Research Topics
Species | ROBERT DE LISLESummaryAffiliation: University of Kansas Medical Center Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10Oxana Norkina
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
BMC Genet 6:29. 2005..In this work potential modifier loci of the CF intestinal phenotype were identified...- Caerulein-induced acute pancreatitis in mice that constitutively overexpress Reg/PAP genesOxana Norkina
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas, USA
BMC Gastroenterol 6:16. 2006..These genes are suggested to be involved in protection or recovery from pancreatic injury... - Eradication of small intestinal bacterial overgrowth in the cystic fibrosis mouse reduces mucus accumulationRobert C De Lisle
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
J Pediatr Gastroenterol Nutr 42:46-52. 2006.... - Altered transit and bacterial overgrowth in the cystic fibrosis mouse small intestineRobert C De Lisle
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Am J Physiol Gastrointest Liver Physiol 293:G104-11. 2007..In conclusion, small intestinal transit was significantly slower in CF mice, and this is likely a major factor in SIBO in CF... - Effects of laxative and N-acetylcysteine on mucus accumulation, bacterial load, transit, and inflammation in the cystic fibrosis mouse small intestineRobert C De Lisle
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Am J Physiol Gastrointest Liver Physiol 293:G577-84. 2007..These results suggest that both mucus accumulation and slowed interdigestive small intestinal transit contribute to SIBO in the CF intestine... - Effects of Muclin (Dmbt1) deficiency on the gastrointestinal systemRobert C De Lisle
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Am J Physiol Gastrointest Liver Physiol 294:G717-27. 2008..Thus Muclin deficiency impairs trafficking of regulated proteins to a stimulus-releasable pool in the exocrine pancreas... - Altered eicosanoid metabolism in the cystic fibrosis mouse small intestineRobert C De Lisle
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
J Pediatr Gastroenterol Nutr 47:406-16. 2008..Imbalances in essential fatty acid levels have been reported in cystic fibrosis (CF), which may relate to elevated proinflammatory eicosanoid generation. The aim of this work was to better define eicosanoid metabolism in the CF intestine... - Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouseRobert C De Lisle
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas, United States of America
PLoS ONE 4:e4283. 2009..The aim of this study was to evaluate the potential role of mast cells in gastrointestinal dysmotility using the CF mouse (Cftr(tm1UNC), Cftr knockout)... - Pass the bicarb: the importance of HCO3- for mucin releaseRobert C De Lisle
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
J Clin Invest 119:2535-7. 2009..The authors propose a model whereby CFTR-mediated bicarbonate secretion must be concurrent with mucin exocytosis for proper mucin release... - Enteric circular muscle dysfunction in the cystic fibrosis mouse small intestineR C De Lisle
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS, USA
Neurogastroenterol Motil 22:341-e87. 2010..CONCLUSIONS & INFERENCES These results suggest that the enteric microbiota modulates PGE(2) levels in a complex manner, which affects enteric smooth muscle activity and contributes to slower small intestinal transit in CF... - Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotypeRobert C De Lisle
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
BMC Gastroenterol 10:107. 2010..We investigated whether lubiprostone, which can activate the CLC2 Cl- channel, would improve the intestinal phenotype in CF mice... - MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouseR C De Lisle
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, USA
Gastroenterology 113:521-32. 1997.... - Expression of pro-Muclin in pancreatic AR42J cells induces functional regulated secretory granulesRobert C De Lisle
Anatomy and Cell Biology, MS 3038, University of Kansas School of Medicine, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Am J Physiol Cell Physiol 289:C1169-78. 2005..Overall, the data show that pro-Muclin acts as a sorting receptor that can induce RSG, and that its cytosolic tail is important in this process... - Impaired mucosal barrier function in the small intestine of the cystic fibrosis mouseRobert C De Lisle
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
J Pediatr Gastroenterol Nutr 53:371-9. 2011..Also tested were the effects of exogenous IAP administration... - Bacterial overgrowth in the cystic fibrosis transmembrane conductance regulator null mouse small intestineOxana Norkina
Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
Infect Immun 72:6040-9. 2004..These data suggest that bacterial overgrowth in the CF mouse small intestine has a role in inflammation and contributes to the failure to thrive in this mouse model of CF... - Processing of pro-Muclin and divergent trafficking of its products to zymogen granules and the apical plasma membrane of pancreatic acinar cellsR C De Lisle
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City 66160, USA
Eur J Cell Biol 79:892-904. 2000..We present a working model for pro-Muclin as a Golgi cargo receptor for exocrine secretory granule formation at the trans Golgi network... - Changes in the exocrine pancreas secondary to altered small intestinal function in the CF mouseR C De Lisle
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Am J Physiol Gastrointest Liver Physiol 281:G899-906. 2001.... - Role of sulfated O-linked glycoproteins in zymogen granule formationRobert C De Lisle
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City 66160, USA
J Cell Sci 115:2941-52. 2002.... - Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreasSimran Kaur
Dept of Anatomy and Cell Biology, Univ of Kansas School of Medicine, Kansas City, KS 66160, USA
Am J Physiol Gastrointest Liver Physiol 287:G480-90. 2004..It is concluded that the acidic duodenal pH in CF contributes to the stress on the exocrine pancreas and that normalizing duodenal pH reduces this stress... - Inflammation of the cystic fibrosis mouse small intestineOxana Norkina
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Am J Physiol Gastrointest Liver Physiol 286:G1032-41. 2004..Immune cell infiltration was confirmed histologically by staining for mast cells and neutrophils. These data demonstrate that the CF intestine exhibits an inflammatory state with upregulation of components of the innate immune system... - Binding of the Golgi sorting receptor muclin to pancreatic zymogens through sulfated O-linked oligosaccharidesIgor Boulatnikov
Department of Anatomy, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA
J Biol Chem 279:40918-26. 2004..The behavior of Muclin fulfils the requirement of a Golgi cargo receptor to bind to regulated secretory proteins under the mildly acidic pH conditions that exist in the trans-Golgi network... - Altered posttranslational processing of glycoproteins in cerulein-induced pancreatitisRobert C De Lisle
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Exp Cell Res 308:101-13. 2005.... - Decreased gastric bacterial killing and up-regulation of protective genes in small intestine in gastrin-deficient mouseFrancis J Sun
Laboratory Animal Resources, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Dig Dis Sci 48:976-85. 2003..Bacterial survival is associated with increased expression of muclin and sprr2a in the intestine, indicating that these genes play protective roles in the intestine... - Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilationBrenda S Magenheimer
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Am Soc Nephrol 17:3424-37. 2006.... - Apactin is involved in remodeling of the actin cytoskeleton during regulated exocytosisChanderdeep Tandon
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA
Eur J Cell Biol 83:79-89. 2004..Thus, apactin is involved in remodeling the apical cytoskeleton during regulated exocytosis in a manner controlled by phosphorylation of the apactin C-Tail...
Research Grants
- PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEMROBERT DE LISLE; Fiscal Year: 2003..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
- TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTIONROBERT DE LISLE; Fiscal Year: 2003..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..