Research Topics
Genomes and Genes
| Tomas GanzSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Copy number polymorphisms are not a common feature of innate immune genesRose M Linzmeier
Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1690, USA
Genomics 88:122-6. 2006....- The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disordersTomas Ganz
Department of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA
Hematology Am Soc Hematol Educ Program 2011:538-42. 2011.... - Iron imports. IV. Hepcidin and regulation of body iron metabolismTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
Am J Physiol Gastrointest Liver Physiol 290:G199-203. 2006..Hepcidin deficiency due to the dysregulation of its synthesis causes most known forms of hemochromatosis... - Molecular pathogenesis of anemia of chronic diseaseTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Pediatr Blood Cancer 46:554-7. 2006..Hepcidin blocks the release of iron from macrophages, hepatocytes, and enterocytes, causing the characteristic hypoferremia associated with this anemia and iron-deprivation of the developing erythrocytes... - Defensins and other antimicrobial peptides: a historical perspective and an updateTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
Comb Chem High Throughput Screen 8:209-17. 2005.... - Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophagesTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
Best Pract Res Clin Haematol 18:171-82. 2005..At the opposite extreme, early studies indicate that hepcidin deficiency--due to the dysregulation of its synthesis or mutations in the hepcidin gene itself--is the immediate cause of most forms of hemochromatosis... - Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiationAlice Y Liu
Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
J Invest Dermatol 118:275-81. 2002..Defensins and other antimicrobial peptides of inflamed epidermis are likely to play an important antimicrobial role in host defense against cutaneous pathogens... - Epithelia: not just physical barriersTomas Ganz
Department of Medicine, School of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 99:3357-8. 2002 - Defensins: antimicrobial peptides of vertebratesTomas Ganz
CHS 37 055, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
C R Biol 327:539-49. 2004..The main focus is on vertebrate defensins, a family of cysteine-rich antimicrobial peptides abundantly represented in human cells and tissues... - Hepcidin in iron metabolismTomas Ganz
Departments of Medicine and Pathology, David Geffen School of Medicine University of California, Los Angeles, California 90095 1690, USA
Curr Opin Hematol 11:251-4. 2004..Connecting iron metabolism to innate immunity, hepcidin is a key mediator of hypoferremia of inflammation... - Antimicrobial polypeptidesTomas Ganz
David Geffen School of Medicine, University of California, Los Angeles, CA, USA
J Leukoc Biol 75:34-8. 2004..Since then, a number of additional antimicrobial components have been identified, and there is increasing insight into their complex interactions. This review is an update of my previous summary of this area... - Defensins: antimicrobial peptides of innate immunityTomas Ganz
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1690, USA
Nat Rev Immunol 3:710-20. 2003..This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins... - Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammationTomas Ganz
Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 37 055, University of California, Los Angeles, CA 90095 1690, USA
Blood 102:783-8. 2003..The discovery of hepcidin and its role in iron metabolism could lead to new therapies for hemochromatosis and anemia of inflammation... - Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycanTomas Ganz
Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095 1690, USA
Blood 101:2388-92. 2003..Our data indicate that tissue injury is normally limited by prompt degradation of bacterial macromolecules that trigger innate immunity and inflammation... - Immunology. Versatile defensinsTomas Ganz
Department of Medicine, University of California, Los Angeles, CA 90095, USA
Science 298:977-9. 2002 - Regulation of iron acquisition and iron distribution in mammalsTomas Ganz
Department of Medicine and Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1690, USA
Biochim Biophys Acta 1763:690-9. 2006..Deficiency of hepcidin is the unifying cause of hereditary hemochromatoses, and excessive cytokine-stimulated hepcidin production causes hypoferremia and contributes to anemia of inflammation... - Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolismT Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90095 1690, USA
Curr Top Microbiol Immunol 306:183-98. 2006..The decrease in extracellular iron concentrations due to hepcidin probably limits iron availability to invading microorganisms, thus contributing to host defense... - Molecular control of iron transportTomas Ganz
