Research Topics
| Grant DorseySummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malariaSue J Lee
Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
Malar J 7:149. 2008..Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other...- Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysisJulien Zwang
Shoklo Malaria Research Unit, Mae Sot, Thailand
Malar J 8:203. 2009..It was necessary to evaluate the efficacy of ACT, recently adopted by the World Health Organization (WHO) and deployed over 80 countries, in order to make an evidence-based drug policy... - Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected childrenShereen Katrak
Oregon Health and Science University, Portland, USA
Malar J 8:272. 2009..However, there is limited data on the safety and tolerability of these drugs, especially in young children and patients co-infected with HIV... - Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistanceAnne F Gasasira
School of Medicine, Makerere University Kampala, Uganda
Malar J 9:177. 2010..This study assessed the incidence of falciparum malaria and the prevalence of resistance-conferring Plasmodium falciparum mutations in HIV-infected children receiving daily TS and HIV-uninfected children not taking TS... - Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan childrenCatherine Maiteki-Sebuguzi
Department of Medicine, Makerere University, Kampala, Uganda
Malar J 7:106. 2008..This study compared the safety and tolerability of three combination antimalarial regimens in a cohort of Ugandan children... - Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan childrenTrevor P Jensen
Department of Medicine, University of California, San Francisco, USA
Malar J 8:213. 2009..Yet measurement of incidence is challenging. The slide positivity rate (SPR) has been used as a surrogate measure of malaria incidence, but limited data exist on the relationship between SPR and the incidence of malaria... - Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in UgandaVinay Gupta
Department of Medicine, University of California, San Francisco, CA 94143, USA
Malar J 9:19. 2010..The use of capillary instead of agarose gel electrophoresis for genotyping offers technical advantages, but it is unclear whether capillary electrophoresis will result in improved classification of anti-malarial treatment outcomes... - Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of UgandaPatrick M Newman
School of Medicine, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94131, USA
Malar J 8:254. 2009..TS decreases the risk of malaria in HIV-infected adults and children but has not been evaluated among pregnant women... - The effect of varying analytical methods on estimates of anti-malarial clinical efficacyWendy J Verret
Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
Malar J 8:77. 2009..The aim of this study was to quantify the magnitude of the differences between efficacy estimates derived from these approaches and identify the factors underlying these differences... - Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African childrenElizabeth A Ashley
Epicentre, Paris, France
Malar J 7:154. 2008..Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy... - Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan childrenDenise Njama-Meya
Makerere University Medical School, Kampala, Uganda
Malar J 6:7. 2007..However, with the introduction of new artemisinin-based combination therapy (ACT), presumptive treatment becomes economically and clinically less acceptable... - The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005William J Collins
Department of Medicine, University of California, San Francisco, Box 0811, CA 94143, USA
Malar J 5:122. 2006..However, genotyping-adjusted drug efficacy estimates may vary between trials due to the use of different genotyping methods and to the different settings in which these methods are applied... - Monitoring antimalarial safety and tolerability in clinical trials: a case study from UgandaSarah G Staedke
London School of Hygiene and Tropical Medicine, London, UK
Malar J 7:107. 2008..Here the reporting system is described, and difficulties faced in analysing and interpreting the safety results are illustrated, using data from the trials... - Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trialGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
JAMA 297:2210-9. 2007..Combination therapy is now widely advocated as first-line treatment for uncomplicated malaria in Africa. However, it is not clear which treatment regimens are optimal or how to best assess comparative efficacies in highly endemic areas... - Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistanceBryan Greenhouse
Department of Medicine, University of California, San Francisco, California, USA
J Infect Dis 199:758-65. 2009..Improved control efforts are reducing the burden of malaria in Africa but may result in decreased antimalarial immunity... - Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan childrenTamara D Clark
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e11759. 2010..Combination therapies are now recommended to treat uncomplicated malaria. We used a longitudinal design to assess the incidence of malaria and compare the efficacies of 3 combination regimens in Kampala, Uganda... - Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistanceDamon Francis
Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94110, USA
J Infect Dis 193:978-86. 2006..Our findings strongly suggest that geographic differences in response to antimalarial therapy in Uganda are primarily mediated by acquired immunity associated with malaria transmission intensity, rather than by parasite factors... - Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in UgandaAlissa Myrick
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 74:758-61. 2006..These results highlight the complexity of malaria in Africa and have implications for efficacy trials, because missing late reappearances of strains could lead to misclassification of outcomes... - Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in UgandaGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 71:758-63. 2004..The dhps Glu-540 mutation played a principal role and the dhfr Arg-59 mutation a secondary role in mediating resistance to SP alone and in combination... - Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina FasoChristian Dokomajilar
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 75:162-5. 2006..The dhfr 164L and dhps 540E mutations were not seen in any isolates. These results clarify the key roles of a small number of mutations in P. falciparum resistance to SP and AQ in west Africa... - Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemicChristian Dokomajilar
Department of Medicine, University of California-San Francisco, San Francisco General Hospital, Box 0811, San Francisco, CA 94143, USA
Antimicrob Agents Chemother 50:1893-5. 2006..All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response... - Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trialsBryan Greenhouse
Department of Medicine, University of California, San Francisco, Box 0811, San Francisco, CA 94143, USA
Antimicrob Agents Chemother 51:3096-103. 2007..Genotyping-adjusted estimates of treatment failure from high-transmission sites may represent substantial overestimates of the true risk of treatment failure... - Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malariaGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, San Francisco 94143, USA
J Infect Dis 188:1231-8. 2003..Our results suggest that the use of combination antimalarial therapy in Africa may slow the spread of drug-resistant malaria and prolong the therapeutic life span of available treatment regimens... - Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurpAdithya Cattamanchi
Department of Medicine, San Francisco General Hospital University of California, San Francisco, San Francisco, California 94143, USA
Am J Trop Med Hyg 68:133-9. 2003..Comparing the 3 studied genes, msp-2 results were most accurate, and analysis of this single gene effectively distinguished recrudescence from reinfection in our study population... - Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trialSarah G Staedke
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
Lancet 364:1950-7. 2004..Combinations of amodiaquine and sulfadoxine-pyrimethamine or artesunate were significantly more efficacious, and each regimen could be an appropriate alternative for treatment of uncomplicated malaria in Africa... - Factors determining the heterogeneity of malaria incidence in children in Kampala, UgandaTamara D Clark
Department of Medicine, University of California, San Francisco, CA 94143, USA
J Infect Dis 198:393-400. 2008..Malaria risk may be heterogeneous in urban areas of Africa. Identifying those at highest risk for malaria may lead to more targeted approaches to malaria control... - Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, UgandaHeidi Hopkins
University of California, San Francisco, San Francisco, California 94143, USA
Am J Trop Med Hyg 76:1092-7. 2007..RDTs may provide an effective strategy for improving rational delivery of antimalarial therapy; in Kampala, either test could dramatically decrease inappropriate presumptive treatments... - Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, UgandaJulia Mwesigwa
Department of Medicine, 1001 Potrero Avenue, Building 30, Room 3402, University of California, San Francisco, San Francisco, CA 94143 0811, USA
Antimicrob Agents Chemother 54:52-9. 2010..For the artemisinin derivatives, differences between children and adults were variable and drug specific. The PK results generated for children must be considered to optimize the dosing strategies for these widely utilized ACT regimens... - Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trialGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
Lancet 360:2031-8. 2002..We aimed to compare the short-term and long-term effectiveness of three antimalarial regimens in children from Kampala, Uganda... - Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trialTaylor G Sandison
Department of Medicine, University of Washington, UW FHCRC Clinical Research, Box 358080, Seattle, WA 98195 8080, USA
BMJ 342:d1617. 2011..To evaluate the protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children (uninfected children born to HIV infected mothers) in Africa... - Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malariaDarren Creek
