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Genomes and Genes | Sean P DidionSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetesSean P Didion
Department of Internal Medicine, University of Iowa Carver College of Medicine Iowa City, IA 52242, USA
Stroke 36:342-7. 2005..The goals of this study were to examine the role of superoxide in impaired endothelium-dependent responses and to examine the influence of Rho-kinase on vascular tone in the cerebral microcirculation in type II diabetes...- Ceramide-induced impairment of endothelial function is prevented by CuZn superoxide dismutase overexpressionSean P Didion
Department of Internal Medicine, 2000 Medical Laboratories, Cardiovascular Center, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Arterioscler Thromb Vasc Biol 25:90-5. 2005..The goal of this study was to determine whether overexpression of CuZn superoxide dismutase (SOD) protects against ceramide-induced increases in vascular superoxide and endothelial dysfunction... - Critical role for CuZn-superoxide dismutase in preventing angiotensin II-induced endothelial dysfunctionSean P Didion
Department of Internal Medicine, Cardiovascular Center, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Hypertension 46:1147-53. 2005..These findings provide the first direct evidence that CuZnSOD limits Ang II-mediated impairment of endothelial function and that loss of 1 copy of the CuZnSOD gene is sufficient to enhance Ang II-induced vascular dysfunction... - Cerebral vascular dysfunction in TallyHo mice: a new model of Type II diabetesSean P Didion
Dept of Internal Medicine, The Univ of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Am J Physiol Heart Circ Physiol 292:H1579-83. 2007.... - Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with agingSean P Didion
Department of Internal Medicine, Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City 52242, USA
Hypertension 48:1072-9. 2006.... - Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutaseGary L Baumbach
Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Stroke 37:1850-5. 2006..Reactive oxygen species are believed to be an important determinant of vascular growth. We examined effects of genetic deficiency of copper-zinc superoxide dismutase (CuZnSOD; SOD1) on structure and function of cerebral arterioles... - Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in miceMichael J Ryan
Department of Internal Medicine, Cardiovascular Center, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USA
Hypertension 43:1074-9. 2004..These data demonstrate that the AT1A receptor is required for Ang II-induced changes in carotid artery function... - Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with agingMary L Modrick
Department of Internal Medicine, Carver College of Medicine, University of Iowa, E318 2 GH, Iowa City, IA 52242 1081, USA
Am J Physiol Heart Circ Physiol 296:H1914-9. 2009..Our findings suggest a novel and fundamental role for ANG II and AT(1) receptors in age-induced vascular dysfunction... - Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunctionSean P Didion
Department of Internal Medicine, Division of Cardiovascular Diseases, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1081, USA
Hypertension 54:619-24. 2009.... - IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophyLaura I Schrader
Department of Internal Medicine, Division of Cardiovascular Medicine, 340 G Eckstein Medical Research Building, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Arterioscler Thromb Vasc Biol 27:2576-81. 2007..The goal of this study was to test the hypothesis that IL-6 mediates the increases in superoxide, vascular hypertrophy, and endothelial dysfunction in response to angiotensin II (Ang II)... - Cerebral vascular effects of angiotensin II: new insights from genetic modelsFrank M Faraci
Department of Internal Medicine, Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1081, USA
J Cereb Blood Flow Metab 26:449-55. 2006..There are marked gender differences in cerebral vascular responses to Ang II. Endothelial function is greatly impaired in a genetic model of Ang II-dependent hypertension via a mechanism that involves superoxide... - Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunctionSophocles Chrissobolis
Department of Internal Medicine, Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1081, USA
