Seth Field

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis
    Seth J Field
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 15:1407-12. 2005
  2. ncbi The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
    Ji Luo
    Department of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 170:455-64. 2005
  3. ncbi The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
    Or Gozani
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 114:99-111. 2003
  4. ncbi Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms
    Or Gozani
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Adv Enzyme Regul 45:171-85. 2005
  5. ncbi A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
    Prasenjit Mitra
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Rm 819, Worcester, MA 01605, USA
    J Cell Biol 166:205-11. 2004
  6. ncbi Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
    Xiaoyong Yang
    Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 451:964-9. 2008

Research Grants

  1. PI-3-Kinase Signaling over Physiologic Time-Scales/Response to Insulin or IGF-1
    Seth Field; Fiscal Year: 2007
  2. PI-3-kinase mediated signaling by insulin and IGF-1
    Seth Field; Fiscal Year: 2007
  3. Targeting a Novel Phosphoinositide Signaling Pathway for Cancer Therapy
    Seth J Field; Fiscal Year: 2010

Collaborators

Detail Information

Publications6

  1. ncbi PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis
    Seth J Field
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 15:1407-12. 2005
    ..We conclude that PtdIns(4,5)P2 is present at the cleavage furrow and is required for normal cytokinesis at least in part because of a role in adhesion between the contractile ring and the plasma membrane...
  2. ncbi The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
    Ji Luo
    Department of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 170:455-64. 2005
    ..These results suggest a mechanism of signal down-regulation of IRS-1 that is mediated by monomeric p85 through the formation of a sequestration complex between p85 and IRS-1...
  3. ncbi The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
    Or Gozani
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 114:99-111. 2003
    ..Together, our data identify the PHD finger as a phosphoinositide binding module and a nuclear PtdInsP receptor, and suggest that PHD-phosphoinositide interactions directly regulate nuclear responses to DNA damage...
  4. ncbi Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms
    Or Gozani
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Adv Enzyme Regul 45:171-85. 2005
    ..Finally, our work supports a model that endogenous PtdInsPs regulate sub-nuclear localization and function of endogenous nuclear PtdInsP-binding proteins...
  5. ncbi A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
    Prasenjit Mitra
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Rm 819, Worcester, MA 01605, USA
    J Cell Biol 166:205-11. 2004
    ..These studies suggest that a pathway for PI(3,4,5)P3 synthesis downstream of a class III phosphoinositide 3-kinase evolved before the appearance of class I phosphoinositide 3-kinases...
  6. ncbi Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
    Xiaoyong Yang
    Howard Hughes Medical Institute and Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 451:964-9. 2008
    ..These findings identify a molecular mechanism by which nutritional cues regulate insulin signalling through O-GlcNAc, and underscore the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes...

Research Grants4

  1. PI-3-Kinase Signaling over Physiologic Time-Scales/Response to Insulin or IGF-1
    Seth Field; Fiscal Year: 2007
    ..We expect that improved understanding of the insulin signaling pathway will eventually lead to improved treatment strategies for insulin resistance and type II diabetes mellitus. ..
  2. PI-3-kinase mediated signaling by insulin and IGF-1
    Seth Field; Fiscal Year: 2007
    ..Field. Under the mentorship of Dr. Lewis Cantley and Dr. Anne Klibanski this career development award is expected to foster Dr. Field's development into a successful independent clinician-scientist. ..
  3. Targeting a Novel Phosphoinositide Signaling Pathway for Cancer Therapy
    Seth J Field; Fiscal Year: 2010
    ..abstract_text> ..