Departments of Medicine and Pathology, David Geffen School of Medicine, 10833 Le Conte Avenue, CHS 37 055, University of California, Los Angeles, CA 90095 1690, USA
J Am Soc Nephrol 18:394-400. 2007..Hepcidin deficiency plays a central role in most iron overload disorders. The role of hepcidin abnormalities in anemias that are associated with renal disease and in resistance to erythropoietic therapies remains to be elucidated... - Hepcidin and iron regulation, 10 years laterTomas Ganz
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Blood 117:4425-33. 2011..This response also restricts the iron supply to erythropoietic precursors and may cause or contribute to the anemia associated with infections and inflammatory disorders... - Hepcidin and disorders of iron metabolismTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Annu Rev Med 62:347-60. 2011..The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias... - Iron sequestration and anemia of inflammationTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Semin Hematol 46:387-93. 2009..The supply of iron to hemoglobin synthesis becomes limiting, eventually resulting in anemia. Depending on the details of the underlying disease, other inflammation-related mechanisms may also contribute to anemia... - The role of hepcidin in iron sequestration during infections and in the pathogenesis of anemia of chronic diseaseTomas Ganz
Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Isr Med Assoc J 4:1043-5. 2002.... - Iron in innate immunity: starve the invadersTomas Ganz
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, United States
Curr Opin Immunol 21:63-7. 2009..Specialized inflammation-regulated proteins chelate iron, trap siderophores, and transport iron or modulate its transport to alter its tissue distribution during infections... - Iron homeostasis: fitting the puzzle pieces togetherTomas Ganz
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
Cell Metab 7:288-90. 2008.... - Immunoassay for human serum hepcidinTomas Ganz
Intrinsic LifeSciences LLC, La Jolla, CA, USA
Blood 112:4292-7. 2008..The new serum hepcidin enzyme-linked immunosorbent assay yields accurate and reproducible measurements that appropriately reflect physiologic, pathologic, and genetic influences, and is informative about the etiology of iron disorders... - Reduction of serum hepcidin by hemodialysis in pediatric and adult patientsJoshua Zaritsky
Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Clin J Am Soc Nephrol 5:1010-4. 2010.... - The hepcidin-binding site on ferroportin is evolutionarily conservedIvana De Domenico
Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
Cell Metab 8:146-56. 2008..The affinity of hepcidin for the HBD permits a rapid, sensitive assay of hepcidin from all species and yields insights into the evolution of hepcidin... - Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase proteinElizabeta Nemeth
Department of Medicine, David Geffen School of Medicine, and the West Los Angeles Veterans Administration Hospital, University of California, Los Angeles 90095, USA
Blood 101:2461-3. 2003..The linkage of hepcidin induction to inflammation in humans supports its proposed role as a key mediator of anemia of inflammation... - The molecular mechanism of hepcidin-mediated ferroportin down-regulationIvana De Domenico
Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA
Mol Biol Cell 18:2569-78. 2007..Depletion of proteins involved in multivesicular body trafficking (Endosome Sorting Complex Required for Transport proteins), by small-interfering RNA, reduces the trafficking of Fpn-green fluorescent to the lysosome... - Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overloadGloria C Preza
Department of Pathology, UCLA, Los Angeles, California, USA
J Clin Invest 121:4880-8. 2011..Moreover, liver iron concentrations were lower in mice chronically treated with minihepcidins than those in mice treated with solvent alone. Minihepcidins may be useful for the treatment of iron overload disorders... - Involvement of hepcidin in the anemia of multiple myelomaSanjai Sharma
West Los Angeles VA University of California Los Angeles Medical Center, Los Angeles, CA 90073, USA
Clin Cancer Res 14:3262-7. 2008..Because interleukin (IL)-6 is a potent inducer of hepcidin expression and its levels are elevated in multiple myeloma, we studied the role of hepcidin in the anemia of multiple myeloma... - IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidinElizabeta Nemeth
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
J Clin Invest 113:1271-6. 2004.... - Hepcidin--a potential novel biomarker for iron status in chronic kidney diseaseJoshua Zaritsky
Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Clin J Am Soc Nephrol 4:1051-6. 2009..Hepcidin is a key regulator of iron homeostasis, but its study in the setting of chronic kidney disease (CKD) has been hampered by the lack of validated serum assays... - The molecular basis of hepcidin-resistant hereditary hemochromatosisAugustine Fernandes
