JAMES TILFORD ELDER

..The aim of this study was to develop a clinical-grade, automated, multiplex system for the differential diagnosis and molecular stratification of rheumatoid arthritis (RA)...

..This gene is likely to be identified soon. Further development and use of linkage disequilibrium resources will provide a powerful tool for the identification of the remaining psoriasis genes...

..quot; The results integrate genetics and immunology, further reinforcing our emerging understanding of psoriasis...

..Taken together, these results indicate that cluster 17 does not carry a psoriasis-susceptibility allele, and expand the PSORS1 risk interval to approximately 300 kb...

..Together with recent genetic and therapeutic evidence implicating IL-23, these findings suggest a genetic basis for Th17-mediated inflammation in psoriasis...

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..These results indicate that local, gene-specific factors play an important role in the regulation of EDC gene expression in the keratinocyte lineage and during keratinocyte terminal differentiation...

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..Here, we review the epidemiology, immunopathology, and genetics of psoriasis, and present a disease model integrating its genetics and immunology...

..Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders...

..These results strongly suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis...

..Our results confirm associations between IL12B and IL23R and psoriasis in Caucasians, and provide a genetic basis for the clinical association between psoriasis and Crohn's disease...

..These results define an amphiregulin- and ErbB1-dependent mechanism by which autocrine ERK activation is maintained in NHKs, even when ErbB1 autophosphorylation and internalization are limited...

..Our results suggest that targeting ErbB1 signaling might be of benefit in the treatment of SCC...

..022). This finding was confirmed in an independent set of mice analyzed by quantitative RT-PCR (8.8-fold vs. 1.2-fold, n = 4, P = 0.001). The finding of persistent dermal DNA damage after suberythemal doses of SSR merits further study...

..These data also indicate that autocrine heparin-binding epidermal growth factor expression is not regulated by p38...

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..These data show that distinct EGFR ligands stimulate KC behavior in different cellular contexts, and in an MP-dependent fashion...

..Taken together, our results identify a "pre-psoriatic" gene expression signature, suggesting decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin...

..These results demonstrate that there are at least two additional loci within the MHC conferring risk of psoriasis...

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..This comprehensive analysis of differentially regulated transcripts in psoriasis provides additional insight into the pathogenic mechanisms involved and emphasizes the need for more complex yet tractable experimental models of psoriasis...

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..We also replicated a recently identified association signal near RNF114 (rs495337, combined P = 2 × 10??)...

..Therefore, the BRAF mutational status does not separate all Spitz nevi from spitzoid melanomas and non-Spitz types of melanocytic proliferations, contrary to previous reports...

..We suggest that BRAF mutations contribute to benign melanocytic hyperplasia, but are likely to contribute to invasive melanoma only in conjunction with other mutations...

..The absence of elevated Hh target gene expression in lesional psoriatic skin indicates that the Hh pathway is not activated in this disease, raising questions regarding the proposed use of Hh antagonists as antipsoriatic agents...

..Additional independent studies will be required to elucidate relationships between genetic variation in the EGF gene and risk of melanoma...

..In this review, we describe various animal models, detail the immunologic and intracellular pathways that mediate these phenotypes and assess the utility of these models to better understand this disease...

..In this article, we will focus on the epidemiology of psoriasis and its associated arthritis...

..There is anecdotal evidence to suggest that gluten sensitivity may play a role in psoriasis, and patients with psoriasis in Europe have been reported to improve on a gluten-free diet...

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..We propose that EGFR ligands are important modifiers of IL-1 activity, synergizing with IL-1 to stimulate epidermal production of hBD-2, S100A7, and CCL20, three of the most upregulated transcripts in psoriatic plaques...

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..These results identify S100A2 oxidation and translocation as markers for early cellular responses to oxidative stress, which are markedly attenuated in immortalized and malignant keratinocytes...

..These results suggest that ErbB1 and ErbB2 employ different mechanisms of plasma membrane targeting during keratinocyte differentiation, and that cytoskeletal association may facilitate the coupling of activated ErbB1 and ERK...

..The lack of clinical differences between "familial" and "sporadic" psoriasis may reflect a similar genetic basis for both conditions, at least when onset is early...

..The role of the epidermal growth factor receptor (ErbB1) in the progression of prostate cancer is incompletely understood...

..This article is a summary of that presentation and a review of the literature...

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..Our results suggest that this MAPK-dependent ROS/p53 feedback loop is a point of vulnerability of melanoma cells that can be exploited for rational drug design...

..A favourable side effect profile has also been shown for this agent...

..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..

..4. To test two functional candidates (the KIR gene cluster and TNFalpha) for genetic involvement in psoriasis, using available families and/or the cases and controls collected in Aim 2. ..

..abstract_text> ..

..Identification of the remaining psoriasis susceptibility genes will elucidate the molecular basis of this enigmatic disease, and identify targets for more specific and effective therapy. ..

..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..

..If successful, this research will have important public health consequences not only in psoriasis but also in a wide variety of dermatoses characterized by epidermal hyperplasia. ..

..Its cause is not well understood. Identification of genes that increase risk of psoriatic arthritis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..

..Identification of the remaining psoriasis susceptibility genes will elucidate the molecular basis of this enigmatic disease, and identify targets for more specific and effective therapy. ..

..Its cause is not well understood. Identification of genes that increase risk of psoriasis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..

..D.s with strong research potential. Finally, they have created a Web site for dissemination of detailed information about the program to all potential trainees, including those belonging to underrepresented minorities. ..

..Allelic variation of the genes will be tested for segregation using TDT and MBSA, and by identifying alleles shared across haplotypes in regions of strong linkage disequilibrium. ..

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..Its cause is not well understood. Identification of genes that increase risk of psoriatic arthritis will help us unlock the secrets of this troubling disease, and identify targets for more specific and effective therapy. ..