Research Topics
Species | Christopher J FredericksonSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Depletion of intracellular zinc from neurons by use of an extracellular chelator in vivo and in vitroChristopher J Frederickson
NeuroBioTex, Inc, Galveston, Texas 77550, USA
J Histochem Cytochem 50:1659-62. 2002..Caution is therefore warranted in attempting to manipulate extracellular or intracellular Zn(2+) selectively...- The neurobiology of zinc in health and diseaseChristopher J Frederickson
NeuroBio Tex, Inc, 101 Christopher Columbus Blvd, Galveston, Texas 77550, USA
Nat Rev Neurosci 6:449-62. 2005..However, the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'... - Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentrationChristopher J Frederickson
NeuroBioTex Inc, Galveston, TX 77550, USA
J Neurosci Methods 154:19-29. 2006..We show that common errors can cause up to a 3000-fold underestimation of the concentration of released zinc. The results should help bring consistency to the study of synaptic release of zinc... - Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensorChristopher J Frederickson
NeuroBioTex, Inc, 101 Christopher Columbus Blvd, Galveston, TX 77550, USA
J Neurosci Methods 139:79-89. 2004..Thus, the presence of rapidly-exchangeable, "stainable" perikaryal zinc may be taken as an indicator of cell injury... - Zinc and excitotoxic brain injury: a new modelChristopher J Frederickson
NeuroBioTex, Inc, Galveston, Texas 77550, USA
Neuroscientist 10:18-25. 2004..The authors present a new model of zinc currents and zinc toxicity that offers expanded opportunities for zinc-selective therapeutic chelation interventions... - Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesiclesDavid H Linkous
NeuroBioTex, Inc, 101 Christopher Columbus Blvd, Galveston, TX 77550, USA
J Histochem Cytochem 56:3-6. 2008..Thus, the ZNT3 protein evidently controls not only the "stainability" but also the actual mass of zinc in mossy-fiber synaptic vesicles. This work thus confirms the metal-transporting role of the ZNT3 protein in the brain... - Zinc-secreting Paneth cells studied by ZP fluorescenceLeonard J Giblin
NeuroBioTex, Inc, Galveston, TX 77550, USA
J Histochem Cytochem 54:311-6. 2006..These findings suggest that zinc is coreleased with other Paneth cell anti-microbials, and that the intact intestine is necessary for secretion into the crypt lumen... - Meeting report: zinc signals 2007--expanding roles of the free zinc ion in biologyCathleen Frederickson
NeuroBioTex, Galveston, TX 77550, USA
Sci STKE 2007:pe61. 2007.... - Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brainHelen L Hellmich
Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0830, USA
Neurosci Lett 355:221-5. 2004..Zinc chelation induced the expression of several neuroprotective genes; neuroprotective gene expression correlated with substantially decreased numbers of TUNEL-positive cells... - Fluorophilia: fluorophore-containing compounds adhere non-specifically to injured neuronsBridget E Hawkins
Charles R Allen Research Laboratories, Department of Anesthesiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1102, USA
Brain Res 1432:28-35. 2012..Further experiments may be advised to clarify whether Zn(2+)-binding dyes bind more specifically in intact neurons in culture or organotypic slices... - Neurotoxic zinc translocation into hippocampal neurons is inhibited by hypothermia and is aggravated by hyperthermia after traumatic brain injury in ratsSang Won Suh
Department of Neurology, University of California, San Francisco, California 94121, USA
J Cereb Blood Flow Metab 26:161-9. 2006..We conclude that pathological Zn2+ translocation in brain after TBI is temperature-dependent and that hypothermic neuronal protection might be mediated in part by reduced Zn2+ translocation... - ZP4, an improved neuronal Zn2+ sensor of the Zinpyr familyShawn C Burdette
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Am Chem Soc 125:1778-87. 2003.... - Is zinc the link between compromises of brain perfusion (excitotoxicity) and Alzheimer's disease?Christopher J Frederickson
NeuroBioTex, Inc. and The University of Texas Medical School, Galveston TX 77550, USA
J Alzheimers Dis 8:155-60; discussion 209-15. 2005..Rapid and aggressive administration of zinc buffering compounds to patients suffering brain injury may therefore not only ameliorate the acute injury but might also reduce the risk of subsequent development of Alzheimer's disease... - Clioquinol effects on tissue chelatable zinc in miceYuval B Nitzan
Department of Morphology, Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
J Mol Med 81:637-44. 2003..Thus, our findings indicate that CQ has considerable potential as a versatile scientific and clinical tool used for selective modulation of zinc pools... - High concentration of zinc in sub-retinal pigment epithelial depositsImre Lengyel
Division of Pathology, Institute of Ophthalmology, 11 43 Bath Street, University College London, and Department of Research and Development, Moorfields Eye Hospital, London EC1V 9EL, UK
Exp Eye Res 84:772-80. 2007..Based on the evidence provided here we suggest that zinc plays a role in sub-RPE deposit formation in the aging human eye and possibly also in the development and/or progression of AMD... - Amyloid-beta metal interaction and metal chelationMath P Cuajungco
Harvard Medical School, Boston, MA 02114, USA
Subcell Biochem 38:235-54. 2005..Here we discuss the interaction of Abeta with metals, metal dyshomeostasis in the CNS of patients with AD, and the potential therapeutic effects of metal chelators... - Membrane-permeable and -impermeable sensors of the Zinpyr family and their application to imaging of hippocampal zinc in vivoCarolyn C Woodroofe
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Chem Biol 11:1659-66. 2004..Intracranial microinfusion of ZP1(6-CO2Et) into rat hippocampus produces reduced staining of vesicular zinc in neuropil and very clear delineation of zinc-positive injured neuronal somata and dendrites as compared with ZP1...
Research Grants
- Does Nitric Oxide Control Synaptic Zinc Release?Christopher Frederickson; Fiscal Year: 2003..The objective of the present proposal is to establish with certainty whether, in fact, NO controls Zn2+ release during excitotoxicity. ..
- ZINC-BASED DIAGNOSTIC FOR PROSTATE CANCERChristopher Frederickson; Fiscal Year: 2002..If a zinc-based test were used along with PSA testing, the sales of the tests could be vast, and the contribution to men's health and wellness, equally vast. ..
- HIGH-SPEED MICROFLUIDIC SORTING OF BIOHAZARDOUS CELLS.Christopher Frederickson; Fiscal Year: 2004..abstract_text> ..
- Tools For Measuring Free Zinc (pZn) In The BrainChristopher Frederickson; Fiscal Year: 2006....
- FLOURESCENT TOOLS FOR THE STUDY OF METALLOTHIONEINChristopher Frederickson; Fiscal Year: 2006..healthy cell growth. Our tools will facilitate research in all of those areas and contribute to the advancement and development of diagnostic and therapeutic medical science. ..