Roberta L Debiasi

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Use of PCR for the diagnosis of herpesvirus infections of the central nervous system
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, CO 80262, USA
    J Clin Virol 25:S5-11. 2002
  2. ncbi Molecular methods for diagnosis of viral encephalitis
    Roberta L Debiasi
    Department of Pediatrics, Division of Infectious Diseases, University of Colorado Health Sciences Center, Box A036 B055, Denver, CO 80262, USA
    Clin Microbiol Rev 17:903-25, table of contents. 2004
  3. ncbi Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo
    Roberta L Debiasi
    Pediatrics Infectious Diseases, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B055, Denver, CO 80262, USA
    J Virol 78:11040-50. 2004
  4. ncbi Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system
    Cristen C Hoyt
    Department of Neurology (B-182, University of Colorado Health Sciences Center, 4200 E. 9th Ave, Denver, CO 80262, USA
    J Virol 79:2743-53. 2005
  5. ncbi Critical role for death-receptor mediated apoptotic signaling in viral myocarditis
    Roberta L Debiasi
    Department of Pediatrics, Children s National Medical Center and George Washington University School of Medicine, Washington, DC 20010, USA
    J Card Fail 16:901-10. 2010
  6. ncbi MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts
    Bruce D Cuevas
    Department of Pharmacology, Craniofacial Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    EMBO J 22:3346-55. 2003
  7. ncbi Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 77:8934-47. 2003
  8. ncbi Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    J Infect Dis 186:1547-57. 2002
  9. ncbi Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype
    Shelley D Miyamoto
    Department of Pediatrics, University of Colorado Denver Health Sciences Center, Denver, Colorado, USA
    J Card Fail 15:529-39. 2009
  10. ncbi Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS
    Sarah M Richardson-Burns
    Neuroscience Program, University of Colorado Health Sciences Center, Denver Veterans Affairs Medical Center, 80262, USA
    Arch Neurol 59:1930-6. 2002

Research Grants

  1. Apoptotic Signaling in Viral Myocarditis
    Roberta DeBiasi; Fiscal Year: 2005

Detail Information

Publications12

  1. ncbi Use of PCR for the diagnosis of herpesvirus infections of the central nervous system
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, 80262, Denver, CO 80262, USA
    J Clin Virol 25:S5-11. 2002
    ..This review summarizes the role of CSF PCR in the diagnosis and therapeutic management of herpesvirus infections of the nervous system, particularly those caused by HSV and VZV...
  2. ncbi Molecular methods for diagnosis of viral encephalitis
    Roberta L Debiasi
    Department of Pediatrics, Division of Infectious Diseases, University of Colorado Health Sciences Center, Box A036 B055, Denver, CO 80262, USA
    Clin Microbiol Rev 17:903-25, table of contents. 2004
    ....
  3. ncbi Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo
    Roberta L Debiasi
    Pediatrics Infectious Diseases, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B055, Denver, CO 80262, USA
    J Virol 78:11040-50. 2004
    ....
  4. ncbi Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system
    Cristen C Hoyt
    Department of Neurology (B-182, University of Colorado Health Sciences Center, 4200 E. 9th Ave, Denver, CO 80262, USA
    J Virol 79:2743-53. 2005
    ..These results demonstrate that sigma1s is a determinant of the magnitude and extent of reovirus-induced apoptosis in both the heart and CNS and thereby contributes to reovirus pathogenesis and virulence...
  5. ncbi Critical role for death-receptor mediated apoptotic signaling in viral myocarditis
    Roberta L Debiasi
    Department of Pediatrics, Children s National Medical Center and George Washington University School of Medicine, Washington, DC 20010, USA
    J Card Fail 16:901-10. 2010
    ..The apoptotic signaling pathways that are activated during viral myocarditis and the role that these pathways play in disease pathogenesis have not been clearly delineated...
  6. ncbi MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts
    Bruce D Cuevas
    Department of Pharmacology, Craniofacial Biology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    EMBO J 22:3346-55. 2003
    ..Inhibition of ERK1/2 or calpain, but not of JNK, mimics MEKK1 deficiency. Therefore, MEKK1 regulates calpain-mediated substratum release of migrating fibroblasts...
  7. ncbi Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 77:8934-47. 2003
    ..This provides the first comparative analysis of altered gene expression after infection with viruses of differing apoptotic phenotypes and provides insight into pathogenic mechanisms of virus-induced disease...
  8. ncbi Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262, USA
    J Infect Dis 186:1547-57. 2002
    ..These results suggest that neuronal apoptosis is an important contributing factor to acute CNS injury and may serve as a novel therapeutic target in these patients...
  9. ncbi Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype
    Shelley D Miyamoto
    Department of Pediatrics, University of Colorado Denver Health Sciences Center, Denver, Colorado, USA
    J Card Fail 15:529-39. 2009
    ..The pathophysiologic mechanisms underlying viral myocarditis are not well defined. As a result, effective treatments do not exist and viral myocarditis remains a potentially lethal infection of the heart...
  10. ncbi Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS
    Sarah M Richardson-Burns
    Neuroscience Program, University of Colorado Health Sciences Center, Denver Veterans Affairs Medical Center, 80262, USA
    Arch Neurol 59:1930-6. 2002
    ..Accumulation of viral particles in nuclei of infected cells made it difficult to identify morphologic changes in the nucleus typically associated with apoptosis...
  11. ncbi Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the Oka varicella-zoster virus vaccine
    Myron J Levin
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80045 0508, USA
    J Infect Dis 198:1444-7. 2008
    ..The presence of distinct strains in skin lesions and cerebrospinal fluid indicate that >1 variant strain may reactivate to cause herpes zoster...
  12. ncbi West Nile virus meningoencephalitis
    Roberta L Debiasi
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Nat Clin Pract Neurol 2:264-75. 2006
    ..In this review, we discuss epidemiology, risk factors, clinical features, diagnosis and prognosis of WNV meningoencephalitis, along with potential treatments...

Research Grants1

  1. Apoptotic Signaling in Viral Myocarditis
    Roberta DeBiasi; Fiscal Year: 2005
    ..Identification of these pathways is critical for the development of novel therapies for viral myocarditis and other diseases involving apoptotic tissue damage. ..