Research Topics
| WILLIAM H FENICALSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
New pharmaceuticals from marine organismsW Fenical
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla 92093 0236, USA
Trends Biotechnol 15:339-41. 1997..Current research activities, while primarily within the academic laboratories, have generated convincing evidence that marine drug discovery has an exceedingly bright future...- Developing a new resource for drug discovery: marine actinomycete bacteriaWilliam Fenical
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Nat Chem Biol 2:666-73. 2006 - Culture-dependent and culture-independent diversity within the obligate marine actinomycete genus SalinisporaTracy J Mincer
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA
Appl Environ Microbiol 71:7019-28. 2005..Challenges involved with the direct sequence-based detection of spore-forming microorganisms in environmental samples are discussed... - Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropicaDaniel W Udwary
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0204, USA
Proc Natl Acad Sci U S A 104:10376-81. 2007..This study firmly establishes the genus Salinispora as a rich source of drug-like molecules and importantly reveals the powerful interplay between genomic analysis and traditional natural product isolation studies... - Culturable marine actinomycete diversity from tropical Pacific Ocean sedimentsPaul R Jensen
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
Environ Microbiol 7:1039-48. 2005..These bacteria can be readily cultured using low nutrient media and represent an unexplored resource for pharmaceutical drug discovery... - Marine actinomycete diversity and natural product discoveryPaul R Jensen
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Antonie Van Leeuwenhoek 87:43-8. 2005.... - Phylogenetic diversity of gram-positive bacteria cultured from marine sedimentsErin A Gontang
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0204, USA
Appl Environ Microbiol 73:3272-82. 2007..2%) are likely to represent new taxa. The high degree of phylogenetic novelty observed during this study highlights the fact that a great deal remains to be learned about the diversity of gram-positive bacteria in marine sediments... - Species-specific secondary metabolite production in marine actinomycetes of the genus SalinisporaPaul R Jensen
Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
Appl Environ Microbiol 73:1146-52. 2007.... - Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitorsRyan P McGlinchey
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA
J Am Chem Soc 130:7822-3. 2008.... - Widespread and persistent populations of a major new marine actinomycete taxon in ocean sedimentsTracy J Mincer
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
Appl Environ Microbiol 68:5005-11. 2002..Organic extracts from cultured members of this new group exhibit remarkable biological activity, suggesting that they represent a prolific resource for biotechnological applications... - Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinosporaRobert H Feling
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Angew Chem Int Ed Engl 42:355-7. 2003 - Discovery and development of the anticancer agent salinosporamide A (NPI-0052)William Fenical
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Bioorg Med Chem 17:2175-80. 2009..This paper offers a chronicle of the important events that facilitated the rapid clinical development of this exciting molecule... - Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete "Salinispora pacifica"Dong-Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093, USA
Org Lett 8:1021-4. 2006..The cyanosporasides possess a new 3-keto-pyranohexose sugar as well as a cyano- and chloro-substituted cyclopenta[a]indene ring system. The cyanosporasides are proposed to be cyclization products of an enediyne precursor... - Sequence-based analysis of secondary-metabolite biosynthesis in marine actinobacteriaErin A Gontang
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Appl Environ Microbiol 76:2487-99. 2010.... - Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropicaGreg O Buchanan
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA
Org Lett 7:2731-4. 2005..The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography... - Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensisJi Young Cho
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:1321-8. 2007..Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma... - Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus StreptomycesGlenroy D A Martin
Center for Marine Biotechnology, Scripps Insitution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:1406-9. 2007..For marmycin A ( 1), tumor cell cytotoxicity appeared to coincide with induction of modest apoptosis and arrest in the G1 phase of the cell cycle... - Lodopyridone, a structurally unprecedented alkaloid from a marine actinomyceteKatherine N Maloney
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
Org Lett 11:5422-4. 2009..Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM... - Fijiolides A and B, inhibitors of TNF-alpha-induced NFkappaB activation, from a marine-derived sediment bacterium of the genus NocardiopsisSang Jip Nam
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
J Nat Prod 73:1080-6. 2010..Fijiolide B did not affect QR1 activity, indicating the importance of the nitrogen substitution pattern for biological activity. On the basis of these data, fijiolide A is viewed as a promising lead for more advanced anticancer testing... - Arenamides A-C, cytotoxic NFkappaB inhibitors from the marine actinomycete Salinispora arenicolaRatnakar N Asolkar
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 72:396-402. 2009..Taken together, these data suggest that the chemoprevention and anti-inflammatory characteristics of arenamides A and B warrant further investigation... - Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacificaDong Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 71:570-5. 2008..This relationship was shown to be a consequence of the geometric isomerization of one double bond. The phenomenon of polyketide module skipping is proposed to explain the unusual biosynthesis of the salinipyrones and the pacificanones... - The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces spChambers C Hughes
