Research Topics
Genomes and Genes | D I GabrilovichSummaryAffiliation: University of South Florida Country: USA Publications
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Publications
Immature myeloid cells and cancer-associated immune suppressionSergei Kusmartsev
H. Lee Moffitt Cancer Center, University of South Florida, MRC-2, Room 2067, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Immunol Immunother 51:293-8. 2002..This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression...- Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cellsD I Gabrilovich
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Immunol 166:5398-406. 2001..Differentiation of Gr-1(+) cells in the presence of growth factors and all-trans retinoic acid completely eliminated inhibitory potential of these cells. This may suggest a new approach to cancer treatment... - Dendritic Vaccines--Fifth International Meeting. Dendritic cell vaccination and other strategies to tip the balance of the immune system. 16-18 July 2007, Bamberg, GermanyDmitry Gabrilovich
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
IDrugs 10:699-702. 2007 - INGN 201 (Advexin): adenoviral p53 gene therapy for cancerDmitry I Gabrilovich
University of South Florida, H Lee Moffitt Cancer Center and the Department of Interdisciplinary Oncology, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
Expert Opin Biol Ther 6:823-32. 2006..In addition, there is now data to support the use of Advexin in cancer immunotherapy... - Mechanisms and functional significance of tumour-induced dendritic-cell defectsDmitry Gabrilovich
H Lee Moffitt Cancer Center, University of South Florida, MRC 2067, 12902 Magnolia Drive, Tampa, Florida 33612, USA
Nat Rev Immunol 4:941-52. 2004..This article focuses on the functional consequences and recently described mechanisms of the dendritic-cell defects in cancer... - Combination of chemotherapy and immunotherapy for cancer: a paradigm revisitedDmitry I Gabrilovich
Department of Interdisciplinary Oncology and Molecular Medicine, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Lancet Oncol 8:2-3. 2007 - Tumor escape from immune response: mechanisms and targets of activityDmitry Gabrilovich
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Curr Drug Targets 4:525-36. 2003..However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them... - Notch signaling is necessary but not sufficient for differentiation of dendritic cellsPingyan Cheng
H Lee Moffitt Cancer Center, University of South Florida, MRC 2E, Rm 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
Blood 102:3980-8. 2003..Thus, Notch is required but not sufficient for DC differentiation... - H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factorsDmitry I Gabrilovich
H Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
J Leukoc Biol 72:285-96. 2002..Thus, H1(0) histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression... - Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 proteinPingyan Cheng
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Exp Med 205:2235-49. 2008..This study demonstrates that tumor-induced up-regulation of S100A9 protein is critically important for accumulation of MDSCs and reveals a novel molecular mechanism of immunological abnormalities in cancer... - Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cellsP Cheng
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Immunol 167:4458-67. 2001..However, it was restored by transduction of activated Notch-1 into HPC. Taken together, these data indicate that in HPC NF-kappaB activity is regulated by Notch-1 via transcriptional control of NF-kappaB... - An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53E Y Nikitina
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Gene Ther 9:345-52. 2002..These data demonstrate that activated Ad-p53-infected DCs are able to break tolerance to this protein and can be used in immunotherapy of cancer... - Combination of gamma-irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: approach to treatment of advanced stage cancerE Y Nikitina
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Int J Cancer 94:825-33. 2001..These data suggest that the combination of apoptosis-inducing therapy and DC administration may be an attractive approach to the treatment of advanced cancer... - Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen speciesSergei Kusmartsev
H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
J Immunol 172:989-99. 2004..This study demonstrates a new mechanism of Ag-specific T cell inhibition mediated by ROS produced by ImCs in cancer... - Lipid accumulation and dendritic cell dysfunction in cancerDonna L Herber
Department of Immunology, H Lee Moffitt Cancer Center, Tampa, Florida, USA
Nat Med 16:880-6. 2010..These findings suggest that immune responses in cancer can be improved by manipulating the lipid levels in DCs... - Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancerSrinivas Nagaraj
