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Genomes and Genes | L EckmannSummaryAffiliation: University of California Country: USA Publications
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Defence molecules in intestinal innate immunity against bacterial infectionsLars Eckmann
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Curr Opin Gastroenterol 21:147-51. 2005..Antimicrobial proteins are key effector molecules of innate immunity. The review discusses recent progress in understanding the function of these host defence molecules in intestinal physiology...- Microbes and microbial toxins: paradigms for microbial-mucosal interactions I. Pathophysiological aspects of enteric infections with the lumen-dwelling protozoan pathogen Giardia lambliaL Eckmann
Departments of Medicine and Pathology, University of California, San Diego, La Jolla, California 92093, USA
Am J Physiol Gastrointest Liver Physiol 280:G1-6. 2001.... - Sensor molecules in intestinal innate immunity against bacterial infectionsLars Eckmann
Department of Medicine, University of California, San Diego, La Jolla, California, USA
Curr Opin Gastroenterol 22:95-101. 2006..This review highlights new insights into the functions of these sensors in intestinal physiology... - Cytokines in host defense against SalmonellaL Eckmann
Department of Medicine 0623D, Laboratory of Mucosal Immunology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
Microbes Infect 3:1191-200. 2001..In animal models, protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12, IL-18 and IL-15, whereas IL-4 and IL-10 inhibit host defenses against Salmonella... - NOD2 and Crohn's disease: loss or gain of function?Lars Eckmann
Department of Medicine, UCSD School of Medicine, La Jolla, California 92093, USA
Immunity 22:661-7. 2005..This review focuses on recent insights into the functions of normal and variant NOD2 proteins and the pathogenetic mechanisms underlying NOD2-associated inflammatory diseases... - Animal models of inflammatory bowel disease: lessons from enteric infectionsLars Eckmann
University of California San Diego, Department of Medicine 0665, 9500 Gilman Drive, La Jolla, CA 92093 0665, USA
Ann N Y Acad Sci 1072:28-38. 2006..Furthermore, such models help to determine the physiologic consequences of neutralizing specific mediators and signaling pathways implicated in inflammation on antimicrobial host defense... - NF-?B and mucosal homeostasisLars Eckmann
Department of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0063, USA
Curr Top Microbiol Immunol 349:145-58. 2011..This review focuses on the protective and homeostatic functions of NF-?B, and the importance of NF-?B in determining host-microbe interactions in the intestinal tract... - Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria SalmonellaL Eckmann
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 275:14084-94. 2000..The results also show that evaluation of mRNA expression profiles by cDNA array analysis is a powerful approach to characterizing and understanding host-pathogen interactions... - Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lambliaL Eckmann
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
J Immunol 164:1478-87. 2000..These studies define NO and arginine as central components in a novel cross-talk between a luminal pathogen and host intestinal epithelium... - Mucosal defences against GiardiaLars Eckmann
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Parasite Immunol 25:259-70. 2003..Elucidation of the key anti-giardial effector mechanisms will be important for selecting the best adjuvants in the rational development of vaccination strategies against Giardia... - Opposing functions of IKKbeta during acute and chronic intestinal inflammationLars Eckmann
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:15058-63. 2008..Our findings caution against the therapeutic use of IKKbeta/NF-kappaB inhibitors in acute inflammatory settings dominated by cell loss and ulceration... - Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cellsS K Yang
Department of Medicine, University of California at San Diego, La Jolla, USA
Gastroenterology 113:1214-23. 1997..To further explore this role, the regulated expression of twelve C-X-C, C-C, and C-chemokines by human colon epithelial cells was characterized... - Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunityA Izadpanah
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623, USA
Am J Physiol Gastrointest Liver Physiol 280:G710-9. 2001..The constitutive and regulated expression of MIP-3alpha by human intestinal epithelium is consistent with a role for epithelial cell-produced MIP-3alpha in modulating mucosal adaptive immune responses... - Production of MDC/CCL22 by human intestinal epithelial cellsM C Berin
Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Am J Physiol Gastrointest Liver Physiol 280:G1217-26. 2001..These studies demonstrate the constitutive and regulated production by intestinal epithelial cells of a chemokine known to function in the trafficking of T cells that produce anti-inflammatory cytokines... - Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha productionL Eckmann
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
J Clin Invest 100:296-309. 1997..These studies define a novel autocrine/paracrine function of mediators produced by intestinal epithelial cells in the rapid induction of increased fluid secretion in response to intestinal infection with invasive bacteria... - Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenograftsM C Berin
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Am J Respir Cell Mol Biol 24:382-9. 2001.... - Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processingShin Maeda
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
Science 307:734-8. 2005..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion... - Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cellsM B Dwinell
