Gabriel Fenteany

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration
    Anwar B Beshir
    Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
    Bioorg Med Chem Lett 18:498-504. 2008
  2. ncbi Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement
    Rizwan Farooqui
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607, USA
    J Cell Sci 118:51-63. 2005
  3. ncbi Small-molecule inhibitors of actin dynamics and cell motility
    Gabriel Fenteany
    Department of Chemistry, University of Illinois at Chicago, 845 W Taylor St, Chicago, IL 60607, USA
    Curr Top Med Chem 3:593-616. 2003
  4. ncbi Cytoskeletal remodeling in leukocyte function
    Gabriel Fenteany
    Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607 7061, USA
    Curr Opin Hematol 11:15-24. 2004
  5. ncbi Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion
    Kevin T Mc Henry
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    J Cell Biochem 103:972-85. 2008
  6. ncbi G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells
    Alem W Kahsai
    Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
    Biochim Biophys Acta 1803:300-10. 2010
  7. ncbi Raf kinase inhibitor protein suppresses nuclear factor-?B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression
    Anwar B Beshir
    Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
    Cancer Lett 299:137-49. 2010
  8. ncbi Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site
    Alem W Kahsai
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    J Biol Chem 283:24534-45. 2008
  9. ncbi Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44
    Alem W Kahsai
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    Chem Biol 13:973-83. 2006
  10. ncbi Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration
    Rizwan Farooqui
    Department of Chemistry, University of Illinois, Chicago, IL 60607, USA
    Exp Cell Res 312:1514-25. 2006

Collaborators

  • Roberto Montesano
  • Michael Glogauer
  • John Hartwig
  • T P Stossel
  • Alem W Kahsai
  • Shoutian Zhu
  • Anwar B Beshir
  • Kevin T Mc Henry
  • Rizwan Farooqui
  • Anniefer N Magpusao
  • Kam C Yeung
  • William S Lane
  • Z Melis Altan
  • Richard T Desmond
  • Lauren M Barone
  • Gang Ren
  • Mark W Peczuh
  • Katelyn J Billings
  • H Umit Kaniskan
  • Hui-Hui Tang
  • Hui hui Tang
  • Sankar K Guchhait
  • PHILIP P GARNER
  • Jose A Gascon
  • Junru Cui
  • Duncan J Wardrop
  • Sudha V Ankala
  • Arun K Ghosh

Detail Information

Publications15

  1. ncbi Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration
    Anwar B Beshir
    Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
    Bioorg Med Chem Lett 18:498-504. 2008
    ..Collectively, these results suggest that a two-ligand structure with bulky nonpolar S-substituents in a transoid conformation is important for the antimigratory activity of these metal-ligand complexes...
  2. ncbi Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement
    Rizwan Farooqui
    Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607, USA
    J Cell Sci 118:51-63. 2005
    ..Instead, it apparently serves to replace damaged cells so that intact spread cells can revert to their normal cuboidal morphology and the original cell density of the unbroken sheet can be restored...
  3. ncbi Small-molecule inhibitors of actin dynamics and cell motility
    Gabriel Fenteany
    Department of Chemistry, University of Illinois at Chicago, 845 W Taylor St, Chicago, IL 60607, USA
    Curr Top Med Chem 3:593-616. 2003
    ....
  4. ncbi Cytoskeletal remodeling in leukocyte function
    Gabriel Fenteany
    Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607 7061, USA
    Curr Opin Hematol 11:15-24. 2004
    ..This review focuses on recent developments in understanding the roles and regulation of the cytoskeleton in the function of leukocytes...
  5. ncbi Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion
    Kevin T Mc Henry
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    J Cell Biochem 103:972-85. 2008
    ....
  6. ncbi G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells
    Alem W Kahsai
    Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
    Biochim Biophys Acta 1803:300-10. 2010
    ....
  7. ncbi Raf kinase inhibitor protein suppresses nuclear factor-?B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression
    Anwar B Beshir
    Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
    Cancer Lett 299:137-49. 2010
    ..A regulatory loop involving an opposing relationship between RKIP and the NF-?B pathway may control the level of MMP expression and cell invasion...
  8. ncbi Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site
    Alem W Kahsai
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    J Biol Chem 283:24534-45. 2008
    ..In aggregate, the data suggest that DX-52-1 and HUK-921 inhibit a carbohydrate binding-independent function of galectin-3 that is involved in cell migration...
  9. ncbi Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44
    Alem W Kahsai
    Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA
    Chem Biol 13:973-83. 2006
    ..Small interfering RNA-mediated silencing of radixin expression reduces the rate of cell migration. Finally, we found that DX-52-1 disrupts radixin's ability to interact with both actin and the cell adhesion molecule CD44...
  10. ncbi Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration
    Rizwan Farooqui
    Department of Chemistry, University of Illinois, Chicago, IL 60607, USA
    Exp Cell Res 312:1514-25. 2006
    ....
  11. ncbi A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration
    Shoutian Zhu
    Department of Chemistry, University of Illinois, Chicago, 60607, USA
    Chem Biol 12:981-91. 2005
    ..RKIP is therefore the compound's valid target and a key regulator of cell motility...
  12. ncbi Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones
    Anniefer N Magpusao
    Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
    Bioorg Med Chem Lett 20:5472-6. 2010
    ..These compounds share common structural components, namely the [13]-macro-dilactone templated by an octyl alpha-glucoside 4,6-diol...
  13. ncbi A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration
    Kevin T Mc Henry
    Department of Chemistry University of Illinois at Chicago Chicago, IL 60607, USA
    Chembiochem 3:1105-11. 2002
    ..UIC-1005 therefore represents a new class of bioactive oxazolidinone derivative that may prove useful as a probe for signaling pathways leading to cell motility...
  14. ncbi c-Jun N-terminal kinase regulates lamellipodial protrusion and cell sheet migration during epithelial wound closure by a gene expression-independent mechanism
    Z Melis Altan
    Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA
    Biochem Biophys Res Commun 322:56-67. 2004
    ....
  15. ncbi Cell surface actin remodeling
    Thomas P Stossel
    Hematology Division, Brigham and Women's Hospital, Boston, MA 02115, USA
    J Cell Sci 119:3261-4. 2006