Research Topics
Species | Robert D FrisinaSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Publications
Multivariate search for differentially expressed gene combinationsYuanhui Xiao
Department of Biostatistics and Computational Biology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
BMC Bioinformatics 5:164. 2004..Such tests are essentially univariate and disregard the multidimensional structure of microarray data. A more general two-sample hypothesis is formulated in terms of the joint distribution of any sub-vector of expression signals...- Age-related hearing loss: ear and brain mechanismsRobert D Frisina
Otolaryngology Department, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
Ann N Y Acad Sci 1170:708-17. 2009.... - Auditory efferent feedback system deficits precede age-related hearing loss: contralateral suppression of otoacoustic emissions in miceXiaoxia Zhu
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
J Comp Neurol 503:593-604. 2007..In conclusion, the C57 mouse has MOC function at 6 weeks, but it declines quickly, preceding the progression of peripheral age-related sensitivity deficits and hearing loss in this mouse strain... - Age-related hearing loss: aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrainNathan Christensen
Otolaryngology Department, University of Rochester Medical School, Rochester, NY 14642 8629, USA
Brain Res 1253:27-34. 2009..In regard to central auditory processing at the level of the auditory midbrain, aquaporin gene expression changes may affect neurotransmitter cycling involving supporting cells, thus impairing complex sound neural processing with age... - Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusisOlga N Vasilyeva
Otolaryngology Department, University of Rochester Medical School and Dentistry, 601 Elmwood Ave, Rochester, NY 14642 8629, USA
Hear Res 249:44-53. 2009..On the other hand, initial results of effects from very high blood glucose level (T1DM) on the auditory midbrain showed disruption of central inhibition, increased response synchrony or enhanced excitation in the inferior colliculus... - Novel approach to select genes from RMA normalized microarray data using functional hearing tests in aging miceMary D'Souza
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
J Neurosci Methods 171:279-87. 2008..Lastly, gene expression measures were correlated with pathway/network relationships relevant to the inner ear using Pathway Architect, to identify key pathways consistent with the gene expression changes observed... - Glutamate-related gene expression changes with age in the mouse auditory midbrainSherif F Tadros
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
Brain Res 1127:1-9. 2007..The up-regulation of Slc1a3 gene expression may reflect a cellular compensatory mechanism to protect against age-related glutamate or calcium excitoxicity... - Hormone replacement therapy diminishes hearing in peri-menopausal miceKatharine Price
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
Hear Res 252:29-36. 2009.... - Age-related decline in Kv3.1b expression in the mouse auditory brainstem correlates with functional deficits in the medial olivocochlear efferent systemMartha L Zettel
Department of Otolaryngology, University of Rochester, Rochester, NY 14642, USA
J Assoc Res Otolaryngol 8:280-93. 2007..Thus, Kv3.1b expression declines in MOC neurons by middle age, and these changes appear to correlate with functional declines in efferent activity in both middle-aged CBA mice and Kv3.1b knockout mice... - Murine intracochlear drug delivery: reducing concentration gradients within the cochleaDAVID A BORKHOLDER
Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
Hear Res 268:2-11. 2010..Both the C+C approach and a flow rate increase were found to provide enhanced response for lower frequencies, with evidence suggesting the C+C approach reduces concentration gradients within the cochlea... - Progestin negatively affects hearing in aged womenPatricia Guimaraes
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 103:14246-9. 2006.... - Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposureOksana Polesskaya
Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Hear Res 270:21-7. 2010..Rather, other MLK family members such as MLK1, which is also expressed in cochlea, may have a previously unappreciated role in noise- and aminoglycoside-induced ototoxicity... - F1 (CBA×C57) mice show superior hearing in old age relative to their parental strains: hybrid vigor or a new animal model for "Golden Ears"?Robert D Frisina
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA robert
Neurobiol Aging 32:1716-24. 2011..Therefore, F1s might be an optimal model for studying cases where the peripheral hearing is quite good in old age; thereby allowing isolation of central auditory changes due to brain neurodegeneration... - In-plane biocompatible microfluidic interconnects for implantable microsystemsDean G Johnson
Rochester Institute of Technology, Rochester, NY 14623, USA
IEEE Trans Biomed Eng 58:943-8. 2011..9 N. Each interconnect consumes less than 0.018 mm3 (18 nL) of volume. The low added volume makes this an ideal interconnect technology for medical applications where implant volume is critical... - Serotonin 2B receptor: upregulated with age and hearing loss in mouse auditory systemSherif F Tadros
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
Neurobiol Aging 28:1112-23. 2007..We conclude that serotonin 2B receptors may play a role in the pathogenesis of age-related hearing loss... - Estrogen blockade reduces auditory feedback in CBA miceScott K Thompson
Department of Otolaryngology Head and Neck Surgery, University of Rochester School of Medicine and Dentistry, 973 East Avenue, Rochester, NY 14607, USA