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
Gastroenterology 120:49-59. 2001..IP-10, Mig, and I-TAC are 3 CXC chemokines that are known to act as CD4(+) T-cell chemoattractants... - Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasionD L Rowell
Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
Am J Physiol 273:G322-32. 1997..Together, these studies suggest that hepatocytes can both initiate and amplify acute inflammatory responses in the liver through the regulated expression and secretion of a specific array of proinflammatory cytokines... - Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogensMitsutoshi Iimura
Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
J Immunol 174:4901-7. 2005..Moreover, Cnlp+/+ mice were protected from oral infections with C. rodentium inocula that infected the majority of Cnlp-/- mice. These results establish cathelicidin as an important component of innate antimicrobial defense in the colon... - Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epitheliumChristian Maaser
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Gastroenterology 122:667-80. 2002..MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators important for regulating mucosal immune and inflammatory responses, we sought to determine if these cells produce MIF... - IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerSergei Grivennikov
Laboratory of Gene Regulation and Signal Transduction, UCSD School of Medicine, University of California San Diego, La Jolla, CA 92093 0723, USA
Cancer Cell 15:103-13. 2009..Thus, the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs... - Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epitheliumKoji Hase
Laboratory of Mucosal Immunology Histology Shared Resources, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Infect Immun 70:953-63. 2002.... - A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasionH C Jung
Department of Medicine, University of California, San Diego, La Jolla 92093 0623
J Clin Invest 95:55-65. 1995.... - How bile acids confer gut mucosal protection against bacteriaAlan F Hofmann
Department of Medicine, Division of Gastroenterology, University of California at San Diego, La Jolla, CA 92093-0813, USA
Proc Natl Acad Sci U S A 103:4333-4. 2006 - Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cellsJongdae Lee
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0663, USA
Nat Cell Biol 8:1327-36. 2006..Our data provide a case for organ-specific innate immunity in which TLR expression in polarized IECs has uniquely evolved to maintain colonic homeostasis and regulate tolerance and inflammation... - Toll-like receptor 9-induced type I IFN protects mice from experimental colitisKyoko Katakura
Department of Medicine, UCSD, La Jolla, California 92093 0663, USA
J Clin Invest 115:695-702. 2005..They also underscore the important protective role of type I IFN in intestinal homeostasis and suggest that strategies to modulate innate immunity may be of therapeutic value for the treatment of intestinal inflammatory conditions... - Innate immune defenses in the intestinal tractSara M Dann
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0063, USA
Curr Opin Gastroenterol 23:115-20. 2007..Innate intestinal defenses are important for protection against ingested and commensal microbes. This review highlights recent new insights into innate immune effectors in the intestine... - Nuclear factor-kappa B in intestinal protection and destructionMartina E Spehlmann
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
Curr Opin Gastroenterol 25:92-9. 2009..This review highlights new insights into the functions of NF-kappaB in normal homeostasis and specific disease processes in the intestinal tract... - Regulated production of the chemokine CCL28 in human colon epitheliumHiroyuki Ogawa
Department of Medicine, University of California at San Diego, La Jolla, CA 92093-0623, USA
Am J Physiol Gastrointest Liver Physiol 287:G1062-9. 2004..These findings indicate that CCL28 functions as an "inflammatory" chemokine in human colon epithelium and suggest the notion that CCL28 may act to counterregulate colonic inflammation... - Central importance of immunoglobulin A in host defense against Giardia sppT Dianne Langford
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Infect Immun 70:11-8. 2002..Moreover, B-cell-dependent but IgA-independent and B-cell-independent antigiardial host defenses exist but are less important for controlling infection... - Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetinTineke Lauwaet
Department of Pathology, University of California at San Diego, 214 Dickinson Street, San Diego, CA 92103 8416, USA
J Antimicrob Chemother 65:531-4. 2010..Attachment to the small intestinal mucosa is crucial for initiating and maintaining Giardia infection. We tested the effect of isoflavones on Giardia attachment... - Intestinal mucosal responses to microbial infectionLars Eckmann
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Springer Semin Immunopathol 27:181-96. 2005.... - Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretionS P Cole
Department of Medicine, University of California, San Diego, La Jolla 92093, USA
Infect Immun 65:843-6. 1997..Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells... - CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogenMartina E Spehlmann
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Immunol 183:3332-43. 2009..Thus, CXCR2-dependent processes, particularly mucosal neutrophil influx, not only contribute to host defense against C. rodentium, but provide protection against infection-associated diarrhea... - Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injurySungwon Chae
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
