Research Topics
Genomes and Genes
| Ramon Diaz-ArrastiaSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Evolving treatment strategies for epilepsyRamon Diaz-Arrastia
Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Room F2.302, Dallas, TX 75390-9036, USA
JAMA 287:2917-20. 2002- Usefulness of the abbreviated injury score and the injury severity score in comparison to the Glasgow Coma Scale in predicting outcome after traumatic brain injuryBrandon P Foreman
University of Texas Southwestern Medical Center at Dallas, USA
J Trauma 62:946-50. 2007..We aimed to analyze the usefulness of the head abbreviated injury score (AIS), the injury severity score (ISS), and the Glasgow Coma Scale (GCS) as measures of injury severity and predictors of outcome after traumatic brain injury (TBI)... - Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 alleleRamon Diaz-Arrastia
Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Arch Neurol 60:818-22. 2003..Inheritance of the apolipoprotein E (APOE) epsilon4 allele is associated with increased risk of Alzheimer disease, progression to disability in multiple sclerosis, and poor outcome after traumatic brain injury... - Host genetic polymorphisms in human immunodeficiency virus-related neurologic diseaseRamon Diaz-Arrastia
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
J Neurovirol 10:67-73. 2004..Future studies will require much larger sample sizes and technical advances to allow screening at larger number of candidate loci... - Genetic factors in outcome after traumatic brain injury: what the human genome project can teach us about brain traumaRamon Diaz-Arrastia
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Head Trauma Rehabil 21:361-74. 2006..We conclude that although genetic advances have implications for prognosis, their biggest contribution will be to elucidate the pathophysiology of TBI, potentially leading to new treatments... - Posttraumatic epilepsy: the endophenotypes of a human model of epileptogenesisRamon Diaz-Arrastia
Department of Neurology, University of Texas Southwestern Medical Center, Comprehensive Epilepsy Center, Parkland Memorial Hospital, Dallas, Texas 75390 9036, USA
Epilepsia 50:14-20. 2009..It is likely that better understanding of the subtypes of epilepsy resulting from brain trauma will be required to successfully identify antiepileptogenic therapies... - Regionally selective atrophy after traumatic axonal injuryMatthew A Warner
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
Arch Neurol 67:1336-44. 2010..To determine the spatial distribution of cortical and subcortical volume loss in patients with diffuse traumatic axonal injury and to assess the relationship between regional atrophy and functional outcome... - Brain-derived neurotrophic factor levels in Alzheimer's diseaseSid E O'Bryant
Texas Tech University Health Science Center, Department of Neurology, 3601 4th St STOP 8321, Lubbock, TX 79430, USA
J Alzheimers Dis 17:337-41. 2009..It is likely that the most accurate approach to identifying biomarkers of AD will be through an algorithmic approach that combines multiple markers reflective of various pathways... - Ethnic disparities exist in trauma careShahid Shafi
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Trauma 63:1138-42. 2007..Ethnic disparities in access to health care have been documented in other diseases, but have not been studied in trauma care. We hypothesized that access to rehabilitation after TBI is influenced by race or ethnicity... - A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderlyApril J Ho
Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:8404-9. 2010..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - Assessing spatial relationships between axonal integrity, regional brain volumes, and neuropsychological outcomes after traumatic axonal injuryMatthew A Warner
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
J Neurotrauma 27:2121-30. 2010..Our results suggest that TAI may be a primary mechanism of post-traumatic atrophy, and provide support for regional morphometry as a biomarker for cognitive outcome after injury... - Functional outcome scales in traumatic brain injury: a comparison of the Glasgow Outcome Scale (Extended) and the Functional Status ExaminationAnne M Hudak
Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9055, USA
J Neurotrauma 22:1319-26. 2005..The majority of the variance in outcome is not accounted for by currently available measures of injury severity... - Serum brain-derived neurotrophic factor levels are specifically associated with memory performance among Alzheimer's disease casesSid E O'Bryant
Department of Neurology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