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Blood 114:437-43. 2009..Our observations explain why the mutations in C326 Fpn residue produce a severe form of hemochromatosis with iron overload at an early age... - Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organsSeth Rivera
UCLA Department of Medicine, 10833 Le Conte Ave, CHS 37 131, Los Angeles, CA 90095, USA
Blood 106:2196-9. 2005..The rapid and sustained action of a single dose of hepcidin makes it an appealing agent for the prevention of iron accumulation in hereditary hemochromatosis... - Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationElizabeta Nemeth
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Science 306:2090-3. 2004..The posttranslational regulation of ferroportin by hepcidin may thus complete a homeostatic loop: Iron regulates the secretion of hepcidin, which in turn controls the concentration of ferroportin on the cell surface... - Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemiaSeth Rivera
Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
Blood 105:1797-802. 2005..Hepcidin contributes to AI by shunting iron away from erythropoiesis and sequestering it in the liver, predominantly in hepatocytes... - Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzaeHaa Yung Lee
The Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California 90057, USA
BMC Infect Dis 4:12. 2004.... - Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4Lan Lin
Departments of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
Blood 110:2182-9. 2007..Fresh primary hepatocytes constitute a sufficient system for the regulation of hepcidin by physiologic iron stimuli and will greatly facilitate studies of major disorders of iron homeostasis... - Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR siteLan Lin
Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
Blood Cells Mol Dis 40:122-31. 2008..In this report, we investigate the proteinase involved in the release of s-hemojuvelin and show that s-hemojuvelin is released by a proprotein convertase through the cleavage at a conserved polybasic RNRR site... - The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function studyElizabeta Nemeth
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Blood 107:328-33. 2006..G71D and K83R, substitutions previously described in humans, did not affect hepcidin activity. Apart from the essential nature of the N-terminus, hepcidin structure appears permissive for mutations... - Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in miceEmilio Ramos
Chemistry and Biochemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Hepatology 53:1333-41. 2011..A distinct regulatory mechanism that senses hepatic iron may modulate hepcidin response to chronic iron loading... - TGF-alpha regulates TLR expression and function on epidermal keratinocytesLloyd S Miller
Division of Dermatology, Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 174:6137-43. 2005..These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces... - Lysozyme levels in the nasal secretions of patients with perennial allergic rhinitis and recurrent sinusitisV Cuneyt Kalfa
Division of Pediatric Immunology, Allergy, Rheumatology, Department of Pediatrics, University of California at Los Angeles, Los Angeles, California, USA
Ann Allergy Asthma Immunol 93:288-92. 2004..CONCLUSIONS: The presence of eosinophils and their products and reduced lysozyme concentrations may be critical factors that predispose the airways of patients with PAR to RS... - Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furinErika V Valore
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1690, USA
Blood Cells Mol Dis 40:132-8. 2008..In conclusion, the hepatic prohormone convertase furin mediates the posttranslational processing of hepcidin. The proteolytic cleavage of prohepcidin to hepcidin is not regulated by iron-transferrin or the HIF pathway... - Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelinLan Lin
Dept of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Blood 106:2884-9. 2005..We propose that soluble and cell-associated hemojuvelin reciprocally regulate hepcidin expression in response to changes in extracellular iron concentration... - Suppression of hepcidin during anemia requires erythropoietic activityMihwa Pak
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California (UCLA, Los Angeles, USA
Blood 108:3730-5. 2006..The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia, or erythropoietin... - Animal models of anemia of inflammationSeth Rivera
Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA
Semin Hematol 46:351-7. 2009..We review many of the models reported in the literature or developed in our laboratory, and discuss their respective merits and drawbacks... - Differential regulation of beta-defensin expression in human skin by microbial stimuliOle E Sørensen
