Deborah Fowell

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Signals for the execution of Th2 effector function
    Deborah J Fowell
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Box 609, Rochester, NY 14642, USA
    Cytokine 46:1-6. 2009
  2. ncbi Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses
    Xinyan Zhao
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Immunol 179:8297-304. 2007
  3. ncbi Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site
    Shoshana D Katzman
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    J Clin Invest 118:801-11. 2008
  4. ncbi T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    James J Kobie
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 177:6780-6. 2006
  5. ncbi CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation
    Dorothy K Sojka
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Eur J Immunol 39:1544-51. 2009
  6. ncbi Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
    Vanessa Morales-Tirado
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, NY, USA
    Blood 115:3498-507. 2010
  7. ncbi Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells
    Vanessa Morales-Tirado
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 173:726-30. 2004
  8. ncbi Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function
    Byron B Au-Yeung
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, NY 14642, USA
    J Immunol 176:3895-9. 2006
  9. ncbi Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes
    Angela Hughson
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    Diabetes 60:2125-33. 2011
  10. ncbi Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target
    Dorothy K Sojka
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14624, USA
    Immunology 124:13-22. 2008

Research Grants

  1. Target T Cell Modulation by CD4+CD25+ Regulatory T Cells
    Deborah J Fowell; Fiscal Year: 2010
  2. Target T Cell Modulation by CD4+CD25+ Regulatory T Cells
    Deborah Fowell; Fiscal Year: 2007
  3. The Role of Itk in Th Differentiation
    Deborah Fowell; Fiscal Year: 2005
  4. Visualization of Th2 development in vivo
    Deborah Fowell; Fiscal Year: 2003
  5. Remodeling of lymph node-derived cytokine responses at the infected tissue site
    Deborah J Fowell; Fiscal Year: 2010

Collaborators

  • Chawnshang Chang
  • FRED DOUGLASS FINKELMAN
  • Li Yang
  • Dorothy K Sojka
  • Shoshana D Katzman
  • Vanessa Morales-Tirado
  • Byron B Au-Yeung
  • Angela Hughson
  • Xinyan Zhao
  • James J Kobie
  • Teresa L Sukiennicki
  • Sally Quataert
  • Irina Bromberg
  • Barbara Johnson
  • Nicholas Jospe
  • Joseph F Urban
  • Christopher A Lazarski
  • Yu Hui Huang
  • Yu-Hui Huang
  • Shoshana Katzman
  • Yanfang Huang
  • Wei ping Zeng
  • Bo Zheng
  • Wei-Ping Zeng
  • Dan Yang
  • Pranav R Shah
  • Tim R Mosmann
  • Jonathan A Rebhahn
  • Jinyi Zhang
  • Katherine A Siminovitch
  • Alan Howell
  • Sara Johannson
  • Elaine Hanson

Detail Information

Publications12

  1. ncbi Signals for the execution of Th2 effector function
    Deborah J Fowell
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Box 609, Rochester, NY 14642, USA
    Cytokine 46:1-6. 2009
    ..We also discuss how provision of these execution signals may be spatially segregated in vivo occurring at tissue sites of inflammation and subject to modulation by the pathogen itself...
  2. ncbi Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses
    Xinyan Zhao
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute for Biomedical Sciences, Department of Microbiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    J Immunol 179:8297-304. 2007
    ..In contrast, IL-5 promoter was modestly enhanced by Pias1 and no effect was observed on IL-4 promoter. Thus, both promoter activation and additional mechanisms are responsible for regulation by Pias1...
  3. ncbi Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site
    Shoshana D Katzman
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    J Clin Invest 118:801-11. 2008
    ..Thus, pathogens may edit the LN cytokine repertoire through differential recruitment of cytokine-producing cells...
  4. ncbi T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
    James J Kobie
    David H Smith Center for Vaccine Biology and Immunology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 177:6780-6. 2006
    ..Infiltration of either Treg or Thpp cells at inflammatory sites could potentially convert 5'-AMP generated by neutrophils or dying cells into the anti-inflammatory mediator adenosine, thus dampening excessive immune reactions...
  5. ncbi CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation
    Dorothy K Sojka
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Eur J Immunol 39:1544-51. 2009
    ..Thus, while Treg developing in the absence of CTLA-4 appear to acquire some compensatory suppressive mechanisms in vitro, we identify a non-redundant role for CTLA-4 in Treg function in vivo...
  6. ncbi Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function
    Vanessa Morales-Tirado
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, NY, USA
    Blood 115:3498-507. 2010
    ..Moreover, dominant-negative WASp expression in WT effector T cells blocked IL-4 production, but had no effect on IFNgamma. Thus WASp plays a selective, posttranscriptional role in Th2 effector function...
  7. ncbi Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells
    Vanessa Morales-Tirado
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 173:726-30. 2004
    ..We propose that the use of different secretory pathways for cytokines and chemokines enables CD4(+) T cell activity to be further fine-tuned to serve specialized effector functions...
  8. ncbi Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function
    Byron B Au-Yeung
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, NY 14642, USA
    J Immunol 176:3895-9. 2006
    ..We suggest that the liberation of effector function is tightly controlled through qualitative changes in TCR signals, facilitating postdifferentiation regulation of cytokine responses...
  9. ncbi Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes
    Angela Hughson
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    Diabetes 60:2125-33. 2011
    ..In humans, the CD4+CD25+Foxp3+ T-cell compartment contains both effector and regulatory T cells, and it is not known how their relative proportions vary in disease states...
  10. ncbi Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target
    Dorothy K Sojka
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14624, USA
    Immunology 124:13-22. 2008
    ..Understanding when and where each suppressive tool is most effective will help to fine tune therapeutic strategies to promote or constrain specific arms of Treg suppression...
  11. ncbi A key role for Itk in both IFN gamma and IL-4 production by NKT cells
    Byron B Au-Yeung
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 179:111-9. 2007
    ..The severe defect in NKT cell function may underlie a number of the Th1 and Th2 immune defects in Itk-deficient mice...
  12. ncbi Distinct molecular program imposed on CD4+ T cell targets by CD4+CD25+ regulatory T cells
    Teresa L Sukiennicki
    Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, University of Rochester, Rochester, NY 14642, USA
    J Immunol 177:6952-61. 2006
    ..We suggest that Tregs function by the induction of a distinct set of negative regulatory factors that initiate or maintain target T cells in a nonproliferative state...

Research Grants14

  1. Target T Cell Modulation by CD4+CD25+ Regulatory T Cells
    Deborah J Fowell; Fiscal Year: 2010
    ....
  2. Target T Cell Modulation by CD4+CD25+ Regulatory T Cells
    Deborah Fowell; Fiscal Year: 2007
    ....
  3. The Role of Itk in Th Differentiation
    Deborah Fowell; Fiscal Year: 2005
    ..Our central hypothesis is that Itk conveys information on the quality of TCR/MHC interaction from the cell surface to the nucleus to modulate Th differentiation and survival ..
  4. Visualization of Th2 development in vivo
    Deborah Fowell; Fiscal Year: 2003
    ..We wish to further develop the imaging methods to track the developing immune response on infectious challenge. ..
  5. Remodeling of lymph node-derived cytokine responses at the infected tissue site
    Deborah J Fowell; Fiscal Year: 2010
    ..Developing ways of harnessing a diverse lymph node repertoire to retune immune responses at the infection site, by manipulating the type of effectors recruited to the site, has great therapeutic potential for many disease states. ..