Hypertension 51:872-7. 2008..Thus, genetic and pharmacological evidence suggests a major role for glutathione peroxidase-1 and hydrogen peroxide in Ang II-induced effects on vascular function... - Overexpression of CuZn-SOD prevents lipopolysaccharide-induced endothelial dysfunctionSean P Didion
Department of Internal Medicine, Cardiovascular Center, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242-1081, USA
Stroke 35:1963-7. 2004..Overexpression of the CuZn isoform of SOD effectively prevents LPS-induced oxidative stress and endothelial dysfunction in the carotid artery... - Role of hydrogen peroxide and the impact of glutathione peroxidase-1 in regulation of cerebral vascular toneMary L Modrick
Department of Internal Medicine, Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1081, USA
J Cereb Blood Flow Metab 29:1130-7. 2009..In contrast, cerebral vascular responses to the endothelium-dependent agonist acetylcholine are not mediated by H2O2... - Increased superoxide and vascular dysfunction in CuZnSOD-deficient miceSean P Didion
Department of Internal Medicine, Cardiovascular Center, The University of Iowa College of Medicine, Iowa City, Iowa 52242 1081, USA
Circ Res 91:938-44. 2002..CuZnSOD-deficiency results in altered responsiveness in both large arteries and microvessels... - Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogenSean P Didion
Department of Internal Medicine, Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242, USA
Am J Physiol Heart Circ Physiol 283:H1569-76. 2002..These results suggest that increased superoxide contributes to impaired nitric oxide-mediated relaxation in this genetic model of chronic angiotensin II-dependent hypertension... - PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic miceMichael J Ryan
Ph D Professor, Department of Internal Medicine, 3181 MERF, University of Iowa, Department of Internal Medicine Iowa City, IA 52242, USA
Hypertension 43:661-6. 2004..These data suggest that in addition to potential genomic regulation caused by PPARgamma activation, the direct effect of rosiglitazone in blood vessels may contribute to the improved blood pressure and vessel function... - Angiotensin II produces superoxide-mediated impairment of endothelial function in cerebral arteriolesSean P Didion
Department of Internal Medicine, Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242-1081, USA
Stroke 34:2038-42. 2003..CONCLUSIONS: These findings are the first evidence that local Ang II produces superoxide-mediated vascular dysfunction in cerebral microvessels. The results with DPI suggest that the source of superoxide may be an NAD(P)H oxidase... - Effect of aging, MnSOD deficiency, and genetic background on endothelial function: evidence for MnSOD haploinsufficiencyKathryn A Brown
Departments of Pharmacology, Cardiovascular Center, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
Arterioscler Thromb Vasc Biol 27:1941-6. 2007..The goal of this study was to compare vascular function, superoxide levels, and MnSOD protein expression in young (4 to 7 months) and old (22 to 24 months) MnSOD+/+ and MnSOD-deficient (MnSOD+/-) mice... - Vascular protection: superoxide dismutase isoforms in the vessel wallFrank M Faraci
Department of Internal Medicine, Cardiovascular Center, University of Iowa, Carver College of Medicine, Iowa City, IA 52242 1081, USA
Arterioscler Thromb Vasc Biol 24:1367-73. 2004..This area is important because reactive oxygen species and superoxide anion are thought to play major roles in changes in vascular structure and function in pathophysiology... - Endothelial dysfunction and blood pressure variability in selected inbred mouse strainsMichael J Ryan
Department of Internal Medicine, Cardiovascular Center, University of Iowa, Iowa City 52242, USA
Arterioscler Thromb Vasc Biol 22:42-8. 2002..Although the data do not support the initial hypothesis, the impaired aortic response to ACh in the 129 strains is a novel finding and illustrates the potential impact that genetic background can have on vascular responsiveness... - Effects of NADH and NADPH on superoxide levels and cerebral vascular toneSean P Didion
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Am J Physiol Heart Circ Physiol 282:H688-95. 2002..These data suggest that NADH- and NADPH-induced changes in cerebral vascular tone are mediated by superoxide, produced by a flavin-containing enzyme, most likely NAD(P)H oxidase, but not xanthine oxidase or nitric oxide synthase... - Chlamydophila pneumoniae and endothelial activation: the smoke that precedes the fire of atherosclerosis?Sean P Didion
Circ Res 102:861-3. 2008