Research Topics
| John FarrarSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The clinical importance of changes in the 0 to 10 numeric rating scale for worst, least, and average pain intensity: analyses of data from clinical trials of duloxetine in pain disordersJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA19041, USA
J Pain 11:109-18. 2010..Our findings support a standard definition of a clinically important difference in clinical trials of chronic-pain therapies...- A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic painJohn T Farrar
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Pain Med 11:1313-27. 2010..To evaluate the time of onset, overall efficacy, and safety of fentanyl buccal tablet (FBT) for noncancer-related breakthrough pain (BTP) in opioid-tolerant adults over 12 weeks... - Validity, reliability, and clinical importance of change in a 0-10 numeric rating scale measure of spasticity: a post hoc analysis of a randomized, double-blind, placebo-controlled trialJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall, Room 816, 423 Guardian Drive, Philadelphia, PA 19104, USA
Clin Ther 30:974-85. 2008..In a patient with clinical spasticity, the best judge of the perceived severity of the symptom is the patient... - A comparison of change in the 0-10 numeric rating scale to a pain relief scale and global medication performance scale in a short-term clinical trial of breakthrough pain intensityJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Anesthesiology 112:1464-72. 2010..The correlation of data from patients with breakthrough pain with a Pain Relief Scale and a different global outcome measures will extend our understanding of these measures... - Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritisDorothy Cimino Brown
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 233:1278-83. 2008..To determine whether the Canine Brief Pain Inventory (CBPI) can detect changes in dogs with osteoarthritis treated with an NSAID or a placebo... - Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritisDorothy Cimino Brown
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Vet Res 68:631-7. 2007..To develop and psychometrically test an owner self-administered questionnaire designed to assess severity and impact of chronic pain in dogs with osteoarthritis... - Stability of cerebral blood flow measures using a split-dose technique with (99m)Tc-exametazime SPECTAndrew B Newberg
Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Nucl Med Commun 26:475-8. 2005..Such a paradigm is frequently used in the clinical and research setting to assess various brain states... - Use of complementary and alternative medicine and prayer among a national sample of cancer survivors compared to other populations without cancerJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, 2 Gates Building 3400 Spruce Street, Philadelphia, PA 19104, USA
Complement Ther Med 15:21-9. 2007..Extensive use of complementary and alternative medicine (CAM) among cancer survivors has been described in literature, but the rate has not previously been compared to other groups in a true population sample... - Women suffer more short and long-term pain than men after major thoracotomyEdward A Ochroch
Department of Anesthesiology, University of Pennsylvania Health System, USA
Clin J Pain 22:491-8. 2006..We set out to determine whether sex affected pain and recovery after major surgery by analyzing data originally collected to determine the effect of the timing of epidural analgesia on long-term outcome after thoracotomy... - Pain and neuropathy in cancer survivorsRosemary C Polomano
University of Pennsylvania School of Nursing, Philadelphia, USA
Cancer Nurs 29:39-47. 2006 - Acupuncture expectancy scale: development and preliminary validation in ChinaJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Explore (NY) 3:372-7. 2007.... - Symptom burden among cancer survivors: impact of age and comorbidityJun J Mao
Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Am Board Fam Med 20:434-43. 2007.... - The influence of race and socioeconomic factors on patient acceptance of perioperative epidural analgesiaEdward Andrew Ochroch
Department of Anesthesiology and Critical Care, University of Pennsylvania Health System, University of Pennsylvania, Pennsylvania, USA
Anesth Analg 105:1787-92, table of contents. 2007.... - De qi: Chinese acupuncture patients' experiences and beliefs regarding acupuncture needling sensation--an exploratory surveyJun J Mao
Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicne, USA
Acupunct Med 25:158-65. 2007..The aim of this study was to describe Chinese acupuncture patients' perceived sensations of, and beliefs about, acupuncture needling... - Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicityJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:328-35. 2008..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity... - Use of an activity monitor to detect response to treatment in dogs with osteoarthritisDorothy Cimino Brown
Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Am Vet Med Assoc 237:66-70. 2010..To determine whether an activity monitor (AM) could be used to detect changes in activity in dogs with osteoarthritis treated with carprofen or a placebo... - The effect of OPC Factor on energy levels in healthy adults ages 45-65: a phase IIb randomized controlled trialPatrick J Lariccia
Penn Presbyterian Medical Center, Philadelphia, PA, USA
J Altern Complement Med 14:723-32. 2008..To determine the efficacy of the food supplement OPC Factor to increase energy levels in healthy adults aged 45 to 65... - Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility studyJun James Mao