H Lee Moffitt Cancer Center, Tampa, Florida 33647, USA
Clin Cancer Res 16:1812-23. 2010..Myeloid-derived suppressor cells (MDSC) are one of the major factors responsible for immune suppression in cancer. Therefore, it would be important to identify effective therapeutic means to modulate these cells... - Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen speciesSergei Kusmartsev
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Leukoc Biol 74:186-96. 2003..Thus, this is a first demonstration that tumors may prevent differentiation of antigen-presenting cells by increasing the level of endogenous H(2)O(2) in immature myeloid cells... - Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancerScott J Antonia
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Clin Cancer Res 12:878-87. 2006..CONCLUSIONS: This study provides clinical support for an emerging paradigm in cancer immunotherapy, wherein optimal use of vaccination might be more effective, not as a separate modality, but in direct combination with chemotherapy... - Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathwayYulia Nefedova
Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
Cancer Res 65:9525-35. 2005..This indicates that pharmacologic inhibition of the JAK2/STAT3 pathway can be an important new therapeutic strategy to enhance antitumor activity of cancer immunotherapy... - Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligandsPingyan Cheng
H Lee Moffitt Cancer Center, Department of Interdisciplinary Oncology, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
Blood 109:507-15. 2007..Thus, this study not only revealed the different role of Notch ligands in DC differentiation but also may provide a new insight into regulation of DC differentiation by BMS... - Activation of dendritic cells via inhibition of Jak2/STAT3 signalingYulia Nefedova
Immunology Program, H. Lee Moffitt Cancer Center, and the Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33647, USA
J Immunol 175:4338-46. 2005..This indicates that Jak2/STAT3 play an important role in negative regulation of DC activation, and pharmacological inhibition of the Jak2/STAT3 pathway can be used to enhance DC function... - Mechanism of T cell tolerance induced by myeloid-derived suppressor cellsSrinivas Nagaraj
Department of Immunology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Immunol 184:3106-16. 2010..MDSCs caused dissociation between TCR and CD3zeta molecules, disrupting TCR complexes on T cells. Thus, these data describe a novel mechanism of Ag-specific CD8(+) T cell tolerance in cancer... - Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in miceRupal Ramakrishnan
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Clin Invest 120:1111-24. 2010..In addition, these results provide a strong rationale for combining these modalities for the treatment of patients with advanced cancers... - Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cellsCesar A Corzo
H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA
J Immunol 182:5693-701. 2009..These findings expand our fundamental understanding of the biology of MDSC and may also open new opportunities for therapeutic regulation of these cells in cancer... - Myeloid-derived suppressor cellsSrinivas Nagaraj
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
Adv Exp Med Biol 601:213-23. 2007..In recent years, it has become increasingly evident that MDSCs bring about antigen-specific T cell tolerance by various mechanisms, which is the focus of this chapter... - HIF-1? regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironmentCesar A Corzo
H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
J Exp Med 207:2439-53. 2010.... - Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cellsYulia Nefedova
H Lee Moffitt Cancer Center and University of South Florida, Tampa, Florida 33612, USA
Cancer Res 67:11021-8. 2007..This novel mechanism involves specific up-regulation of GSS and accumulation of GSH and could be used in developing and monitoring therapeutic application of ATRA... - Myeloid-derived suppressor cells as regulators of the immune systemDmitry I Gabrilovich
Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
Nat Rev Immunol 9:162-74. 2009..In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit... - Notch and wingless signaling cooperate in regulation of dendritic cell differentiationJie Zhou
Department of Immunology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
Immunity 30:845-59. 2009..Thus, these data suggest a model of DC differentiation via cooperation between Wnt and Notch pathways... - Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancerSergei Kusmartsev
H Lee Moffitt Cancer Center, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
