Research Topics
Species | Bruce M FentonSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Alterations in daily sequencing of axitinib and fractionated radiotherapy do not affect tumor growth inhibition or pathophysiological responseBruce M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
Radiat Res 171:606-14. 2009..Instead, post- and preirradiation daily drug administration serve equally well in supplementing the response to radiotherapy...- The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculatureBruce M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
Cancer Res 67:9921-8. 2007..Despite the progressive decrease in tumor oxygenation over 3 weeks of treatment, combination therapy remained effective and tumor progression was minimal... - Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosisB M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, NY 14642, USA
Br J Cancer 86:1831-6. 2002.... - Pathophysiological effects of vascular endothelial growth factor receptor-2-blocking antibody plus fractionated radiotherapy on murine mammary tumorsBruce M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
Cancer Res 64:5712-9. 2004.... - Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomasBruce M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Radiat Oncol Biol Phys 57:1038-46. 2003..To better understand the underlying pathophysiologic basis for this radiosensitization, the current study investigated whether short-term endostatin administration is linked to alterations in tumor vascular perfusion and oxygen delivery... - Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumoursB M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Box 704, Rochester, NY 14642, USA
Br J Cancer 90:430-5. 2004..If antiangiogenic agents are also combined with conventional therapies such as irradiation or chemotherapy, microregional deficiencies in oxygenation could play a key role in ultimate therapeutic success... - Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiationLurong Zhang
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642 8647, USA
Int J Radiat Oncol Biol Phys 77:261-8. 2010..Currently, no satisfactory agent exists for mitigation of AGS. A peptide derived from the receptor binding domain of fibroblast growth factor 2 (FGF-P) was synthesized and its mitigation effect on AGS was examined... - Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumorsBruce M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
Radiother Oncol 72:221-30. 2004.... - Enhanced antitumor effect of combined triptolide and ionizing radiationWei Wang
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642 8647, USA
Clin Cancer Res 13:4891-9. 2007..This study explores the enhancement of the therapeutic effect on human pancreatic cancer via the combination of triptolide and ionizing radiation (IR)... - FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing miceIvan Ding
Department of Radiation Oncology, University of Rochester, Box 647, Rochester, NY 14642, USA
Adv Exp Med Biol 530:603-9. 2003..In summary, alteration of tumor oxygenation by local administration of angiogenic growth factors may be mediated by cytokine/chemokine production in the tumor... - Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancerStephanie L Nott
Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York, United States of America
Mol Med 16:10-8. 2010..Moreover, the ERE-binding monotransregulator repressed xenograft tumor growth in a nude mice model. Thus, specific regulation of genes bearing EREs could offer a therapeutic approach for de novo endocrine-resistant breast cancers... - Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular densityPaul Okunieff
Department of Radiation Oncology, University of Rochester, Rochester, NY, USA
Adv Exp Med Biol 530:593-601. 2003..We found that angiogenic factors preserve and augment neovascular function, thus facilitating tumor growth and progression... - Evaluation of microregional variations in tumor hypoxia following the administration of endostatinBruce M Fenton
Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, NY 14642, USA
Adv Exp Med Biol 510:19-24. 2003 - Characterization of the effects of antiangiogenic agents on tumor pathophysiologyB M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York 14642, USA
Am J Clin Oncol 24:453-7. 2001..Successful use of these drugs to enhance radiation response will likely require optimization of drug choice, dose schedule, and direct physiologic monitoring... - Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survivalB M Fenton
Department of Radiation Oncology, University of Rochester School of Medicine, New York, USA
Radiat Res 155:360-8. 2001.... - The effects of carbogen and nicotinamide on intravascular oxyhaemoglobin saturations in SCCVII and KHT murine tumoursB M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, New York 14642, USA
Br J Cancer 71:945-9. 1995..One possible explanation for these findings is that different subpopulations of clonogenic vs non-clonogenic cells may be oxygenated by alternative treatments... - Oxygenation and vascular perfusion in spontaneous and transplanted tumor modelsBruce M Fenton
Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, NY 14642, USA
Adv Exp Med Biol 530:165-76. 2003..These results indicate that spontaneous tumor vascular configuration and function tend to be preserved in 1st generation trochar transplanted tumors... - Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurementsB M Fenton
Department of Radiation Oncology, University of Rochester School of Medicine, NY, USA
Br J Cancer 79:464-71. 1999..This permits vascular configuration to be related to oxygen availability and allows the hypoxic marker intensities to be quantitated in situ... - Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor modelsB M Fenton
Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, NY 14642, USA
Int J Radiat Oncol Biol Phys 49:799-808. 2001..To examine the effects of hydralazine on vascular perfusion and hypoxia in spontaneous vs. first generation and long-term transplanted murine tumor models... - Characterization of the dose perturbation by stents as a function of X-ray beam energyM C Schell
Department of Radiation Oncology, University of Rochester, New York 14642, USA
Cardiovasc Radiat Med 1:154-9. 1999..The present study investigated the effect of beam energy on the dose distribution in the wall of the artery in the presence of stents... - Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor modelsB M Fenton
Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, NY, USA
Int J Cancer 93:693-8. 2001.... - Protective effect of esculentoside A on radiation-induced dermatitis and fibrosisZhenyu Xiao
Department of Radiation Oncology, James P. Wilmot Cancer Center at the University of Rochester Medical Center, Rochester, NY, USA
Int J Radiat Oncol Biol Phys 65:882-9. 2006.... - B1 sequence-based real-time quantitative PCR: a sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiationHengshan Zhang
Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8647, USA
Int J Radiat Oncol Biol Phys 74:1592-9. 2009..We have identified a new technique with the advantage of directly measuring circulating DNA by amplifying inter-B1 regions in the mouse genome, providing a sensitive method for quantitating plasma DNA... - Are direct measures of tumor oxygenation reflective of changes in tumor radiosensitivity following oxygen manipulation?B M Fenton
Department of Radiation Oncology, University of Rochester Medical Center, New York 14642, USA
Acta Oncol 34:307-11. 1995..Thus direct determinations of alterations in tumor oxygenation may not reflect corresponding changes in radiosensitivity... - In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 modelBrian A Winey
Department of Physics and Astronomy, University of Rochester, Rochester, New York, USA
Med Phys 33:1623-33. 2006..Finally, we propose a novel diagnostic algorithm that quantitatively differentiates tumor from nontumor with maximum specificity 0.83, maximum sensitivity 0.79, and area under receiver-operating-characteristics curve 0.90... - Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mountsS A Gerber
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Br J Cancer 88:1453-61. 2003..The combination of the whole mount technique and the GFP transgenic mice provides a powerful method for visualising tumour vasculature and characterising the effects of agents such as cytokines... - Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivoPing Guo
University of Pittsburgh Cancer Institute and Department of Pathology, Research Pavilion at Hillman Cancer Center, Suite 2.26, 5117 Centre Avenue, Pittsburgh, PA 15213-1863, USA
Cancer Res 63:4684-91. 2003..Our data suggest that VEGF stimulation of MCF-7 tumor angiogenesis and growth is mediated by both autocrine and paracrine mechanisms... - Varied response of spontaneous tumors to antiangiogenic agentsBruce M Fenton
Adv Exp Med Biol 566:59-65. 2005..A key focus of future studies will be to investigate the underlying rationale for the widely varying antiangiogenic response among tumors that outwardly appear so similar...
Research Grants
- TUMOR OXYGENATION, VASCULARIZATION, AND RADIORESPONSEBruce Fenton; Fiscal Year: 2007..These results with lead to the more rational and optimal design of effective combined therapies, thereby ultimately accelerating their implementation into clinical protocols. ..
- TUMOR OXYGENATION, VASCULARIZATION, AND RADIORESPONSEBruce Fenton; Fiscal Year: 2003..In summary, our primary goals are to determine the fundamental relationships between molecular and pathophysiological changes in disparate tumor models and whether observed differences can be therapeutically exploited. ..
- TUMOR OXYGENATION AND RADIATION RESPONSEBruce Fenton; Fiscal Year: 1993....
- TUMOR OXYGENATION, HYPOXIA, AND RADIATION RESPONSEBruce Fenton; Fiscal Year: 1999..A final goal will be to combine oxygen manipulative agents with fractionated radiotherapy, in order to better understand the combined physiological effects and to provide a basis for selecting optimal time points. ..
- TUMOR OXYGENATION, VASCULARIZATION, AND RADIORESPONSEBruce Fenton; Fiscal Year: 2009..These results with lead to the more rational and optimal design of effective combined therapies, thereby ultimately accelerating their implementation into clinical protocols. ..