Host Defense Laboratory, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 174:4870-9. 2005..Thus during inflammation, epidermal expression of beta-defensins is mediated by at least three different mechanisms... - Regulation of iron metabolism by hepcidinElizabeta Nemeth
Departments of Medicine and Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Annu Rev Nutr 26:323-42. 2006..The emergence of hepcidin as the pathogenic factor in most systemic iron disorders should provide important opportunities for improving their diagnosis and treatment... - Cationic polypeptides are required for antibacterial activity of human airway fluidAlexander M Cole
Department of Medicine, Division of Pulmonary and Critical Care Medicine, and Will Rogers Institute Pulmonary Research Laboratory, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
J Immunol 169:6985-91. 2002..aeruginosa... - Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2Cheryl J Hertz
Division of Dermatology, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
J Immunol 171:6820-6. 2003..Together, these data suggest that TLRs monitor epithelial surfaces to enhance host defense by inducing the production of an antimicrobial peptide... - Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosisEric Bachman
Department of Medicine, Boston University School of Medicine, 670 Albany Street, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 95:4743-7. 2010..The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown... - Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1Alexander M Cole
Department of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, 10833 Le Conte Ave, Room CHS 37 055, Los Angeles, CA 90095 1690, USA
FEBS Lett 535:195-9. 2003..The strategies employed herein could uncover additional antimicrobial peptides from envelope proteins of other lytic viruses... - Reversible deficiency of antimicrobial polypeptides in bacterial vaginosisErika V Valore
Department of Medicine, CHS 37-055, David Geffen School of Medicine, Los Angeles, CA 90095-1690, USA
Infect Immun 74:5693-702. 2006..The loss of normal immunostimulatory flora in bacterial vaginosis is thus associated with a local deficiency of multiple innate immune factors, and this deficiency could predispose individuals to sexually transmitted diseases... - A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivoGeorge T J Huang
Division of Associated Clinical Specialties, Section of Endodontics, 23 087 CHS, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Hum Gene Ther 13:2017-25. 2002..8 +/- 3.3% viable bacteria. On the basis of this demonstration of HBD-2 in vivo antimicrobial activity, enhancement of antibacterial host defense by HBD-2 gene therapy may be feasible... - Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cellsSung Kyun Moon
Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
Biochim Biophys Acta 1590:41-51. 2002..Moreover, we demonstrate that the transcriptional activation of hBD-2 gene by IL-1 alpha is mediated through an Src-dependent Raf-MEK1/2-ERK signaling pathway... - The role of hepcidin in iron metabolismElizabeta Nemeth
David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Acta Haematol 122:78-86. 2009..Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory... - Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogensBelinda H Tan
Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 177:1864-71. 2006.... - Reduced Paneth cell alpha-defensins in ileal Crohn's diseaseJan Wehkamp
Department of Microbiology and Immunology, School of Medicine, University of California, Davis, 95616, USA
Proc Natl Acad Sci U S A 102:18129-34. 2005..Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease... - Antimicrobial components of vaginal fluidErika V Valore
Department of Medicine and Pathology, School of Medicine, University of California, Los Angeles 90095-1690, USA
Am J Obstet Gynecol 187:561-8. 2002..CONCLUSION: Vaginal fluid exerts selective antimicrobial activity against nonresident bacterial species. The activity is mediated by lactic acid, low pH, and antimicrobial polypeptides... - Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriersKarin M Aberg
Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, California, USA
J Invest Dermatol 128:917-25. 2008..These studies demonstrate that (1) the permeability and antimicrobial barriers are coordinately regulated by permeability barrier requirements and (2) CRAMP is required for permeability barrier homeostasis... - By IL-1 signaling, monocyte-derived cells dramatically enhance the epidermal antimicrobial response to lipopolysaccharideLide Liu
Will Rogers Pulmonary Research Laboratory, Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095-1690, USA
J Immunol 170:575-80. 2003..This pattern of responses establishes a key role for both IL-1 and HBD-2 in the host defense reaction of the epidermis... - Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammationL Liu