Dement Geriatr Cogn Disord 31:31-6. 2011..Our purpose was to study the link between serum brain-derived neurotrophic factor (BDNF) levels and neuropsychological functioning through the Texas Alzheimer's Research Consortium cohort... - Ethnic differences in rehabilitation placement and outcome after TBICarlos Marquez de la Plata
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Head Trauma Rehabil 22:113-21. 2007..To determine whether race/ethnicity and proficiency with the English language influence access to rehabilitation services, and ultimately outcome after traumatic brain injury (TBI)... - Magnetic resonance imaging of diffuse axonal injury: quantitative assessment of white matter lesion volumeCarlos Marquez de la Plata
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
J Neurotrauma 24:591-8. 2007..Patients with greater DAI volume have poorer functional outcomes. These methods may be useful in stratifying injury severity and for the assessment of DAI-directed therapies... - Racial disparities in long-term functional outcome after traumatic brain injuryShahid Shafi
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9158, USA
J Trauma 63:1263-8; discussion 1268-70. 2007..We hypothesized that access to acute rehabilitation and long-term functional outcomes among traumatic brain injury (TBI) patients are influenced by patient race and ethnicity... - Brain morphometry changes and depressive symptoms after traumatic brain injuryAnne Hudak
Dept of Physical Medicine and Rehabilitation, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9055, USA
Psychiatry Res 191:160-5. 2011..Regions associated with depressive symptoms in this pilot study were similar to those implicated in study of spontaneous depression... - Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's diseaseUma S Yezhuvath
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neurobiol Aging 33:75-82. 2012..004). Our data suggest that early AD subjects have evidence of significant forebrain vascular contractility deficits. The localization, while differing from CBF findings, appears to be spatially similar to PIB amyloid imaging findings... - A serum protein-based algorithm for the detection of Alzheimer diseaseSid E O'Bryant
Texas Tech University Health Science Center, Department of Neurology, Lubbock, TX 79430, USA
Arch Neurol 67:1077-81. 2010..To develop an algorithm that separates patients with Alzheimer disease (AD) from controls... - Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injuryAnne M Hudak
Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Head Trauma Rehabil 19:290-5. 2004..However, as such therapy is frequently ineffective, we studied the usefulness of prolonged video electroencephalogram (VEEG) monitoring in the clinical management of paroxysmal behaviors in TBI survivors... - Decreased C-reactive protein levels in Alzheimer diseaseSid E O'Bryant
Department of Neurology, F Marie Hall Institute for Rural and Community Health, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
J Geriatr Psychiatry Neurol 23:49-53. 2010..However, for a subgroup of patients with AD, elevated CRP continues to predict increased dementia severity suggestive of a possible proinflammatory endophenotype in AD... - Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiativeOwen Carmichael
Department of Neurology, School of Medicine, University of California, Davis, CA, USA
Arch Neurol 67:1370-8. 2010.... - Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular diseaseJohn D Rogers
Yarmen Center for Parkinson's Disease, Department of Neurology, Beth Israel Medical Center, New York, NY, USA
Arch Neurol 60:59-64. 2003..These findings have implications for the treatment of PD in patients at risk for vascular disease, and potentially for those at risk for dementia and depression... - Cerebral atrophy after traumatic white matter injury: correlation with acute neuroimaging and outcomeKan Ding
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
J Neurotrauma 25:1433-40. 2008..Our findings suggest that axonal pathology measured as white matter lesions following TBI can be identified using MRI, and may be a useful measure for DAI-directed therapies... - Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrityJinsoo Uh
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
Neurobiol Aging 31:2038-46. 2010..These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity... - Brain MRI, apoliprotein E genotype, and plasma homocysteine in American Indian Alzheimer disease patients and Indian controlsMyron F Weiner
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9129, USA
