Research Topics
Genomes and GenesSpecies | Donald DoughertySummaryAffiliation: University of Texas Health Science Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Impulsivity and clinical symptoms among adolescents with non-suicidal self-injury with or without attempted suicideDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Psychiatry Res 169:22-7. 2009..Risk assessments for adolescents with NSSI+SA should include consideration not only of the severity of clinical symptoms but of the current level impulsivity as well...- Comparison of 50- and 100-g L -tryptophan depletion and loading formulations for altering 5-HT synthesis: pharmacokinetics, side effects, and mood statesDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, School of Medicine, The University of Texas Health Science Center at San Antonio, Mail Code 7793, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Psychopharmacology (Berl) 198:431-45. 2008..While most researchers have used a 100-g formulation, there has been ongoing interest in using smaller-sized formulations... - A test of alcohol dose effects on multiple behavioral measures of impulsivityDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Drug Alcohol Depend 96:111-20. 2008..Acute alcohol administration affects impulsive behavior, although these effects vary as a function of alcohol dose, assessment instrument, and time of measurement following administration... - The effects of alcohol on laboratory-measured impulsivity after L: -Tryptophan depletion or loadingDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Psychopharmacology (Berl) 193:137-50. 2007.... - Serotonin 2a receptor T102C polymorphism and impaired impulse controlJames M Bjork
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, Houston, Texas 77030, USA
Am J Med Genet 114:336-9. 2002..These preliminary data suggest that the T102C 5-HT2a receptor polymorphism may be a marker for impaired behavior control-perhaps in the context of psychiatric disorder history... - Behavioral measures of impulsivity and the lawCharles W Mathias
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry, Mail Code 7792, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Behav Sci Law 26:691-707. 2008..Legal implications for defining behavioral deficits using behavioral measures of impulsivity and their current limitations are discussed... - Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorderAlan C Swann
Department of Psychiatry, University of Texas Medical School at Houston, 1300 Moursund, Rm 270, Houston, TX 77030, USA
Am J Psychiatry 162:1680-7. 2005..The purpose of this study was to investigate the relationship between impulsivity and severity of past suicidal behavior, a potential predictor of eventual suicide, in patients with bipolar disorder... - Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporterMichael A Dawes
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Stud Alcohol Drugs 70:899-907. 2009..Specifically, we wanted to examine the relationships between the following: platelet 5-HTT and 5-HTT genotype; platelet 5-HTT parameters and age at onset, as well as duration of drinking; and 5-HTT genotype and impulse control... - Age at first drink relates to behavioral measures of impulsivity: the immediate and delayed memory tasksDonald M Dougherty
University of Texas Health Science Center at Houston, Neurobehavioral Research Laboratory and Clinic, Houston, Texas 77030, USA
Alcohol Clin Exp Res 28:408-14. 2004..This study examined the relationship between laboratory-measured impulsivity and age at first drink... - Behavioral impulsivity paradigms: a comparison in hospitalized adolescents with disruptive behavior disordersDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77030 3406, USA
J Child Psychol Psychiatry 44:1145-57. 2003..As a result, comparisons between measures are difficult, with little consensus regarding which method may be most sensitive to individual impulsivity differences of different populations... - Commission error rates on a continuous performance test are related to deficits measured by the Benton Visual Retention TestDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 77030, USA
Assessment 10:3-12. 2003..These results may be explained by a shared association between processes of impulsivity and other deficits of executive control that may interfere with successful performance of the Benton... - Candidate endophenotypes for genetic studies of suicidal behaviorJ John Mann
Department of Psychiatry, NewYork State Psychiatric Institute ColumbiaUniversity, 1051 Riverside Drive, New York, NY 10032, USA
Biol Psychiatry 65:556-63. 2009..Other candidate endophenotypes requiring further investigation include serotonergic neurotransmission, second messenger systems, and borderline personality disorder traits... - Two models of impulsivity: relationship to personality traits and psychopathologyAlan C Swann
Department of Psychiatry, University of Texas Medical School, Houston, Texas, USA
Biol Psychiatry 51:988-94. 2002..The relationship appears stronger, however, for rapid-response impulsivity, as measured by the IMT/DMT. Laboratory and personality measures of impulsivity appear to be related to risk of psychopathology... - Impulsivity and phase of illness in bipolar disorderAlan C Swann
Department of Psychiatry, University of Texas Mental Sciences Institute, University of Texas Health Science Center, Houston, TX, USA
J Affect Disord 73:105-11. 2003..Impulsivity is prominent in bipolar disorder, but there is little quantitative information relating it to phase of illness... - Characterizing aggressive behavior with the Impulsive/Premeditated Aggression Scale among adolescents with conduct disorderCharles W Mathias
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Psychiatry Res 151:231-42. 2007..As in the adult and child literature, characterization of aggressive behavior into two subtypes appears to be relevant to understanding individual differences among adolescents with Conduct Disorder... - Impulsive and premeditated subtypes of aggression in conduct disorder: differences in time estimationDonald M Dougherty
Department of Psychiatry and Behavioral Medicine, Neurobehavioral Research Laboratory and Clinic, Wake Forest University School of Medicine Winston Salem, North Carolina 27157, USA
Aggress Behav 33:574-82. 2007..This study confirms the importance of considering the role and type of physical aggression when studying heterogeneous diagnostic groups like CD and supports the relevance of time estimation to certain subgroups of adolescents with CD... - Immediate and delayed memory tasks: a computerized behavioral measure of memory, attention, and impulsivityDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