Departments of Medicine and Pathology and the Will Rogers Institute for Pulmonary Research, UCLA School of Medicine, Los Angeles, CA, USA
Gene 222:237-44. 1998..The HBD-2 gene is the first member of the human defensin family that is locally inducible by inflammation... - Defensins of vertebrate animalsRobert I Lehrer
Department of Medicine Room CHS 37 062, and Molecular Biology Institute University of California at Los Angeles UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA
Curr Opin Immunol 14:96-102. 2002..There is now convincing evidence that defensins augment adaptive immune responses... - Cellular iron: ferroportin is the only way outTomas Ganz
Department of Medicine, David Gefen School of Medicine, Unvirsity of California, Los Angeles, California 90095, USA
Cell Metab 1:155-7. 2005..New studies of ferroportin knockout mice define a key role for this transporter in physiological iron balance... - Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23Rose M Linzmeier
Department of Medicine and Department of Pathology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1690, USA
Genomics 86:423-30. 2005..The remarkable variability in defensin gene copy numbers could contribute to differences in individual resistance to infections... - Antimicrobial polypeptides in host defense of the respiratory tractTomas Ganz
University of California-Los Angeles School of Medicine, Center for the Health Sciences, 10833 LeConte Avenue, 37-055, Los Angeles, CA 90095-1690, USA
J Clin Invest 109:693-7. 2002 - Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantationDavid J Ross
Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute for Pulmonary Research, David Geffen School of Medicine U C L A Medical Center, Los Angeles, CA 90095 1690, USA
Transplantation 78:1222-4. 2004..We therefore speculate that complex interactions between adaptive and innate immunity may contribute to the propagation of airway inflammation in BOS... - Cathelicidins: a family of endogenous antimicrobial peptidesRobert I Lehrer
Department of Medicine, Molecular Biology Institute, University of California at Los Angeles, Los Angeles, California, USA
Curr Opin Hematol 9:18-22. 2002..Porcine protegrins are in stage III clinical trials to prevent oral mucositis caused by radiation or chemo-therapy... - Wound healing and expression of antimicrobial peptides/polypeptides in human keratinocytes, a consequence of common growth factorsOle E Sørensen
Granulocyte Research Laboratory, Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
J Immunol 170:5583-9. 2003..These findings offer an explanation for the expression of these peptides/polypeptides in the skin disease psoriasis and in wound healing and define a host defense role for growth factors in wound healing... - Antimicrobial peptides in mammalian and insect host defenceR I Lehrer
Department of Medicine, The Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
Curr Opin Immunol 11:23-7. 1999..Studies that examined the potential contributions of antimicrobial peptides to regional innate immunity gained in prominence. Efforts to design peptide analogues to prevent or treat infections continued... - Human antimicrobial peptides: analysis and applicationA M Cole
Department of Medicine, UCLA School of Medicine 90095 1690, USA
Biotechniques 29:822-6, 828, 830-1. 2000.... - Purification and antimicrobial properties of three defensins from rat neutrophilsP B Eisenhauer
Department of Medicine, University of California, Los Angeles
Infect Immun 57:2021-7. 1989..The existence of the defensin system in rats should facilitate investigations of the in vivo role of defensins in experimental infections... - Antimicrobial peptides of vertebratesT Ganz
Department of Medicine, University of California School of Medicine, Los Angeles 90095 1690, USA
Curr Opin Immunol 10:41-4. 1998..Other highlights included new insights into the relative selectivity of antimicrobial peptides for microbial membranes, their primary site of action... - Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptidesR I Lehrer
Department of Medicine, UCLA Center for the Health Sciences 90095, USA
Ann N Y Acad Sci 797:228-39. 1996..Defensins and protegrin-like peptides are likely to play a considerable role in innate immunity and may provide molecular templates that can be used to generate novel antibiotics for topical and systemic use... - Antibiotic peptides from higher eukaryotes: biology and applicationsT Ganz
Dept of Medicine and the Will Rogers Institute for Pulmonary Research, UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
Mol Med Today 5:292-7. 1999.... - Antimicrobial proteins and peptides in host defenseT Ganz
UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