J Immunol 177:1214-20. 2006..difficile toxin A exposure that is mediated, at least in part, through promoting epithelial cell survival by abrogating epithelial cell apoptosis... - Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite GiardiaBarbara J Davids
Department of Pathology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92103, USA
J Immunol 177:6281-90. 2006..These results, together with prior data on pIgR-mediated immune neutralization of luminal cholera toxin, suggest that pIgR is essential in intestinal defense against pathogenic microbes with high-level and persistent luminal presence... - Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epitheliumChristian Maaser
Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Immunology 112:437-45. 2004.... - STAT3 and its activators in intestinal defense and mucosal homeostasisPetr Hruz
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0063, USA
Curr Opin Gastroenterol 26:109-15. 2010..The review discusses recent findings on two cytokines, IL-22 and IL-6, and their common signaling pathway, which bridge innate and adaptive immunity in the intestinal tract... - Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cellsKazumichi Abe
Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 104:17022-7. 2007..These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation... - IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancerFlorian R Greten
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
Cell 118:285-96. 2004..In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer... - Analysis of host responses to microbial infection using gene expression profilingM F Kagnoff
University of California, San Diego, Laboratory of Mucosal Immunology, 9500 Gilman Drive, La Jolla, California 92093 0623, USA
Curr Opin Microbiol 4:246-50. 2001.... - Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alphaL Eckmann
Department of Medicine, University of California, San Diego, La Jolla 93093, USA
J Clin Invest 96:1269-79. 1995..These studies define novel mechanisms through which acute inflammation can be initiated in the host in response to a cytolytic pathogen, such as E. histolytica... - IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epitheliumLaurence J Egan
Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 101:2452-7. 2004..Selective preactivation of NF-kappaB through IKKbeta in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy... - Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lambliaCarlos A Valdez
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Med Chem 52:4038-53. 2009..These studies show the potential of combining systematic synthetic approaches with biological and electrochemical evaluations in developing improved 5-NI drugs... - Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunityPetr Hruz
Department of Medicine, University of California, San Diego, La Jolla, California, USA
Curr Opin Gastroenterol 24:108-14. 2008..The present review discusses the physiological functions of selected caspase recruitment domain (CARD)-containing sensor and adaptor proteins and their role in the pathogenesis of intestinal diseases... - Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigDLone S Bertelsen
Department of Medicine, Division of Gastroenterology, UCSD Medical Center 8414, 200 W. Arbor Dr, San Diego, CA 92103-8414, USA
Am J Physiol Cell Physiol 287:C939-48. 2004..We conclude that the Salmonella bacterial effector protein SigD may play critical roles in the pathogenesis of disease caused by this microorganism... - GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogenYoshihiro Hirata
Department of Medicine, University of California, San Diego, La Jolla, 92093 0623, USA
Cell Host Microbe 7:151-63. 2010..Thus, GM-CSF produced in the intestinal mucosa acts to enhance host protection against an enteric bacterial pathogen through regulating recruitment and survival of DCs... - Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2Lone S Bertelsen
Division of Gastroenterology, Department of Medicine, UCSD School of Medicine, Medical Center, 200 W Arbor Street, San Diego, CA 92103 8414, USA
Infect Immun 71:2102-9. 2003..In summary, Salmonella infection rapidly increases Cox-2 expression in human intestinal tissue, accounting for increased epithelial ion transport characteristic of infectious diarrhea... - Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiationLillian J Choi
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 285:12504-11. 2010.... - Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodiesChristian Maaser
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Infect Immun 72:3315-24. 2004..These results indicate that host defense against C. rodentium depends on B cells and IgG antibodies but does not require production or transepithelial transport of IgA or secreted IgM... - Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia sppYolanda S Andersen
Department of Medicine 0665, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0665, USA
Infect Immun 74:2473-6. 2006..Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance... - Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cellsCharles C Yang
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Am J Physiol Cell Physiol 288:C321-8. 2005.... - Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitisJ Fierer
Medical and Pathology Services, VA San Diego Healthcare System, University of California, San Diego, San Diego, California, USA
Infect Immun 66:4397-402. 1998..immitis, but IL-10 has a larger effect and is the cytokine that is consistently associated with susceptibility in all strains of inbred mice... - Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activityS Resta-Lenert
Department of Medicine, University of California, San Diego, School of Medicine, San Diego, California 92103, USA
