A H Elcock

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Computer simulation of protein-protein association kinetics: acetylcholinesterase-fasciculin
    A H Elcock
    Department of Chemistry and Biochemistry, Department of Pharmacology, University of California at San Diego, La Jolla, CA, 92093 0365, USA
    J Mol Biol 291:149-62. 1999
  2. ncbi Electrostatic contributions to the stability of halophilic proteins
    A H Elcock
    Department of Chemistry and Biochemistry, Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0365, USA
    J Mol Biol 280:731-48. 1998
  3. ncbi The stability of salt bridges at high temperatures: implications for hyperthermophilic proteins
    A H Elcock
    Department of Pharmacology, University of California at San Diego, La Jolla, CA, 92093 0365, USA
    J Mol Biol 284:489-502. 1998
  4. ncbi Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge
    S Tara
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0365, USA
    Biopolymers 46:465-74. 1998
  5. ncbi Computer simulations of actin polymerization can explain the barbed-pointed end asymmetry
    D Sept
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093 0365, USA
    J Mol Biol 294:1181-9. 1999
  6. ncbi Evidence for electrostatic channeling in a fusion protein of malate dehydrogenase and citrate synthase
    A H Elcock
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093 0365, USA
    Biochemistry 35:12652-8. 1996
  7. ncbi Realistic modeling of the denatured states of proteins allows accurate calculations of the pH dependence of protein stability
    A H Elcock
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0365, USA
    J Mol Biol 294:1051-62. 1999
  8. ncbi Calculation of weak protein-protein interactions: the pH dependence of the second virial coefficient
    A H Elcock
    Department of Chemistry and Biochemistry, Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0365, USA
    Biophys J 80:613-25. 2001

Detail Information

Publications8

  1. ncbi Computer simulation of protein-protein association kinetics: acetylcholinesterase-fasciculin
    A H Elcock
    Department of Chemistry and Biochemistry, Department of Pharmacology, University of California at San Diego, La Jolla, CA, 92093 0365, USA
    J Mol Biol 291:149-62. 1999
    ..Inclusion of electrostatic desolvation effects also improves reproduction of the experimental ionic strength dependence of the wild-type association rate...
  2. ncbi Electrostatic contributions to the stability of halophilic proteins
    A H Elcock
    Department of Chemistry and Biochemistry, Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0365, USA
    J Mol Biol 280:731-48. 1998
    ..As a consequence, the role of acidic residues in halophilic proteins may be more to prevent aggregation than to make a positive contribution to intrinsic protein stability...
  3. ncbi The stability of salt bridges at high temperatures: implications for hyperthermophilic proteins
    A H Elcock
    Department of Pharmacology, University of California at San Diego, La Jolla, CA, 92093 0365, USA
    J Mol Biol 284:489-502. 1998
    ..The results obtained therefore suggest one possible way in which the apparently destabilising effects of salt bridges at room temperature can be reconciled with their increased abundance in hyperthermophilic proteins...
  4. ncbi Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge
    S Tara
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0365, USA
    Biopolymers 46:465-74. 1998
    ..Asp74 traps the ligand within the gorge, and in this way helps to ensure a reaction...
  5. ncbi Computer simulations of actin polymerization can explain the barbed-pointed end asymmetry
    D Sept
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093 0365, USA
    J Mol Biol 294:1181-9. 1999
    ..Together, the results indicate that simulations provide a realistic description of both polymerization and the binding of more complex structures to actin filaments...
  6. ncbi Evidence for electrostatic channeling in a fusion protein of malate dehydrogenase and citrate synthase
    A H Elcock
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093 0365, USA
    Biochemistry 35:12652-8. 1996
    ..Similar effects may operate between other members of the citric acid metabolon...
  7. ncbi Realistic modeling of the denatured states of proteins allows accurate calculations of the pH dependence of protein stability
    A H Elcock
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093 0365, USA
    J Mol Biol 294:1051-62. 1999
    ..Given its success in the present situation, the protocol employed here for developing simple models of the unfolded state may prove useful in other computer simulation applications...
  8. ncbi Calculation of weak protein-protein interactions: the pH dependence of the second virial coefficient
    A H Elcock
    Department of Chemistry and Biochemistry, Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 0365, USA
    Biophys J 80:613-25. 2001
    ....