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
Org Lett 10:629-31. 2008..The marinopyrroles possess potent antibiotic activities against methicillin-resistant Staphylococcus aureus... - Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "marinispora"Hak Cheol Kwon
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA
J Am Chem Soc 128:1622-32. 2006..The discovery of these new compounds from a new, chemically rich genus further documents that marine actinomycetes are a significant resource for drug discovery... - Phylogenetic analyses and diterpenoid production by marine bacteria of the genus SaprospiraTracy J Mincer
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204, USA
Curr Microbiol 49:300-7. 2004..grandis Gross, and the sole member of the closely related phylotype B. The discovery of two new neoverrucosane diterpenoids produced by phylotype B has also been documented... - Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales)Ji Young Cho
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
Org Lett 8:2471-4. 2006..The structure was rigorously determined by NMR spectroscopy and X-ray crystallography. A possible biosynthetic origin of this unusual ring system is proposed. [structure: see text].. - Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus CryptosphaeriaHyuncheol Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 73:998-1001. 2010..It also showed significant cytotoxicity against an HCT-116 human colon carcinoma cell line, indicating that the compound may be of value in exploring the Mcl-1 pathway as a target for cancer chemotherapy... - Structures, reactivities, and antibiotic properties of the marinopyrroles A-FChambers C Hughes
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Org Chem 75:3240-50. 2010..Halogenation of this material with N-bromosuccinimide cleanly furnished the 4,4',5,5'-tetrahalogenated core that characterizes this class of marine-derived metabolites... - Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacteriumWendy K Strangman
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Med Chem 52:2317-27. 2009..This study provides the foundation for the optimization of these potent anti-inflammatory compounds for development in the treatment of asthma... - Marineosins A and B, cytotoxic spiroaminals from a marine-derived actinomyceteChollaratt Boonlarppradab
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
Org Lett 10:5505-8. 2008..5 microM for marineosin A) and selective activities in diverse cancer cell types... - An N-acyl homolog of mycothiol is produced in marine actinomycetesGerald L Newton
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
Arch Microbiol 190:547-57. 2008..The results demonstrate that major thiol/disulfide changes accompany secondary metabolite production and suggest that mycothiol-dependent detoxification is important at this developmental stage... - Marinopyrrole A target elucidation by acyl dye transferChambers C Hughes
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Am Chem Soc 131:12094-6. 2009..In this study, the combination of cell, protein, and amino acid analysis arose from a single sample of material, thereby, suggesting a means to streamline and reduce material requirements involved in mode of action studies... - Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-cultureDong Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:515-20. 2007..Emericellamides A and B show modest antibacterial activities against methicillin-resistant Staphylococcus aureus with MIC values of 3.8 and 6.0 microM, respectively... - Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicolaPhilip G Williams
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
J Org Chem 72:5025-34. 2007..The relative and absolute stereochemistries of 1-3 were assigned by a combination of J-based configurational analyses and chemical derivatization... - New cytotoxic salinosporamides from the marine Actinomycete Salinispora tropicaPhilip G Williams
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA
J Org Chem 70:6196-203. 2005..New SAR data for all eight compounds, derived from extensive testing against the human colon carcinoma HCT-116 and the 60-cell-line panel at the NCI, indicate that the chloroethyl moiety plays a major role in the enhanced activity of 1... - Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085Ratnakar N Asolkar
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
J Nat Prod 69:1756-9. 2006..The daryamides show weak to moderate cytotoxic activity against the human colon carcinoma cell line HCT-116 and very weak antifungal activities against Candida albicans... - Bohemamines from a marine-derived Streptomyces spTim S Bugni
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Nat Prod 69:1626-8. 2006..The structures were elucidated using NMR methods, and the relative stereochemistry was determined using double-pulsed-field-gradient spin echo (DPFGSE) NOE studies... - Saliniketals A and B, bicyclic polyketides from the marine actinomycete Salinispora arenicolaPhilip G Williams
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093 0204, USA
J Nat Prod 70:83-8. 2007..Saliniketals A and B were found to inhibit ornithine decarboxylase induction, an important target for the chemoprevention of cancer, with IC50 values of 1.95 +/- 0.37 and 7.83 +/- 1.2 microg/mL, respectively... - Seaweed resistance to microbial attack: a targeted chemical defense against marine fungiJulia Kubanek
Center for Marine Biotechnology and Biomedicine, The Scripps Institution of Oceanography, La Jolla, CA 92037-0204, USA
Proc Natl Acad Sci U S A 100:6916-21. 2003.... - Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virensEliane Garo
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, California 92093-0204, USA
J Nat Prod 66:423-6. 2003..Trichodermamide B displayed significant in vitro cytotoxicity against HCT-116 human colon carcinoma with an IC(50) of 0.32 microg/mL... - Total synthesis of the ammosamidesChambers C Hughes
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0204, USA
J Am Chem Soc 132:2528-9. 2010..Compared to synthetic deschloro ammosamide B, natural ammosamide B is much less susceptible to oxidative degradation... - Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus AspergillusMercedes Cueto
