Kevin K Frick

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expression
    K K Frick
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol 277:F750-5. 1999
  2. ncbi Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1
    Kevin K Frick
    Division of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 24:305-13. 2009
  3. ncbi RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro
    Kevin K Frick
    Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Renal Physiol 289:F1005-11. 2005
  4. ncbi Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblasts
    Kevin K Frick
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Am J Physiol Renal Physiol 299:F418-25. 2010
  5. ncbi Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism
    Kevin K Frick
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 18:1317-25. 2003
  6. ncbi Molecular mechanisms of primary hypercalciuria
    Kevin K Frick
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Am Soc Nephrol 14:1082-95. 2003
  7. ncbi Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro
    Nancy S Krieger
    Department of Medicine, Division of Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 22:907-17. 2007
  8. ncbi Mechanism of acid-induced bone resorption
    Nancy S Krieger
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Curr Opin Nephrol Hypertens 13:423-36. 2004
  9. ncbi Cortisol inhibits acid-induced bone resorption in vitro
    Nancy S Krieger
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Am Soc Nephrol 13:2534-9. 2002
  10. ncbi Cellular mechanisms of bone resorption induced by metabolic acidosis
    Nancy S Krieger
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Semin Dial 16:463-6. 2003

Detail Information

Publications12

  1. ncbi In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expression
    K K Frick
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol 277:F750-5. 1999
    ..Thus, although several aspects of bone cell function are dependent on the type of acidosis, expression of these two matrix genes appears to be regulated by extracellular pH, independently of the type of acidosis...
  2. ncbi Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1
    Kevin K Frick
    Division of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 24:305-13. 2009
    ..Perfusion with MET induced a rapid increase in Ca(i) in OGR1-transfected CHO cells. These data indicate that OGR1 induces an increase in Ca(i) in response to MET and is a prime candidate for an osteoblast proton sensor...
  3. ncbi RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro
    Kevin K Frick
    Nephrology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Renal Physiol 289:F1005-11. 2005
    ....
  4. ncbi Effect of metabolic and respiratory acidosis on intracellular calcium in osteoblasts
    Kevin K Frick
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Am J Physiol Renal Physiol 299:F418-25. 2010
    ....
  5. ncbi Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism
    Kevin K Frick
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 18:1317-25. 2003
    ..Acidosis resulted in a significant cyclo-oxygenase-dependent increase in RANKL RNA levels, which would be expected to induce the associated increase in bone resorption...
  6. ncbi Molecular mechanisms of primary hypercalciuria
    Kevin K Frick
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Am Soc Nephrol 14:1082-95. 2003
  7. ncbi Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro
    Nancy S Krieger
    Department of Medicine, Division of Nephrology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Bone Miner Res 22:907-17. 2007
    ..We report here that acidosis increases both osteoblastic RNA and protein levels for COX-2 and that genetic deficiency or pharmacologic inhibition of COX-2 significantly reduces acid-induced Ca efflux from bone...
  8. ncbi Mechanism of acid-induced bone resorption
    Nancy S Krieger
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    Curr Opin Nephrol Hypertens 13:423-36. 2004
    ..The apparent protective function of bone to help maintain systemic pH, which has a clear survival advantage for mammals, will come partly at the expense of its mineral stores...
  9. ncbi Cortisol inhibits acid-induced bone resorption in vitro
    Nancy S Krieger
    Department of Medicine, Nephrology Unit, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Am Soc Nephrol 13:2534-9. 2002
    ..These results suggest that the osteopenia observed in response to metabolic acidosis in vivo is not due to an increase in endogenous cortisol production...
  10. ncbi Cellular mechanisms of bone resorption induced by metabolic acidosis
    Nancy S Krieger
    Nephrology Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Semin Dial 16:463-6. 2003
    ..Both responses were inhibited in the presence of indomethacin. Thus metabolic, but not respiratory, acidosis induces production of bone PGE2, which mediates acid-induced bone resorption...
  11. ncbi The effects of acid on bone
    D A Bushinsky
    Department of Medicine, University of Rochester School of Medicine, New York, USA
    Curr Opin Nephrol Hypertens 9:369-79. 2000
    ..Osteoblastic immediate early response genes are inhibited as are genes controlling matrix formation...
  12. ncbi Genetic hypercalciuric stone-forming rats
    David A Bushinsky
    Division of Nephrology, Department of Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Curr Opin Nephrol Hypertens 15:403-18. 2006
    ..We will describe the pathophysiology of hypercalciuria and the mechanism of the resultant stone formation in a rat model and draw parallels to human hypercalciuria and stone formation...