensitized in CHF, which is related to the dysfunction of P2X and VR1 receptors... - Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failureSumit Kar
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
J Appl Physiol 108:923-32. 2010..These data suggest that the activation of the central RAS in animals with CHF involves an imbalance of ACE and ACE2 in regions of the brain that regulate autonomic function and that EX can reverse this imbalance... - Brain-selective overexpression of Angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failureLiang Xiao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850
Hypertension 58:1057-65. 2011..The mechanism for this effect involves angiotensin (1-7) mas signaling, as well as a decrease in angiotensin II type 1 receptor signaling in the medulla... - Endogenous reactive oxygen species modulates voltage-gated sodium channels in dorsal root ganglia of ratsHan Jun Wang
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Appl Physiol 110:1439-47. 2011..These data suggest that ROS modulates the EPR by affecting the activity of the Na(v) channels on muscle afferents... - Interaction of transthoracic ultrasound and intravenous microbubbles with cardiac mechanoreceptorsFeng Xie
Department of Internal Medicine, Section of Cardiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Ultrasound Med Biol 33:136-44. 2007..The changes in RSNA induced by TTU and MB in all rabbits were abolished by vagotomy. TTU, in the presence of MB, stimulates mechanoreceptors in the heart reflexively to reduce RSNA... - Effects of angiotensin II on autonomic components of nasopharyngeal stimulation in male conscious rabbitsTarek M Mousa
Department of Cellular and Integrative Physiology, 985850 Nebraska Medical Center, Omaha, NE 68198-5850, USA
J Appl Physiol 98:1607-11. 2005..This effect may be due to an augmentation of baseline sympathetic outflow and a reduction in reflex sensitivity similar to the effect of ANG II on baroreflex function... - Baroreceptor reflex in heart failureWei Wang
Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198 4575, USA
Sheng Li Xue Bao 56:269-81. 2004.... - The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutaseErin G Rosenbaugh
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Biomaterials 31:5218-26. 2010..Importantly, neither the PEI-PEG polymer alone nor the CuZnSOD nanozyme induced neuronal toxicity. These findings indicate that CuZnSOD nanozyme inhibits AngII intra-neuronal signaling in vitro and in vivo... - Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious ratsJuan Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, USA
Am J Hypertens 24:724-30. 2011..In this study, we investigated the effects of intracerebroventricular (icv) infusion of Compound 21 (C21), the first selective nonpeptide AT2R agonist, on norepinephrine (NE) excretion and BP in rats... - Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neuronsAmit K Mitra
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
Am J Physiol Cell Physiol 299:C561-9. 2010..a cell neuronal model. These data imply a positive feedback mechanism that may impact neuronal discharge sensitivity in response to ANG II... - Abnormal baroreflex function is dissociated from central angiotensin II receptor expression in chronic heart failureMohammad Fahim
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA
Shock 37:319-24. 2012.... - Developmental changes in AT1 and AT2 receptor-protein expression in ratsLi Yu
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
J Renin Angiotensin Aldosterone Syst 11:214-21. 2010.... - AT2 receptor signaling and sympathetic regulationLie Gao
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
Curr Opin Pharmacol 11:124-30. 2011..The evidence for this concept is reviewed and a model is put forward to support the rationale that therapeutic targeting of the central AT2R may be beneficial in the setting of chronic heart failure... - Cardiac sympathetic afferent stimulation impairs baroreflex control of renal sympathetic nerve activity in ratsLie Gao
Department of Physiology and Biophysics, University of Nebraska Medical Center, University of Nebraska College of Medicine, Omaha, Nebraska 68198-4575, USA
Am J Physiol Heart Circ Physiol 286:H1706-11. 2004.... - The regulation of sympathetic nerve activity by angiotensin II involves reactive oxygen species and MAPKIrving H Zucker
Circ Res 97:737-9. 2005 - ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failureGuo-Qing Zhu
Department of Physiology, Nanjing Medical University, Nanjing 210029, Peoples Republic of China
J Appl Physiol 97:1746-54. 2004.... - Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidineWei Zhong Wang
Department of Physiology, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China
Am J Physiol Regul Integr Comp Physiol 293:R1232-8. 2007.... - Sympathoexcitation of moxonidine in the caudal ventrolateral medulla is dependent on I1-imidazoline receptors in anesthetized ratsLi Gang Wang
Department of Physiology, Second Military Medical University, Shanghai 200433, China
Neurosci Lett 426:91-6. 2007..The current data suggest that moxonidine injection into the CVLM has an excitatory effect on cardiovascular activity, which is mediated by an I(1)R dependent mechanism... - Statins and sympathetic nerve activity in heart failureIrving H Zucker
J Card Fail 12:759. 2006
Research Grants
- AT2 Receptors in the RVLM: Regulation of Sympathetic Outflow in Heart FailureLie Gao; Fiscal Year: 2010..The results from this project will provide a potential strategy for the treatment of sympatho-excitatory diseases such as heart failure, hypertension, and diabetes. ..