R Detels

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Early versus deferred zidovudine monotherapy: impact on AIDS-free time and survival in the multicenter AIDS cohort study
    R Detels
    Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095 1772, USA
    Antivir Ther 2:21-9. 1997
  2. ncbi Methods to assess population effectiveness of therapies in human immunodeficiency virus incident and prevalent cohorts
    P M Tarwater
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 154:675-81. 2001
  3. ncbi Increase and plateau of CD4 T-cell counts in the 3(1/2) years after initiation of potent antiretroviral therapy
    P M Tarwater
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 27:168-75. 2001
  4. ncbi Effectiveness of potent antiretroviral therapies on the incidence of opportunistic infections before and after AIDS diagnosis
    R Detels
    School of Public Health, University of California, Los Angeles, 90095 1772, USA
    AIDS 15:347-55. 2001
  5. ncbi Longitudinal patterns of HIV type 1 RNA among individuals with late disease progression
    S J Gange
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 17:1223-9. 2001
  6. ncbi Determinants of heterogeneous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study
    C A Kleeberger
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 26:82-92. 2001
  7. ncbi Thrush and fever as markers of immune competence in the era of highly active antiretroviral therapy
    R L Skolasky
    Department of Epidemiology, Johns Hopkins University School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 17:1311-6. 2001
  8. ncbi Identification of inflections in T-cell counts among HIV-1-infected individuals and relationship with progression to clinical AIDS
    S J Gange
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:10848-53. 1998
  9. ncbi Therapy naivete in the era of potent antiretroviral therapy
    L P Jacobson
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Clin Epidemiol 54:149-56. 2001
  10. ncbi Protease inhibitors and cardiovascular disease: analysis of the Los Angeles County adult spectrum of disease cohort
    G Vaughn
    UCLA School of Public Health, Epidemiology, Los Angeles, USA
    AIDS Care 19:492-9. 2007