Department of Family Medicine and Community Health, Center for Clinical Epidemiology and Biostatistics, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
J Soc Integr Oncol 7:52-8. 2009..Acupuncture has the potential to prevent RT-related fatigue, which will need to be confirmed by conducting a randomized controlled trial... - Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivorsJun J Mao
Department of Family Medicine and Community Health, University of Pennsylvania Health System, Philadelphia, PA, USA
Cancer 115:3631-9. 2009..The objective of this study was to evaluate the perceived onset, characteristics, and risk factors for AI-related arthralgia (AIA)... - Feasibility trial of electroacupuncture for aromatase inhibitor--related arthralgia in breast cancer survivorsJames J Mao
Department of Family Medicine and Community Health, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Integr Cancer Ther 8:123-9. 2009..Given the existing evidence for electroacupuncture (EA) for treatment of osteoarthritis in the general population, this study aims to establish the feasibility of studying EA for treating AI-related arthralgia... - Development of and psychometric testing for the Brief Pain Inventory-Facial in patients with facial pain syndromesJohn Y K Lee
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19107, USA
J Neurosurg 113:516-23. 2010..The complete 18-item instrument is referred to as the BPI-Facial... - Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Gastroenterology 129:1865-74. 2005..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs... - Is satisfaction with pain management a valid and reliable quality indicator for use in nursing homes?David J Casarett
Philadelphia VA Medical Center, Pennsylvania, USA
J Am Geriatr Soc 50:2029-34. 2002..To determine whether satisfaction with pain management can be measured reliably in nursing homes and to gather preliminary data about the validity of satisfaction assessments in this population... - Use of the cumulative proportion of responders analysis graph to present pain data over a range of cut-off points: making clinical trial data more understandableJohn T Farrar
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Pain Symptom Manage 31:369-77. 2006..Whether as a primary or secondary approach to a clinical trial of pain therapy, the display of data in a CPRA format may be useful in the understanding of results and applicability to patient care... - Advances in clinical research methodology for pain clinical trialsJohn T Farrar
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Nat Med 16:1284-93. 2010.... - Cerebral blood flow effects of pain and acupuncture: a preliminary single-photon emission computed tomography imaging studyAndrew B Newberg
Department of Radiology, University of Pennsylvania Health System, Philadelphia, USA
J Neuroimaging 15:43-9. 2005..The purpose of this study was to investigate the cerebral blood flow changes associated with the analgesic effect of acupuncture in patients with chronic pain... - Pain and neuropathy in cancer survivors. Surgery, radiation, and chemotherapy can cause pain; research could improve its detection and treatmentRosemary C Polomano
University of Pennsylvania School of Nursing, Philadelphia, USA
Am J Nurs 106:39-47. 2006 - Prescribing NSAIDs to patients on SSRIs: possible adverse drug interaction of importance to dental practitionersAndres Pinto
Oral Medicine Clinical Center, Department of Oral Medicine, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA
Compend Contin Educ Dent 30:142-51; quiz 152, 154. 2009..Nonetheless, a causal inference cannot be made based on the available evidence and the lack of randomized controlled clinical trials... - A novel approach to the use of animals in studies of pain: validation of the canine brief pain inventory in canine bone cancerDorothy Cimino Brown
Department of Clinical Studies, and Mari Lowe Center for Comparative Oncology Research, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6010, USA
Pain Med 10:133-42. 2009..To validate the Canine Brief Pain Inventory (CBPI), which is based on the human Brief Pain Inventory (BPI), in a canine model of spontaneous bone cancer... - Clinically important changes in acute pain outcome measures: a validation studyJohn T Farrar
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Pain Symptom Manage 25:406-11. 2003..This provides support for the usefulness of these values in future clinical trials of pain therapy... - Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medicationsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Am J Gastroenterol 97:2540-9. 2002..Changing rates of peptic ulcer disease morbidity and mortality were temporally related to increasing sales of antiulcerants but not to change in sales of NSAIDs... - Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposureJames D Lewis
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 15:39-45. 2006..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse... - Cerebral blood flow effects of yoga training: preliminary evaluation of 4 casesDebbie L Cohen
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
J Altern Complement Med 15:9-14. 2009..Experienced practitioners of yoga have been shown to alter brain function, but this case series measured cerebral blood flow before and after a 12-week training program in Iyengar yoga (IY) for naïve subjects... - Tolerability of red yeast rice (2,400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intoleranceSteven C Halbert
