Research Topics
| Ken Ichiro FukuchiSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's diseaseKen Ichiro Fukuchi
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, PO Box 1649, Peoria, IL 61656, USA
Neurobiol Dis 23:502-11. 2006..Because the scFv lacks the Fc portion of the immunoglobulin molecule, this modality may be a feasible solution for AD without eliciting inflammation...- Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's diseaseHong Duck Kim
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, PO Box 1649, Peoria, IL 61656, USA
J Gene Med 9:88-98. 2007.... - Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse modelKen Ichiro Fukuchi
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Box 1649, Peoria, IL 61656, USA
Biochem Biophys Res Commun 344:79-86. 2006..Because scFvs lack the Fc portion of the immunoglobulin molecule, human scFvs against Abeta may be useful to treat AD patients without eliciting brain inflammation... - Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's diseaseHong Duck Kim
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, P O Box 1649, Peoria, IL 61656, USA
Immunol Lett 112:30-8. 2007.... - TLR4 mutation reduces microglial activation, increases A? deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's diseaseMin Song
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, PO Box 1649, Peoria, IL 61656, USA
J Neuroinflammation 8:92. 2011..Here, we investigated the role of TLR4 signaling and microglial activation in early stages using 5-month-old AD mouse models when A? deposits start... - The effects of MyD88 deficiency on exploratory activity, anxiety, motor coordination, and spatial learning in C57BL/6 and APPswe/PS1dE9 miceJeong Eun Lim
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, P O Box 1649, Peoria, IL 61656, USA
Behav Brain Res 227:36-42. 2012..Our findings suggest that the MyD88-dependent pathway contributes to behavioral functions in an AD mouse model and its control group... - Simvastatin enhances immune responses to A? vaccination and attenuates vaccination-induced behavioral alterationsJinghong Kou
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, PO Box 1649, Peoria, IL 61656, USA
Brain Res 1356:102-11. 2010..Our results indicate that simvastatin clearly enhances the immune responses of C57BL/6 mice to the nasal vaccination with AdPEDI-(A?1-6)(11). Simvastatin may be effective in preventing behavioral changes associated with vaccination... - Anti-Amyloid-? Single-Chain Antibody Brain Delivery Via AAV Reduces Amyloid Load But May Increase Cerebral Hemorrhages in an Alzheimer's Disease Mouse ModelJinghong Kou
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61656, USA
J Alzheimers Dis 27:23-38. 2011..While immunotherapy has great potential for clearing cerebral A?, caution for cerebrovascular effects should be exercised when rAAV-mediated anti-A? immunotherapy is applied... - MyD88 deficiency ameliorates ?-amyloidosis in an animal model of Alzheimer's diseaseJeong Eun Lim
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA
Am J Pathol 179:1095-103. 2011..These findings also suggest that chronic inflammatory responses induced by A? accumulation via the MyD88-dependent signaling pathway exacerbate ?-amyloidosis in AD... - Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's diseaseJing Ji Jin
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Box 1649, Peoria, IL 61656, USA
J Neuroinflammation 5:23. 2008..Here, we investigated the roles of TLR4 in Abeta-induced upregulation of cytokines and chemokines, Abeta-induced activation of microglia and astrocytes and Abeta-induced immigration of leukocytes... - Induction of anti-inflammatory immune response by an adenovirus vector encoding 11 tandem repeats of Abeta1-6: toward safer and effective vaccines against Alzheimer's diseaseHong-Duck Kim
Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, P.O. Box 1649, Peoria, IL 61656, USA
Biochem Biophys Res Commun 336:84-92. 2005..Thus, the adenovirus vector encoding 11 tandem repeats of Abeta1-6 may be a safer alterative to peptide-based vaccines... - Role of toll-like receptor signalling in Abeta uptake and clearanceKazuki Tahara
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
Brain 129:3006-19. 2006..These results suggest that TLR signalling pathway(s) may be involved in clearance of Abeta-deposits in the brain and that TLRs can be a therapeutic target for Alzheimer's disease... - Simvastatin enhances learning and memory independent of amyloid load in miceLing Li
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Ann Neurol 60:729-39. 2006..Our objective was to determine whether administering a statin drug (simvastatin) would protect against the development of behavioral deficits in an established mouse model of Alzheimer's disease... - Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic miceDongfeng Cao
Atherosclerosis Research Unit, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 658, Birmingham, AL 35294, USA
Neurobiol Aging 27:1632-43. 2006..Our results suggest that the LDLR plays a role in the development of Alzheimer-type learning impairment and amyloidosis and can be a novel therapeutic target for AD... - Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid beta-protein and GM-CSFHong-Duck Kim
Department of Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, KHGB 640B, 720 20th Street South, Birmingham, AL 35294-0024, USA
Vaccine 23:2977-86. 2005..Thus, adjuvantation is essential for induction of an immune response against Abeta by adenovirus-mediated nasal vaccination... - Immunization of Alzheimer model mice with adenovirus vectors encoding amyloid beta-protein and GM-CSF reduces amyloid load in the brainHong-Duck Kim
Department of Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, KHGB 640B, 720 20th Street South, Birmingham, AL 35294-0024, USA
Neurosci Lett 370:218-23. 2004..Thus, intranasal administration of adenovirus vectors encoding Abeta and GM-CSF may be effective in prevention and treatment of AD... - Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's diseaseLing Li
Departments of Medicine, Pharmacology, and Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Pathol 163:2155-64. 2003..Our results suggest that synergistic mechanisms may be involved in the pathogenesis of atherosclerosis and AD. These findings may have important implications in the prevention and treatment of cardiovascular diseases as well as AD... - Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolismKan Liu
Department Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, 35294, USA
J Neurochem 89:1044-55. 2004..Later, some hippocampal cells, but not Purkinje cells, undergo apoptosis. These observations suggest that the O-GlcNAc system may participate in neurodegeneration, particularly in the hippocampus...
Research Grants
- Skin-patch Vaccination against Alzheimer's DiseaseKen Ichiro Fukuchi; Fiscal Year: 2002..This novel vaccination modality may have benefit to patients with these diseases and commercial value. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
- Alzheimer Vaccines: Noninvasive Vaccination by DNA-Base*Ken Ichiro Fukuchi; Fiscal Year: 2005..The nasal membrane application procedure eliminates pain and other problems associated with needle injection, protein purification, and adjuvant modification, and so may reduce medical costs. ..
- Adenovirus vectored vaccines for Alzheimer's diseaseKen Ichiro Fukuchi; Fiscal Year: 2007..To date, no satisfactory treatments are available for AD. We propose to test the efficacy and safety of a RCA-free adenovirus vectored vaccine using animal models of AD in order to treat and prevent AD. ..
- AAV-mediated muscle-directed gene transfer for Alzheimer's diseaseKen Ichiro Fukuchi; Fiscal Year: 2007..The long-term goal is to establish the logical basis for developing safe and effective gene therapy modalities for AD utilizing rAAV and scFv. ..
- Therapeutic delivery of single chain antibody for Alzheimer's diseaseKen Ichiro Fukuchi; Fiscal Year: 2007..This study will serve as a proof of principle to demonstrate if our novel immune gene therapy modality for therapeutic antibody delivery is effective in treating an animal model of AD. Public Hea ..