Research Topics
| ERIC CHRISTIAN DONNYSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Self-administered and yoked nicotine produce robust increases in blood pressure and changes in heart rate with modest effects of behavioral contingency in ratsEric C Donny
Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Pharmacol Biochem Behav 99:459-67. 2011..Effects of behavioral contingency were observed, but differences were limited. Other non-pharmacological factors such as baseline shifts potentially related to nicotine-associated cues deserve further attention...- The absence of DSM-IV nicotine dependence in moderate-to-heavy daily smokersEric C Donny
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Drug Alcohol Depend 89:93-6. 2007..Current theoretical models of nicotine dependence assume a close relationship between use and dependence; however, previous data suggest that many daily smokers fail to develop nicotine dependence... - Comparing the physiological and subjective effects of self-administered vs yoked cocaine in humansEric C Donny
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
Psychopharmacology (Berl) 186:544-52. 2006..Studies with laboratory animals demonstrating different effects of self- vs experimenter-administered drug suggest that the ability to control or predict drug delivery may be an important determinant of drug action... - Smoking in the absence of nicotine: behavioral, subjective and physiological effects over 11 daysEric C Donny
Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Addiction 102:324-34. 2007..The purpose of this experiment was to characterize the effects of smoking stimuli delivered in the absence of nicotine over an extended (11-day) exposure... - The relationship between cigarette use, nicotine dependence, and craving in laboratory volunteersEric C Donny
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nicotine Tob Res 10:447-55. 2008..Further research into the sources of this variance is critical to understanding the process of and risk for nicotine dependence... - The relationship between cigarette use, nicotine dependence, and craving in laboratory volunteersEric C Donny
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nicotine Tob Res 10:934-42. 2008..Further research into the sources of this variance is critical to understanding the process of and risk for nicotine dependence... - The reinforcement-enhancing effects of nicotine: implications for the relationship between smoking, eating and weightEric C Donny
Department of Psychology, University of Pittsburgh, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Physiol Behav 104:143-8. 2011..Better understanding of the mechanisms underlying the reinforcement-enhancing effects of nicotine broadly, and the effects on food reinforcement per se, may aid in the development of new treatments with better long term outcomes... - Prolonged exposure to denicotinized cigarettes with or without transdermal nicotineEric C Donny
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15217, USA
Drug Alcohol Depend 104:23-33. 2009.... - Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcementNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 184:353-66. 2006..Although considerable progress has been made, we do not yet fully understand the behavioral and neurobiological basis of nicotine reinforcement, and without this knowledge, treatment strategies aimed at reducing smoking remain deficient... - Operant responding for conditioned and unconditioned reinforcers in rats is differentially enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotineNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
Psychopharmacology (Berl) 189:27-36. 2006.... - Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in ratsMatthew I Palmatier
Department of Psychology, Kansas State University, Manhattan, KS 66502, USA
Psychopharmacology (Berl) 207:381-90. 2009..One of the most successful pharmacotherapies for smoking cessation, bupropion, also increases responding for nondrug reinforcers such as food and brain stimulation rewards... - Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotineMatthew I Palmatier
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
Neuropsychopharmacology 33:2139-47. 2008..These findings are consistent with other studies suggesting that mGlu5 receptors mediate nicotine seeking, but do not alter the reinforcement enhancing effects of nicotine... - Self-administered and noncontingent nicotine enhance reinforced operant responding in rats: impact of nicotine dose and reinforcement scheduleNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
Psychopharmacology (Berl) 190:353-62. 2007.... - Choosing to take cocaine in the human laboratory: effects of cocaine dose, inter-choice interval, and magnitude of alternative reinforcementEric C Donny
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 69:289-301. 2003..Inter-choice interval did not affect cocaine choices. These results illustrate the persistence of cocaine self-administration once cocaine-taking has been initiated... - Cue-induced reinstatement of nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests, and its dependence on training doseXiu Liu
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 196:365-75. 2008..In addition, the issue of whether bupropion (an FDA-approved smoking cessation medication) interferes with the conditioned incentive of nicotine cues remains to be addressed... - Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotineMatthew I Palmatier
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 195:235-43. 2007..We have proposed that the reinforcement derived from these conditional stimuli can be inflated by a nonassociative "reinforcement-enhancing" effect of nicotine... - Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in ratsXiu Liu
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 194:463-73. 2007..Recent studies have demonstrated that nicotine can enhance operant responding for other nonpharmacological reinforcing stimuli. However, the nature of the reinforcement-enhancing effect of nicotine remains largely unknown... - The role of nicotine in smoking: a dual-reinforcement modelAnthony R Caggiula
Department of Psychology, 3131 Sennott Square, 210 South Bouquet Street, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nebr Symp Motiv 55:91-109. 2009.... - Prevalence of and associations with waterpipe tobacco smoking among U.S. university studentsBrian A Primack
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Ann Behav Med 36:81-6. 2008..Although waterpipe tobacco smoking seems to be increasing on U.S. university campuses, these data have come from convenience samples... - Delay discounting and smoking: association with the Fagerström Test for Nicotine Dependence but not cigarettes smoked per dayMaggie M Sweitzer
