Research Topics
Genomes and Genes | Camin DeanSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive functionCamin Dean
Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
Trends Neurosci 29:21-9. 2006..Here, we review several recent studies that offer clues as to how these proteins form synapses and how they might function in the brain to establish and modify neuronal network properties and cognition...
Neurexin mediates the assembly of presynaptic terminalsCamin Dean
Department of Molecular and Cell Biology, University of California, Berkeley, 271 LSA, California 94720, USA
Nat Neurosci 6:708-16. 2003..In response to this clustering, neurexins nucleate the assembly of a cytoplasmic scaffold to which the exocytotic apparatus is recruited...
Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminalsZhenjie Zhang
Department of Physiology, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, Wisconsin 53706, USA
Nat Neurosci 12:163-71. 2009..Given the neuroendocrine functions of the posterior pituitary, changes in Syt IV levels could be involved in endocrine transitions involving alterations in the release of the neuropeptides oxytocin and vasopressin...
Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin IHuisheng Liu
Howard Hughes Medical Institute and Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 29:7395-403. 2009..Thus, aspects of synaptic transmission differ between autaptic and dissociated cultures, and the synaptic transmission phenotype, resulting from loss of syt-I, is dictated by the connectivity of neurons...
Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF releaseCamin Dean
Department of Physiology, University of Wisconsin, Madison, Wisconsin, USA
Nat Neurosci 12:767-76. 2009..Thus, regulation of BDNF secretion by syt-IV emerges as a mechanism for maintaining synaptic strength in a useful range during LTP...
SV2 is the protein receptor for botulinum neurotoxin AMin Dong
Howard Hughes Medical Institute and Department of Physiology, University of Wisconsin, Madison, WI 53706, USA
Science 312:592-6. 2006..Finally, mice that lacked an SV2 isoform (SV2B) displayed reduced sensitivity to BoNT/A. Thus, SV2 acts as the protein receptor for BoNT/A...
Neuronal activation by GPI-linked neuroligin-1 displayed in synthetic lipid bilayer membranesMichael M Baksh
Department of Chemistry, University of California Berkeley, 94720, USA
Langmuir 21:10693-8. 2005..In addition, the synthetic membrane environment affords control over both lipid and protein composition. This technology is easily implemented and can be applied to a wide variety of cellular studies...