Curr Alzheimer Res 6:52-8. 2009..In combined AD subjects and controls, WBV correlated with BMI and age. WMHV and WMHV/WBV correlated inversely with MMSE scores (p = 0.001, 0.002, respectively). In addition, WMHV correlated positively with % Indian heritage (p = 0.047)... - Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injuryMyron F Weiner
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Brain Inj 22:611-5. 2008..To determine if plasma levels of 24S-hydroxycholesterol, the primary catabolite of brain cholesterol, provide a measure of axonal damage in acute brain trauma... - A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer diseasePaul S Aisen
Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA
Am J Geriatr Psychiatry 11:246-9. 2003..CONCLUSION: High-dose vitamin supplementation reduces homocysteine levels in patients with AD. The effect of supplementation on rate of cognitive decline will be assessed later in a randomized, double-blind study... - Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injuryCarlos D Marquez de la Plata
Center for Brain Health, University of Texas at Dallas, Richardson, USA
Arch Neurol 68:74-84. 2011..To examine the functional connectivity of hippocampal and selected frontal lobe circuits in patients with traumatic axonal injury (TAI)... - Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errorsKyle B Womack
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9129, USA
Arch Neurol 68:329-37. 2011.... - Impact of age on long-term recovery from traumatic brain injuryCarlos D Marquez de la Plata
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Arch Phys Med Rehabil 89:896-903. 2008..To determine whether older persons are at increased risk for progressive functional decline after traumatic brain injury (TBI)... - Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's diseasePadraig E O'Suilleabhain
Department of Neurology, University of Texas Southwestern Medical School, Dallas, Texas, USA
Mov Disord 19:1403-8. 2004..Levodopa elevates tHcy and lowers vitamin B12 concentration to modest degrees. The clinical implications, if any, have not yet been determined... - Clinical course in Parkinson's disease with elevated homocysteinePadraig E O'Suilleabhain
Department of Neurology, Southwestern Medical Center at Dallas, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
Parkinsonism Relat Disord 12:103-7. 2006..03). We conclude that hyperhomocysteinemia does not predict significantly worse progression over 2 years in early PD. The data raised the possibility of higher mortality, but the number of deaths was small... - Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associationsPadraig E O'Suilleabhain
Department of Neurology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Arch Neurol 61:865-8. 2004..An Hcy elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hcy level in patients with PD is unknown... - A comprehensive reliability assessment of quantitative diffusion tensor tractographyJun Yi Wang
School of Brain and Behavioral Sciences, University of Texas at Dallas, Dallas, TX, USA
Neuroimage 60:1127-38. 2012..Increasing the number of gradient directions from 15 to 30 with equivalent scan time reduced variability whereas increasing repetition from 1 to 2 for 30-direction DTI improved the accuracy of tractography measurements... - Serum biomarkers for Alzheimer's disease: proteomic discoveryDwight C German
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
Biomed Pharmacother 61:383-9. 2007..The identification of these peptides/proteins, and their direct measurement in patient serum, may allow the development of a simple, cost-effective test for AD... - Deep venous thrombosis management following traumatic brain injury: a practice survey of the traumatic brain injury model systemsMary C Carlile
Department of Physical Medicine and Rehabilitation, Baylor Institute for Rehabilitation, Dallas, TX 75246, USA
J Head Trauma Rehabil 21:483-90. 2006..To determine national patterns of screening, prophylaxis, and treatment of deep venous thrombosis (DVT) following traumatic brain injury (TBI) within the Traumatic Brain Injury Model Systems (TBIMS)... - Prophylaxis for venous thromboembolism during rehabilitation for traumatic brain injury: a multicenter observational studyMary Carlile
North Texas Traumatic Brain Injury Model System, Baylor Institute for Rehabilitation, Dallas, Texas 75246, USA
J Trauma 68:916-23. 2010..Deep venous thrombosis (DVT) is a major cause of mortality and morbidity after traumatic brain injury (TBI). There is no consensus regarding appropriate screening, prophylaxis, or treatment during acute rehabilitation... - Voxelwise genome-wide association study (vGWAS)Jason L Stein
Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
Neuroimage 53:1160-74. 2010..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure... - Intracranial pressure monitoring in brain-injured patients is associated with worsening of survivalShahid Shafi