Otolaryngol Head Neck Surg 135:100-5. 2006..To examine the effects of estrogen suppression on age-related changes in distortion product otoacoustic emissions (DPOAEs) and contralateral suppression (CS) of DPOAEs in CBA mice... - Age-related alterations in the neural coding of envelope periodicitiesJoseph P Walton
Department of Surgery, Otolaryngology Division, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 8629, USA
J Neurophysiol 88:565-78. 2002..We postulate that this age-related difference in rate coding of SAM noise carriers is consistent with a loss, or imbalance, of excitatory and inhibitory neural mechanisms known to shape encoding of envelope periodicities in the IC... - Effects of age on contralateral suppression of distortion product otoacoustic emissions in human listeners with normal hearingSunghee Kim
Otolaryngology Division, Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Audiol Neurootol 7:348-57. 2002..These findings suggest that a functional decline of the MOC system with age precedes OHC degeneration. Moreover, the MOC system maintains better function in the 1- to 2-kHz range than in the 4- to 6-kHz range as a function of age... - The effects of early bilateral deafening on calretinin expression in the dorsal cochlear nucleus of aged CBA/CaJ miceMartha L Zettel
Department of Surgery, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642 8629, USA
Hear Res 183:57-66. 2003.... - Contralateral suppression of distortion-product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listenersMichael Jacobson
Division of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642-8629, USA
Laryngoscope 113:1707-13. 2003..Loss of medial olivocochlear suppressive function may play a role in the development of presbycusis in both clinical cases and animal models... - Sex differences in distortion product otoacoustic emissions as a function of age in CBA micePatricia Guimaraes
Department of Surgery, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Hear Res 192:83-9. 2004..Understanding sex differences in age-related sensory disorders will be quite helpful for the goals of preventing, slowing or curing sensory problems in old age for both women and men... - Age reduces response latency of mouse inferior colliculus neurons to AM soundsHenry Simon
International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester, New York 14623, USA
J Acoust Soc Am 116:469-77. 2004..These latency changes will result in age-related timing variations in brainstem responses to stimulus onsets, and therefore affect the encoding of complex sounds... - Loss of peripheral right-ear advantage in age-related hearing lossSherif F Tadros
International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Audiol Neurootol 10:44-52. 2005..On the contrary, HINT results showed a continuous dominance of the right ear (left hemisphere) in both groups, which was consistent with previous reports showing that the right hemisphere is more affected by age than the left hemisphere... - Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusisSherif F Tadros
International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, NY 14623, USA
Hear Res 209:10-8. 2005..We conclude that aldosterone hormone may have a protective effect on hearing in old age. This effect is more peripheral than central, appearing to affect inner hair cells more than outer hair cells... - Age-related declines in distortion product otoacoustic emissions utilizing pure tone contralateral stimulation in CBA/CaJ miceGeorge I Varghese
Department of Otolaryngology, University of Rochester School of Medicine and Dentistry, NY 14642-8629, USA
Hear Res 209:60-7. 2005..These findings reinforce the idea that age-related changes in the MOC or the operating points of OHCs play a role in the progression of presbycusis - age-related hearing loss in mammals... - Characterization of hearing loss in aged type II diabeticsSusan T Frisina
International Center for Hearing and Speech Research, National Technical Institute for the Deaf, Rochester Institute of Technology, Rochester, NY, USA
Hear Res 211:103-13. 2006..Consequences of elevated blood sugar levels as possible underlying physiological mechanisms for the hearing loss are discussed... - Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noiseRobert D Frisina
J Acoust Soc Am 121:EL29-34. 2007..The C57s showed normal hearing, measured with DPOAE amplitudes and auditory brainstem response thresholds, but showed little CS, suggesting a loss of efferent dynamics preceding any deficiencies of the afferent auditory system... - Age-related structural and functional changes in the cochlear nucleusRobert D Frisina
Otolaryngology Department, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
Hear Res 216:216-23. 2006..To the extent that this sensory deficit resides in the central auditory system, including the cochlear nucleus, future neural therapies will be able to improve hearing in the elderly... - Micro-molded cannulae for intracochlear infusions in small rodentsDean G Johnson
Rochester Institute of Technology, Rochester, NY, 14623 USA
Conf Proc IEEE Eng Med Biol Soc 2007:6617-20. 2007..Histological evaluation revealed the cannula to be located correctly within the basal portion of scala tympani... - Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochleaWilliam J Bowers
Center for Aging and Developmental Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642-8629, USA
Mol Ther 6:12-8. 2002..The potency of NT-3 in SGN neuroprotection suggests that in vivo neurotrophin-based gene therapy is a promising preventative treatment for chemical-induced hearing disorders, and potentially for hearing degeneration due to normal aging...
Research Grants
- Core--CoordinationRobert Frisina; Fiscal Year: 2007..abstract_text> ..