Cancer Metastasis Rev 25:323-31. 2006..The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed... - Dendritic cell vaccines for cancer treatmentDmitry I Gabrilovich
H Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
Curr Opin Mol Ther 4:452-8. 2002..We will discuss requirements for DC activation as pre-requisite for the success of cancer immunotherapy... - STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletionSergei Kusmartsev
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Immunol 174:4880-91. 2005..Using the analysis of STAT activity in combination with STAT knockout mice, we have determined that STAT1, but not STAT3 or STAT6, was responsible for TAM-suppressive activity... - Role of immature myeloid cells in mechanisms of immune evasion in cancerSergei Kusmartsev
H. Lee Moffitt Cancer Center and Research Institute and The Department of Interdisciplinary Oncology, University of South Florida, MRC 2067, 12902 Magnolia Dr, Tampa, FL 33612, USA
Cancer Immunol Immunother 55:237-45. 2006.... - Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cellsSergei Kusmartsev
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
J Immunol 175:4583-92. 2005..Thus, this is a first demonstration that in tumor-bearing mice CD8+ T cell tolerance is induced primarily by ImC that may have direct implications for cancer immunotherapy... - Dendritic cells and tumor microenvironment: a dangerous liaisonIngo Fricke
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
Immunol Invest 35:459-83. 2006..The tumor microenvironment has emerged as an important component contributing to DC malfunction. In this review we will discuss the potential role of tumor microenvironment in DC dysfunction... - Subsets of myeloid-derived suppressor cells in tumor-bearing miceJe In Youn
H Lee Moffitt Cancer Center and Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
J Immunol 181:5791-802. 2008..These data indicate that suppressive features of MDSC is caused not by expansion of a specific subset but more likely represent a functional state of these cells... - Combined modality immunotherapy and chemotherapy: a new perspectiveRupal Ramakrishnan
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Cancer Immunol Immunother 57:1523-9. 2008..In clinical trials, immune responses elicited by cancer vaccines appear to augment the effectiveness of subsequent conventional cancer therapies... - All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patientsNoweeda Mirza
H. Lee Moffitt Cancer Center and the Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
Cancer Res 66:9299-307. 2006..ATRA treatment did not result in significant toxicity and it could be tested in therapeutic combination with cancer vaccines... - Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responsesIngo Fricke
H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
Clin Cancer Res 13:4840-8. 2007..It has been proposed that inhibition of VEGF may result in improved immune responses. The goal of this study was to test this hypothesis... - Targeting of Jak/STAT pathway in antigen presenting cells in cancerYulia Nefedova
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Curr Cancer Drug Targets 7:71-7. 2007..The different approaches to pharmacological regulation of this pathway and their effects on DC function and antitumor immune responses will be discussed... - Dendritic cell-based full-length survivin vaccine in treatment of experimental tumorsSrinivas Nagaraj
H Lee Moffitt Cancer Center and Department of Interdisciplinary Oncology, University of South Florida, Tampa, FL 33612, USA
J Immunother 30:169-79. 2007..Despite the fact that combination of 2 vaccines generated potent antigen specific T-cell responses against both molecules they did not result in the improvement of antitumor effect in any of the tested experimental tumor models... - Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancerSrinivas Nagaraj
H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33647, USA
Nat Med 13:828-35. 2007..These data identify a previously unknown mechanism of T-cell tolerance in cancer that is also pertinent to many pathological conditions associated with accumulation of MDSCs... - Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapyYulia Nefedova
H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA
Blood 111:2220-9. 2008..Thus, this study demonstrates that inhibition of Notch signaling prevents BM-mediated drug resistance and sensitizes myeloma cells to chemotherapy. This may represent a promising approach for therapeutic intervention in multiple myeloma... - Mechanism and therapeutic reversal of immune suppression in cancerDonna L Herber
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer Res 67:5067-9. 2007 - INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effectAlberto A Chiappori
