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Species | John A FaulknerSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Age-related changes in the structure and function of skeletal musclesJohn A Faulkner
Molecular and Integrative Physiology, and Biomedical Engineering, Biomedical Science Research Building, University of Michigan, Ann Arbor, Michigan, USA
Clin Exp Pharmacol Physiol 34:1091-6. 2007....- Diaphragm muscle strip preparation for evaluation of gene therapies in mdx miceJohn A Faulkner
Department of Molecular and Integrative Physiology, School of Medicine, University of Ann Arbor, Michigan 48109 2200, USA
Clin Exp Pharmacol Physiol 35:725-9. 2008..With the 2 year life span of the mdx mouse, the impact of age-related effects can be studied in this model... - Terminology for contractions of muscles during shortening, while isometric, and during lengtheningJohn A Faulkner
Deprtment of Physiology and Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2007, USA
J Appl Physiol 95:455-9. 2003.... - The aging of elite male athletes: age-related changes in performance and skeletal muscle structure and functionJohn A Faulkner
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
Clin J Sport Med 18:501-7. 2008..The paper addresses the degree to which the attainment of the status as an elite athlete in different sports ameliorates the known age-related losses in skeletal muscle structure and function... - Effect of cleft palate repair on the susceptibility to contraction-induced injury of single permeabilized muscle fibers from congenitally-clefted goat palatesErik P Rader
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Cleft Palate Craniofac J 45:113-20. 2008..As an initial step to determining the validity of this theory, we tested the hypothesis that, in most cases, repair induces the transformation to type 1 fibers, thus diminishing susceptibility to injury... - The effect of cleft palate repair on contractile properties of single permeabilized muscle fibers from congenitally cleft goat palatesMichael C Hanes
Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109 2200, USA
Ann Plast Surg 60:188-93. 2008..No differences in sF(0) were observed. nP(max) increased with presence of type 2 fibers. The persistent state of type 2 fibers following palatoplasty leads to increased fatigue in the LVP of MRP subjects and may cause VPI symptoms... - Contractile properties of single permeabilized muscle fibers from congenital cleft palates and normal palates of Spanish goatsMichael C Hanes
Section of Plastic Surgery, Division of Geriatric Medicine, and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109 2007, USA
Plast Reconstr Surg 119:1685-94. 2007..The authors hypothesized that levator veli palatini muscle dysfunction inherent to cleft palates could affect the timing and outcome of cleft palate repair... - Electrical stimulation attenuates denervation and age-related atrophy in extensor digitorum longus muscles of old ratsDouglas E Dow
Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109-2007, USA
J Gerontol A Biol Sci Med Sci 60:416-24. 2005..These data provide support for the hypothesis that during aging, lack of contractile activity in fibers contributes to muscle atrophy and weakness... - Electrical stimulation of denervated muscles of rats maintains mass and force, but not recovery following graftingDouglas E Dow
Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109-2007, USA
Restor Neurol Neurosci 24:41-54. 2006.... - Electrical stimulation prior to delayed reinnervation does not enhance recovery in muscles of ratsDouglas E Dow
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2200, USA
Restor Neurol Neurosci 25:601-10. 2007.... - Adaptive changes in structure of skeletal muscles from adult Sod1 homozygous knockout miceTatiana Y Kostrominova
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 2007, USA
Cell Tissue Res 327:595-605. 2007.... - Characterization of skeletal muscle effects associated with daptomycin in ratsTatiana Y Kostrominova
Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, Michigan, USA
Muscle Nerve 42:385-93. 2010..Some fibers were Evans Blue Dye-positive but were not yet infiltrated by neutrophils. This suggests that the sarcolemma may be the primary target for the observed effects... - Age-related changes in the mechanical properties of the epimysium in skeletal muscles of ratsYingxin Gao
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
J Biomech 41:465-9. 2008..The age-related increase in the stiffness of the epimysium could play an important role in the impaired lateral force transmission in the muscles of the elderly... - Tendons of myostatin-deficient mice are small, brittle, and hypocellularChristopher L Mendias
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 105:388-93. 2008..We conclude that, in addition to the regulation of muscle mass and force, myostatin regulates the structure and function of tendon tissues... - Contraction-induced injury to single permeabilized muscle fibers from normal and congenitally-clefted goat palatesErik P Rader
Department of Surgery, University of Michigan, Ann Arbor, MI 48109 2200, USA
Cleft Palate Craniofac J 44:216-22. 2007..We tested the hypothesis that, compared with single permeabilized levator veli palatini muscle fibers from normal palates of adult goats, those from cleft palates are more susceptible to lengthening contraction-induced injury... - Number of contractions to maintain mass and force of a denervated rat muscleDouglas E Dow
Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, USA
Muscle Nerve 30:77-86. 2004..Protocols of stimulation that maintain muscle mass and force during prolonged periods of denervation may minimize problems clinically associated with denervation atrophy... - Comparison of gene expression of 2-mo denervated, 2-mo stimulated-denervated, and control rat skeletal musclesTatiana Y Kostrominova
Institute of Gerontology, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 2007, USA
Physiol Genomics 22:227-43. 2005.... - Distribution of rest periods between electrically generated contractions in denervated muscles of ratsDouglas E Dow
Institute of Gerontology, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Artif Organs 29:432-5. 2005.... - Effect of aging on the recovery following contraction-induced injury in muscles of female miceErik P Rader
Department of Biomedical Engineering and Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109-2200, USA
J Appl Physiol 101:887-92. 2006..We conclude that, as reported previously for old male mice, a severe contraction-induced injury to muscles of old female mice results in prolonged deficits in mass and force... - Recovery from contraction-induced injury is impaired in weight-bearing muscles of old male miceErik P Rader