Collaborators

Detail Information

Publications26

  1. ncbi Early versus deferred zidovudine monotherapy: impact on AIDS-free time and survival in the multicenter AIDS cohort study
    R Detels
    Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095 1772, USA
    Antivir Ther 2:21-9. 1997
    ..The analytical technique used is applicable to other observational studies of treatment...
  2. ncbi Methods to assess population effectiveness of therapies in human immunodeficiency virus incident and prevalent cohorts
    P M Tarwater
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 154:675-81. 2001
    ..38), and 0.31 (95% CI: 0.21, 0.45). These results extend the measurement of population effectiveness from incident to prevalent cohorts and demonstrate the ability of cohort studies to complement information provided by clinical trials...
  3. ncbi Increase and plateau of CD4 T-cell counts in the 3(1/2) years after initiation of potent antiretroviral therapy
    P M Tarwater
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 27:168-75. 2001
    ..The single most important predictor of the steady state CD4 cell count that was maintained between 2 and 3(1/2) years after initiation was the change in plasma HIV-RNA in the first year after initiation of potent ART...
  4. ncbi Effectiveness of potent antiretroviral therapies on the incidence of opportunistic infections before and after AIDS diagnosis
    R Detels
    School of Public Health, University of California, Los Angeles, 90095 1772, USA
    AIDS 15:347-55. 2001
    ..To determine the effectiveness of potent antiretroviral therapy in reducing opportunistic infections (OI) as both a presenting event and subsequent to an AIDS-defining event...
  5. ncbi Longitudinal patterns of HIV type 1 RNA among individuals with late disease progression
    S J Gange
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 17:1223-9. 2001
    ..8 years prior to the onset of AIDS. These results provide evidence that an increase in the slope of plasma levels of HIV RNA is a sign of incipient progression of HIV disease...
  6. ncbi Determinants of heterogeneous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study
    C A Kleeberger
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 26:82-92. 2001
    ..Identification of individuals with characteristics associated with lower adherence provides the basis for interventions to enhance adherence and optimize effective therapies...
  7. ncbi Thrush and fever as markers of immune competence in the era of highly active antiretroviral therapy
    R L Skolasky
    Department of Epidemiology, Johns Hopkins University School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 17:1311-6. 2001
    ..These results provide evidence that increases in CD4+ T cell count due to HAART represent a reconstitution of immune function...
  8. ncbi Identification of inflections in T-cell counts among HIV-1-infected individuals and relationship with progression to clinical AIDS
    S J Gange
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:10848-53. 1998
    ....
  9. ncbi Therapy naivete in the era of potent antiretroviral therapy
    L P Jacobson
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Clin Epidemiol 54:149-56. 2001
    ..In this era of effective ART, use was not universal. Besides disease markers, these nonclinical determinants need to be considered for promoting population therapy effectiveness...
  10. ncbi Protease inhibitors and cardiovascular disease: analysis of the Los Angeles County adult spectrum of disease cohort
    G Vaughn
    UCLA School of Public Health, Epidemiology, Los Angeles, USA
    AIDS Care 19:492-9. 2007
    ..Clinicians should monitor treatment of HIV-infected patients for adverse CVD events, and consider alternate forms of drug therapy and CVD-preventing drugs, particularly for those with a personal or family history of CVD...
  11. ncbi Fraction of cases of acquired immunodeficiency syndrome prevented by the interactions of identified restriction gene variants
    M J Silverberg
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 159:232-41. 2004
    ..Additional research is needed to identify AIDS restriction genes with stronger and long-lasting protection to better characterize the genetic epidemiology of HIV-1...
  12. ncbi AIDS diagnosis and depression in the Multicenter AIDS Cohort Study: the ameliorating impact of pet ownership
    J M Siegel
    University of California, Los Angeles, USA
    AIDS Care 11:157-70. 1999
    ..This beneficial effect of pet ownership occurred principally among persons who reported fewer confidants. These results suggest that by enhancing companionship for some HIV-infected persons, pets may buffer the stressful impact of AIDS...
  13. ncbi Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration. Multicenter AIDS Cohort Study Investigators
    R Detels
    School of Public Health, University of California, Los Angeles 90095 1772, USA
    JAMA 280:1497-503. 1998
    ..Cohort studies following up persons with human immunodeficiency virus (HIV) infection in periods characterized by different therapies offer the opportunity to estimate therapy effectiveness at the population level...
  14. ncbi Oral fluids as an alternative to serum for measurement of markers of immune activation
    P Nishanian
    Center for Interdisciplinary Research in Immunology and Disease, Jonsson Comprehensive Cancer Center, School of Medicine, University of California at Los Angeles, 90095 1747, USA
    Clin Diagn Lab Immunol 5:507-12. 1998
    ....
  15. ncbi Evaluation of the effectiveness of highly active antiretroviral therapy in persons with human immunodeficiency virus using biomarker-based equivalence of disease progression
    L P Jacobson
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 155:760-70. 2002
    ....
  16. ncbi The effects of establishment practices, knowledge and attitudes on condom use among Filipina sex workers
    D E Morisky
    University of California, Los Angeles, USA, School of Public Health, Center for Health Sciences 90095 1772, USA
    AIDS Care 10:213-20. 1998
    ..The preliminary findings point to the importance of an intervention that stresses changes in establishment policies and expectations as a means of reducing risk behaviours associated with HIV/STD transmission...
  17. ncbi Factors associated with HIV infection among Indian women
    P Ghosh
    Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA
    Int J STD AIDS 22:140-5. 2011
    ..Empowerment of women is fundamental to HIV/AIDS prevention in India...
  18. ncbi Stigmatization and shame: consequences of caring for HIV/AIDS patients in China
    L Li
    University of California, Los Angeles, CA 90024, USA
    AIDS Care 19:258-63. 2007
    ....
  19. ncbi Do STD clinics correctly diagnose STDs? An assessment of STD management in Hefei, China
    H Liu
    School of Public Health, University of California, Los Angeles, CA 90095- 1772, USA
    Int J STD AIDS 14:665-71. 2003
    ..Over half of those previously infected had not received education to prevent reinfection. Thus, the quality of clinic laboratory testing was not high and physicians often misdiagnosed STDs...
  20. ncbi Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study
    D H McDermott
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    AIDS 14:2671-8. 2000
    ..To examine whether polymorphism in the RANTES gene is associated with HIV disease outcome...
  21. ncbi Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study
    W S Modi
    SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Genes Immun 6:691-8. 2005
    ..63, P=0.01). In the MACS cohort, rs1801157 was associated with AIDS-87 (RH=0.31, P=0.02) and with death (RH=0.18, P=0.02). Significant associations to a single disease outcome were found for two SNPs and one haplotype in AA...
  22. ncbi Cross-sectional study of sexual behaviour and knowledge about HIV among urban, rural, and minority residents in Viet Nam
    T D Bui
    National Institute for Hygiene and Epidemiology, Hanoi, Viet Nam
    Bull World Health Organ 79:15-21. 2001
    ..If this happens, the potential for HIV to be spread through heterosexual sex will increase...
  23. ncbi Prevalence of HIV infection among former commercial plasma donors in rural eastern China
    Z Wu
    National Center for AIDS Prevention and Control, Chinese Academy of Preventive Medicine, Beijing, People's Republic of China
    Health Policy Plan 16:41-6. 2001
    ..Other countries can benefit from the experience of China in reducing the risk of HIV transmission from plasma donating...
  24. ncbi HIV-1 IgA specific serum antibodies and disease progression during HIV-1 infection
    M Margalith
    Virology Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
    J Hum Virol 4:269-77. 2001
    ..CONCLUSIONS: HIV-1 IgA serum antibodies did not predict the progression of the disease. Correlation between HIV-1 IgA antibodies titer, viral load, and CD4 cell counts was not detected...
  25. ncbi Risk factors for HIV-1 seropositivity in drug users under 30 years old in Haiphong, Vietnam
    T A Nguyen
    National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    Addiction 96:405-13. 2001
    ..Interventions through public sexually transmitted infection (STI) clinics are unlikely to have much impact, as only 16% of IDUs with an STI attended a public STI clinic...
  26. ncbi The role of epidemiology in challenging the HIV/AIDS pandemic
    R Detels
    University of California, Los Angeles School of Public Health, USA
    J Epidemiol 11:95-102. 2001
    ..Examples of the application of these epidemiologic strategies are presented...