Division of Burns, Department of Surgery, Trauma Critical Care, University of Texas Southwestern Medical School, Dallas, Texas, USA
J Trauma 64:335-40. 2008..However, benefits of ICP monitoring have not been documented. We hypothesized that BTF criteria for ICP monitoring in blunt TBI do not identify patients who are likely to benefit from it... - Postinjury employment as a surrogate for functional outcomes: a quality indicator for trauma systemsJennifer K Parks
Department of Surgery, Division of Burns, Trauma, Surgical Critical Care Parks, Gentilello and the Department of Neurology Diaz Arrastia, The University of Texas Southwestern Medical Center, Dallas, Texas and the Institute for Health Care Research and Improvement, Baylor Health Care System, Dallas, Texas Shafi
Proc (Bayl Univ Med Cent) 23:355-8. 2010..Once validated in other studies, postinjury employment may be used as an indicator to monitor functional outcomes in trauma registries... - Vascular disease and risk factors, rate of progression, and survival in Alzheimer's diseaseDeepika Bhargava
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
J Geriatr Psychiatry Neurol 19:78-82. 2006.... - Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factorsClaudia Erbel-Sieler
Departments of Biochemistry and Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 101:13648-53. 2004..These observations raise the possibility that a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis... - Arterial-cardiac baroreflex function: insights from repeated squat-stand maneuversRong Zhang
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center, Dallas, TX 75231, USA
Am J Physiol Regul Integr Comp Physiol 297:R116-23. 2009..Furthermore, baroreflex function can be assessed using the transfer function method during large perturbations in arterial pressure... - Transfusions and long-term functional outcomes in traumatic brain injuryMatthew A Warner
Department of Neurology, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Texas, USA
J Neurosurg 113:539-46. 2010..While evidence suggests that transfusions are associated with poor hospital outcomes, no study has examined transfusions and long-term functional outcomes in this population. The preferred transfusion threshold remains controversial... - Development of the Texas Spanish Naming Test: a test for Spanish speakersCarlos Marquez de la Plata
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
Clin Neuropsychol 22:288-304. 2008..Results support the clinical utility of the TNT when dementia among Spanish speakers is suspected... - Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulationEstelle Sontag
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:2751-9. 2007..The link between homocysteine, PPMT, PP2A methylation, and key CNS proteins involved in AD pathogenesis provides new mechanistic insights into this disorder... - Effect of alcohol on Glasgow Coma Scale in head-injured patientsLance Stuke
Department of Surgery, Division of Burns, Trauma and Surgical Critical Care, University of Texas Southwestern Medical School, Dallas, TX 75390 9158, USA
Ann Surg 245:651-5. 2007..The purpose of this study was to test the hypothesis that the presence of blood alcohol has a clinically significant impact on GCS in TBI patients... - Waiting for the patient to "sober up": Effect of alcohol intoxication on glasgow coma scale score of brain injured patientsJason L Sperry
Division of Burns, Trauma and Surgical Critical Care, Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390-9158, USA
J Trauma 61:1305-11. 2006..Hence, alterations in GCS score after TBI should not be attributed to alcohol intoxication, as doing so might result in inappropriate delays in monitoring and therapeutic interventions...
Research Grants
- Phase II, randomized controlled trial of brain tissue oxygen monitoringRamon Diaz Arrastia; Fiscal Year: 2009....
- Traumatic Brain Injury Clinical Trials NetworkRamon Diaz Arrastia; Fiscal Year: 2007..The concept proposal aims to determine whether aggressive treatment of NCS results in improved functional outcome. ..
- Genetic factors in outcome from traumatic brain injuryRamon Diaz Arrastia; Fiscal Year: 2007..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
- Hyperhomocysteinemia in Alzheimer's DiseaseRamon Diaz Arrastia; Fiscal Year: 2003..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
- Candidate genetic polymorphisms/ HIV-associated dementiaRamon Diaz Arrastia; Fiscal Year: 2002..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
- Phase II, randomized controlled trial of brain tissue oxygen monitoringNancy R Temkin; Fiscal Year: 2010....