Am J Physiol Cell Physiol 281:C1837-49. 2001..However, these effects may not all be equally important in determining Cl(-) secretion in response to physiologically relevant secretagogues... - IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogensSara M Dann
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
J Immunol 180:6816-26. 2008..Thus, IL-6 is an important regulator of host defense against C. rodentium by protecting the mucosa against ulcerations which can act as a microbial niche for the bacteria... - Prolonged interferon-gamma exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivoLone S Bertelsen
Division of Gastroenterology, Department of Medicine, University of California-San Diego School of Medicine, San Diego, California 92103-8414, USA
Am J Physiol Gastrointest Liver Physiol 286:G157-65. 2004..These findings demonstrate the implications of elevated IFN-gamma levels in human small intestine and validate the human intestinal xenograft as a model to study chronic effects of physiologically relevant stimuli... - Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2Hiroshi Nishihara
Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 100:8921-6. 2003.... - Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pyloriKoji Hase
Department of Medicine, University of California at San Diego, La Jolla, 92093, USA
Gastroenterology 125:1613-25. 2003..pylori survival mechanisms that govern chronic infection with this gastric pathogen... - Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayersLaurence J Egan
Laboratory of Mucosal Immunology, Department of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA
Am J Physiol Cell Physiol 285:C1028-35. 2003.... - Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic modelSamuel G Melendez Lopez
Department of Pathology, University of California, San Diego, San Diego, California 92103 8416, USA
Eukaryot Cell 6:1130-6. 2007..The resultant dramatic inhibition of invasion by both inhibitors in this human colonic model of amebiasis strongly suggests a significant role of secreted amebic proteinases, such as EhCP1, in the pathogenesis of amebiasis... - Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lambliaNoa Tejman-Yarden
University of California, San Diego, Department of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
Antimicrob Agents Chemother 55:4643-51. 2011..However, the data also caution that some forms of Mz resistance do not markedly interfere with in vivo infectivity... - Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8Kelly S Doran
Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
J Infect Dis 185:196-203. 2002..These data indicate that the GBS beta-h/c contributes to invasion and immune activation of lung epithelial cells and may represent a multifunctional virulence factor in the early pulmonary stages of GBS infection... - A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptideLi Chung Hsu
Departments of Pharmacology and Pathology, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 105:7803-8. 2008..Thus, NOD2 plays a key role in the B. anthracis-induced inflammatory response by being a critical mediator of IL-1beta secretion... - NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activationPetr Hruz
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 106:12873-8. 2009.... - NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbetaFlorian R Greten
Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
Cell 130:918-31. 2007..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition... - The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitisThomas W Spahn
Department of Medicine, Munster University Hospital, Munster, Germany
Gastroenterology 127:1463-73. 2004..We studied the role of lymphotoxin alpha 1 beta 2 /lymphotoxin-beta receptor signaling in Citrobacter rodentium -induced colitis... - Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasisColby Zaph
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nature 446:552-6. 2007..These results indicate that the balance of IKK-beta-dependent gene expression in the intestinal epithelium is crucial in intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation... - An important role for polymeric Ig receptor-mediated transport of IgA in protection against Streptococcus pneumoniae nasopharyngeal carriageKeer Sun
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
J Immunol 173:4576-81. 2004..The results demonstrate the critical role of secretory IgA in protection against pneumococcal nasal colonization and suggest that directed targeting to mucosal tissues will be needed for effective vaccination in humans... - Nod2 mediates susceptibility to Yersinia pseudotuberculosis in miceUlrich Meinzer
INSERM, U843, Universite Paris 7, Hopital Robert Debre, Paris, France
PLoS ONE 3:e2769. 2008..This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice... - Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cellsEmma Ringqvist
Department of Cell and Molecular Biology, BMC, Uppsala University, Uppsala, Sweden
Mol Biochem Parasitol 159:85-91. 2008..These results indicate that contact of Giardia with epithelial cells triggers metabolic enzyme release, which might facilitate effective colonization of the human small intestine...
Research Grants
- Next-generation 5-nitroimidazoles against giardiasisLars Eckmann; Fiscal Year: 2007....
- Mutant NOD2 in Intestinal Inflammation and Host DefenseLars Eckmann; Fiscal Year: 2007..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
- MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATIONLars Eckmann; Fiscal Year: 2007..abstract_text> ..
- HOST DEFENSES AGAINST PATHOGENIC E. coliLars Eckmann; Fiscal Year: 2007..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
- HOST DEFENSES AGAINST PATHOGENIC E. coliLars Eckmann; Fiscal Year: 2006..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
- MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASELars Eckmann; Fiscal Year: 2010..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..