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 83:873-5. 2010..27, P = 0.02). Our findings indicate that AL may be better tolerated than DP among young breastfeeding children treated for uncomplicated malaria... - CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malariaMark P Eggena
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 74:41-3. 2006..The results provide insight into the role of cellular immunity in response to antimalarial therapy and underscore the need to investigate the mechanisms behind immune activation... - Prevention and treatment strategies used for the community management of childhood fever in Kampala, UgandaSarah K Kemble
Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
Am J Trop Med Hyg 74:999-1007. 2006..The only independent predictor of treatment with an adequate anti-malarial was accessing a clinic or hospital as the first source of care. In this urban area, use of appropriate malaria control measures occurs uncommonly... - Rapid diagnostic tests for malaria at sites of varying transmission intensity in UgandaHeidi Hopkins
University of California, San Francisco, San Francisco, California, USA
J Infect Dis 197:510-8. 2008..In Africa, fever is often treated presumptively as malaria, resulting in misdiagnosis and the overuse of antimalarial drugs. Rapid diagnostic tests (RDTs) for malaria may allow improved fever management... - Effect of nutritional status on response to treatment with artemisinin-based combination therapy in young Ugandan children with malariaWendy J Verret
Epidemiology Division, School of Public Health, University of California, 101 Haviland Hall, Berkeley, CA 94720 7358, USA
Antimicrob Agents Chemother 55:2629-35. 2011..However, children with mild to moderate chronic malnutrition not taking TS are at higher risk for recurrent parasitemia and may be considered a target for chemoprevention... - Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, UgandaSarah G Staedke
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
Trop Med Int Health 9:624-9. 2004..The use of molecular markers of SP resistance to predict treatment failure rates should take age into account... - Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapyEdwin D Charlebois
School of Medicine, University of California, San Francisco, CA 94105, USA
J Acquir Immune Defic Syndr 55:330-5. 2010..Increasing numbers of HIV-infected children not yet eligible for antiretroviral therapy (ART) are entering health care in Africa. We sought to characterize the risk of short-term disease progression in this population... - Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic reviewJimee Hwang
Department of Internal Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Trop Med Int Health 11:789-99. 2006..To compare the efficacies against uncomplicated falciparum malaria of chloroquine (CQ), amodiaquine (AQ), sulfadoxine-pyrimethamine (SP) and combinations of these inexpensive drugs... - Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan childrenEmmanuel Arinaitwe
Makerere University University of California San Francisco Research Collaboration, University of California, San Francisco 94143, USA
Clin Infect Dis 49:1629-37. 2009..However, which therapies are optimal is a matter of debate. We aimed to compare the short- and longer-term efficacy of 2 leading therapies in a cohort of young Ugandan children... - Breastfeeding and the risk of malaria in children born to HIV-infected and uninfected mothers in rural UgandaNeil Vora
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 55:253-61. 2010..However, data on whether breastfeeding reduces the risk of malaria in HIV-exposed and HIV-infected children is limited... - Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitmentJennifer C Davis
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Malar J 5:18. 2006..To generate a sampling frame for a longitudinal study of malaria incidence and treatment in Kampala, Uganda, a census, mapping and survey project was conducted... - Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacyMadeline Slater
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 73:256-62. 2005..The method used to classify treatment outcomes can have a major impact on estimates of drug efficacy, especially in areas of high transmission intensity... - Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemicBryan Greenhouse
Department of Medicine, University of California, San Francisco, CA, USA
J Infect Dis 204:19-26. 2011..falciparum and protection against disease... - Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infectionsBryan Greenhouse
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA
Am J Trop Med Hyg 75:836-42. 2006..31 versus P = 0.03). Four microsatellite markers performed well on polyclonal samples and may provide a valuable addition to genotyping for clinical drug efficacy studies in high transmission areas... - PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan childrenMichelle S Hsiang
Department of Global Health Sciences, Division of Pediatric Infectious Diseases, University of California, San Francisco, San Francisco, CA 94105, USA