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Nicotine Tob Res 10:1571-5. 2008..These results suggest that DD among smokers is not simply the result of nicotine exposure, but may be an important marker for dependence, especially urgency to smoke in the morning... - The reinforcement enhancing effects of nicotine depend on the incentive value of non-drug reinforcers and increase with repeated drug injectionsMatthew I Palmatier
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet Street, Pittsburgh, PA 15260, USA
Drug Alcohol Depend 89:52-9. 2007.... - The role of nicotinic acetylcholine receptors in the primary reinforcing and reinforcement-enhancing effects of nicotineMatthew I Palmatier
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 32:1098-108. 2007..The two reinforcement-related effects of nicotine are mediated by nAChRs but can be dissociated by acute and chronic profiles... - Environmental stimuli promote the acquisition of nicotine self-administration in ratsAnthony R Caggiula
Department of Psychology, University of Pittsburgh, 3131 Sennott Square, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 163:230-7. 2002.... - Importance of nonpharmacological factors in nicotine self-administrationAnthony R Caggiula
Department of Psychology, University of Pittsburgh, 3131 Sennott Square, 210 Bouquet Street, 15260, Pittsburgh, PA, USA
Physiol Behav 77:683-7. 2002.... - Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcementEric C Donny
Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 169:68-76. 2003..Nicotine self-administration and smoking may be largely dependent upon this later action... - Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcersMatthew I Palmatier
Department of Psychology, University of Pittsburgh, 3137 Sennott Square, 210 S Bouquet St, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 184:391-400. 2006..It serves as a primary reinforcer by increasing the probability of behaviors that result in nicotine delivery. However, nicotine also potently enhances behaviors that result in the delivery of nonpharmacological reinforcers... - Using growth models to relate acquisition of nicotine self-administration to break point and nicotinic receptor bindingEric C Donny
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 75:23-35. 2004..The relationships revealed demonstrate the usefulness of growth models in the quantitative analysis of individual differences in drug self-administration behavior... - Sex differences in the contribution of nicotine and nonpharmacological stimuli to nicotine self-administration in ratsNadia Chaudhri
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Psychopharmacology (Berl) 180:258-66. 2005.... - Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteersEric C Donny
Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA
Addiction 100:1496-509. 2005..CONCLUSIONS: These results support other clinical and laboratory-based research indicating that persistent heroin use may be reduced by providing larger methadone maintenance doses that produce more effective cross-tolerance to heroin... - Trajectories of smoking among freshmen college students with prior smoking history and risk for future smoking: data from the University Project Tobacco Etiology Research Network (UpTERN) studyCraig R Colder
Department of Psychology, State University of New York, University at Buffalo, Buffalo, NY, USA
Addiction 103:1534-43. 2008..Little is known about smoking during the transition to college. The current study examined trajectories of smoking among college freshmen, how trajectories predicted later smoking and the social context of smoking... - High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humansEric C Donny
Behavioral Pharmacology Research Unit, Department of Psychiatry, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 161:202-12. 2002..The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin... - Assessing the initiation of cocaine self-administration in humans during abstinence: effects of dose, alternative reinforcement, and primingEric C Donny
Behavioral Pharmacology Research Unit, Johns Hopkins School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 172:316-23. 2004..One potential trigger of cocaine-taking is exposure to cocaine (i.e. priming)... - Experimental evidence for a causal relationship between smoking lapse and relapseLaura M Juliano
Department of Psychology, American University, Washington, DC 20016, USA
J Abnorm Psychol 115:166-73. 2006..Smoking outcomes did not differ between nicotine-containing and denicotinized cigarettes. The data suggest that stimulus factors may play an important role in lapse to relapse processes... - Analyzing the acquisition of drug self-administration using growth curve modelsStephanie T Lanza
The Methodology Center, The Pennsylvania State University, 159 South Henderson, University Park, PA 16802, USA
Drug Alcohol Depend 75:11-21. 2004..Growth curve modeling captures the process of acquisition of drug self-administration and facilitates a greater understanding of the individual differences in change in drug-taking behavior over time... - Different lengths of times for progressions in adolescent substance involvementTy A Ridenour
The Pennsylvania State University, Prevention Research Center, State College 16801, United States
Addict Behav 31:962-83. 2006..Females had shorter transition times, though gender differences were small. Some evidence was found for a familial influence on transition times above what was accounted for by differences between substances... - Guidelines on nicotine dose selection for in vivo researchShannon G Matta
Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
Psychopharmacology (Berl) 190:269-319. 2007..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...
Research Grants
- Mechanisms of Smoking ReinforcementEric Donny; Fiscal Year: 2006..Given the grave health consequences of tobacco use, further understanding of the role of nicotine in smoking reinforcement is critically important. ..
- Are Some Regular Smokers Resistant to Nicotine Dependence?Eric Donny; Fiscal Year: 2007..Identifying the mechanisms which account for individual differences in nicotine dependence may highlight novel approaches to both prevention and treatment of nicotine addiction. ..
- Effects of Self-Administered Versus Noncotigent NicotineEric Donny; Fiscal Year: 2009....
- Effects of Self-Administered Versus Noncotigent NicotineERIC CHRISTIAN DONNY; Fiscal Year: 2010....