Semin Respir Infect 16:4-10. 2001..Several peptides have properties that make them suitable for pharmaceutical development as topical or systemic antimicrobial agents... - In human epidermis, beta-defensin 2 is packaged in lamellar bodiesA Oren
Department of Medicine and Pathology, Geffen School of Medicine at University of California, at Los Angeles, Los Angeles, CA 90095, USA
Exp Mol Pathol 74:180-2. 2003..These findings suggest that HBD-2 is released with the contents of the LBs. Along with other investigations, our findings indicate that the lipid "permeability" barrier of the skin contains antimicrobial substances... - Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activityA M Cole
Department of Medicine, Division of Pulmonary and Critical Care, University of California School of Medicine, Los Angeles, CA 90095, USA
J Immunol 167:623-7. 2001..IFN-gamma-inducible chemokines may directly inactivate microbes before attracting other host defense cells to the area of infection... - Calcitermin, a novel antimicrobial peptide isolated from human airway secretionsA M Cole
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
FEBS Lett 504:5-10. 2001..4) and in the presence of micromolar concentrations of ZnCl(2). Analysis revealed a putative zinc-binding consensus sequence as well as an alpha-helical conformation in structure-promoting solvents... - Antimicrobial peptides and proteins in the CF airwayAlexander M Cole
Department of Medicine, Will Rogers Institute Pulmonary Research Laboratory, UCLA School of Medicine, Los Angeles, CA, USA
Methods Mol Med 70:447-64. 2002 - The structure of the rabbit macrophage defensin genes and their organ-specific expressionT Ganz
Will Rogers Institute of Pulmonary Research, UCLA, Los Angeles, CA 90024 1736
J Immunol 143:1358-65. 1989..In macrophages, the expression of MCPs appears to be a marker of lung-specific differentiation... - Structures of genes for two cathelin-associated antimicrobial peptides: prophenin-2 and PR-39C Zhao
Department of Medicine, UCLA Center for the Health Sciences 90095 1678, USA
FEBS Lett 376:130-4. 1995.... - Human beta-defensin-1: an antimicrobial peptide of urogenital tissuesE V Valore
Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Clin Invest 101:1633-42. 1998..coli in unconcentrated (low conductance) urine, and the 36 aa form was microbicidal even in normal (high conductance) urine. Production of HBD-1 in the urogenital tract could contribute to local antimicrobial defense... - Therapeutic effect of a pig-derived peptide antibiotic on porcine wound infectionsA V Ceccarelli
Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Comp Med 51:75-9. 2001..Therapeutics used in the same animal species from which they were derived are a promising means for preventing and treating localized infections... - Posttranslational processing of defensins in immature human myeloid cellsE V Valore
Will Rogers Institute Pulmonary Research Laboratory, University of California, Los Angeles
Blood 79:1538-44. 1992..Further studies will be required to determine the role of this processing pathway in subcellular targeting to azurophil granules and avoidance of autocytotoxicity... - DefensinsT Ganz
Department of Medicine, University of California School of Medicine, Los Angeles 90024 1736, USA
Pharmacol Ther 66:191-205. 1995..They contribute to host defense against microbes and may participate in tissue inflammation and endocrine regulation during infection. Bioengineered defensins are potentially useful as prophylactic and therapeutic agents in infections... - Defensins: antimicrobial and cytotoxic peptides of mammalian cellsR I Lehrer
Department of Medicine, University of California, Los Angeles 90024
Annu Rev Immunol 11:105-28. 1993..Defensins are a newly delineated family of effector molecules whose contribution to host defense, inflammation, and cytotoxicity may be considerable for humans, even though it is unlikely to be revealed by experimentation with mice... - Hepcidin, a urinary antimicrobial peptide synthesized in the liverC H Park
Departments of Medicine and Pathology, UCLA School of Medicine, Los Angeles, California 90059, USA
J Biol Chem 276:7806-10. 2001..Hepcidin may be a vertebrate counterpart of cysteine-rich antimicrobial peptides produced in the fat body of insects... - The structure of porcine protegrin genesC Zhao
Department of Medicine, UCLA School of Medicine, UCLA Center for the Health Sciences 90095 1678, USA
FEBS Lett 368:197-202. 1995..Southern blot probed with an oligonucleotide specific for protegrin genes suggested that several identical or nearly identical protegrin genes were densely clustered in the pig chromosome... - Localization of human intestinal defensin 5 in Paneth cell granulesE M Porter
Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
Infect Immun 65:2389-95. 1997..Since Paneth cells release their granules adjacent to the mitotic cells of the intestinal crypts, HD could protect this cell population against invasion and parasitization by microbes... - Detection of beta-defensins secreted by human oral epithelial cellsD L Diamond