J Clin Microbiol 48:3539-43. 2010.... - The impact of age, temperature, and parasite density on treatment outcomes from antimalarial clinical trials in Kampala, UgandaGrant Dorsey
Department of Medicine, San Francisco General Hospital, University of California San Francisco, Parnassus Avenue Box 0811, San Francisco, CA 94143, USA
Am J Trop Med Hyg 71:531-6. 2004..Caution should be taken when comparing results from drug efficacy studies with different subject selection criteria... - Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteersPolina German
Department of Clinical Pharmacy, Drug Research, University of California, School of Medicine, San Francisco, CA 94143 0622, USA
J Acquir Immune Defic Syndr 51:424-9. 2009.... - Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan childrenSarah G Staedke
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California 94143, USA
Am J Trop Med Hyg 69:244-6. 2003..6-6.9, P < 0.001) between residence within a swamp and >100 meters from a swamp. In this urban setting, incidence of clinical episodes of malaria was strongly associated with proximity of residence to potential mosquito breeding sites... - Host polymorphisms and the incidence of malaria in Ugandan childrenSunil Parikh
Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
Am J Trop Med Hyg 71:750-3. 2004..69, P = 0.05). Host polymorphisms appear to impact upon the incidence of uncomplicated malaria in Ugandan children... - Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan childrenTheodore D Ruel
Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0136, USA
J Acquir Immune Defic Syndr 56:44-50. 2011..We sought to determine the prevalence of early virologic failure (EVF), to characterize the evolution of ARV-resistance mutations and to predict the impact on second-line therapy... - Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmissionLisa M Butler
University of California, San Francisco, 50 Beale St, Suite 120, San Francisco, California 94105, USA
J Infect Dis 200:430-8. 2009..However, few studies have directly examined children, particularly in locations where KS is not commonly endemic... - Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypesPeilin Li
University of California, San Francisco UCSF, Department of Medicine, San Francisco, CA 94121, USA
J Virol Methods 170:115-20. 2010..765, p<0.0001). This approach to Taqman probe design should be explored further for use in diagnosis and monitoring of HIV in resource-limited settings, especially where several subtypes co-circulate... - Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic servicesJlucian Davis
Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, California
Am J Respir Crit Care Med 184:362-7. 2011..Real-time monitoring and evaluation of adherence to widely endorsed standards of tuberculosis care might facilitate improved case finding... - Asymptomatic parasitaemia as a risk factor for symptomatic malaria in a cohort of Ugandan childrenDenise Njama-Meya
Department of Medicine, Makerere University Medical School, Kampala, Uganda
Trop Med Int Health 9:862-8. 2004..To assess the prevalence of asymptomatic parasitaemia, determine its association with symptomatic malaria, and identify independent predictors of asymptomatic parasitaemia in a cohort of children from Kampala, Uganda... - Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in UgandaAdoke Yeka
Uganda Malaria Surveillance Project, Kampala, Uganda
PLoS ONE 3:e2390. 2008..We compared the efficacy and safety of AL with DP in Kanungu, an area of moderate malaria transmission... - False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malariaAnne F Gasasira
Department of Medicine, Makerere University Medical School, Kampala, Uganda
J Clin Microbiol 44:3021-4. 2006..We found poor positive predictive values (53% and 76%), particularly with younger age. Combining EIAs eliminated false positives but missed 21% of true positives. Performance of HIV EIAs in malaria may be unsatisfactory... - Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in UgandaSulggi A Lee
Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, USA
J Infect Dis 193:1160-3. 2006.... - Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based studyMoses R Kamya
Department of Medicine, Makerere University Medical School, Kampala, Uganda
J Infect Dis 193:9-15. 2006..We investigated the seroprevalence rate of HIV-1 infection and its effect on antimalarial treatment outcomes in adults and children with uncomplicated falciparum malaria in Uganda... - Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina FasoIssaka Zongo
Institut de Recherche en Science de la Sant, Bobo-Dioulasso, Burkina Faso
Am J Trop Med Hyg 73:826-32. 2005..1%, P < 0.001 for both comparisons). No serious adverse events were seen. AQ + SP appears to offer a highly effective, inexpensive, and available therapy for the treatment of uncomplicated malaria in Burkina Faso... - Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in UgandaAdoke Yeka
Ministry of Health, Kampala, Uganda