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA
Org Lett 4:1583-5. 2002..The carbon skeleton of 1 represents a new addition to the architectural diversity of the sesterterpenoid (C25) class of secondary metabolites... - Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureusNina M Haste
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
J Antibiot (Tokyo) 63:219-24. 2010..These studies will also guide future isolation and preclinical development of depsipeptide anti-MRSA compounds from marine-derived actinomycetes... - A central strategy for converting natural products into fluorescent probesMatthew D Alexander
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Chembiochem 7:409-16. 2006 - Cytotoxic macrolides from a new species of the deep-water marine sponge LeiodermatiumJoel S Sandler
Center for Marine Biotechnology and Biomedicine (CMBB, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Org Chem 71:7245-51. 2006..Leiodolide A showed significant cytotoxicity (average GI(50) = 2.0 microM) in the National Cancer Institute's 60 cell line panel with enhanced activity against HL-60 leukemia and OVCAR-3 ovarian cancer cell lines... - Marinisporolides, polyene-polyol macrolides from a marine actinomycete of the new genus MarinisporaHak Cheol Kwon
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 0204, USA
J Org Chem 74:675-84. 2009..Although polyenes, marinisporolides A (1) and B (2) showed weak to no antifungal activity against Candida albicans... - New neoverrucosane diterpenoids produced by the marine gliding bacterium Saprospira grandisAllan Spyere
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204, USA
J Nat Prod 66:818-22. 2003..This study adds to the rare observation of terpene production by prokaryotic microorganisms and suggests that marine gliding bacteria may be a significant source for new terpenoid secondary metabolites... - Scytalidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus ScytalidiumLik Tong Tan
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA
J Org Chem 68:8767-73. 2003..Scytalidamides A (1) and B (2) showed moderate in vitro cytotoxicity toward HCT-116 human colon adenocarcinoma with IC(50) values of 2.7 and 11.0 microM, respectively... - Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira spDong Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, USA
Org Lett 9:1525-8. 2007.... - Secondary metabolite chemistry of the marine-derived fungus Massarina sp., strain CNT-016Mohamed A Abdel-Wahab
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Phytochemistry 68:1212-8. 2007..The fungal strain was isolated as a sterile mycelium from an ocean mud sample and identified using ITS sequence analysis... - Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus AspergillusMercedes Cueto
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego La Jolla, CA 92093-0204, USA
Phytochemistry 67:1826-31. 2006..Tropolactones A, B and C showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 13.2, 10.9 and 13.9 microg/mL... - Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competitionDong-Chan Oh
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA
Bioorg Med Chem 13:5267-73. 2005..The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 microM)... - Fluorescent profiling of natural product producersJoel S Sandler
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Am Chem Soc 127:9320-1. 2005..Through real-time multicolor microscopy, the processing, storage, and effects of a natural product are rapidly screened at the level of the strain and individual organism... - Halovirs A-E, new antiviral agents from a marine-derived fungus of the genus ScytalidiumDavid C Rowley
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093 0204, USA
Bioorg Med Chem 11:4263-74. 2003..A qualitative analysis of the secondary structures of these molecules using variable temperature NMR experiments and NOE analyses is also reported... - Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus streptomyces (actinomycetales)Ji Young Cho
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, 92093-0204, USA
J Nat Prod 69:425-8. 2006.... - Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratumRen Xiang Tan
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0204, USA
J Nat Prod 67:1374-82. 2004..Rostratins A, B, C, and D showed in vitro cytotoxicity against human colon carcinoma (HCT-116) with IC50 values of 8.5, 1.9, 0.76, and 16.5 microg/mL, respectively... - Synthesis and structure-activity relationships of the halovirs, antiviral natural products from a marine-derived fungusDavid C Rowley
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093 0204, USA
Bioorg Med Chem 12:4929-36. 2004..Results demonstrate that an N(alpha)-acyl chain of at least 14 carbons and an Aib-Pro dipeptide are critical for maintaining the antiviral activity...
Research Grants
- The Discovery of New Antibiotics from Deep Sea Actinomycete BacteriaWilliam Fenical; Fiscal Year: 2010....
- NMR Instrumentation for Marine Natural Product ChemistryWilliam Fenical; Fiscal Year: 2003..The acquisition of a high field instrument (500 MHz) will allow this group of researchers to undertake experiments currently unavailable at SIO. ..
- ANTITUMOR ANTIBIOTICS FROM MARINE ORGANISMSWilliam Fenical; Fiscal Year: 2003..The collection will grow with respect to the new fungi and gliding bacteria we will add during this project period. ..
- ANTITUMOR-ANTIBIOTICS FROM MARINE MICROORGANISMSWilliam Fenical; Fiscal Year: 2007..abstract_text> ..
- Training Program in Marine BiotechnologyWilliam Fenical; Fiscal Year: 2007..Together, these resources will create a multidisciplinary training experience difficult to achieve elsewhere. ..
- The Discovery of New Antibiotics from Deep Sea Actinomycete BacteriaWilliam Fenical; Fiscal Year: 2009....
- ANTITUMOR-ANTIBIOTICS FROM MARINE MICROORGANISMSWilliam Fenical; Fiscal Year: 1993..New projects will be identified and prioritized as the discovery process continues. It is anticipated that approximately 20 active leads can be chemically investigated per year...
- The Discovery of New Antibiotics from Deep Sea Actinomycete BacteriaWilliam Fenical; Fiscal Year: 2009....