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Cardiol 105:198-204. 2010..In conclusion, red yeast rice was tolerated as well as pravastatin and achieved a comparable reduction of low-density lipoprotein cholesterol in a population previously intolerant to statins... - What postoperative outcomes matter to pediatric patients?Giovanni Cucchiaro
Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Anesth Analg 102:1376-82. 2006..Children can express opinions about preferred postoperative outcomes and provide useful input about their care. Girls, more than boys, seem to perceive vomiting as less important than improved pain control in the postoperative period... - Core outcome domains for chronic pain clinical trials: IMMPACT recommendationsDennis C Turk
Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA
Pain 106:337-45. 2003.... - Long-term use of controlled-release oxycodone for noncancer pain: results of a 3-year registry studyRussell K Portenoy
Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY 10003, USA
Clin J Pain 23:287-99. 2007..To evaluate the outcomes associated with the use of controlled-release (CR) oxycodone for up to 3 years in the treatment of noncancer pain... - Spinal fusion or exercise and cognitive intervention? In search of the answersRosemary C Polomano
Pain 122:4-5. 2006 - Core outcome measures for chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 113:9-19. 2005 - Identifying important outcome domains for chronic pain clinical trials: an IMMPACT survey of people with painDennis C Turk
Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA
Pain 137:276-85. 2008..These multiple outcomes should be considered when evaluating the efficacy and effectiveness of chronic pain treatments... - Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Pain 9:105-21. 2008.... - Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studiesDaniel K Kajdasz
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Clin Ther 29:2536-46. 2007.... - Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendationsDennis C Turk
University of Washington, Seattle, WA 98195, USA
Pain 125:208-15. 2006 - A titration strategy is needed to manage breakthrough cancer pain effectively: observations from data pooled from three clinical trialsNeil A Hagen
Department of Medicine, Tom Baker Cancer Centre, 1331 29 Street NW, Calgary, Alberta, Canada
J Palliat Med 10:47-55. 2007..Breakthrough pain is a prevalent and serious problem in patients with cancer. However, it is not known how best to predict the effective dose of breakthrough opioid for any given patient... - Comparison of logistic regression versus propensity score when the number of events is low and there are multiple confoundersM Soledad Cepeda
School of Medicine, Javeriana University, Bogota, Colombia
Am J Epidemiol 158:280-7. 2003..Logistic regression is the technique of choice when there are at least eight events per confounder... - Point of viewJohn T Farrar
Clin J Pain 20:367. 2004 - Economic evaluation of oral treatments for neuropathic painM Soledad Cepeda
Department of Anesthesia and Clinical Epidemiology Unit, Javeriana University School of Medicine, Bogota, Colombia
J Pain 7:119-28. 2006..We report a cost-effectiveness evaluation of treatments for neuropathic pain... - Side effects of opioids during short-term administration: effect of age, gender, and raceM Soledad Cepeda
Department of Anesthesiology, and Clinical Epidemiology Unit. Javeriana Univeristy, Bogota, Colombia
Clin Pharmacol Ther 74:102-12. 2003..The risk of respiratory depression increases substantially after 60 years of age. Women have nausea and vomiting more often than men. The effect of race deserves further investigation... - The effect of group aerobic exercise and t'ai chi on functional outcomes and quality of life for persons living with acquired immunodeficiency syndromeMary Lou Galantino
Richard Stockton College of New Jersey, Pomona, NJ 08240, USA
J Altern Complement Med 11:1085-92. 2005..Further research is warranted to evaluate additional exercise interventions that are accessible, safe, and cost-effective for the HIV population... - Pharmacologic management of neuropathic pain: evidence-based recommendationsRobert H Dworkin
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 132:237-51. 2007..Long-term studies, head-to-head comparisons between medications, studies involving combinations of medications, and RCTs examining treatment of central NP are lacking and should be a priority for future research... - The impact of modified Hatha yoga on chronic low back pain: a pilot studyMary Lou Galantino
Program in Physical Therapy, Richard Stockton College of New Jersey, USA
Altern Ther Health Med 10:56-9. 2004..Additional functional outcome measures should be explored. This pilot study supports the need for more research investigating the effect of yoga for this population... - Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Meedicine and Dentistry, Rochester, NY 14642
Arch Neurol 60:1524-34. 2003..Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach...
Research Grants
- METHOD FOR THE ANALYSIS OF PAIN CLINICAL TRIALSJohn Farrar; Fiscal Year: 2001..Over this time period, not only will adjunct does be varied upward or downward, depending on the complaint of side effect, whereas the opiod dose will be varied in response to pain complaint. ..
- Efficacy of Acupuncture with PT for Knee Osteo-ArthritisJohn Farrar; Fiscal Year: 2005..However, if the results are negative, then the addition of acupuncture to EPT should be generally curtailed. ..