PLoS Med 2:e190. 2005..The high endemicity of malaria in Africa may impact on the efficacy of artemisinin-based combination therapy. The registration number for this trial is ISRCTN67520427 (http://www.controlled-trials.com/isrctn/trial/|/0/67520427.html)... - Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in UgandaNathan Bakyaita
Ministry of Health, Kampala, Uganda
Am J Trop Med Hyg 72:573-80. 2005..Amodiaquine plus sulfadoxine-pyrimethamine was significantly more efficacious; however, existing levels of resistance raises concern about the useful therapeutic life-span of this regimen... - Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan childrenSammuel L Nsobya
Makerere University Medical School, Kampala, Uganda
J Infect Dis 189:2220-6. 2004..Asymptomatic parasitemia detected by microscopy, but not by PCR, strongly predicted subsequent clinical malaria, often due to persistent infection... - Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malariaDaniel Kyabayinze
Department of Biochemistry, Makerere University Medical School, Kampala, Uganda
Am J Trop Med Hyg 69:247-52. 2003..7, P = 0.009). These results support a previously proposed method of predicting clinical outcomes based on the prevalence of these two mutations... - Urban malaria: primary caregivers' knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan childrenDenise Njama
Makerere University Medical School, Kampala, Uganda
Trop Med Int Health 8:685-92. 2003.... - Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trialIssaka Zongo
Institut de recherche en sciences de la sante, Bobo Dioulasso, Burkina Faso
Lancet 369:491-8. 2007..Our aim was to compare the risk of recurrent parasitaemia in patients given artemether-lumefantrine with that in those given amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated malaria... - Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenzPolina German
Clin Infect Dis 44:889-91. 2007 - Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in UgandaSamuel L Nsobya
Department of Medicine, Makerere University, Kampala, Uganda
Antimicrob Agents Chemother 51:3023-5. 2007..For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine... - High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in UgandaAnne F Gasasira
Department of Internal Medicine, Makerere University, Mulago Hospital, Kampala, Uganda
Clin Infect Dis 46:985-91. 2008..Artemisinin-based combination therapies are rapidly being adopted for the treatment of malaria in Africa; however, there are limited data on their safety and efficacy among human immunodeficiency virus (HIV)-infected populations... - Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparumRajeev K Mehlotra
Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Wolstein Research Building, room no 4204, 2103 Cornell Road, Cleveland, OH 44106 7286, USA
Antimicrob Agents Chemother 52:2212-22. 2008.... - HIV-1 infection in patients referred for malaria blood smears at government health clinics in UgandaLisa M Bebell
Columbia University College of Physicians and Surgeons, New York, NY, USA
J Acquir Immune Defic Syndr 46:624-30. 2007..In children, the relationship between HIV and malaria is less clear. We investigated the relationship between malaria and HIV-1 infection among adults and children referred for malaria blood smears at government health clinics in Uganda... - Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina FasoIssaka Zongo
Institut de recherche en sciences de la sante, Bobo Dioulasso, Burkina Faso
Clin Infect Dis 45:1453-61. 2007.... - Pattern of malaria-specific T-cell responses in a cohort of Ugandan childrenIsaac Ssewanyana
Joint Clinical Research Centre, Kampala, Uganda
J Trop Pediatr 54:6-13. 2008..Our data supports focusing on high-risk children in future preventive vaccination efforts to ensure the generation and maintenance of effective anti-malarial cellular immune responses... - Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan childrenMoses R Kamya
Makerere University Medical School, Kampala, Uganda
AIDS 21:2059-66. 2007..The efficacy of TMP/SMX may be diminished where antifolate resistance to malaria is high. We evaluated the efficacy of these interventions for malaria prevention among Ugandan children... - World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugsRic N Price
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
Malar J 6:119. 2007..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed... - Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household membersSamuel S Malamba
Centers for Disease Control and Prevention Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, Entebbe, Uganda
Am J Trop Med Hyg 75:375-80. 2006.... - Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, UgandaAnne F Gasasira
Makerere University Medical School, Kampala, Uganda
Am J Trop Med Hyg 68:127-32. 2003..SP/AQ was the most efficacious. This low-cost combination regimen may provide an optimal alternative to CQ for the treatment of uncomplicated malaria in Uganda... - Profile of T cell immune responses in HIV-infected children from UgandaIsaac Ssewanyana
Joint Clinical Research Centre, Kampala, Uganda
J Infect Dis 196:1667-70. 2007..Understanding the balance between immune activation and T cell immunity in HIV-infected children may provide further insights into the mechanisms leading to effective immune control...