Behav Res Methods Instrum Comput 34:391-8. 2002..Preliminary studies have demonstrated that these laboratory tasks are sensitive to group differences, produce stable baselines of performance, and are sensitive to drug-induced performance decrements... - Suicidal behaviors and drug abuse: impulsivity and its assessmentDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
Drug Alcohol Depend 76:S93-S105. 2004..To better account for influence of impulsivity in these psychiatric disturbances, no single source of measurement should be used without the consideration of other types of instruments... - Reliability estimates for the immediate and delayed memory tasksCharles W Mathias
Neurobehavioral Research Laboratory and Clinic, University of Texas Health Science Center at Houston, 77030, USA
Percept Mot Skills 95:559-69. 2002..Analyses indicated that the primary variable of interest, i.e., commission of errors, showed acceptable reliability within and across testing periods... - Laboratory behavioral measures of impulsivityDonald M Dougherty
Department of Psychiatry and Behavioral Medicine, School of Medicine, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
Behav Res Methods 37:82-90. 2005..The four paradigms in this software package are available at no cost and can be obtained by contacting the corresponding author... - Familial transmission of Continuous Performance Test behavior: attentional and impulsive response characteristicsDonald M Dougherty
Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77030, USA
J Gen Psychol 130:5-21. 2003..e., BIS) was correlated with commission errors for parents, but not for adolescents. The findings of this study support the use of an objective behavioral measure of impulsivity to assess familial relationships of impulsivity... - Acute yohimbine increases laboratory-measured impulsivity in normal subjectsAlan C Swann
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas 77030, USA
Biol Psychiatry 57:1209-11. 2005.... - The biphasic effects of alcohol: comparisons of subjective and objective measures of stimulation, sedation, and physical activityMerideth A Addicott
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Alcohol Clin Exp Res 31:1883-90. 2007..However, little is known about the effects of alcohol on physical activity or the relationship between physical activity and subjective self-report measures of stimulation and sedation following alcohol consumption in humans... - Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjectsIgnacio H Valdes
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund, Houston, TX 77030, USA
Psychiatry Res 147:239-42. 2006..A significant correlation between BIS scores and DLPFC activation was found, supporting a role for the DLPFC in BIS-measured impulsivity... - Laboratory-measured aggressive behavior of women: acute tryptophan depletion and augmentationDawn M Marsh
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
Neuropsychopharmacology 26:660-71. 2002..These findings indicate that both T+ and T- can influence aggressive behavior and that certain subgroups of women may be more susceptible to serotonin manipulation... - Functional MRI study of working memory in MDMA usersF Gerard Moeller
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, 1300 Moursund, Houston, TX 77030, USA
Psychopharmacology (Berl) 177:185-94. 2004..Similarly, behavioral studies in human MDMA users regularly find abnormalities in memory, mood, and impulse control. However, studies of brain function using brain imaging in MDMA users have been less consistent... - P300 event-related potential amplitude and impulsivity in cocaine-dependent subjectsF Gerard Moeller
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, Moursund, Houston, Texas, USA
Neuropsychobiology 50:167-73. 2004..This study supports the hypothesis that the basic neurophysiology responsible for the P300 amplitude in cocaine-dependent individuals is associated with impulsivity independent of a history of childhood conduct disorder symptoms... - Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggressionF Gerard Moeller
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, 1300 Moursund, Houston, TX 77030, USA
Drug Alcohol Depend 68:105-11. 2002..This study supports the hypothesis that the increased impulsivity as measured by the BIS-11 in cocaine dependent individuals is not exclusively due to concomitant increases in aggression or ASPD... - Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imagingFrederick Gerard Moeller
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Neuropsychopharmacology 30:610-7. 2005....
Research Grants
- Impulsivity and Information Processing in Adolescent Cannabis AbuseDonald Dougherty; Fiscal Year: 2007....
- Impulsivity and Biological Markers for Suicidality and Drug Use in AdolescentsDonald M Dougherty; Fiscal Year: 2010....
- Behavioral Models of Impulsivity: ETOH and 5-HT EffectsDonald Dougherty; Fiscal Year: 2009....
- Impulsivity and Biological Markers for Suicidality and Drug Use in AdolescentsDonald Dougherty; Fiscal Year: 2009....
- Binge Drinking: Individual Differences in the Capacity to Alter Drinking PatternsDonald M Dougherty; Fiscal Year: 2010....
- Behavioral Models of Impulsivity: ETOH and 5-HT EffectsDonald Dougherty; Fiscal Year: 2009....
- Behavioral Models of Impulsivity: ETOH and 5-HT EffectsDonald Dougherty; Fiscal Year: 2005....
- Impulsivity Models: Behavioral MechanismsDonald Dougherty; Fiscal Year: 2006..This research will advance our understanding of the construct of impulsivity and will provide a firmer context within which future research can better study the role impulsivity plays in the development of severe conduct problems. ..
- The Relationship of Impulsivity to Symptoms of SuicideDonald Dougherty; Fiscal Year: 2004....
- AGGRESSION AND WOMEN--ALCOHOL AND SEROTONIN RELATIONSHIPDonald Dougherty; Fiscal Year: 2003..These proposed studies will answer several questions regarding how alcohol, serotonin, premenstrual symptomatology, and the menstrual cycle are related to the susceptibility for aggressive behavior. ..
- Consequences of Adolescent Substance Use on the Development of Impulse ControlDonald M Dougherty; Fiscal Year: 2010..The advancement of better prevention programs and substance use treatments are dependent on a gaining a better understanding of these complex relationships. ..