Department of Biomedical Engineering, Institute of Gerontology, Univ. of Michigan, Ann Arbor, MI 48109-2007, USA
J Appl Physiol 100:656-61. 2006..We conclude that a severe contraction-induced injury to large, weight-bearing muscles of old mice causes permanent deficits in mass and force... - Poloxamer 188 reduces the contraction-induced force decline in lumbrical muscles from mdx miceRainer Ng
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2200, USA
Am J Physiol Cell Physiol 295:C146-50. 2008..The results provide a basis for potential therapeutic strategies directed at membrane stabilization of dystrophin-deficient skeletal muscle fibers... - Non-uniform distribution of strain during stretch of relaxed skeletal muscle fibers from rat soleus muscleMark L Palmer
School of Kinesiology, University of Michigan, Ann Arbor, MI, USA
J Muscle Res Cell Motil 32:39-48. 2011.... - Contractile properties of EDL and soleus muscles of myostatin-deficient miceChristopher L Mendias
Dept of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 2007, USA
J Appl Physiol 101:898-905. 2006..The results support a significant role for myostatin not only in the mass of muscles but also in the contractility and the composition of the extracellular matrix of muscles... - Lateral transmission of force is impaired in skeletal muscles of dystrophic mice and very old ratsKrishnan S Ramaswamy
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
J Physiol 589:1195-208. 2011..In contrast, in muscles of dystrophic or very old animals, disruptions in DGC structure and function impair lateral transmission of force causing instability and increased susceptibility of fibres to contraction-induced injury... - Reactive oxygen species on bone mineral density and mechanics in Cu,Zn superoxide dismutase (Sod1) knockout miceMichael J Smietana
Biomedical Engineering, University of Michigan, 2025 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
Biochem Biophys Res Commun 403:149-53. 2010.... - Magnitude of sarcomere extension correlates with initial sarcomere length during lengthening of activated single fibers from soleus muscle of ratsAppaji Panchangam
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Biophys J 95:1890-901. 2008..The findings support the hypothesis that during stretches of maximally activated skeletal muscles, sarcomeres at longer lengths are more susceptible to damage by excessive strain... - Micromechanical modeling of the epimysium of the skeletal musclesYingxin Gao
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
J Biomech 41:1-10. 2008..This model allows the analysis of mechanical behavior of most soft tissues if appropriate experimental data are available... - Soleus muscle in glycosylation-deficient muscular dystrophy is protected from contraction-induced injuryJessica D Gumerson
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
Am J Physiol Cell Physiol 299:C1430-40. 2010.... - Raising the antioxidant levels within mouse muscle fibres does not affect contraction-induced injuryErik P Rader
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2007, USA
Exp Physiol 91:781-9. 2006.... - An implantable device for stimulation of denervated muscles in ratsRobert G Dennis
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
Med Eng Phys 25:239-53. 2003..4 ms bipolar pulse width, 100 Hz, 20 pulses per contraction, and 100 or 300 contractions generated per day maintained muscle mass and maximum force in denervated EDL muscles of rats at values near control values for innervated muscles... - Effect of daptomycin on primary rat muscle cell cultures in vitroTatiana Y Kostrominova
Department of Molecular and Integrative Physiology, BSRB, University of Michigan, Ann Arbor, MI 48109 2200, USA
In Vitro Cell Dev Biol Anim 46:613-8. 2010..These results suggest that the putative targets for daptomycin effects on skeletal muscle are structures on the plasma membrane of highly differentiated myotubes... - Effects of long-term denervation on skeletal muscle in old ratsBruce M Carlson
Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109 2007, USA
J Gerontol A Biol Sci Med Sci 57:B366-74. 2002..Although many aspects of postdenervation reactions do not differ greatly between young and old animals, the lesser degree of atrophy in the old rats may reflect significant age-based mechanisms... - Overexpression of HSP70 in mouse skeletal muscle protects against muscle damage and age-related muscle dysfunctionAnne McArdle
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK
FASEB J 18:355-7. 2004..These data indicate that a diminished production of HSP70 in muscles of old mammals has a major effect on age-related functional deficits... - Force deficits and breakage rates after single lengthening contractions of single fast fibers from unconditioned and conditioned muscles of young and old ratsGordon S Lynch
Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
Am J Physiol Cell Physiol 295:C249-56. 2008.... - Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophyFlorian L Muller
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Free Radic Biol Med 40:1993-2004. 2006..Thus, the absence of CuZnSOD imposes elevated oxidative stress, loss of muscle mass, and physiological consequences that resemble an acceleration of normal age-related sarcopenia... - Transgenic mice expressing the myotilin T57I mutation unite the pathology associated with LGMD1A and MFMSean M Garvey
Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Hum Mol Genet 15:2348-62. 2006..These data provide evidence that myotilin mutations promote aggregate-dependent contractile dysfunction. In sum, we have established a promising patho-physiological mouse model that unifies the phenotypes of LGMD1A, MFM and SBM... - Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcomaJeffrey S Chamberlain
Department of Neurology, K243b HSB, Box 357720, 1959 N E Pacific St, University of Washington School of Medicine, Seattle, WA 98195 7720, USA
FASEB J 21:2195-204. 2007..Rhabdomyosarcomas have not been observed previously in nontransgenic mice. The results substantiate the mdx mouse as an important model system for studies of the pathogenesis of and potential remedies for DMD... - A highly functional mini-dystrophin/GFP fusion gene for cell and gene therapy studies of Duchenne muscular dystrophySheng Li
Department of Neurology, University of Washington School of Medicine, Seattle, 98195 7720, USA
Hum Mol Genet 15:1610-22. 2006..We suggest that these transgenic mdx(4Cv) mice are highly useful for developing autologous cell therapies for DMD...