Ciphergen Biosystems, Fremont, CA, USA
J Immunol Methods 256:65-76. 2001..This methodology offers several technical advantages for detection of defensins in biological fluids, including ease and speed of screening, no need for HPLC preliminary processing, and small sample size... - Hepcidin and iron-loading anemiasElizabeta Nemeth
Haematologica 91:727-32. 2006 - Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophilsOfer Levy
Division of Infectious Diseases, General Clinical Research Center, and Medicine, Children's Hospital, Boston, Massachusetts, USA
Transplantation 73:1522-6. 2002..Any deficiencies of neutrophil function during this phase are not due to inadequate expression of these antimicrobial (poly)peptides but could reflect abnormalities in other aspects of neutrophil function... - Endogenous antimicrobial peptides and skin infections in atopic dermatitisPeck Y Ong
Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
N Engl J Med 347:1151-60. 2002..aureus. CONCLUSIONS: A deficiency in the expression of antimicrobial peptides may account for the susceptibility of patients with atopic dermatitis to skin infection with S. aureus... - Microbiology: Gut defenceTomas Ganz
Nature 422:478-9. 2003 - Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptorOle E Sørensen
Section of Clinical and Experimental Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
J Clin Invest 116:1878-85. 2006..These data demonstrate that sterile wounding initiates an innate immune response that increases resistance to overt infection and microbial colonization... - Severe hemochromatosis in a Portuguese family associated with a new mutation in the 5'-UTR of the HAMP geneThomas Matthes
Division of Hematology, University Hospital, Geneva, Switzerland
Blood 104:2181-3. 2004..The decrease of hepcidin production would thus lead to increased iron absorption, resulting in iron deposition in parenchymal tissues. Phlebotomy therapy of the 2 patients resulted in impressive clinical improvement... - Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme MAlexander M Cole
Department of Molecular Biology and Microbiology, Biomolecular Science Center, University of Central Florida, Orlando 32816, USA
J Leukoc Biol 78:1081-5. 2005..aeruginosa compared with their lys M+/- or lys M+/+ littermates. Lysozyme contributes to optimal clearance of P. aeruginosa from the murine airways... - Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosisAlberto Piperno
Department of Clinical Medicine and Prevention, Milano Bicocca University, San Gerardo Hospital, Monza, Italy
Blood 110:4096-100. 2007..The hepcidin response to oral iron is blunted in HFE-related hemochromatosis and not improved after iron depletion. The findings support the involvement of HFE in iron sensing and subsequent regulation of hepcidin...
Research Grants
- INNATE HOST DEFENSE IN THE HUMAN VAGINATomas Ganz; Fiscal Year: 2004..abstract_text> ..
- The role of hemojuvelin in the regulation of iron metabolismTomas Ganz; Fiscal Year: 2007....
- Hepcidin and Anemia of InflammationTomas Ganz; Fiscal Year: 2007..This work is important both for the fundamental understanding of iron metabolism and for its exciting translational potential in the treatment of anemia of inflammation and some forms of hemochromatosis. ..
- THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLYTomas Ganz; Fiscal Year: 2010..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
- Hepcidin, ferroportin and iron disordersTomas Ganz; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: The proposed project will help understand and treat disorders of iron metabolism including hemochromatosis and thalassemias. ..
- THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLYTomas Ganz; Fiscal Year: 2010..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
- Human Defensins in Phagocytes and EpitheliaTomas Ganz; Fiscal Year: 2004..In the aggregate, these studies will expand our understanding of is ubiquitous and multifunctional family of human host defense peptides, this time also in their role as effectors of innate immunity in epithelia. ..
- PRODUCTION OF DEFENSINS BY HUMAN GRANULOCYTESTomas Ganz; Fiscal Year: 1993..In the longer term, these studies may lead to therapeutic strategies for targeting exogenous microbicidal proteins into the cytoplasmic granules of human or animal neutrophils, monocytes and macrophages...
- PRODUCTION OF ANTIMICROBIAL PEPTIDES BY HUMAN NEUTROPHILTomas Ganz; Fiscal Year: 2000..Thus the overall goal of the proposal is to define a recently recognized human host defense mechanism that may be important in resistance to microbial infection. ..
- Hepcidin, ferroportin and iron disordersTomas Ganz; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: The proposed project will help understand and treat disorders of iron metabolism including hemochromatosis and thalassemias. ..