Department of Thoracic Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Expert Opin Biol Ther 10:983-91. 2010..p53 gene mutations often occur, resulting in tumoral protein overexpression and allowing for their recognition by p53-specific cytotoxic T cells... - Tumor escape mechanism governed by myeloid-derived suppressor cellsSrinivas Nagaraj
H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
Cancer Res 68:2561-3. 2008..Elucidation of this mechanism of T-cell tolerance offers new opportunities for therapeutic corrections of immune escape in cancer... - Myeloid-derived suppressor cells in human cancerSrinivas Nagaraj
Division of Translational Medicine, Department of Internal Medicine, University of South Florida, Tampa, FL, USA
Cancer J 16:348-53. 2010..Here, we give an overview of the myeloid-derived suppressor cells field focusing primarily on the studies in cancer patients and current and future therapeutic options targeting these cells... - Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell linesYulia Nefedova
H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Blood 103:3503-10. 2004..Thus, this is a first report demonstrating that Notch-1 signaling may be a primary mechanism mediating the BMS influence on hematologic malignant cell growth and survival... - The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneityJe In Youn
H Lee Moffitt Cancer Center, Tampa, FL, USA
Eur J Immunol 40:2969-75. 2010..In this review, we will discuss recent findings that help to better clarify these issues and to determine the place of MDSC within the myeloid cell lineage... - Full-length dominant-negative survivin for cancer immunotherapyVladimir Pisarev
University of Nebraska Medical Center Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
Clin Cancer Res 9:6523-33. 2003..This response does not significantly affect HPCs. Thus, this study may provide rationale for immunotherapeutic clinical trials using a DC vaccine transduced with the dominant-negative survivin... - Developing dendritic cells become 'lacy' cells packed with fat and glycogenAsher Maroof
Antigen Presentation Research Group, Imperial College London, Harrow, UK
Immunology 115:473-83. 2005.... - VEGF inhibits T-cell development and may contribute to tumor-induced immune suppressionJoyce E Ohm
Department of Cancer Biology and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
Blood 101:4878-86. 2003..These data demonstrate that at pathophysiologic concentrations, VEGF interferes with the development of T cells from early hematopoetic progenitor cells and this may contribute to tumor-associated immune deficiencies... - MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsisMatthew J Delano
Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Exp Med 204:1463-74. 2007..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization... - Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological TherapyUlrich Keilholz
UKBF Free University, Berlin, Germany
J Immunother (1997) 25:97-138. 2002..At present, assays appear to be most useful as measures of vaccine potency. Careful immune monitoring in association with larger scale clinical trials ultimately may enable the correlation of monitoring results with clinical benefit... - Molecular mechanisms and therapeutic reversal of immune suppression in cancerDmitry I Gabrilovich
Curr Cancer Drug Targets 7:1. 2007 - The terminology issue for myeloid-derived suppressor cellsDmitry I Gabrilovich
Cancer Res 67:425; author reply 426. 2007 - Rational design of shepherdin, a novel anticancer agentJanet Plescia
Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Cancer Cell 7:457-68. 2005..Systemic administration of shepherdin in vivo is well tolerated, and inhibits human tumor growth in mice without toxicity. Shepherdin could provide a potent and selective anticancer agent in humans...
Research Grants
- Role of lipids in dendritic cell functionDmitry Gabrilovich; Fiscal Year: 2007..This new mechanism may suggest an entirely new approach to the treatment of immune defects associated with such disease as cancer by inhibiting accumulation of lipids. ..
- ATRA effect on myeloid cell differentiation in cancerDmitry Gabrilovich; Fiscal Year: 2005..In the proposed clinical trial we will test the hypothesis that ATRA eliminates immature myeloid cells and improves differentiation of DC in cancer patients. If proven this approach can be used to enhance the effects of cancer vaccines. ..
- Conference on immune suppression in cancerDmitry Gabrilovich; Fiscal Year: 2007..Examine how different molecular pathways contribute to tumor escape of immune system control; Review and discuss how our knowledge of new mechanisms of tumor associated immune suppression can be translated into new therapeutics ..
- P53 Based Vaccine for Small Cell Lung CancerDmitry Gabrilovich; Fiscal Year: 2007..Specific Aim 2. Determine the immune modifying effect of immunization and chemotherapy on p53-specific immunity. ..